biomer and Inflammation

biomer has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for biomer and Inflammation

Article	Year
Biodegradation of a polyurethane in vitro. Journal of biomedical materials research, 1987, Volume: 21, Issue:2 This study examines the effect of in vitro exposure to enzymes on the performance properties of Biomer, a segmented polyetherurethane used in a number of blood-contacting devices such as catheters, heart assist pumps, and chambers for artificial hearts. The ultrathin samples were treated with two proteolytic enzymes, papain and urease, for periods of 1-6 months at 37 degrees C. The treated Biomer samples were subjected to chemical and physical analysis. Effects of biodegradation by the enzymes were assessed by fatigue tests, gel permeation chromatography (GPC), and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) analysis. Papain was found to be more effective in degrading the polymer than urease. Mechanisms for enzymic degradation are proposed. Topics: Biodegradation, Environmental; Chromatography, Gel; Fourier Analysis; In Vitro Techniques; Inflammation; Molecular Weight; Papain; Polyurethanes; Spectrophotometry, Infrared; Stress, Mechanical; Time Factors; Urease	1987
The effects of an enhanced inflammatory reaction on the surface properties of cast Biomer. Journal of biomedical materials research, 1986, Volume: 20, Issue:2 The ability of a biomaterial to withstand the rigors of the harsh biologic environment is an important consideration when considering a material for long-term biomedical applications. Using a cage implant system, the effects of an intense inflammatory reaction on cast Biomer have been investigated. The inflammatory response to cast Biomer was greatly increased by coimplanting Biomer films with a cytotoxic poly(vinyl chloride) (PVC) in rats for a period of 21 days. Cast Biomer films were characterized by weight, advancing contact angle with water in air, attenuated total reflectance infrared spectroscopy and scanning electron microscopy (SEM). The analyses were performed before any treatment, after autoclaving and sonication, and after 21 days implantation with the cytotoxic (PVC) in rats. The results of the study indicated that cast Biomer does not undergo significant chemical degradation when subjected to the effects of an intense inflammatory reaction for 21 days. Implantation does, however, lead to rearrangement that results in a more polar and hydrophilic surface, suggesting that the polymer adapts to the hydrophilic environment of the inflammatory exudate. Topics: Animals; Biocompatible Materials; Female; Inflammation; Polyurethanes; Rats; Rats, Inbred Strains; Surface Properties	1986

Article

Year

Biodegradation of a polyurethane in vitro.

Journal of biomedical materials research, 1987, Volume: 21, Issue:2

This study examines the effect of in vitro exposure to enzymes on the performance properties of Biomer, a segmented polyetherurethane used in a number of blood-contacting devices such as catheters, heart assist pumps, and chambers for artificial hearts. The ultrathin samples were treated with two proteolytic enzymes, papain and urease, for periods of 1-6 months at 37 degrees C. The treated Biomer samples were subjected to chemical and physical analysis. Effects of biodegradation by the enzymes were assessed by fatigue tests, gel permeation chromatography (GPC), and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) analysis. Papain was found to be more effective in degrading the polymer than urease. Mechanisms for enzymic degradation are proposed.

Topics: Biodegradation, Environmental; Chromatography, Gel; Fourier Analysis; In Vitro Techniques; Inflammation; Molecular Weight; Papain; Polyurethanes; Spectrophotometry, Infrared; Stress, Mechanical; Time Factors; Urease

1987

The effects of an enhanced inflammatory reaction on the surface properties of cast Biomer.

Journal of biomedical materials research, 1986, Volume: 20, Issue:2

The ability of a biomaterial to withstand the rigors of the harsh biologic environment is an important consideration when considering a material for long-term biomedical applications. Using a cage implant system, the effects of an intense inflammatory reaction on cast Biomer have been investigated. The inflammatory response to cast Biomer was greatly increased by coimplanting Biomer films with a cytotoxic poly(vinyl chloride) (PVC) in rats for a period of 21 days. Cast Biomer films were characterized by weight, advancing contact angle with water in air, attenuated total reflectance infrared spectroscopy and scanning electron microscopy (SEM). The analyses were performed before any treatment, after autoclaving and sonication, and after 21 days implantation with the cytotoxic (PVC) in rats. The results of the study indicated that cast Biomer does not undergo significant chemical degradation when subjected to the effects of an intense inflammatory reaction for 21 days. Implantation does, however, lead to rearrangement that results in a more polar and hydrophilic surface, suggesting that the polymer adapts to the hydrophilic environment of the inflammatory exudate.

Topics: Animals; Biocompatible Materials; Female; Inflammation; Polyurethanes; Rats; Rats, Inbred Strains; Surface Properties

1986