bimatoprost and Facial-Dermatoses

Topics: 11-beta-Hydroxysteroid Dehydrogenases; Alopecia Areata; Anthralin; Bimatoprost; Cyclopropanes; Dermatologic Agents; Drug Therapy, Combination; Eyebrows; Eyelashes; Facial Dermatoses; Humans; Latanoprost; Minoxidil; Photosensitizing Agents; Prostaglandins F, Synthetic

Background: Hypopigmentation is a common cutaneous manifestation that frequently poses a therapeutic challenge for dermatologists. Current treatments have varying efficacies and rarely provide patients with long-term results. However, new treatments are emerging, and head-to-head studies comparing these treatments are warranted.\ \ Methods & Materials: In this prospective, Institutional Review Board (IRB)-approved, double-blinded study, 40 subjects with moderate to severe hypopigmentation were randomized into 1 of 4 treatment arms; non-ablative fractional laser, ablative fractional laser, ablative fractional laser with laser-assisted delivered bimatoprost, and an epidermal harvesting system.\ \ Results: All patients in this study showed improvement regardless of the treatment modality. The average improvement score was calculated on a 0 to 4 scale, and Group 3 (fractional ablative laser and bimatoprost) was found to have a significantly higher average improvement than all other treatments, with 76% of the patients exhibiting at least a grade 3 (over 50%) improvement over the treatment course. Group 1 (non-ablative fractional) also had a significantly higher average score compared with group 2 (fractional ablative laser).\ \ Conclusion: New and emerging therapies have shown promise in helping re-pigmentation of cutaneous hypopigmentation. In this head-to-head trial, it was shown that laser-assisted delivery of bimatoprost had a greater statistically significant improvement compared with 3 possible treatment modalities for stimulation of pigment in medical and cosmetic hypopigmentation.\ \ J Drugs Dermatol. 2019;18(11):1090-1096.

Topics: Adult; Bimatoprost; Dermatologic Agents; Double-Blind Method; Facial Dermatoses; Female; Humans; Hypopigmentation; Lasers, Solid-State; Male; Melanocytes; Middle Aged; Prospective Studies; Tissue and Organ Harvesting; Treatment Outcome

Vitiligo is one of the commonest pigmentary disorders characterized by destruction of melanocytes.. To evaluate the efficacy of topical bimatoprost ophthalmic solution in stable facial vitiligo.. Eight cases of stable facial vitiligo were treated with bimatoprost 0.03% ophthalmic solution once daily for 12 weeks. Photographic records were taken at 2 weeks follow-up along with dermoscopic (Polarized, 10×) evaluation.. Four cases had excellent repigmentation, two cases had partial repigmentation and two cases had poor response.. Bimatoprost seems to be promising in treating stable vitiligo but large-scale studies are required.

Topics: Administration, Cutaneous; Adolescent; Bimatoprost; Child; Dermoscopy; Facial Dermatoses; Female; Humans; Male; Ophthalmic Solutions; Photography; Skin Pigmentation; Treatment Outcome; Vitiligo