bilobalide has been researched along with Disease Models, Animal in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Akca, M; Gedikli, Ö; Yildirim, M | 1 |
| Li, H; Mao, D; Xu, J; Yu, C; Zhang, L; Zhang, Q | 1 |
| Li, D; Li, K; Wang, J; Wang, Q; Wang, Y; Xie, S; Zhao, J; Zuo, Z | 1 |
| Liu, J; Orange, M; Wu, Z; Yang, B; Yao, M; Yi, F; Zheng, Y; Zhu, H | 1 |
| Fan, X; Gong, X; Ke, H; Li, C; Liu, T; Wang, Q; Xiaoyan, L; Zhang, J | 1 |
| Cao, L; Ma, CG; Miao, Q; Song, LJ; Sui, RX; Wang, J; Wang, Q; Xiao, BG; Xiao, W; Yu, JW | 1 |
| Huang, H; Li, WZ; Wu, WY; Wu, YY; Yin, YY | 1 |
| Dolan, S; Goldie, M | 1 |
| Klein, J; Koch, KA; Schwarzkopf, TM | 1 |
| Jiang, M; Li, J; Liu, W; Liu, Y; Luo, C; Mo, Z; Peng, J; Peng, Q; Yung, KK | 1 |
| Shui, L; Song, Z; Tai, F; Wang, S; Wu, R | 1 |
| Liu, LG; Rong, S; Sun, ZD; Xie, BJ; Xu, JQ; Zhang, L; Zhang, YJ | 1 |
| Klein, J; Lang, D; Schubert-Zsilavecz, M; Ude, C; Wurglics, M | 1 |
| Cho, BJ; Cho, HJ; Choi, SH; Jang, HC; Kang, SM; Kim, HS; Kim, M; Kim, YB; Lim, S; Park, HS; Park, KS; Shin, H; Yoon, JW | 1 |
| Chandrasekaran, K; Chinopoulos, C; Drieu, K; Fiskum, G; Mehrabian, Z; Spinnewyn, B | 1 |
| Buckley, F; Sacks, B | 1 |
| Fei, XF; Gu, ZL; Li, LY; Liang, ZQ; Qin, ZH; Zhao, XL | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
1 trial(s) available for bilobalide and Disease Models, Animal
| Article | Year |
|---|---|
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Furans; Ginkgolides; Hindlimb; Hyperalgesia; Inflammation; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sensory System Agents; Vocalization, Animal | 2013 |
17 other study(ies) available for bilobalide and Disease Models, Animal
| Article | Year |
|---|---|
Investigating the mechanism of action of ginkgolides and bilobalide on absence seizures in male WAG/Rij rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bilobalides; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Antagonists; Ginkgolides; Male; Nicardipine; Rats; Seizures | 2023 |
Bilobalide alleviates IL-17-induced inflammatory injury in ATDC5 cells by downregulation of microRNA-125a.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Survival; Cyclopentanes; Disease Models, Animal; Down-Regulation; Furans; Ginkgo biloba; Ginkgolides; Inflammation; Interleukin-17; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinases; Mice; MicroRNAs; Molecular Mimicry; NF-kappa B; Plant Extracts; Signal Transduction; Spondylitis, Ankylosing; Transfection | 2019 |
Enhanced anti-amnestic effect of donepezil by Ginkgo biloba extract (EGb 761) via further improvement in pro-cholinergic and antioxidative activities.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Cell Line; Cholinergic Agents; Cognitive Dysfunction; Cyclopentanes; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Furans; Ginkgo biloba; Ginkgolides; Humans; Male; Malondialdehyde; Maze Learning; Nootropic Agents; Plant Extracts; Rats, Wistar; Superoxide Dismutase | 2021 |
By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion.
Topics: Animals; Apoptosis; Autophagy; Brain; Caspase 3; Cyclopentanes; Disease Models, Animal; Furans; Ginkgolides; Infarction, Middle Cerebral Artery; Male; Microtubule-Associated Proteins; Neovascularization, Physiologic; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Endothelial Growth Factor A | 2018 |
Chemical analysis, pharmacological activity and process optimization of the proportion of bilobalide and ginkgolides in Ginkgo biloba extract.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclopentanes; Disease Models, Animal; Embryo, Nonmammalian; Fibrinolytic Agents; Furans; Ginkgo biloba; Ginkgolides; Humans; Mass Spectrometry; Models, Animal; Phenylhydrazines; Plant Extracts; Plant Leaves; Quality Control; Technology, Pharmaceutical; Thrombosis; Zebrafish | 2018 |
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Topics: Animals; Autoantibodies; Behavior, Animal; Corpus Callosum; Cuprizone; Cyclopentanes; Cytokines; Demyelinating Diseases; Disease Models, Animal; Furans; Ginkgolides; Humans; Immunity, Humoral; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuroprotective Agents; Oligodendroglia | 2019 |
Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia.
Topics: Animals; Apoptosis; Brain; Cyclopentanes; Dementia, Vascular; Disease Models, Animal; Furans; Ginkgo biloba; Ginkgolides; Glutathione; Learning; Male; Malondialdehyde; Memory; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Plant Leaves; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Infarction; Cyclopentanes; Disease Models, Animal; Extracellular Fluid; Female; Furans; Ginkgolides; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Locomotion; Mice; Microdialysis; Mitochondria; Multienzyme Complexes; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Phosphorylation | 2013 |
Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.
Topics: Animals; Brain Ischemia; Cyclopentanes; Disease Models, Animal; Down-Regulation; Enzyme Activation; Furans; Ginkgolides; Male; MAP Kinase Signaling System; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2014 |
Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice.
Topics: Animals; Behavior, Animal; Cognition Disorders; Corticosterone; Cyclopentanes; Depression; Discrimination Learning; Disease Models, Animal; Furans; Ginkgolides; Hypothalamo-Hypophyseal System; Male; Maze Learning; Mice; Neuroprotective Agents; Pituitary-Adrenal System; Stress, Psychological | 2016 |
The mixture of procyanidins extracted from the lotus seed pod and bilobalide ameliorates scopolamine-induced memory impairment in mice.
Topics: Animals; Behavior, Animal; Cyclopentanes; Disease Models, Animal; Drug Therapy, Combination; Furans; Ginkgolides; Lotus; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred Strains; Plant Extracts; Proanthocyanidins; Reaction Time; Scopolamine; Seeds; Statistics, Nonparametric | 2009 |
Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.
Topics: Animals; Biological Availability; Blood-Brain Barrier; Brain; Chromatography, Liquid; Cyclopentanes; Disease Models, Animal; Female; Furans; Ginkgo biloba; Ginkgolides; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Mass Spectrometry; Mice; Microdialysis; Permeability; Time Factors | 2010 |
EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes.
Topics: Animals; Apoptosis; Atherosclerosis; Caspase 3; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclopentanes; Diabetes Mellitus, Type 2; Disease Models, Animal; Furans; Ginkgo biloba; Ginkgolides; Humans; Immunoblotting; Kaempferols; Male; Muscle, Smooth, Vascular; Plant Extracts; Quercetin; Rats; Rats, Inbred OLETF; Reverse Transcriptase Polymerase Chain Reaction; Tunica Intima; U937 Cells | 2011 |
Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Cyclopentanes; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Electron Transport Complex IV; Furans; Gerbillinae; Ginkgo biloba; Ginkgolides; Glutamic Acid; Glycine; Hippocampus; In Situ Hybridization; In Vitro Techniques; Inhibitory Concentration 50; Male; Membrane Proteins; Plant Extracts; Rats; Reperfusion; RNA, Messenger; Saccharomyces cerevisiae Proteins; Trauma, Nervous System | 2003 |
Drug treatment improves memory in mice.
Topics: Animals; Central Nervous System Stimulants; Chromosomes, Human, Pair 21; Cyclopentanes; Disease Models, Animal; Down Syndrome; Furans; GABA Antagonists; Ginkgolides; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Neuropsychological Tests; Pentylenetetrazole; Picrotoxin | 2007 |
Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra.
Topics: Animals; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Ginkgolides; Male; Neurons; Neuroprotective Agents; NF-kappa B; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics | 2008 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |