Page last updated: 2024-11-08

biguanides and Tooth Discoloration

biguanides has been researched along with Tooth Discoloration in 37 studies

Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.

Tooth Discoloration: Any change in the hue, color, or translucency of a tooth due to any cause. Restorative filling materials, drugs (both topical and systemic), pulpal necrosis, or hemorrhage may be responsible. (Jablonski, Dictionary of Dentistry, 1992, p253)

Research Excerpts

ExcerptRelevanceReference
"The primary purpose of this study was to determine the safety and effectiveness of alexidine in the control of plaque and gingivitis in humans."9.04Effects of an alexidine mouthwash on dental plaque and gingivitis in humans over a six-month period. ( Finn, SB; Jamison, HC; Weatherford, TW, 1977)
"05% chlorhexidine gluconate solutions used on the toothbrush subsequent to scaling were for at least 45 days able to maintain plaque and gingivitis scores lower than those obtained 14 days after scaling and oral hygiene instruction."9.04Effect of toothbrushing with different concentrations of chlorhexidine on the development of dental plaque and gingivitis. ( Bay, LM, 1978)
"The primary purpose of this study was to determine the safety and effectiveness of alexidine in the control of plaque and gingivitis in humans."5.04Effects of an alexidine mouthwash on dental plaque and gingivitis in humans over a six-month period. ( Finn, SB; Jamison, HC; Weatherford, TW, 1977)
"05% chlorhexidine gluconate solutions used on the toothbrush subsequent to scaling were for at least 45 days able to maintain plaque and gingivitis scores lower than those obtained 14 days after scaling and oral hygiene instruction."5.04Effect of toothbrushing with different concentrations of chlorhexidine on the development of dental plaque and gingivitis. ( Bay, LM, 1978)
"Hibitane is a valuable drug in the treatment of denture stomatitis when used as a denture disinfectant."2.64Hibitane in the treatment of oral candidiasis. ( Budtz-Jörgensen, E, 1977)
" Only one significant adverse effect has been identified during medical use, namely, the production of sensorineural deafness after direct instillation into the middle ear, a property shared by several commonly used antiseptics."1.26Safety of Hibitane. II. Human experience. ( Rushton, A, 1977)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199037 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moran, J1
Addy, M2
Roberts, WR1
Löe, H3
Schiött, CR1
Karring, G1
Karring, T1
Storhaug, K1
Weatherford, TW1
Finn, SB1
Jamison, HC1
Carlson, HC1
Porter, K1
Alms, TH1
Rushton, A1
Gjermo, P10
Curtis, SN1
Dooley, CL1
Nordbøo, H1
Hoyos, DF1
Murray, JJ1
Shaw, L1
Svantun, B1
Eriksen, HM4
Rolla, G3
Spolsky, VW1
Forsythe, AB1
Budtz-Jörgensen, E1
Bay, LM1
Bain, MJ1
Strahan, JD1
Formicola, AJ1
Deasy, MJ1
Johnson, DH1
Howe, EE1
Lennon, MA1
Davies, RM1
Bassiouny, MA1
Grant, AA1
Hansen, F1
Johansen, JR2
Plüss, E1
Hamp, SE1
Flotra, L2
Heyden, G1
Jensen, SB2
Kobylańska, M1
Bergenholtz, A1
Hänström, L1
Waerhaug, J1
Nordbö, H1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract and Its Role in Reducing Oral Biofilm and Gingival Inflammation. A Randomized, Triple Masked Clinical Trial.[NCT05138484]Phase 354 participants (Actual)Interventional2017-10-20Completed
Comparative Evaluation of the Plaque Removal Efficacy and Patient Acceptability of the Knotted Floss Technique With Conventional Flossing Technique and Interdental Brushing in Type II Gingival Embrasures - A Clinical Crossover Study[NCT03414073]45 participants (Actual)Interventional2018-02-05Completed
Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial[NCT02911766]Phase 459 participants (Anticipated)Interventional2016-11-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for biguanides and Tooth Discoloration

ArticleYear
Chlorhexidine in dental practice.
    Journal of clinical periodontology, 1974, Volume: 1, Issue:3

    Topics: Animals; Anti-Infective Agents, Local; Biguanides; Candida albicans; Candidiasis, Oral; Chlorobenzen

1974
Does chlorhexidine have a place in the prophylaxis of dental diseases?
    Journal of periodontal research. Supplement, 1973, Volume: 12

    Topics: Absorption; Animals; Anti-Infective Agents, Local; Biguanides; Humans; Mouth Diseases; Mouth Mucosa;

1973
Studies on the effect and mode of action of chlorhexidine in dental plaque inhibition.
    Den Norske tannlaegeforenings tidende, 1974, Volume: 84, Issue:6

    Topics: Administration, Topical; Biguanides; Carbon Radioisotopes; Clinical Trials as Topic; Dental Plaque;

1974
[Chemical control of dental plaque].
    Den Norske tannlaegeforenings tidende, 1971, Volume: 81, Issue:9

    Topics: Anti-Bacterial Agents; Biguanides; Dental Plaque; Dextranase; Drug Resistance, Microbial; Gingival D

1971

Trials

17 trials available for biguanides and Tooth Discoloration

ArticleYear
Comparison of the bisbiguanide antiseptics alexidine and chlorhexidine. II. Clinical and in vitro staining properties.
    Journal of clinical periodontology, 1981, Volume: 8, Issue:3

    Topics: Biguanides; Chlorhexidine; Color; Humans; In Vitro Techniques; Mouthwashes; Random Allocation; Tea;

1981
Two years oral use of chlorhexidine in man. I. General design and clinical effects.
    Journal of periodontal research, 1976, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Calculus; D

1976
Two years oral use of chlorhexidine in man. I. General design and clinical effects.
    Journal of periodontal research, 1976, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Calculus; D

1976
Two years oral use of chlorhexidine in man. I. General design and clinical effects.
    Journal of periodontal research, 1976, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Calculus; D

1976
Two years oral use of chlorhexidine in man. I. General design and clinical effects.
    Journal of periodontal research, 1976, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Calculus; D

1976
Effects of an alexidine mouthwash on dental plaque and gingivitis in humans over a six-month period.
    Journal of the American Dental Association (1939), 1977, Volume: 94, Issue:3

    Topics: Adolescent; Adult; Aged; Biguanides; Dental Plaque; Drug Evaluation; Female; Gingivitis; Humans; Mal

1977
The effect of chlorhexidine gel on plaque and gingivitis in children.
    British dental journal, 1977, Jun-07, Volume: 142, Issue:11

    Topics: Adolescent; Biguanides; Child; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Female; Gels;

1977
A comparison of the plaque-inhibiting effect of stannous fluoride and chlorhexidine.
    Acta odontologica Scandinavica, 1977, Volume: 35, Issue:5

    Topics: Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Double-Blind Method; Female; Flu

1977
Effects of alexidine.2HCL mouthwash on plaque and gingivitis after six months.
    Journal of dental research, 1977, Volume: 56, Issue:11

    Topics: Adult; Biguanides; Clinical Trials as Topic; Color; Composite Resins; Dental Plaque; Double-Blind Me

1977
Hibitane in the treatment of oral candidiasis.
    Journal of clinical periodontology, 1977, Volume: 4, Issue:5

    Topics: Biguanides; Candida albicans; Candidiasis, Oral; Chlorhexidine; Clinical Trials as Topic; Denture, C

1977
Effect of toothbrushing with different concentrations of chlorhexidine on the development of dental plaque and gingivitis.
    Journal of dental research, 1978, Volume: 57, Issue:2

    Topics: Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Dental Scaling; Double-Bl

1978
The effect of a 1% chlorhexidine gel in the initial therapy of chronic periodontal disease.
    Journal of periodontology, 1978, Volume: 49, Issue:9

    Topics: Adolescent; Adult; Biguanides; Chlorhexidine; Chronic Disease; Clinical Trials as Topic; Dental Plaq

1978
Tooth staining effects of an alexidine mouthwash.
    Journal of periodontology, 1979, Volume: 50, Issue:4

    Topics: Adolescent; Adult; Aged; Biguanides; Clinical Trials as Topic; Coffee; Dental Plaque; Dental Prophyl

1979
A short-term evaluation of a chlorhexidine gel on plaque deposits and gingival status.
    Pharmacology and therapeutics in dentistry, 1975, Volume: 2, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Biguanides; Chlorhexidine; Dental Plaque; Dentifrices; Gels

1975
The toothbrush application of chlorhexidine. A clinical trial.
    British dental journal, 1975, Oct-21, Volume: 139, Issue:8

    Topics: Administration, Topical; Adult; Aged; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Ca

1975
The effect of a chlorhexidine-containing gel on oral cleanliness and gingival health in young adults.
    Journal of clinical periodontology, 1975, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Female; Gels;

1975
Effect of 2-years' use of chlorhexidine-containing dentifrices on plaque, gingivitis, and caries.
    Scandinavian journal of dental research, 1975, Volume: 83, Issue:5

    Topics: Adult; Biguanides; Chlorhexidine; Clinical Trials as Topic; Dental Caries; Dental Plaque; Dentifrice

1975
Different modes of chlorhexidine application and related local side effects.
    Journal of periodontal research. Supplement, 1973, Volume: 12

    Topics: Biguanides; Clinical Trials as Topic; Dental Plaque; Dentifrices; Gingival Diseases; Humans; Mouth D

1973
Incidence of stained tooth surfaces in students using chlorhexidine-containing dentifrices.
    Scandinavian journal of dental research, 1973, Volume: 81, Issue:7

    Topics: Biguanides; Coffee; Dentifrices; Humans; Incisor; Mandible; Placebos; Smoking; Tea; Time Factors; To

1973
Studies on the effect and mode of action of chlorhexidine in dental plaque inhibition.
    Den Norske tannlaegeforenings tidende, 1974, Volume: 84, Issue:6

    Topics: Administration, Topical; Biguanides; Carbon Radioisotopes; Clinical Trials as Topic; Dental Plaque;

1974

Other Studies

17 other studies available for biguanides and Tooth Discoloration

ArticleYear
The effect of surface adsorption and staining reactions on the antimicrobial properties of some cationic antiseptic mouthwashes.
    Journal of periodontology, 1984, Volume: 55, Issue:5

    Topics: Adsorption; Anti-Infective Agents, Local; Bacteria; Biguanides; Cetylpyridinium; Chlorhexidine; Dent

1984
Hibitane in oral disease in handicapped patients.
    Journal of clinical periodontology, 1977, Volume: 4, Issue:5

    Topics: Biguanides; Chlorhexidine; Dental Plaque; Disabled Persons; Drug Evaluation; Humans; Mouthwashes; Ti

1977
The effect of an alexidine mouthwash on dental plaque and gingivitis.
    Journal of periodontology, 1977, Volume: 48, Issue:4

    Topics: Adolescent; Adult; Aged; Biguanides; Color; Dental Plaque; Gingivitis; Humans; Middle Aged; Mouthwas

1977
Safety of Hibitane. II. Human experience.
    Journal of clinical periodontology, 1977, Volume: 4, Issue:5

    Topics: Administration, Oral; Biguanides; Chlorhexidine; Dental Plaque; Drug Evaluation; Humans; Mouthwashes

1977
Hibitane in periodontal disease.
    Journal of clinical periodontology, 1977, Volume: 4, Issue:5

    Topics: Biguanides; Chlorhexidine; Dental Plaque; Gingivitis; Humans; Periodontal Diseases; Time Factors; To

1977
Cariostatic activity of (1,6-bis-[2-ethylhexylbiguanido]-hexane) in conventional rats.
    Journal of dental research, 1979, Volume: 58, Issue:4

    Topics: Animals; Biguanides; Cariostatic Agents; Chlorhexidine; Chlorides; Dental Caries; Diet, Cariogenic;

1979
Ability of chlorhexidine and benzalkonium chloride to catalyze browning reactions in vitro.
    Journal of dental research, 1979, Volume: 58, Issue:4

    Topics: Benzalkonium Compounds; Biguanides; Catalysis; Chlorhexidine; Dental Deposits; Humans; Tooth Discolo

1979
Plaque inhibition and staining by hibitane and vantocil.
    Helvetica odontologica acta, 1975, Volume: 19, Issue:2

    Topics: Adult; Biguanides; Chlorhexidine; Dental Plaque; Female; Humans; Male; Placebos; Tooth Discoloration

1975
Long term effect of chlorhexidine on developing gingivitis in the Beagle dog.
    Journal of periodontal research, 1973, Volume: 8, Issue:2

    Topics: Animals; Biguanides; Dental Calculus; Dental Plaque; Dogs; Gingivitis; Mouthwashes; Time Factors; To

1973
Relation between locally high concentration of chlorhexidine and staining as seen in the clinic.
    Journal of periodontal research. Supplement, 1973, Volume: 12

    Topics: Autoradiography; Biguanides; Carbon Isotopes; Coloring Agents; Histocytochemistry; Humans; Tooth Dis

1973
[Studies on new possibilities in plaque removable].
    Deutsche zahnarztliche Zeitschrift, 1972, Volume: 27, Issue:4

    Topics: Anti-Infective Agents, Local; Biguanides; Dental Plaque; Dental Prophylaxis; Dextranase; Gingivitis;

1972
[Chlorhexidine for removal of dental plaque].
    Czasopismo stomatologiczne, 1972, Volume: 25, Issue:7

    Topics: Biguanides; Dental Plaque; Humans; Mouth Mucosa; Mouthwashes; Taste; Tooth Discoloration

1972
[Studies on new possibilities in plaque removal].
    Deutsche zahnarztliche Zeitschrift, 1972, Volume: 27, Issue:4

    Topics: Anti-Infective Agents, Local; Biguanides; Dental Plaque; Dental Prophylaxis; Dextranase; Gingivitis;

1972
The plaque-inhibiting effect of hexetidine (Oraldene)-mouthwash compared to that of chlorhexidine.
    Community dentistry and oral epidemiology, 1974, Volume: 2, Issue:2

    Topics: Adult; Biguanides; Dental Plaque; Dental Prophylaxis; Female; Gingivitis; Hexetidine; Humans; Male;

1974
Side effects of chlorhexidine mouth washes.
    Scandinavian journal of dental research, 1971, Volume: 79, Issue:2

    Topics: Adult; Anti-Infective Agents, Local; Biguanides; Humans; Male; Mouth Diseases; Mouth Mucosa; Mouthwa

1971
The plaque-inhibiting effect of chlorhexidine-containing dentifrices.
    Scandinavian journal of dental research, 1971, Volume: 79, Issue:2

    Topics: Adult; Anti-Infective Agents, Local; Biguanides; Dental Plaque; Dentifrices; Disinfectants; Humans;

1971
Discoloration of human teeth by a combination of chlorhexidine and aldehydes or ketones in vitro.
    Scandinavian journal of dental research, 1971, Volume: 79, Issue:5

    Topics: Acetaldehyde; Acetoacetates; Acetone; Aldehydes; Biguanides; Dental Cementum; Dental Enamel; Dextran

1971