biguanides has been researched along with Seizures in 9 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 7.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "Peripheral administration of nicotinic receptor antagonists with a quaternary ammonium group (hexamethonium and chlorisondamine) did not prevent the development of seizures induced by systemic treatment with nicotine in the toxic dose." | 7.74 | Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice. ( Efremov, OM; Gmiro, VE; Serdyuk, SE, 2008) |
| "Stroke was rendered in rats by introduction of an autologous clot into the middle cerebral artery (MCA)." | 5.37 | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. ( Barzegar-Fallah, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mohammadi-Rick, S; Rahimian, R; Shabanzadeh, AP, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 5.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| " In the present study, we investigated the effect of genistein on pentylenetetrazole-induced seizures in ovariectomized mice and the possible involvement of estrogenic and serotonergic pathways in the probable effects of genistein." | 3.85 | Genistein modulation of seizure: involvement of estrogen and serotonin receptors. ( Algazo, M; Alshaib, H; Amiri Gheshlaghi, S; Dehpour, AR; Mohammad Jafari, R; Rahimi, N, 2017) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 3.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "Peripheral administration of nicotinic receptor antagonists with a quaternary ammonium group (hexamethonium and chlorisondamine) did not prevent the development of seizures induced by systemic treatment with nicotine in the toxic dose." | 3.74 | Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice. ( Efremov, OM; Gmiro, VE; Serdyuk, SE, 2008) |
| "Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders." | 1.38 | 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide. ( Amouzegar, A; Bahremand, A; Dehpour, AR; Payandemehr, B; Rahimian, R; Sharifzadeh, M; Ziai, P, 2012) |
| "Stroke was rendered in rats by introduction of an autologous clot into the middle cerebral artery (MCA)." | 1.37 | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. ( Barzegar-Fallah, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mohammadi-Rick, S; Rahimian, R; Shabanzadeh, AP, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 1.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| "The early events include clonic convulsions, and the later, more general excitation, includes tremor and culminates in the development of a fatal tonic convulsion." | 1.30 | Investigation of the actions and antagonist activity of some polyamine analogues in vivo. ( Doyle, KM; Shaw, GG, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amiri Gheshlaghi, S | 1 |
| Mohammad Jafari, R | 1 |
| Algazo, M | 1 |
| Rahimi, N | 1 |
| Alshaib, H | 1 |
| Dehpour, AR | 4 |
| Mishra, A | 1 |
| Goel, RK | 1 |
| Gmiro, VE | 2 |
| Serdyuk, SE | 2 |
| Efremov, OM | 1 |
| Rahimian, R | 3 |
| Daneshmand, A | 1 |
| Mehr, SE | 1 |
| Barzegar-Fallah, A | 1 |
| Mohammadi-Rick, S | 1 |
| Fakhfouri, G | 2 |
| Shabanzadeh, AP | 1 |
| Bahremand, A | 2 |
| Payandemehr, B | 2 |
| Ziai, P | 2 |
| Pourmand, N | 1 |
| Loloee, S | 1 |
| Ebrahimi, A | 1 |
| Ghasemi, A | 1 |
| Ghasemi, M | 1 |
| Amouzegar, A | 1 |
| Sharifzadeh, M | 1 |
| Doyle, KM | 1 |
| Shaw, GG | 1 |
| Yourick, DL | 1 |
| Repasi, RT | 1 |
| Rittase, WB | 1 |
| Staten, LD | 1 |
| Meyerhoff, JL | 1 |
9 other studies available for biguanides and Seizures
| Article | Year |
|---|---|
Genistein modulation of seizure: involvement of estrogen and serotonin receptors.
Topics: Animals; Anticonvulsants; Biguanides; Dose-Response Relationship, Drug; Fabaceae; Female; Genistein; | 2017 |
Chronic 5-HT
Topics: Animals; Anticonvulsants; Biguanides; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus | 2016 |
Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia.
Topics: Animals; Ataxia; Biguanides; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Male | 2008 |
Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice.
Topics: Adamantane; Animals; Biguanides; Male; Mice; Nicotine; Receptors, AMPA; Receptors, Nicotinic; Seizur | 2008 |
Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Topics: Analysis of Variance; Animals; Biguanides; Blood Gas Analysis; Brain Edema; Brain Infarction; Brain | 2011 |
The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Biguanides; Citalopram; Disease Models, Animal; Dose | 2011 |
5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide.
Topics: Animals; Anticonvulsants; Biguanides; Citalopram; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2012 |
Investigation of the actions and antagonist activity of some polyamine analogues in vivo.
Topics: Animals; Behavior, Animal; Biguanides; Central Nervous System; Diamines; Dose-Response Relationship, | 1998 |
Ifenprodil and arcaine alter amygdala-kindling development.
Topics: Amygdala; Animals; Anticonvulsants; Biguanides; Brain; Dose-Response Relationship, Drug; Electric St | 1999 |