biguanides has been researched along with Pregnancy in 49 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome." | 7.91 | Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019) |
| "Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil." | 7.68 | Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993) |
| "Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome." | 3.91 | Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019) |
| "Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil." | 3.68 | Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993) |
| " As an essential complication provoked by biguanides a lactic acidosis may be elicited which--though seldom occurring--then in most cases takes a fatal course." | 3.67 | [Drug-induced harm due to antidiabetics]. ( Verlohren, HJ, 1984) |
| "Chronic treatment of female rats with buformin (k mg/day per rat) is shown to decrease the body weight, to increase the average life span by 9% and to reduce the incidence of spontaneous tumors." | 3.66 | [Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats]. ( Anisimov, VN, 1980) |
| "Gestational Diabetes is characterized by different degrees of glucose intolerance that produce a series of fetal and perinatal alterations." | 2.44 | [Effectiveness of oral hypoglycemic drugs in the metabolic control of patients with gestational diabetes]. ( Barrera H, C; Candía P, P; Lahsen M, R; Soto-Chacón, E; Valdés R, E, 2008) |
| "The similarity between gestational diabetes mellitus and type 2 diabetes is highlighted." | 2.41 | When diet fails: insulin and oral hypoglycemic agents as alternatives for the management of gestational diabetes mellitus. ( Langer, O, 2002) |
| "A vitamin B12 deficiency is unusual in pregnant women who consume a normal, varied diet." | 2.37 | Clinical chemistry of vitamin B12. ( Davis, RE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (75.51) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 7 (14.29) | 29.6817 |
| 2010's | 2 (4.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, L | 1 |
| Gao, X | 1 |
| Zhuang, J | 1 |
| Wallen, M | 1 |
| Leng, S | 1 |
| Xu, F | 1 |
| Reichart-Peter, S | 1 |
| Manousaridis, K | 1 |
| Dirschmid, H | 1 |
| Mennel, S | 1 |
| Valdés R, E | 1 |
| Soto-Chacón, E | 1 |
| Lahsen M, R | 1 |
| Barrera H, C | 1 |
| Candía P, P | 1 |
| Slocum, JM | 1 |
| Sosa, ME | 1 |
| Langer, O | 2 |
| Merlob, P | 1 |
| Levitt, O | 1 |
| Stahl, B | 1 |
| Levin, PA | 1 |
| McLaughlin, J | 1 |
| Kowarski, AA | 1 |
| Verlohren, HJ | 1 |
| Durán García, S | 1 |
| Hernández Herrero, C | 1 |
| Tengborn, L | 1 |
| Hedner, U | 1 |
| Nilsson, IM | 1 |
| Anisimov, VN | 2 |
| Aleksandrov, VA | 1 |
| Belous, NM | 1 |
| Vasil'eva, IA | 1 |
| Matson, VB | 1 |
| Gris, JC | 1 |
| Neveu, S | 1 |
| Tailland, ML | 1 |
| Courtieu, C | 1 |
| Marès, P | 1 |
| Schved, JF | 1 |
| Wangboonskul, J | 1 |
| White, NJ | 1 |
| Nosten, F | 1 |
| ter Kuile, F | 1 |
| Moody, RR | 1 |
| Taylor, RB | 1 |
| Bolaños, CA | 1 |
| Trksak, GH | 1 |
| Glatt, SJ | 1 |
| Jackson, D | 1 |
| Joyston-Bechal, S | 1 |
| Smales, FC | 1 |
| Duckworth, R | 1 |
| Bloom, A | 1 |
| Landgraf, R | 1 |
| Dieterle, C | 1 |
| Ennis, G | 1 |
| Wishart, MM | 1 |
| Riley, TV | 1 |
| Roszkowski, I | 1 |
| Leibschang, J | 1 |
| Mirouze, J | 1 |
| Cartry, E | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Whitaker-Azmitia, PM | 1 |
| Davis, RE | 1 |
| Notelovitz, M | 1 |
| David, V | 1 |
| Kuffer, R | 1 |
| Vigne, J | 1 |
| Chebotar', NA | 1 |
| Panzram, G | 1 |
| Gillespie, WA | 1 |
| Corner, BD | 1 |
| Burman, D | 1 |
| Alder, VG | 1 |
| Schultze, WD | 1 |
| Smith, JW | 1 |
| Breidahl, HD | 1 |
| Ennis, GC | 1 |
| Martin, FI | 1 |
| Stawell, JR | 1 |
| Taft, P | 1 |
| Baranov, VG | 1 |
| Orkodashvili, LSh | 1 |
| Kangas, T | 1 |
| Carty MJchatfield, WR | 1 |
| McAllister, TA | 1 |
| Hockaday, TD | 1 |
| Beuningh, H | 1 |
| Kopf, A | 1 |
| Tchobroutsky, G | 1 |
| Eschwege, E | 1 |
| Heisig, N | 2 |
| Thervet, F | 1 |
| Deuil, R | 1 |
| Drury, MI | 1 |
| Adam, PA | 1 |
| Schwartz, R | 1 |
14 reviews available for biguanides and Pregnancy
| Article | Year |
|---|---|
[Effectiveness of oral hypoglycemic drugs in the metabolic control of patients with gestational diabetes].
Topics: Administration, Oral; Biguanides; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; | 2008 |
Use of antidiabetes agents in pregnancy: current practice and controversy.
Topics: Administration, Oral; Benzamides; Biguanides; Diabetes, Gestational; Enzyme Inhibitors; Female; Glyc | 2002 |
When diet fails: insulin and oral hypoglycemic agents as alternatives for the management of gestational diabetes mellitus.
Topics: Administration, Oral; Biguanides; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetes, Ges | 2002 |
Oral antihyperglycemic agents during pregnancy and lactation: a review.
Topics: Administration, Oral; Biguanides; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; | 2002 |
Oral anti-hyperglycemic agents for the management of gestational diabetes mellitus.
Topics: Administration, Oral; Biguanides; Diabetes, Gestational; Female; Glycoside Hydrolase Inhibitors; Hum | 2007 |
[Physiologic and physiopathologic implications of insulin-receptor interaction (II). Pathologic situations in which changes in insulin-receptor interaction are detected].
Topics: Acanthosis Nigricans; Animals; Biguanides; Child; Diabetes Complications; Diabetes Mellitus, Type 1; | 1984 |
Some practical aspects of the management of diabetes.
Topics: Adult; Biguanides; Body Weight; Child; Contraceptives, Oral; Diabetes Complications; Diabetes Mellit | 1977 |
[Recent development in the diabetes-therapy].
Topics: Biguanides; Blood Glucose; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Female; Humans; | 1977 |
Clinical chemistry of vitamin B12.
Topics: Absorption; Adult; Alcoholism; Anemia, Pernicious; Ascorbic Acid; Autoantibodies; Biguanides; Biolog | 1985 |
Insulin and oral hypoglycaemic agents. II. Clinical and therapeutic aspects.
Topics: Administration, Oral; Adult; Biguanides; Blood Glucose; Coronary Disease; Diabetes Complications; Di | 1972 |
[Initial phases of diabetes mellitus].
Topics: Biguanides; Blood Glucose; Cortisone; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathi | 1973 |
[The use of oral antidiabetics].
Topics: Abnormalities, Drug-Induced; Administration, Oral; Biguanides; Female; Humans; Hypoglycemic Agents; | 1974 |
Diabetes mellitus.
Topics: Alcohol Drinking; Anxiety; Biguanides; Blood Glucose; Blood Pressure; Body Weight; Cholesterol, Diet | 1974 |
Glibenclamide: a review.
Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Biguanides; Blood Glucose; Carbon Isotopes; | 1971 |
3 trials available for biguanides and Pregnancy
| Article | Year |
|---|---|
Prospective study of a phenformin-like substance (moroxydine chloride) in patients with deficient vessel wall fibrinolysis.
Topics: Adolescent; Adult; Aged; Biguanides; Ethylestrenol; Female; Fibrinolysis; Humans; Male; Middle Aged; | 1982 |
Use of a low-molecular weight heparin (enoxaparin) or of a phenformin-like substance (moroxydine chloride) in primary early recurrent aborters with an impaired fibrinolytic capacity.
Topics: Abortion, Habitual; Adult; Biguanides; Double-Blind Method; Enoxaparin; Female; Fibrinolysis; Humans | 1995 |
Antiseptic prophylaxis of bacteriuria following catheterisation in labour.
Topics: Anti-Infective Agents, Urinary; Bacteriuria; Biguanides; Escherichia coli; Female; Labor, Obstetric; | 1974 |
32 other studies available for biguanides and Pregnancy
| Article | Year |
|---|---|
Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT
Topics: Animals; Animals, Newborn; Apnea; Biguanides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; | 2019 |
[Good outcome in Acanthamoeba keratitis].
Topics: Acanthamoeba Keratitis; Adult; Antiprotozoal Agents; Benzamidines; Biguanides; Dose-Response Relatio | 2017 |
Blockade of 5-HT(3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25--35)-induced neurotoxicity in cultured rat cortical neurons.
Topics: Amyloid beta-Peptides; Animals; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Caspas | 2005 |
Diabetes mellitus: customizing management.
Topics: Adult; Aging; Biguanides; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Ty | 1984 |
[Drug-induced harm due to antidiabetics].
Topics: Abnormalities, Drug-Induced; Acidosis; Biguanides; Bone Marrow; Cardiovascular Diseases; Chemical an | 1984 |
[Inhibition of the transplacental blastomogenic effect of N-nitrosomethylurea in rats by buformin].
Topics: Animals; Antineoplastic Agents; Biguanides; Blood Glucose; Buformin; Castration; Cholesterol; Female | 1980 |
[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats].
Topics: Animals; Biguanides; Body Weight; Buformin; Estrus; Female; Longevity; Neoplasms, Experimental; Phen | 1980 |
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy | 1993 |
Prenatal cocaine exposure increases serotonergic inhibition of electrically evoked acetylcholine release from rat striatal slices at adulthood.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Biguanides; Cocaine; Dopamine; Dopamine Uptake Inhibit | 2000 |
The use of a chlorhexidine-containing gel in a plaque control programme.
Topics: Adolescent; Adult; Aged; Biguanides; Chlorhexidine; Dental Plaque; Double-Blind Method; Female; Gels | 1979 |
Oral hypoglycaemic agents--dangers and contraindications.
Topics: Aged; Biguanides; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; L | 1976 |
Infection with Pseudomonas maltophilia hospital outbreak due to contaminated disinfectant.
Topics: Adult; Aged; Australia; Biguanides; Cetrimonium Compounds; Chlorhexidine; Cross Infection; Disease O | 1976 |
[Clinical and laboratory evaluation of Hibiscrub].
Topics: Biguanides; Chlorhexidine; Cross Infection; Disinfectants; Female; Humans; Personnel, Hospital; Preg | 1975 |
[Diabetes mellitus under 30 years of age. Results of 18 years experience with oral treatment (author's transl)].
Topics: Administration, Oral; Adolescent; Adult; Biguanides; Child; Child, Preschool; Diabetes Complications | 1975 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |
Letter: Oral hypoglycaemic therapy in diabetic pregnancies.
Topics: Administration, Oral; Antigens; Biguanides; Blood Glucose; Chlorpropamide; Female; Humans; Insulin; | 1974 |
[Test of an antiviral treatment in some cutaneo-mucosal diseases].
Topics: Adolescent; Adult; Aged; Antiviral Agents; Biguanides; Female; Herpes Zoster; Herpesviridae Infectio | 1967 |
[Oral antidiabetics (hypoglycemic sulfamides and biguanides)].
Topics: Administration, Oral; Biguanides; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Pregnancy; | 1974 |
Embryotoxic and teratogenic action of proguanil, chlorproguanil, and cycloguanil on albino rats.
Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Biguanides; Embryo, Mammalian; Female; Fertiliz | 1974 |
[Possibilities and limits of primary prevention in diabetes mellitus].
Topics: Biguanides; Body Weight; Diabetes Mellitus; Diabetic Angiopathies; Dietary Carbohydrates; Female; Hu | 1974 |
Absorption of hexachlorophane from dusting powder on newborn infant's skin.
Topics: Anti-Infective Agents, Local; Biguanides; Blood; Chlorobenzenes; Female; Hexachlorophene; Humans; In | 1974 |
Effectiveness of postmilking teat dips.
Topics: Actinomyces; Animals; Biguanides; Cattle; Escherichia coli; Female; Iodine; Lactation; Mammary Gland | 1972 |
[Study of the value of a chlorohexidine containing spray for prevention of puerperal mastitis].
Topics: Anti-Infective Agents, Local; Biguanides; Female; Humans; Mastitis; Pregnancy; Puerperal Infection | 1972 |
Serial postprandial blood glucose levels in 309 subjects with and without diabetes.
Topics: Adolescent; Adult; Age Factors; Aged; Biguanides; Blood Glucose; Diabetes Mellitus; Diet, Diabetic; | 1973 |
Diabetes mellitus--refractory obesity.
Topics: Biguanides; Diabetes Mellitus; Diet Therapy; Female; Fetal Death; Glucose Tolerance Test; Glycosuria | 1972 |
[Critical reflections on the present status or oral diabetes therapy in pregnancy].
Topics: Administration, Oral; Biguanides; Carbutamide; Chlorpropamide; Female; Humans; Hypoglycemic Agents; | 1971 |
[Oral hypoglycemic agents in the treatment of diabetes mellitus].
Topics: Administration, Oral; Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Hypogl | 1970 |
[Insulin therapy in 1970 and various reflections on the oral treatment of diabetes].
Topics: Administration, Oral; Adolescent; Adult; Biguanides; Child; Diabetes Mellitus; Diabetes Mellitus, Ty | 1970 |
[Oral antidiabetics in pregnancy].
Topics: Abnormalities, Drug-Induced; Biguanides; Carbutamide; Chlorpropamide; Female; Fetus; Humans; Hypogly | 1971 |
Drugs and their abuse. II. Oral hypoglycaemic agents.
Topics: Adult; Biguanides; Female; Humans; Hypoglycemic Agents; Pregnancy; Substance-Related Disorders; Sulf | 1971 |
Diagnosis and treatment: should oral hypoglycemic agents be used in pediatric and pregnant patients?
Topics: Abnormalities, Drug-Induced; Biguanides; Diabetes Mellitus, Type 1; Female; Fetal Death; Humans; Hyp | 1968 |
[Oral therapy of diabetes].
Topics: Adolescent; Adult; Aged; Biguanides; Blood Glucose; Body Weight; Child; Diabetes Complications; Diab | 1969 |