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biguanides and Pregnancy

biguanides has been researched along with Pregnancy in 49 studies

Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome."7.91Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019)
"Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil."7.68Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993)
"Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome."3.91Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019)
"Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil."3.68Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993)
" As an essential complication provoked by biguanides a lactic acidosis may be elicited which--though seldom occurring--then in most cases takes a fatal course."3.67[Drug-induced harm due to antidiabetics]. ( Verlohren, HJ, 1984)
"Chronic treatment of female rats with buformin (k mg/day per rat) is shown to decrease the body weight, to increase the average life span by 9% and to reduce the incidence of spontaneous tumors."3.66[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats]. ( Anisimov, VN, 1980)
"Gestational Diabetes is characterized by different degrees of glucose intolerance that produce a series of fetal and perinatal alterations."2.44[Effectiveness of oral hypoglycemic drugs in the metabolic control of patients with gestational diabetes]. ( Barrera H, C; Candía P, P; Lahsen M, R; Soto-Chacón, E; Valdés R, E, 2008)
"The similarity between gestational diabetes mellitus and type 2 diabetes is highlighted."2.41When diet fails: insulin and oral hypoglycemic agents as alternatives for the management of gestational diabetes mellitus. ( Langer, O, 2002)
"A vitamin B12 deficiency is unusual in pregnant women who consume a normal, varied diet."2.37Clinical chemistry of vitamin B12. ( Davis, RE, 1985)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199037 (75.51)18.7374
1990's3 (6.12)18.2507
2000's7 (14.29)29.6817
2010's2 (4.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhao, L1
Gao, X1
Zhuang, J1
Wallen, M1
Leng, S1
Xu, F1
Reichart-Peter, S1
Manousaridis, K1
Dirschmid, H1
Mennel, S1
Valdés R, E1
Soto-Chacón, E1
Lahsen M, R1
Barrera H, C1
Candía P, P1
Slocum, JM1
Sosa, ME1
Langer, O2
Merlob, P1
Levitt, O1
Stahl, B1
Levin, PA1
McLaughlin, J1
Kowarski, AA1
Verlohren, HJ1
Durán García, S1
Hernández Herrero, C1
Tengborn, L1
Hedner, U1
Nilsson, IM1
Anisimov, VN2
Aleksandrov, VA1
Belous, NM1
Vasil'eva, IA1
Matson, VB1
Gris, JC1
Neveu, S1
Tailland, ML1
Courtieu, C1
Marès, P1
Schved, JF1
Wangboonskul, J1
White, NJ1
Nosten, F1
ter Kuile, F1
Moody, RR1
Taylor, RB1
Bolaños, CA1
Trksak, GH1
Glatt, SJ1
Jackson, D1
Joyston-Bechal, S1
Smales, FC1
Duckworth, R1
Bloom, A1
Landgraf, R1
Dieterle, C1
Ennis, G1
Wishart, MM1
Riley, TV1
Roszkowski, I1
Leibschang, J1
Mirouze, J1
Cartry, E1
Bell, J1
Zhang, XN1
Whitaker-Azmitia, PM1
Davis, RE1
Notelovitz, M1
David, V1
Kuffer, R1
Vigne, J1
Chebotar', NA1
Panzram, G1
Gillespie, WA1
Corner, BD1
Burman, D1
Alder, VG1
Schultze, WD1
Smith, JW1
Breidahl, HD1
Ennis, GC1
Martin, FI1
Stawell, JR1
Taft, P1
Baranov, VG1
Orkodashvili, LSh1
Kangas, T1
Carty MJchatfield, WR1
McAllister, TA1
Hockaday, TD1
Beuningh, H1
Kopf, A1
Tchobroutsky, G1
Eschwege, E1
Heisig, N2
Thervet, F1
Deuil, R1
Drury, MI1
Adam, PA1
Schwartz, R1

Reviews

14 reviews available for biguanides and Pregnancy

ArticleYear
[Effectiveness of oral hypoglycemic drugs in the metabolic control of patients with gestational diabetes].
    Revista medica de Chile, 2008, Volume: 136, Issue:7

    Topics: Administration, Oral; Biguanides; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans;

2008
Use of antidiabetes agents in pregnancy: current practice and controversy.
    The Journal of perinatal & neonatal nursing, 2002, Volume: 16, Issue:2

    Topics: Administration, Oral; Benzamides; Biguanides; Diabetes, Gestational; Enzyme Inhibitors; Female; Glyc

2002
When diet fails: insulin and oral hypoglycemic agents as alternatives for the management of gestational diabetes mellitus.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2002, Volume: 11, Issue:4

    Topics: Administration, Oral; Biguanides; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetes, Ges

2002
Oral antihyperglycemic agents during pregnancy and lactation: a review.
    Paediatric drugs, 2002, Volume: 4, Issue:11

    Topics: Administration, Oral; Biguanides; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans;

2002
Oral anti-hyperglycemic agents for the management of gestational diabetes mellitus.
    Obstetrics and gynecology clinics of North America, 2007, Volume: 34, Issue:2

    Topics: Administration, Oral; Biguanides; Diabetes, Gestational; Female; Glycoside Hydrolase Inhibitors; Hum

2007
[Physiologic and physiopathologic implications of insulin-receptor interaction (II). Pathologic situations in which changes in insulin-receptor interaction are detected].
    Medicina clinica, 1984, Apr-14, Volume: 82, Issue:14

    Topics: Acanthosis Nigricans; Animals; Biguanides; Child; Diabetes Complications; Diabetes Mellitus, Type 1;

1984
Some practical aspects of the management of diabetes.
    Clinics in endocrinology and metabolism, 1977, Volume: 6, Issue:2

    Topics: Adult; Biguanides; Body Weight; Child; Contraceptives, Oral; Diabetes Complications; Diabetes Mellit

1977
[Recent development in the diabetes-therapy].
    Der Internist, 1977, Volume: 18, Issue:10

    Topics: Biguanides; Blood Glucose; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Female; Humans;

1977
Clinical chemistry of vitamin B12.
    Advances in clinical chemistry, 1985, Volume: 24

    Topics: Absorption; Adult; Alcoholism; Anemia, Pernicious; Ascorbic Acid; Autoantibodies; Biguanides; Biolog

1985
Insulin and oral hypoglycaemic agents. II. Clinical and therapeutic aspects.
    Drugs, 1972, Volume: 3, Issue:3

    Topics: Administration, Oral; Adult; Biguanides; Blood Glucose; Coronary Disease; Diabetes Complications; Di

1972
[Initial phases of diabetes mellitus].
    Sovetskaia meditsina, 1973, Volume: 36, Issue:12

    Topics: Biguanides; Blood Glucose; Cortisone; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathi

1973
[The use of oral antidiabetics].
    Duodecim; laaketieteellinen aikakauskirja, 1974, Volume: 90, Issue:4

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Biguanides; Female; Humans; Hypoglycemic Agents;

1974
Diabetes mellitus.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Alcohol Drinking; Anxiety; Biguanides; Blood Glucose; Blood Pressure; Body Weight; Cholesterol, Diet

1974
Glibenclamide: a review.
    Drugs, 1971, Volume: 1, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Biguanides; Blood Glucose; Carbon Isotopes;

1971

Trials

3 trials available for biguanides and Pregnancy

ArticleYear
Prospective study of a phenformin-like substance (moroxydine chloride) in patients with deficient vessel wall fibrinolysis.
    Journal of medicine, 1982, Volume: 13, Issue:5-6

    Topics: Adolescent; Adult; Aged; Biguanides; Ethylestrenol; Female; Fibrinolysis; Humans; Male; Middle Aged;

1982
Use of a low-molecular weight heparin (enoxaparin) or of a phenformin-like substance (moroxydine chloride) in primary early recurrent aborters with an impaired fibrinolytic capacity.
    Thrombosis and haemostasis, 1995, Volume: 73, Issue:3

    Topics: Abortion, Habitual; Adult; Biguanides; Double-Blind Method; Enoxaparin; Female; Fibrinolysis; Humans

1995
Antiseptic prophylaxis of bacteriuria following catheterisation in labour.
    Current medical research and opinion, 1974, Volume: 2, Issue:6

    Topics: Anti-Infective Agents, Urinary; Bacteriuria; Biguanides; Escherichia coli; Female; Labor, Obstetric;

1974

Other Studies

32 other studies available for biguanides and Pregnancy

ArticleYear
Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:10

    Topics: Animals; Animals, Newborn; Apnea; Biguanides; Bronchoalveolar Lavage Fluid; Disease Models, Animal;

2019
[Good outcome in Acanthamoeba keratitis].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2017, Volume: 114, Issue:7

    Topics: Acanthamoeba Keratitis; Adult; Antiprotozoal Agents; Benzamidines; Biguanides; Dose-Response Relatio

2017
Blockade of 5-HT(3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25--35)-induced neurotoxicity in cultured rat cortical neurons.
    European journal of pharmacology, 2005, Sep-27, Volume: 520, Issue:1-3

    Topics: Amyloid beta-Peptides; Animals; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Caspas

2005
Diabetes mellitus: customizing management.
    Hospital practice (Office ed.), 1984, Volume: 19, Issue:10

    Topics: Adult; Aging; Biguanides; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Ty

1984
[Drug-induced harm due to antidiabetics].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984, Jan-01, Volume: 39, Issue:1

    Topics: Abnormalities, Drug-Induced; Acidosis; Biguanides; Bone Marrow; Cardiovascular Diseases; Chemical an

1984
[Inhibition of the transplacental blastomogenic effect of N-nitrosomethylurea in rats by buformin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:7

    Topics: Animals; Antineoplastic Agents; Biguanides; Blood Glucose; Buformin; Castration; Cholesterol; Female

1980
[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats].
    Voprosy onkologii, 1980, Volume: 26, Issue:6

    Topics: Animals; Biguanides; Body Weight; Buformin; Estrus; Female; Longevity; Neoplasms, Experimental; Phen

1980
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
    European journal of clinical pharmacology, 1993, Volume: 44, Issue:3

    Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy

1993
Prenatal cocaine exposure increases serotonergic inhibition of electrically evoked acetylcholine release from rat striatal slices at adulthood.
    Synapse (New York, N.Y.), 2000, Volume: 36, Issue:1

    Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Biguanides; Cocaine; Dopamine; Dopamine Uptake Inhibit

2000
The use of a chlorhexidine-containing gel in a plaque control programme.
    British dental journal, 1979, Feb-20, Volume: 146, Issue:4

    Topics: Adolescent; Adult; Aged; Biguanides; Chlorhexidine; Dental Plaque; Double-Blind Method; Female; Gels

1979
Oral hypoglycaemic agents--dangers and contraindications.
    The Medical journal of Australia, 1976, Oct-16, Volume: 2, Issue:16

    Topics: Aged; Biguanides; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; L

1976
Infection with Pseudomonas maltophilia hospital outbreak due to contaminated disinfectant.
    The Medical journal of Australia, 1976, Nov-06, Volume: 2, Issue:19

    Topics: Adult; Aged; Australia; Biguanides; Cetrimonium Compounds; Chlorhexidine; Cross Infection; Disease O

1976
[Clinical and laboratory evaluation of Hibiscrub].
    Ginekologia polska, 1975, Volume: 46, Issue:5

    Topics: Biguanides; Chlorhexidine; Cross Infection; Disinfectants; Female; Humans; Personnel, Hospital; Preg

1975
[Diabetes mellitus under 30 years of age. Results of 18 years experience with oral treatment (author's transl)].
    Diabete & metabolisme, 1975, Volume: 1, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Biguanides; Child; Child, Preschool; Diabetes Complications

1975
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
    Brain research, 1992, Feb-07, Volume: 571, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem

1992
Letter: Oral hypoglycaemic therapy in diabetic pregnancies.
    Lancet (London, England), 1974, Oct-12, Volume: 2, Issue:7885

    Topics: Administration, Oral; Antigens; Biguanides; Blood Glucose; Chlorpropamide; Female; Humans; Insulin;

1974
[Test of an antiviral treatment in some cutaneo-mucosal diseases].
    Semaine therapeutique, 1967, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Biguanides; Female; Herpes Zoster; Herpesviridae Infectio

1967
[Oral antidiabetics (hypoglycemic sulfamides and biguanides)].
    Bruxelles medical, 1974, Volume: 54, Issue:2

    Topics: Administration, Oral; Biguanides; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Pregnancy;

1974
Embryotoxic and teratogenic action of proguanil, chlorproguanil, and cycloguanil on albino rats.
    Bulletin of experimental biology and medicine, 1974, Volume: 77, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Biguanides; Embryo, Mammalian; Female; Fertiliz

1974
[Possibilities and limits of primary prevention in diabetes mellitus].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Sep-15, Volume: 29, Issue:18

    Topics: Biguanides; Body Weight; Diabetes Mellitus; Diabetic Angiopathies; Dietary Carbohydrates; Female; Hu

1974
Absorption of hexachlorophane from dusting powder on newborn infant's skin.
    The Journal of hygiene, 1974, Volume: 73, Issue:2

    Topics: Anti-Infective Agents, Local; Biguanides; Blood; Chlorobenzenes; Female; Hexachlorophene; Humans; In

1974
Effectiveness of postmilking teat dips.
    Journal of dairy science, 1972, Volume: 55, Issue:4

    Topics: Actinomyces; Animals; Biguanides; Cattle; Escherichia coli; Female; Iodine; Lactation; Mammary Gland

1972
[Study of the value of a chlorohexidine containing spray for prevention of puerperal mastitis].
    Nederlands tijdschrift voor geneeskunde, 1972, Sep-23, Volume: 116, Issue:39

    Topics: Anti-Infective Agents, Local; Biguanides; Female; Humans; Mastitis; Pregnancy; Puerperal Infection

1972
Serial postprandial blood glucose levels in 309 subjects with and without diabetes.
    Diabetes, 1973, Volume: 22, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aged; Biguanides; Blood Glucose; Diabetes Mellitus; Diet, Diabetic;

1973
Diabetes mellitus--refractory obesity.
    British medical journal, 1972, Jul-15, Volume: 3, Issue:5819

    Topics: Biguanides; Diabetes Mellitus; Diet Therapy; Female; Fetal Death; Glucose Tolerance Test; Glycosuria

1972
[Critical reflections on the present status or oral diabetes therapy in pregnancy].
    Archiv fur Gynakologie, 1971, Jun-04, Volume: 211, Issue:1

    Topics: Administration, Oral; Biguanides; Carbutamide; Chlorpropamide; Female; Humans; Hypoglycemic Agents;

1971
[Oral hypoglycemic agents in the treatment of diabetes mellitus].
    Les Cahiers de medecine, 1970, Volume: 11

    Topics: Administration, Oral; Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Hypogl

1970
[Insulin therapy in 1970 and various reflections on the oral treatment of diabetes].
    Acquisitions medicales recentes, 1970

    Topics: Administration, Oral; Adolescent; Adult; Biguanides; Child; Diabetes Mellitus; Diabetes Mellitus, Ty

1970
[Oral antidiabetics in pregnancy].
    Medizinische Klinik, 1971, Mar-19, Volume: 66, Issue:12

    Topics: Abnormalities, Drug-Induced; Biguanides; Carbutamide; Chlorpropamide; Female; Fetus; Humans; Hypogly

1971
Drugs and their abuse. II. Oral hypoglycaemic agents.
    Journal of the Irish Medical Association, 1971, May-27, Volume: 64, Issue:412

    Topics: Adult; Biguanides; Female; Humans; Hypoglycemic Agents; Pregnancy; Substance-Related Disorders; Sulf

1971
Diagnosis and treatment: should oral hypoglycemic agents be used in pediatric and pregnant patients?
    Pediatrics, 1968, Volume: 42, Issue:5

    Topics: Abnormalities, Drug-Induced; Biguanides; Diabetes Mellitus, Type 1; Female; Fetal Death; Humans; Hyp

1968
[Oral therapy of diabetes].
    La Presse medicale, 1969, Jun-25, Volume: 77, Issue:31

    Topics: Adolescent; Adult; Aged; Biguanides; Blood Glucose; Body Weight; Child; Diabetes Complications; Diab

1969