biguanides has been researched along with Metabolic Acidosis in 76 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported." | 7.66 | Buformin concentrations in a case of fatal lactic acidosis. ( de Groot, G; Maes, RA; Sangster, B; van Heijst, AN; Verdonck, LF, 1981) |
| " All the patients had taken guanidine derivates (phenformine, buformine) because of diabetes mellitus." | 7.65 | [Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)]. ( Butt, H; Reitinger, J, 1977) |
| "The paper presents an analysis of clinical symptoms, signs and laboratory data of 330 diabetic patients who developed lactic acidosis after having been treated with biguanides (phenformin, buformin, metformin)." | 4.75 | Lactic acidosis in biguanide-treated diabetics: a review of 330 cases. ( Eggstein, M; Luft, D; Schmülling, RM, 1978) |
| " As an essential complication provoked by biguanides a lactic acidosis may be elicited which--though seldom occurring--then in most cases takes a fatal course." | 3.67 | [Drug-induced harm due to antidiabetics]. ( Verlohren, HJ, 1984) |
| " The most dangerous side-effect of biguanides is lactic acidosis." | 3.67 | Incidence of severe sideeffects during therapy with sulfonylureas and biguanides. ( Berger, W, 1985) |
| "A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported." | 3.66 | Buformin concentrations in a case of fatal lactic acidosis. ( de Groot, G; Maes, RA; Sangster, B; van Heijst, AN; Verdonck, LF, 1981) |
| " It is not justifiable to quote a specific serum level of biguanides in defining lactic acidosis." | 3.66 | [Biguanide-induced and - associated lactic acidosis: serum and tissue biguanide levels in hyperlactaemia and lactic acidosis (author's transl)]. ( Irsigler, K; Kaspar, L; Kritz, H; Regal, H, 1979) |
| "In 4 out of 9711 (= 1:2400) patients, lactice acidosis due to biguanides was diagnosed." | 3.66 | [Lactacidosis in biguanide therapy: diagnosis and therapy. 4 cases compared to 179 cases in the world literature]. ( Cyran, J; Lüderitz, B; Zähringer, J, 1978) |
| " In Austria, the association of lactic acidosis with biguanide therapy has led to a cancellation of the registration of buformin and phenformin." | 3.66 | [Biguanides: reasons for withdrawal of drugs and remaining indications]. ( Bolzano, K, 1978) |
| " All the patients had taken guanidine derivates (phenformine, buformine) because of diabetes mellitus." | 3.65 | [Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)]. ( Butt, H; Reitinger, J, 1977) |
| "A survey of the literature leads to the conclusion that lactic acidosis should be considered as a side effect of therapy with biguanides." | 3.65 | [The importance of lactate acidosis as a side effect of biguanide therapy]. ( Förster, H, 1976) |
| " At the same time about 1/3 of these serious adverse drug reactions (ADR) was found to have been reported to the ADR-register." | 1.27 | Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden. ( Westerholm, B; Wiholm, BE, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (98.68) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.32) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayama, N | 1 |
| Verlohren, HJ | 1 |
| Auzepy, P | 1 |
| Caquet, R | 1 |
| Kreisberg, RA | 1 |
| Wood, BC | 1 |
| Paterson, KR | 1 |
| Paice, BJ | 1 |
| Lawson, DH | 1 |
| Wiholm, BE | 1 |
| Westerholm, B | 1 |
| Bordone, C | 1 |
| Vannati, G | 1 |
| Lamedica, G | 1 |
| Verdonck, LF | 1 |
| Sangster, B | 1 |
| van Heijst, AN | 1 |
| de Groot, G | 1 |
| Maes, RA | 1 |
| Assan, R | 3 |
| Januszko, J | 1 |
| Alberti, KG | 1 |
| Nattrass, M | 1 |
| Haslbeck, M | 2 |
| van der Kuy, A | 1 |
| Stowers, JM | 2 |
| Borthwick, LJ | 1 |
| Luft, D | 2 |
| Schmülling, RM | 1 |
| Eggstein, M | 1 |
| Berger, W | 4 |
| Offerhaus, L | 1 |
| Irsigler, K | 4 |
| Kritz, H | 4 |
| Regal, H | 4 |
| Kaspar, L | 3 |
| Korhonen, T | 1 |
| Idänpään-Heikkilä, J | 1 |
| Aro, A | 2 |
| Nawar, NN | 1 |
| Kamel, I | 1 |
| Schoukri, NA | 1 |
| Bally, C | 1 |
| Assal, JP | 1 |
| Brändle, J | 1 |
| Lageder, H | 2 |
| Cohen, RD | 1 |
| Iles, RA | 1 |
| Klein, W | 2 |
| Althoff, PH | 2 |
| Fassbinder, W | 2 |
| Neubauer, M | 2 |
| Koch, KM | 2 |
| Schöffling, K | 2 |
| Roggenkämper, P | 1 |
| Hirsch, E | 1 |
| Spaethe, R | 1 |
| Otto, H | 1 |
| Heuclin, C | 2 |
| Girard, JR | 2 |
| Beaujean, MA | 1 |
| Muller, M | 1 |
| Daubresse, JC | 1 |
| Luyckx, AS | 1 |
| Sodoyez, JC | 1 |
| Van Cauwenberge, H | 1 |
| Lavieuville, M | 1 |
| Isnard, F | 1 |
| Amrein, R | 1 |
| Foltin, E | 1 |
| Kimbel, KH | 1 |
| Deppermann, D | 2 |
| Heidland, A | 2 |
| Ritz, E | 2 |
| Hörl, W | 1 |
| Zähringer, J | 1 |
| Cyran, J | 1 |
| Lüderitz, B | 1 |
| Hörl, WH | 1 |
| Maurer, H | 1 |
| Jung, N | 1 |
| Herold, M | 1 |
| Adolph, W | 1 |
| Bolzano, K | 1 |
| Phillips, PJ | 2 |
| Thomas, DW | 1 |
| Harding, PE | 1 |
| Pain, RW | 1 |
| Vogelberg, KH | 1 |
| Gries, FA | 1 |
| Koschinsky, T | 1 |
| Schreiber, FK | 1 |
| Wittmann, P | 1 |
| Bachmann, W | 1 |
| Mehnert, H | 1 |
| Müller, PH | 1 |
| Butt, H | 1 |
| Reitinger, J | 1 |
| Raisp, I | 1 |
| But, H | 1 |
| Thimme, W | 1 |
| Buschmann, HJ | 1 |
| Dissmann, W | 1 |
| Amft, R | 1 |
| Förster, H | 1 |
| Mehnert-Aner, S | 1 |
| Mülly, K | 1 |
| Heierli, C | 1 |
| Ritz, R | 1 |
| Karam, JH | 1 |
| Matin, SB | 1 |
| Forsham, PH | 1 |
| Talke, H | 1 |
| Maier, KP | 1 |
| Scholz, H | 1 |
| Jontofsohn, R | 1 |
| Clavadetscher, P | 1 |
| Bischof, P | 1 |
| Wegmann, T | 1 |
| Attali, JR | 1 |
| Poli, S | 1 |
| Vincent, A | 1 |
| Perret, C | 1 |
| Nazzari, M | 1 |
| Fabbri, C | 1 |
| Zanasi, S | 1 |
| Guidotti, M | 1 |
| Solé Violán, J | 1 |
| Martínez Chuecos, J | 1 |
| Molinero Somolinos, F | 1 |
| Marco Moreno, JM | 1 |
| Ito, T | 1 |
| Pedersen, J | 1 |
| Hermann, LS | 1 |
| Dahl, S | 1 |
| Tschudi-Steiner, I | 1 |
| Sieberová, R | 1 |
| Fövényi, J | 1 |
| McKiddie, MT | 1 |
| Buchanan, KD | 1 |
| Hunter, IA | 1 |
| Tilling, W | 1 |
| Stein, G | 1 |
| Lippmann, HG | 2 |
| Takác, A | 1 |
| Schäfer, H | 1 |
| Zillmann, R | 1 |
16 reviews available for biguanides and Metabolic Acidosis
| Article | Year |
|---|---|
[Drug-induced acidosis].
Topics: Acetazolamide; Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Biguanides; Central Nervous Sys | 2007 |
[Severe hypoglycemia due to insulin. Risks and adverse effects of antidiabetic drugs].
Topics: Acidosis; Aged; Biguanides; Brain Diseases; Digestive System Diseases; Drug Eruptions; Drug Interact | 1983 |
Drug and chemical-induced metabolic acidosis.
Topics: Acidosis; Adenosine Triphosphate; Age Factors; Animals; Biguanides; Carbon Monoxide; Catecholamines; | 1983 |
Undesired effects of biguanide therapy.
Topics: Acidosis; Biguanides; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Drug Interact | 1984 |
[Lactic acidosiss as a consequence of treatment with biguanide derivatives].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Hydrogen-Ion Concentration; Insulin; Lactates; Mode | 1979 |
[New aspects of therapy with oral antidiabetic agents].
Topics: Acidosis; Biguanides; Blood Proteins; Chlorpropamide; Diabetes Mellitus; Diabetic Nephropathies; Dru | 1979 |
Oral hypoglycaemic drugs: clinical pharmacology and therapeutic use.
Topics: Acidosis; Animals; Biguanides; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; H | 1977 |
Lactic acidosis in biguanide-treated diabetics: a review of 330 cases.
Topics: Acidosis; Biguanides; Buformin; Diabetes Complications; Diabetes Mellitus; Humans; Hypoglycemic Agen | 1978 |
Antidiabetic drugs after the University Group Diabetes Program (UGDP).
Topics: Acidosis; Biguanides; Diabetes Mellitus; Drug Interactions; Hemodynamics; Hypoglycemic Agents; Islet | 1975 |
[Lactic acidosis].
Topics: Acidosis; Bicarbonates; Biguanides; Diabetes Mellitus; Epilepsy; Ethanol; Fructose; Heart Failure; H | 1985 |
[Lactic acidosis: review of the principles of physiopathology and treatment].
Topics: Acidosis; Biguanides; Humans; Lactates; Neoplasms; Short Bowel Syndrome | 1985 |
Oral treatment in diabetes.
Topics: Acetohexamide; Acidosis; Administration, Oral; Animals; Biguanides; Cardiovascular Diseases; Chlorpr | 1972 |
[Oral antidiabetics].
Topics: Acidosis; Biguanides; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Gastrointesti | 1972 |
[Glucose-lactic acid metabolism during clinical use of biguanides].
Topics: Acidosis; Biguanides; Blood Glucose; Clinical Trials as Topic; Depression, Chemical; Diabetes Mellit | 1973 |
Biguanides and lactate metabolism: a review.
Topics: Acidosis; Animals; Biguanides; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus; Gluconeogenes | 1973 |
[Adverse effects of important long-term-therapeutics].
Topics: Acidosis; Animals; Antidepressive Agents; Antitubercular Agents; Biguanides; Central Nervous System; | 1970 |
3 trials available for biguanides and Metabolic Acidosis
| Article | Year |
|---|---|
[The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Exercise Test; Female; Humans; Lactates; Male; Me | 1978 |
[Biguanide-induced lactate acidoses in diabetic patients].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates | 1977 |
[Glucose-lactic acid metabolism during clinical use of biguanides].
Topics: Acidosis; Biguanides; Blood Glucose; Clinical Trials as Topic; Depression, Chemical; Diabetes Mellit | 1973 |
58 other studies available for biguanides and Metabolic Acidosis
| Article | Year |
|---|---|
[Drug-induced harm due to antidiabetics].
Topics: Abnormalities, Drug-Induced; Acidosis; Biguanides; Bone Marrow; Cardiovascular Diseases; Chemical an | 1984 |
Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden.
Topics: Acidosis; Aged; Anti-Infective Agents, Urinary; Biguanides; Congenital Abnormalities; Contraceptives | 1984 |
[A case of lactic acidosis, induced by biguanides, treated with insulin and glucose].
Topics: Acidosis; Aged; Biguanides; Female; Glucose; Humans; Insulin; Lactates | 1982 |
Buformin concentrations in a case of fatal lactic acidosis.
Topics: Acidosis; Aged; Biguanides; Buformin; Diabetes Complications; Female; Humans; Lactates; Tissue Distr | 1981 |
[Lactic acidosis in 1980].
Topics: Acidosis; Biguanides; Humans; Hypoglycemic Agents; Lactates; Middle Aged | 1980 |
Lactic acidosis.
Topics: Acetates; Acidosis; Bicarbonates; Biguanides; Diabetes Complications; Dietary Carbohydrates; Fructos | 1977 |
[The occurrence of lactic acid acidosis with biguanides].
Topics: Acidosis; Biguanides; Humans; Lactates | 1977 |
[Lactic acidosis (author's transl)].
Topics: Acidosis; Alcoholic Intoxication; Bicarbonates; Biguanides; Diabetes Complications; Fructose; Hepati | 1978 |
[Biguanides and lactate acidosis; consequences for registration advice].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug and Narcotic Control; Humans; Lactates; Neth | 1979 |
[Biguanide-induced and - associated lactic acidosis: serum and tissue biguanide levels in hyperlactaemia and lactic acidosis (author's transl)].
Topics: Acidosis; Aged; Biguanides; Diabetes Mellitus; Glomerular Filtration Rate; Humans; Lactates; Male; M | 1979 |
Biguanide-induced lactic acidosis in Finland.
Topics: Acidosis; Aged; Biguanides; Finland; Humans; Hypoglycemic Agents; Lactates; Metformin; Middle Aged; | 1979 |
The histological changes in the diabetic adrenal gland after biguanide induced lactic acidosis.
Topics: Acidosis; Adrenal Glands; Animals; Biguanides; Diabetes Mellitus, Experimental; Lactates; Male; Nerv | 1979 |
[Oral antidiabetics].
Topics: Acidosis; Administration, Oral; Biguanides; Humans; Hypoglycemic Agents; Sulfonylurea Compounds | 1979 |
Treament of biguanide-induced lactic acidosis with dichloroacetate. 3 case histories.
Topics: Acetates; Acidosis; Aged; Biguanides; Dichloroacetic Acid; Female; Humans; Lactates; Male; Middle Ag | 1979 |
Lactic acidosis: some physiological and clinical considerations.
Topics: Acidosis; Biguanides; Biological Transport; Cell Membrane Permeability; Gluconeogenesis; Humans; Kid | 1977 |
[Lactate acidosis during giguanide therapy for diabetes mellitus].
Topics: Acidosis; Adolescent; Biguanides; Diabetes Mellitus; Humans; Lactates; Male | 1977 |
[Haemodialysis in the treatment of biguanide-induced lactate acidosis (author's transl)].
Topics: Acidosis; Acute Kidney Injury; Adult; Aged; Anuria; Biguanides; Buformin; Diabetes Mellitus; Female; | 1978 |
[Eye-symptoms in a case of lactate acidosis caused by Biguanide-therapy (author's transl)].
Topics: Acidosis; Biguanides; Edema; Eye Manifestations; Female; Humans; Lactates; Middle Aged; Retinal Hemo | 1978 |
[Indications for blood lactate determination].
Topics: Acidosis; Biguanides; Blood Gas Analysis; Humans; Hypoxia; Lactates; Methods; Reference Values; Shoc | 1978 |
[Biguanides and lactic acidosis].
Topics: Acidosis; Biguanides; Buformin; Humans; Lactates; Metformin; Phenformin | 1978 |
[Four cases of fatal lactic acidosis during biguanide therapy (author's transl)].
Topics: Acidosis; Aged; Biguanides; Female; Humans; Lactates; Male; Middle Aged | 1978 |
An experimental model of phenformin-induced lactic acidosis in rats.
Topics: Acidosis; Animals; Biguanides; Disease Models, Animal; Lactates; Male; Nephrectomy; Phenformin; Rats | 1978 |
[What the physician should know about lactic acidosis and biguanides].
Topics: Acidosis; Aged; Biguanides; Diabetes Mellitus; Humans; Lactates; Middle Aged | 1978 |
[Focus on antidiabetic biguanides].
Topics: Acidosis; Biguanides; Drug and Narcotic Control; Europe; France; Humans; Lactates; Pharmacy and Ther | 1978 |
[Lactic acidosis associated with various types of biguanide-therapy (phenformin, buformin, metformin). Results of a survey of the years 1972--1977 in Switzerland (author's transl)].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates; Retrospective Studies; Switzerland | 1978 |
Biguanides and lactic acidosis.
Topics: Acidosis; Biguanides; Humans; Lactates; Phenformin | 1978 |
[Biguanides].
Topics: Acidosis; Biguanides; Buformin; Humans; Metformin; Phenformin | 1978 |
[Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Humans; Kinetics; Lactates; Pyruvates; Renal Dial | 1978 |
[Lactacidosis in biguanide therapy: diagnosis and therapy. 4 cases compared to 179 cases in the world literature].
Topics: Acidosis; Aged; Bicarbonates; Biguanides; Dehydration; Diabetes Mellitus; Female; Humans; Lactates; | 1978 |
Lactic acidosis.
Topics: Acidosis; Bicarbonates; Biguanides; Dichloroacetic Acid; Gluconeogenesis; Glycolysis; Humans; Insuli | 1978 |
[Legal problems in biguanide therapy].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Ethics, Medical; Informed Consent; Jurisprudence | 1978 |
[Lactacidosis in guanide treatment--a current disease syndrome].
Topics: Acidosis; Aged; Biguanides; Diabetes Mellitus; Female; Humans | 1978 |
[Biguanides: reasons for withdrawal of drugs and remaining indications].
Topics: Acidosis; Austria; Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Legislation, Drug; Met | 1978 |
Biguanides and lactic acidosis.
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates | 1977 |
Phenformin, tetracycline and lactic acidosis.
Topics: Acidosis; Biguanides; Diabetes Mellitus; Drug Interactions; Humans; Phenformin; Tetracycline | 1977 |
[Hemodialysis therapy of biguanide-induced lactate acidosis].
Topics: Acidosis; Biguanides; Humans; Lactates; Renal Dialysis | 1977 |
[Biguanide therapy of diabetes mellitus].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates | 1977 |
[Hemodialysis therapy of biguanide-induced lactate acidosis].
Topics: Acidosis; Biguanides; Humans; Lactates; Renal Dialysis | 1977 |
[Lactacidosis in diabetic patients treated with biguanides].
Topics: Acidosis; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Lactates; Male; Middle Aged; Phenform | 1977 |
[Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)].
Topics: Acidosis; Aged; Bicarbonates; Biguanides; Buformin; Diabetes Mellitus; Female; Glomerular Filtration | 1977 |
[Lactate acidosis in biguanide therapy of diabetes mellitus].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates | 1977 |
[Lactate acidoses in biguanide therapy of diabetes mellitus].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates | 1977 |
[Lactacidosis in biguanide therapy of diabetes mellitus].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Humans; Lactates | 1977 |
[Lactic acidosis and biguanid therapy (author's transl)].
Topics: Acidosis; Aged; Anti-Bacterial Agents; Bicarbonates; Biguanides; Buffers; Buformin; Diabetes Mellitu | 1976 |
[The importance of lactate acidosis as a side effect of biguanide therapy].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug Therapy, Combination; Ethanol; Humans; Kidne | 1976 |
[10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Glucagon; Humans; Lactates; Liver; Metformin; Phe | 1976 |
[Therapy of biguanidine-induced lactate acidosis].
Topics: Acidosis; Biguanides; Humans; Lactates; Renal Dialysis | 1975 |
[Lactic acidosis after administration of buformine (author's transl)].
Topics: Acidosis; Aged; Bicarbonates; Biguanides; Buformin; Diabetes Mellitus; Diabetic Coma; Female; Humans | 1976 |
[Lactic acidosis induced by biguanides].
Topics: Acidosis; Biguanides; Diabetes Mellitus; Gluconeogenesis; Humans; Lactates; Phenformin | 1976 |
Incidence of severe sideeffects during therapy with sulfonylureas and biguanides.
Topics: Acidosis; Biguanides; Chlorpropamide; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemia; Hypog | 1985 |
[Overdose of biguanides].
Topics: Acidosis; Adolescent; Biguanides; Buformin; Female; Humans; Hypoglycemia; Lactates; Lactic Acid | 1985 |
[Letter: Biguanide and lactic acidosis].
Topics: Acidosis; Biguanides; Glucagon; Gluconeogenesis; Humans; Intestinal Absorption; Lactates | 1973 |
Clinical experience with the oral administration of the antidiabetic buformin.
Topics: Acidosis; Administration, Oral; Biguanides; Diabetes Mellitus; Drug Synergism; Female; Humans; Hypog | 1971 |
Biguanides. Mode of action and role in the up-to-date treatment of diabetes mellitus.
Topics: Acidosis; Administration, Oral; Biguanides; Delayed-Action Preparations; Diabetes Complications; Dia | 1971 |
Plasma insulin studies in two hundred patients with diabetes mellitus.
Topics: Acidosis; Adult; Age Factors; Aged; Biguanides; Blood Glucose; Body Weight; Diabetes Mellitus; Diabe | 1969 |
[Lactate acidosis].
Topics: Acidosis; Biguanides; Diabetes Complications; Diabetes Mellitus; Female; Humans; Lactates; Middle Ag | 1970 |
[Studies on the effect of Nl,n-butylbiguanide on the blood ketone bodies in eviscerated rabbits with experimental ketosis].
Topics: Acidosis; Animals; Biguanides; Blood Glucose; Caproates; Fatty Acids, Nonesterified; Female; Injecti | 1967 |
[On the problem of the development of lactacidosis under biguanide effect].
Topics: Acidosis; Animals; Biguanides; Blood Glucose; Carbohydrate Metabolism; Female; Lactates; Male; Pyruv | 1967 |