biguanides has been researched along with Malaria in 28 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil." | 7.68 | Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993) |
| "A mechanism of action is proposed that encompasses almost all of the main categories of antimalarial agents: quinones and precursors, dapsone metabolites, metal complexes of thiosemicarbazones and biguanides, iminium-type ions from acridines and quinolines, and peroxides." | 7.67 | Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, iminium ions, and peroxides. ( Ames, JR; Klayman, DL; Kovacic, P; Ryan, MD, 1985) |
| "Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil." | 3.68 | Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993) |
| "A mechanism of action is proposed that encompasses almost all of the main categories of antimalarial agents: quinones and precursors, dapsone metabolites, metal complexes of thiosemicarbazones and biguanides, iminium-type ions from acridines and quinolines, and peroxides." | 3.67 | Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, iminium ions, and peroxides. ( Ames, JR; Klayman, DL; Kovacic, P; Ryan, MD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (92.86) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, X | 1 |
| Liu, F | 1 |
| Bai, J | 1 |
| Zhang, Y | 1 |
| Cui, L | 1 |
| Cao, Y | 1 |
| Luo, E | 1 |
| BAMI, HL | 2 |
| GUPTA, PR | 3 |
| GUHA, PC | 3 |
| CHOUDHURY, M | 1 |
| IYER, BH | 2 |
| GUBA, PC | 1 |
| MAY, EL | 2 |
| CURD, FH | 3 |
| ROSE, FL | 3 |
| DAVEY, DG | 2 |
| DHATT, MS | 1 |
| SINGH, H | 1 |
| BASU, PC | 1 |
| HENDRY, JA | 1 |
| SIRSI, M | 1 |
| RAMA RAO, R | 1 |
| DE, NN | 1 |
| GRANT, JS | 1 |
| GUNTHER, CE | 1 |
| BISHOP, A | 1 |
| McCONNACHIE, EW | 1 |
| CIUCA, M | 1 |
| BALLIF, L | 1 |
| DIXON, DS | 1 |
| BRUCE-CHWATT, LJ | 1 |
| BRUCE-CHWATT, JM | 1 |
| DRANE, P | 1 |
| PERRILL, CV | 1 |
| HUVE, P | 1 |
| Wangboonskul, J | 1 |
| White, NJ | 1 |
| Nosten, F | 1 |
| ter Kuile, F | 1 |
| Moody, RR | 1 |
| Taylor, RB | 1 |
| Spicer, AJ | 1 |
| Ames, JR | 1 |
| Ryan, MD | 1 |
| Klayman, DL | 1 |
| Kovacic, P | 1 |
| Macmillan, AL | 1 |
| Bengtsson, E | 1 |
| Hall, SA | 1 |
1 review available for biguanides and Malaria
| Article | Year |
|---|---|
Malaria treatment and prevention. A review.
Topics: Adolescent; Adult; Africa, Eastern; Antimalarials; Biguanides; Child; Child, Preschool; Chloroquine; | 1969 |
27 other studies available for biguanides and Malaria
| Article | Year |
|---|---|
Phosphatase inhibitors BVT-948 and alexidine dihydrochloride inhibit sexual development of the malaria parasite Plasmodium berghei.
Topics: Animals; Antimalarials; Biguanides; Culicidae; Enzyme Inhibitors; Humans; Malaria; Male; Parasites; | 2022 |
Studies in sulpha-biguanides: some N1-aryl-N5-p-(2-pyridyl) phenylsulphonamide-biguanides.
Topics: Antimalarials; Biguanides; Malaria; Sulfanilamide; Sulfanilamides; Sulfonamides | 1950 |
Studies in antimalarials; some N1-(8-chloro-5-quinolyl)-N5-substituted biguanides.
Topics: Antimalarials; Biguanides; Malaria | 1948 |
Paludrine, a new anti-malarial drug.
Topics: Antimalarials; Biguanides; Malaria; Proguanil | 1947 |
Studies in antimalarials; some N1-(8-quinolyl)-N5-phenyl-biguanides.
Topics: Antimalarials; Biguanides; Humans; Malaria | 1948 |
Metachloridine-substituted aryl biguanides as possible antimalarial compounds.
Topics: Antimalarials; Biguanides; Malaria; Proguanil; Sulfonamides | 1948 |
Attempts to find new antimalarials; guanidine and biguanide derivatives of phenanthrene.
Topics: Antimalarials; Biguanides; Guanidine; Guanidines; Malaria; Phenanthrenes | 1947 |
Attempts to find new antimalarials; biguanide derivatives of phenanthrene.
Topics: Antimalarials; Biguanides; Guanidines; Malaria; Phenanthrenes | 1947 |
Synthetic antimalarials; some aryl-diguanide ("-biguanide") derivatives.
Topics: Antimalarials; Biguanides; Guanidines; Malaria | 1946 |
Studies on synthetic antimalarial drugs; some biguanide derivatives as new types of antimalarial substances with both therapeutic and causal prophylactic activity.
Topics: Antimalarials; Biguanides; Guanidine; Guanidines; Humans; Malaria | 1945 |
SCREENING OF POTENTIAL ANTIMALARIALS AGAINST P. GALLINACEUM IN CHICKS. IX. SOME DERIVATIVES OF 4-AMINOQUINAZOLINE, 4 (3)-QUINAZOLONE,4-AMINO-BENZ (H) QUINALDINE, BIGUANIDES AND CERTAIN INDIGENOUS DRUGS.
Topics: Animals; Antimalarials; Biguanides; Chickens; Guanidines; Heterocyclic Compounds; India; Malaria; Ma | 1964 |
N1-3:4-dichlorophenyl-N5-isopropyl diguanide, a derivative of proguanil highly active in avian malaria.
Topics: Animals; Biguanides; Humans; Malaria; Malaria, Avian; Proguanil | 1950 |
N4-(Biguanidyl-substituted)-N1-benzoyl sulphanilamides.
Topics: Biguanides; Malaria; Sulfanilamide; Sulfanilamides; Sulfonamides | 1950 |
Antibacterial properties of some quinoline substituted guanides with special reference to the acute toxicity and the bacteriostatic activity of N'-(p-chlorophenyl)-N5-(8'chloro-5'quinolyl) biguanide acetate.
Topics: Acetates; Anti-Bacterial Agents; Biguanides; DDT; Malaria; Quinolines | 1950 |
Acquired resistance to chloroguanide in the pigeon strain of Plasmodium relictum (Grassi and Feletti, 1891).
Topics: Animals; Biguanides; Columbidae; Humans; Immunologic Tests; Malaria; Plasmodium; Proguanil | 1950 |
Proguanil hydrochloride (paludrine) in the prevention and treatment of malaria in New Guinea.
Topics: Biguanides; Biomedical Research; Humans; Malaria; New Guinea; Proguanil | 1951 |
The stability of paludrine-resistance in Plasmodium gallinaceum in the absence of the drug.
Topics: Biguanides; Malaria; Plasmodium gallinaceum; Proguanil | 1950 |
Paludrine treatment of experimental malaria infection; effective minimum doses.
Topics: Biguanides; Malaria; Proguanil | 1950 |
Paludrine (proguanil) as a malarial prophylactic amongst African labour in Kenya.
Topics: Biguanides; Black People; Humans; Kenya; Malaria; Proguanil | 1950 |
Antimalarial drugs in West Africa, with particular reference to proguanil; results of a survey in Nigeria.
Topics: Africa, Western; Antimalarials; Biguanides; Data Collection; Humans; Malaria; Nigeria; Proguanil | 1950 |
The use of paludrine in malaria prevention.
Topics: Biguanides; Malaria; Proguanil | 1950 |
Prophylaxis and treatment of malaria with diguanyl (paludrine)
Topics: Biguanides; Humans; Malaria | 1949 |
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy | 1993 |
Treatment and chemoprophylaxis of malaria.
Topics: Aminoquinolines; Antimalarials; Biguanides; Chloroquine; Dapsone; Humans; Malaria; Plasmodium falcip | 1979 |
Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, iminium ions, and peroxides.
Topics: Aminacrine; Aminoquinolines; Biguanides; Dapsone; Electron Transport; Free Radicals; Imines; Ions; M | 1985 |
Generalised pustular drug rash.
Topics: Adult; Aged; Biguanides; Chloramphenicol; Chloroquine; Cross Reactions; Digoxin; Drug Eruptions; Fur | 1973 |
[Malaria prevention for Swedish tourists in West-Africa].
Topics: Africa, Western; Antimalarials; Biguanides; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodiu | 1974 |