biguanides has been researched along with Leg Ulcer in 11 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders." | 5.33 | Leg ulcer in a patient associated with hydroxyurea therapy. ( Dissemond, J; Franckson, T; Goos, M; Hoeft, D; Knab, J; Kroger, K, 2006) |
| "Pain was lower in the intervention group at week six, compared with controls (p=0." | 3.11 | Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT. ( McMillan, D; Vallejo, A; Wallis, M, 2022) |
| "28 leg ulcers were treated (12 venous, 5 diabetic, 8 thraumatic, 3 mixed) in 25 patients." | 1.48 | Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide. ( Botta, G; Cuomo, R; D'Aniello, C; Mancini, S; Poggialini, M, 2018) |
| "Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders." | 1.33 | Leg ulcer in a patient associated with hydroxyurea therapy. ( Dissemond, J; Franckson, T; Goos, M; Hoeft, D; Knab, J; Kroger, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Vallejo, A | 2 |
| Wallis, M | 2 |
| McMillan, D | 2 |
| Radischat, N | 1 |
| Augustin, M | 1 |
| Herberger, K | 2 |
| Wille, A | 1 |
| Goroncy-Bermes, P | 1 |
| Horton, E | 1 |
| Mancini, S | 1 |
| Cuomo, R | 1 |
| Poggialini, M | 1 |
| D'Aniello, C | 1 |
| Botta, G | 1 |
| Jockenhöfer, F | 1 |
| Gollnick, H | 1 |
| Isbary, G | 1 |
| Renner, R | 1 |
| Stücker, M | 1 |
| Valesky, E | 1 |
| Wollina, U | 1 |
| Weichenthal, M | 1 |
| Karrer, S | 1 |
| Stoffels-Weindorf, M | 1 |
| Dissemond, J | 2 |
| Schrøder, MA | 1 |
| Kirketerp-Møller, K | 1 |
| Winther, L | 1 |
| Bervoets, A | 1 |
| Aerts, O | 1 |
| Sibbald, RG | 1 |
| Coutts, P | 1 |
| Woo, KY | 1 |
| Hoeft, D | 1 |
| Knab, J | 1 |
| Franckson, T | 1 |
| Kroger, K | 1 |
| Goos, M | 1 |
| From, E | 1 |
| Heydenreich, G | 1 |
| Siboni, K | 1 |
3 trials available for biguanides and Leg Ulcer
| Article | Year |
|---|---|
Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT.
Topics: Adult; Biguanides; Debridement; Humans; Leg Ulcer; Pain; Quality of Life; Ultrasonics; Wound Healing | 2022 |
Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT protocol.
Topics: Biguanides; Debridement; Disinfectants; Humans; Leg Ulcer; Randomized Controlled Trials as Topic; Ul | 2021 |
Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Biguanides; Canada; Chro | 2011 |
8 other studies available for biguanides and Leg Ulcer
| Article | Year |
|---|---|
Influence of human wound exudate on the bactericidal efficacy of antiseptic agents in quantitative suspension tests on the basis of European Standards (DIN EN 13727).
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biguanides; Chlorhexidine; Exudates and Trans | 2020 |
Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide.
Topics: Aged; Aged, 80 and over; Bacterial Load; Biguanides; Debridement; Disinfectants; Humans; Leg Ulcer; | 2018 |
W.A.R. scores in patients with chronic leg ulcers: results of a multicentre study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biguanides; Child; Chronic Diseas | 2014 |
[Suspected anaphylaxis by wound treatment with polyhexanide derivate wound products].
Topics: Aged; Anaphylaxis; Biguanides; Disinfectants; Female; Humans; Leg Ulcer | 2014 |
Polyhexamethylene biguanide in wound care products: a non-negligible cause of peri-ulcer dermatitis.
Topics: Biguanides; Dermatitis, Allergic Contact; Disinfectants; Female; Humans; Leg Ulcer; Middle Aged | 2016 |
[Treatment of ulcus cruris and other chronic wounds. Waiting can cost the foot].
Topics: Biguanides; Chronic Disease; Drug Therapy, Combination; Humans; Leg Ulcer; Silver; Wound Healing; Wo | 2008 |
Leg ulcer in a patient associated with hydroxyurea therapy.
Topics: Alginates; Antineoplastic Agents; Bandages; Biguanides; Debridement; Glucuronic Acid; Hexuronic Acid | 2006 |
Tetracycline-resistant haemolytic streptococci in patients with leg ulcers. An argument for changing the topical treatment.
Topics: Aged; Biguanides; Drug Resistance, Microbial; Female; Humans; Leg Ulcer; Male; Microbial Sensitivity | 1972 |