Page last updated: 2024-11-08

biguanides and Leg Ulcer

biguanides has been researched along with Leg Ulcer in 11 studies

Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.

Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.

Research Excerpts

ExcerptRelevanceReference
"Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders."5.33Leg ulcer in a patient associated with hydroxyurea therapy. ( Dissemond, J; Franckson, T; Goos, M; Hoeft, D; Knab, J; Kroger, K, 2006)
"Pain was lower in the intervention group at week six, compared with controls (p=0."3.11Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT. ( McMillan, D; Vallejo, A; Wallis, M, 2022)
"28 leg ulcers were treated (12 venous, 5 diabetic, 8 thraumatic, 3 mixed) in 25 patients."1.48Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide. ( Botta, G; Cuomo, R; D'Aniello, C; Mancini, S; Poggialini, M, 2018)
"Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders."1.33Leg ulcer in a patient associated with hydroxyurea therapy. ( Dissemond, J; Franckson, T; Goos, M; Hoeft, D; Knab, J; Kroger, K, 2006)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Vallejo, A2
Wallis, M2
McMillan, D2
Radischat, N1
Augustin, M1
Herberger, K2
Wille, A1
Goroncy-Bermes, P1
Horton, E1
Mancini, S1
Cuomo, R1
Poggialini, M1
D'Aniello, C1
Botta, G1
Jockenhöfer, F1
Gollnick, H1
Isbary, G1
Renner, R1
Stücker, M1
Valesky, E1
Wollina, U1
Weichenthal, M1
Karrer, S1
Stoffels-Weindorf, M1
Dissemond, J2
Schrøder, MA1
Kirketerp-Møller, K1
Winther, L1
Bervoets, A1
Aerts, O1
Sibbald, RG1
Coutts, P1
Woo, KY1
Hoeft, D1
Knab, J1
Franckson, T1
Kroger, K1
Goos, M1
From, E1
Heydenreich, G1
Siboni, K1

Trials

3 trials available for biguanides and Leg Ulcer

ArticleYear
Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT.
    Journal of wound care, 2022, Aug-02, Volume: 31, Issue:8

    Topics: Adult; Biguanides; Debridement; Humans; Leg Ulcer; Pain; Quality of Life; Ultrasonics; Wound Healing

2022
Use of low-frequency contact ultrasonic debridement with and without polyhexamethylene biguanide in hard-to-heal leg ulcers: an RCT protocol.
    Journal of wound care, 2021, May-02, Volume: 30, Issue:5

    Topics: Biguanides; Debridement; Disinfectants; Humans; Leg Ulcer; Randomized Controlled Trials as Topic; Ul

2021
Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results.
    Advances in skin & wound care, 2011, Volume: 24, Issue:2

    Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Biguanides; Canada; Chro

2011

Other Studies

8 other studies available for biguanides and Leg Ulcer

ArticleYear
Influence of human wound exudate on the bactericidal efficacy of antiseptic agents in quantitative suspension tests on the basis of European Standards (DIN EN 13727).
    International wound journal, 2020, Volume: 17, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biguanides; Chlorhexidine; Exudates and Trans

2020
Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide.
    Acta bio-medica : Atenei Parmensis, 2018, 01-16, Volume: 88, Issue:4

    Topics: Aged; Aged, 80 and over; Bacterial Load; Biguanides; Debridement; Disinfectants; Humans; Leg Ulcer;

2018
W.A.R. scores in patients with chronic leg ulcers: results of a multicentre study.
    Journal of wound care, 2014, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biguanides; Child; Chronic Diseas

2014
[Suspected anaphylaxis by wound treatment with polyhexanide derivate wound products].
    Ugeskrift for laeger, 2014, Dec-15, Volume: 176, Issue:25A

    Topics: Aged; Anaphylaxis; Biguanides; Disinfectants; Female; Humans; Leg Ulcer

2014
Polyhexamethylene biguanide in wound care products: a non-negligible cause of peri-ulcer dermatitis.
    Contact dermatitis, 2016, Volume: 74, Issue:1

    Topics: Biguanides; Dermatitis, Allergic Contact; Disinfectants; Female; Humans; Leg Ulcer; Middle Aged

2016
[Treatment of ulcus cruris and other chronic wounds. Waiting can cost the foot].
    MMW Fortschritte der Medizin, 2008, Dec-11, Volume: 150, Issue:51-52

    Topics: Biguanides; Chronic Disease; Drug Therapy, Combination; Humans; Leg Ulcer; Silver; Wound Healing; Wo

2008
Leg ulcer in a patient associated with hydroxyurea therapy.
    International journal of dermatology, 2006, Volume: 45, Issue:2

    Topics: Alginates; Antineoplastic Agents; Bandages; Biguanides; Debridement; Glucuronic Acid; Hexuronic Acid

2006
Tetracycline-resistant haemolytic streptococci in patients with leg ulcers. An argument for changing the topical treatment.
    Acta dermato-venereologica, 1972, Volume: 52, Issue:1

    Topics: Aged; Biguanides; Drug Resistance, Microbial; Female; Humans; Leg Ulcer; Male; Microbial Sensitivity

1972