Compounds > biguanides
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biguanides and Infections, Plasmodium

biguanides has been researched along with Infections, Plasmodium in 28 studies

Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.

Research Excerpts

ExcerptRelevanceReference
"Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil."7.68Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993)
"A mechanism of action is proposed that encompasses almost all of the main categories of antimalarial agents: quinones and precursors, dapsone metabolites, metal complexes of thiosemicarbazones and biguanides, iminium-type ions from acridines and quinolines, and peroxides."7.67Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, iminium ions, and peroxides. ( Ames, JR; Klayman, DL; Kovacic, P; Ryan, MD, 1985)
"Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil."3.68Single dose pharmacokinetics of proguanil and its metabolites in pregnancy. ( Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ, 1993)
"A mechanism of action is proposed that encompasses almost all of the main categories of antimalarial agents: quinones and precursors, dapsone metabolites, metal complexes of thiosemicarbazones and biguanides, iminium-type ions from acridines and quinolines, and peroxides."3.67Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, iminium ions, and peroxides. ( Ames, JR; Klayman, DL; Kovacic, P; Ryan, MD, 1985)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199026 (92.86)18.7374
1990's1 (3.57)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Jia, X1
Liu, F1
Bai, J1
Zhang, Y1
Cui, L1
Cao, Y1
Luo, E1
BAMI, HL2
GUPTA, PR3
GUHA, PC3
CHOUDHURY, M1
IYER, BH2
GUBA, PC1
MAY, EL2
CURD, FH3
ROSE, FL3
DAVEY, DG2
DHATT, MS1
SINGH, H1
BASU, PC1
HENDRY, JA1
SIRSI, M1
RAMA RAO, R1
DE, NN1
GRANT, JS1
GUNTHER, CE1
BISHOP, A1
McCONNACHIE, EW1
CIUCA, M1
BALLIF, L1
DIXON, DS1
BRUCE-CHWATT, LJ1
BRUCE-CHWATT, JM1
DRANE, P1
PERRILL, CV1
HUVE, P1
Wangboonskul, J1
White, NJ1
Nosten, F1
ter Kuile, F1
Moody, RR1
Taylor, RB1
Spicer, AJ1
Ames, JR1
Ryan, MD1
Klayman, DL1
Kovacic, P1
Macmillan, AL1
Bengtsson, E1
Hall, SA1

Reviews

1 review available for biguanides and Infections, Plasmodium

ArticleYear
Malaria treatment and prevention. A review.
    East African medical journal, 1969, Volume: 46, Issue:10

    Topics: Adolescent; Adult; Africa, Eastern; Antimalarials; Biguanides; Child; Child, Preschool; Chloroquine;

1969

Other Studies

27 other studies available for biguanides and Infections, Plasmodium

ArticleYear
Phosphatase inhibitors BVT-948 and alexidine dihydrochloride inhibit sexual development of the malaria parasite Plasmodium berghei.
    International journal for parasitology. Drugs and drug resistance, 2022, Volume: 19

    Topics: Animals; Antimalarials; Biguanides; Culicidae; Enzyme Inhibitors; Humans; Malaria; Male; Parasites;

2022
Studies in sulpha-biguanides: some N1-aryl-N5-p-(2-pyridyl) phenylsulphonamide-biguanides.
    Indian journal of malariology, 1950, Volume: 4, Issue:2

    Topics: Antimalarials; Biguanides; Malaria; Sulfanilamide; Sulfanilamides; Sulfonamides

1950
Studies in antimalarials; some N1-(8-chloro-5-quinolyl)-N5-substituted biguanides.
    Current science, 1948, Volume: 17, Issue:6

    Topics: Antimalarials; Biguanides; Malaria

1948
Paludrine, a new anti-malarial drug.
    The Antiseptic, 1947, Volume: 44, Issue:9

    Topics: Antimalarials; Biguanides; Malaria; Proguanil

1947
Studies in antimalarials; some N1-(8-quinolyl)-N5-phenyl-biguanides.
    Current science, 1948, Volume: 17, Issue:2

    Topics: Antimalarials; Biguanides; Humans; Malaria

1948
Metachloridine-substituted aryl biguanides as possible antimalarial compounds.
    Nature, 1948, Jul-24, Volume: 162, Issue:4108

    Topics: Antimalarials; Biguanides; Malaria; Proguanil; Sulfonamides

1948
Attempts to find new antimalarials; guanidine and biguanide derivatives of phenanthrene.
    The Journal of organic chemistry, 1947, Volume: 12, Issue:3

    Topics: Antimalarials; Biguanides; Guanidine; Guanidines; Malaria; Phenanthrenes

1947
Attempts to find new antimalarials; biguanide derivatives of phenanthrene.
    The Journal of organic chemistry, 1947, Volume: 12, Issue:3

    Topics: Antimalarials; Biguanides; Guanidines; Malaria; Phenanthrenes

1947
Synthetic antimalarials; some aryl-diguanide ("-biguanide") derivatives.
    Journal of the Chemical Society, 1946

    Topics: Antimalarials; Biguanides; Guanidines; Malaria

1946
Studies on synthetic antimalarial drugs; some biguanide derivatives as new types of antimalarial substances with both therapeutic and causal prophylactic activity.
    Annals of tropical medicine and parasitology, 1945, Dec-31, Volume: 39

    Topics: Antimalarials; Biguanides; Guanidine; Guanidines; Humans; Malaria

1945
SCREENING OF POTENTIAL ANTIMALARIALS AGAINST P. GALLINACEUM IN CHICKS. IX. SOME DERIVATIVES OF 4-AMINOQUINAZOLINE, 4 (3)-QUINAZOLONE,4-AMINO-BENZ (H) QUINALDINE, BIGUANIDES AND CERTAIN INDIGENOUS DRUGS.
    Indian journal of physiology and pharmacology, 1964, Volume: 8

    Topics: Animals; Antimalarials; Biguanides; Chickens; Guanidines; Heterocyclic Compounds; India; Malaria; Ma

1964
N1-3:4-dichlorophenyl-N5-isopropyl diguanide, a derivative of proguanil highly active in avian malaria.
    British journal of pharmacology and chemotherapy, 1950, Volume: 5, Issue:3

    Topics: Animals; Biguanides; Humans; Malaria; Malaria, Avian; Proguanil

1950
N4-(Biguanidyl-substituted)-N1-benzoyl sulphanilamides.
    Current science, 1950, Volume: 19, Issue:10

    Topics: Biguanides; Malaria; Sulfanilamide; Sulfanilamides; Sulfonamides

1950
Antibacterial properties of some quinoline substituted guanides with special reference to the acute toxicity and the bacteriostatic activity of N'-(p-chlorophenyl)-N5-(8'chloro-5'quinolyl) biguanide acetate.
    Current science, 1950, Volume: 19, Issue:10

    Topics: Acetates; Anti-Bacterial Agents; Biguanides; DDT; Malaria; Quinolines

1950
Acquired resistance to chloroguanide in the pigeon strain of Plasmodium relictum (Grassi and Feletti, 1891).
    Journal. National Malaria Society (U.S.), 1950, Volume: 9, Issue:3

    Topics: Animals; Biguanides; Columbidae; Humans; Immunologic Tests; Malaria; Plasmodium; Proguanil

1950
Proguanil hydrochloride (paludrine) in the prevention and treatment of malaria in New Guinea.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1951, Volume: 44, Issue:4

    Topics: Biguanides; Biomedical Research; Humans; Malaria; New Guinea; Proguanil

1951
The stability of paludrine-resistance in Plasmodium gallinaceum in the absence of the drug.
    Parasitology, 1950, Volume: 40, Issue:1-2

    Topics: Biguanides; Malaria; Plasmodium gallinaceum; Proguanil

1950
Paludrine treatment of experimental malaria infection; effective minimum doses.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1950, Volume: 43, Issue:4

    Topics: Biguanides; Malaria; Proguanil

1950
Paludrine (proguanil) as a malarial prophylactic amongst African labour in Kenya.
    East African medical journal, 1950, Volume: 27, Issue:3

    Topics: Biguanides; Black People; Humans; Kenya; Malaria; Proguanil

1950
Antimalarial drugs in West Africa, with particular reference to proguanil; results of a survey in Nigeria.
    British medical journal, 1950, Jul-01, Volume: 2, Issue:4669

    Topics: Africa, Western; Antimalarials; Biguanides; Data Collection; Humans; Malaria; Nigeria; Proguanil

1950
The use of paludrine in malaria prevention.
    The Journal of the Christian Medical Association of India, 1950, Volume: 25, Issue:3

    Topics: Biguanides; Malaria; Proguanil

1950
Prophylaxis and treatment of malaria with diguanyl (paludrine)
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1949, Jun-26, Volume: 25, Issue:47

    Topics: Biguanides; Humans; Malaria

1949
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
    European journal of clinical pharmacology, 1993, Volume: 44, Issue:3

    Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy

1993
Treatment and chemoprophylaxis of malaria.
    The Practitioner, 1979, Volume: 223, Issue:1336

    Topics: Aminoquinolines; Antimalarials; Biguanides; Chloroquine; Dapsone; Humans; Malaria; Plasmodium falcip

1979
Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, iminium ions, and peroxides.
    Journal of free radicals in biology & medicine, 1985, Volume: 1, Issue:5-6

    Topics: Aminacrine; Aminoquinolines; Biguanides; Dapsone; Electron Transport; Free Radicals; Imines; Ions; M

1985
Generalised pustular drug rash.
    Dermatologica, 1973, Volume: 146, Issue:5

    Topics: Adult; Aged; Biguanides; Chloramphenicol; Chloroquine; Cross Reactions; Digoxin; Drug Eruptions; Fur

1973
[Malaria prevention for Swedish tourists in West-Africa].
    Nordisk medicin, 1974, Volume: 89, Issue:10

    Topics: Africa, Western; Antimalarials; Biguanides; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodiu

1974