biguanides has been researched along with Infection, Wound in 42 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compares treatment with a polihexanide-containing biocellulose wound dressing (BWD+PHMB) versus the best local standard of silver dressings (Ag) in painful, critically colonised (wounds-at-risk) or locally-infected wounds." | 5.16 | Comparison of PHMB-containing dressing and silver dressings in patients with critically colonised or locally infected wounds. ( Abel, M; Eberlein, T; Gruber Moesenbacher, U; Haemmerle, G; Mittlboeck, M; Signer, M; Strohal, R; Traber, J, 2012) |
| "2% chlorhexidine digluconate (SNC) showed that all were comparably effective in protecting burns from infection." | 5.04 | Topical chemoprophylaxis with silver sulphadiazine and silver nitrate chlorhexidine creams: emergence of sulphonamide-resistant Gram-negative bacilli. ( Babb, JR; Bridges, K; Jackson, DM; Lowbury, EJ, 1976) |
| "Prevention of wound infections is a challenge in clinical practice." | 2.87 | Randomized controlled clinical trial on the antiseptic efficacy of polihexanide 0.04% on acute traumatic wounds. ( Brill, FHH; Csuka, E; Hintzpeter, M; Pahl, S; Payne, B; Simmen, HP, 2018) |
| " Few adverse effects from the substance were reported." | 2.53 | Polyhexanide - safety and efficacy as an antiseptic. ( Fjeld, H; Lingaas, E, 2016) |
| "Complex stalled wounds feature an alkaline milieu that favors tissue destruction and microbial growth." | 1.46 | Antibacterial activity of polihexanide formulations in a co-culture of HaCaT keratinocytes and Staphylococcus aureus and at different pH levels. ( Andriessen, A; Eberlein, T; Wiegand, C, 2017) |
| "The use of antibiotics to treat wound infections has decreased due to the increased risk of antibiotic resistance ( Swanson et al, 2014 )." | 1.46 | Wound-bed preparation: a vital step in the healing process. ( Barrett, S, 2017) |
| "A primary strategy for preventing and treating wound infection in chronic wounds is the use of topical antiseptics and wound irrigating agents." | 1.37 | Antimicrobial activity of clinically used antiseptics and wound irrigating agents in combination with wound dressings. ( Goertz, O; Hirsch, T; Jacobsen, F; Lahmer, A; Limoochi-Deli, S; Seipp, HM; Steinau, HU; Steinstraesser, L, 2011) |
| "In clinical practice, too many chronic wounds are regarded as being at risk of infection, and therefore many topical antimicrobials - in terms of frequency and duration of use - are applied to wounds." | 1.37 | Classification of wounds at risk and their antimicrobial treatment with polihexanide: a practice-oriented expert recommendation. ( Assadian, O; Dissemond, J; Eberlein, T; Gerber, V; Kingsley, A; Kramer, A; Leaper, DJ; Mosti, G; Piatkowski de Grzymala, A; Riepe, G; Risse, A; Romanelli, M; Strohal, R; Traber, J; Vasel-Biergans, A; Wild, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.52) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 28 (66.67) | 24.3611 |
| 2020's | 5 (11.90) | 2.80 |
| Authors | Studies |
|---|---|
| Ramasamy, S | 1 |
| Muthusamy, S | 1 |
| Nagarajan, S | 1 |
| Nath, AV | 1 |
| Savarimuthu, JS | 1 |
| Jayaprakash, J | 1 |
| Gurunadhan, RM | 1 |
| Rippon, MG | 1 |
| Rogers, AA | 1 |
| Westgate, S | 1 |
| Stoffel, JJ | 1 |
| Kohler Riedi, PL | 1 |
| Hadj Romdhane, B | 1 |
| Jin, J | 1 |
| Chen, ZL | 1 |
| Xiang, Y | 1 |
| Tang, T | 1 |
| Zhou, H | 1 |
| Hong, XD | 1 |
| Fan, H | 1 |
| Zhang, XD | 1 |
| Luo, PF | 1 |
| Ma, B | 1 |
| Wang, GY | 1 |
| Xia, ZF | 1 |
| Sams-Dodd, J | 1 |
| Sams-Dodd, F | 1 |
| Weigelt, MA | 1 |
| McNamara, SA | 1 |
| Sanchez, D | 1 |
| Hirt, PA | 1 |
| Kirsner, RS | 1 |
| Wiegand, C | 1 |
| Eberlein, T | 3 |
| Andriessen, A | 2 |
| Kapalschinski, N | 1 |
| Seipp, HM | 2 |
| Kückelhaus, M | 1 |
| Harati, KK | 1 |
| Kolbenschlag, JJ | 1 |
| Daigeler, A | 1 |
| Jacobsen, F | 2 |
| Lehnhardt, M | 1 |
| Hirsch, T | 2 |
| Barrett, S | 1 |
| Payne, B | 1 |
| Simmen, HP | 1 |
| Csuka, E | 1 |
| Hintzpeter, M | 1 |
| Pahl, S | 1 |
| Brill, FHH | 1 |
| Winter, S | 1 |
| Nolff, MC | 1 |
| Reese, S | 1 |
| Meyer-Lindenberg, A | 1 |
| de Mattos, IB | 1 |
| Holzer, JCJ | 1 |
| Tuca, AC | 1 |
| Groeber-Becker, F | 1 |
| Funk, M | 1 |
| Popp, D | 1 |
| Mautner, S | 1 |
| Birngruber, T | 1 |
| Kamolz, LP | 1 |
| Dalla Paola, L | 1 |
| Back, DA | 1 |
| Scheuermann-Poley, C | 1 |
| Willy, C | 1 |
| Jockenhöfer, F | 1 |
| Gollnick, H | 1 |
| Herberger, K | 1 |
| Isbary, G | 1 |
| Renner, R | 1 |
| Stücker, M | 1 |
| Valesky, E | 1 |
| Wollina, U | 1 |
| Weichenthal, M | 1 |
| Karrer, S | 1 |
| Stoffels-Weindorf, M | 1 |
| Dissemond, J | 2 |
| Kim, PJ | 1 |
| Attinger, CE | 1 |
| Steinberg, JS | 1 |
| Evans, KK | 1 |
| Powers, KA | 1 |
| Hung, RW | 1 |
| Smith, JR | 1 |
| Rocha, ZM | 1 |
| Lavery, L | 1 |
| Harding, K | 1 |
| Napavichayanun, S | 1 |
| Amornsudthiwat, P | 1 |
| Pienpinijtham, P | 1 |
| Aramwit, P | 1 |
| Fjeld, H | 1 |
| Lingaas, E | 1 |
| Krezdorn, N | 1 |
| Könneker, S | 1 |
| Paprottka, FJ | 1 |
| Tapking, C | 1 |
| Mett, TR | 1 |
| Brölsch, GF | 1 |
| Boyce, M | 1 |
| Ipaktchi, R | 1 |
| Vogt, PM | 1 |
| Hurlow, J | 1 |
| Kramer, A | 5 |
| Hübner, NO | 2 |
| Assadian, O | 2 |
| Mulder, G | 1 |
| Roth, B | 2 |
| Brill, FH | 1 |
| Kaehn, K | 1 |
| Roth, C | 1 |
| Beule, AG | 1 |
| Hosemann, W | 1 |
| Kohlmann, T | 1 |
| Scharf, C | 1 |
| Limoochi-Deli, S | 1 |
| Lahmer, A | 1 |
| Goertz, O | 1 |
| Steinau, HU | 1 |
| Steinstraesser, L | 1 |
| Gerber, V | 1 |
| Kingsley, A | 1 |
| Leaper, DJ | 1 |
| Mosti, G | 1 |
| Piatkowski de Grzymala, A | 1 |
| Riepe, G | 1 |
| Risse, A | 1 |
| Romanelli, M | 1 |
| Strohal, R | 2 |
| Traber, J | 3 |
| Vasel-Biergans, A | 1 |
| Wild, T | 1 |
| Hotz, D | 1 |
| Mayer, D | 1 |
| Läuchli, S | 1 |
| Jiang, B | 1 |
| Larson, JC | 1 |
| Drapala, PW | 1 |
| Pérez-Luna, VH | 1 |
| Kang-Mieler, JJ | 1 |
| Brey, EM | 1 |
| Lenselink, E | 1 |
| Haemmerle, G | 1 |
| Signer, M | 1 |
| Gruber Moesenbacher, U | 1 |
| Mittlboeck, M | 1 |
| Abel, M | 1 |
| Ulmer, M | 1 |
| Patzelt, A | 1 |
| Vergou, T | 1 |
| Richter, H | 1 |
| Müller, G | 1 |
| Sterry, W | 1 |
| Czaika, V | 1 |
| Lademann, J | 1 |
| Werthén, M | 1 |
| Davoudi, M | 1 |
| Sonesson, A | 1 |
| Nitsche, DP | 1 |
| Mörgelin, M | 1 |
| Blom, K | 1 |
| Schmidtchen, A | 1 |
| Motta, GJ | 1 |
| Trigilia, D | 1 |
| Fleck, CA | 1 |
| Willenegger, H | 2 |
| Schmit-Neuerburg, KP | 1 |
| Bettag, C | 1 |
| Schlickewei, W | 1 |
| Fabry, W | 1 |
| Hanke, J | 1 |
| Renzing-Köhler, K | 1 |
| Hirche, H | 1 |
| Kock, HJ | 1 |
| Müller, J | 1 |
| Lusser, G | 1 |
| Good, H | 1 |
| Lawrence, JC | 1 |
| Lowbury, EJ | 1 |
| Babb, JR | 1 |
| Bridges, K | 1 |
| Jackson, DM | 1 |
| Wechselberger, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Micro/Nanobubbles (MNBs) and Wound Therapy: A Pilot Study Involving a Novel Oxygen Delivery System for Treatment of Acute and Chronic Wounds[NCT05169814] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2021-10-09 | Recruiting | ||
| [NCT01740245] | Phase 4 | 0 participants | Interventional | Completed | |||
| [NCT01571141] | Phase 4 | 0 participants | Interventional | Completed | |||
| Kerlix AMD Gauze Study In A Burn Trauma Unit and Its Effect on Healthcare Associated Infections in Burn Patients[NCT00656708] | 108 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for biguanides and Infection, Wound
| Article | Year |
|---|---|
Evidence-Based Review of Antibiofilm Agents for Wound Care.
Topics: Animals; Anti-Infective Agents, Local; Bandages; Benzalkonium Compounds; Biguanides; Biofilms; Disin | 2021 |
Diabetic foot wounds: the value of negative pressure wound therapy with instillation.
Topics: Anti-Bacterial Agents; Biguanides; Chondroitin Sulfates; Collagen; Debridement; Diabetic Foot; Granu | 2013 |
Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions - when, where and how to use: what does the evidence show?
Topics: Acetic Acid; Anti-Infective Agents, Local; Biguanides; Cross Infection; Evidence-Based Medicine; Hum | 2013 |
Polyhexanide - safety and efficacy as an antiseptic.
Topics: Anti-Infective Agents, Local; Biguanides; Candida albicans; Gram-Negative Bacteria; Gram-Positive Ba | 2016 |
Polihexanide: a safe and highly effective biocide.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacteria; Biguanides; Biofilms; Disinf | 2010 |
Review on the efficacy, safety and clinical applications of polihexanide, a modern wound antiseptic.
Topics: Adsorption; Animals; Anti-Infective Agents, Local; Biguanides; Clinical Trials as Topic; Drug Resist | 2010 |
[Recommendations for the use of polyhexanide-containing products for the treatment of wounds].
Topics: Anti-Infective Agents, Local; Biguanides; Consensus; Critical Pathways; Humans; Wound Infection | 2011 |
Fighting infection in chronic wounds.
Topics: Acrylic Resins; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Benchmarking; Biguani | 2006 |
[Local antiseptics in surgery--rebirth and advances].
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Biguanides; Fracture Fixation, Inter | 1994 |
7 trials available for biguanides and Infection, Wound
| Article | Year |
|---|---|
Randomized controlled clinical trial on the antiseptic efficacy of polihexanide 0.04% on acute traumatic wounds.
Topics: Adult; Aged; Anti-Infective Agents, Local; Bacterial Load; Biguanides; Colony Count, Microbial; Doub | 2018 |
A cohort study on the efficacy of a polyhexanide-containing biocellulose dressing in the treatment of biofilms in wounds.
Topics: Biguanides; Biofilms; Cellulose; Chronic Disease; Disinfectants; Female; Humans; Male; Middle Aged; | 2011 |
Comparison of PHMB-containing dressing and silver dressings in patients with critically colonised or locally infected wounds.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Bacterial Infections; Bacterial Load; | 2012 |
In vivo investigation of the efficiency of a nanoparticle-emulsion containing polihexanide on the human skin.
Topics: Adult; Anti-Infective Agents, Local; Biguanides; Colony Count, Microbial; Disinfection; Double-Blind | 2013 |
The effect of an antimicrobial drain sponge dressing on specific bacterial isolates at tracheostomy sites.
Topics: Adult; Aged; Aged, 80 and over; Bandages; Biguanides; Clinical Nursing Research; Disinfectants; Ente | 2005 |
[Effectiveness of an improved antiseptic in treatment of contaminated soft tissue wounds].
Topics: Adult; Aged; Anti-Infective Agents, Local; Bacterial Infections; Biguanides; Double-Blind Method; Fe | 2001 |
Topical chemoprophylaxis with silver sulphadiazine and silver nitrate chlorhexidine creams: emergence of sulphonamide-resistant Gram-negative bacilli.
Topics: Administration, Topical; Adolescent; Adult; Bacteria; Biguanides; Burns; Child; Child, Preschool; Ch | 1976 |
26 other studies available for biguanides and Infection, Wound
| Article | Year |
|---|---|
Fabrication of collagen with polyhexamethylene biguanide: A potential scaffold for infected wounds.
Topics: Anti-Bacterial Agents; Bandages; Biguanides; Collagen; Humans; Wound Infection | 2022 |
Treating drug-resistant wound pathogens with non-medicated dressings: an
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Biguanides; Biofilms; Culture Techniques; Methicillin- | 2019 |
A multimodel regime for evaluating effectiveness of antimicrobial wound care products in microbial biofilms.
Topics: Acinetobacter baumannii; Administration, Topical; Animals; Anti-Infective Agents, Local; Benzalkoniu | 2020 |
Development of a PHMB hydrogel-modified wound scaffold dressing with antibacterial activity.
Topics: Acinetobacter baumannii; Animals; Anti-Infective Agents, Local; Bandages; Biguanides; Disinfectants; | 2020 |
Micropore Particle Technology Promotes Wound Healing, Whereas Polyhexamethylene Biguanide Causes Tissue Degeneration: A Case Report.
Topics: Abscess; Aged; Anti-Infective Agents, Local; Biguanides; Biomedical Technology; Debridement; Exudate | 2020 |
Antibacterial activity of polihexanide formulations in a co-culture of HaCaT keratinocytes and Staphylococcus aureus and at different pH levels.
Topics: Anti-Bacterial Agents; Bandages; Biguanides; Coculture Techniques; Humans; Hydrogen-Ion Concentratio | 2017 |
Albumin reduces the antibacterial efficacy of wound antiseptics against Staphylococcus aureus.
Topics: Anti-Infective Agents, Local; Biguanides; Ethylene Glycols; Exudates and Transudates; Humans; Imines | 2017 |
Wound-bed preparation: a vital step in the healing process.
Topics: Administration, Cutaneous; Anti-Bacterial Agents; Anti-Infective Agents, Local; Biguanides; Biofilms | 2017 |
[Comparison of the antibacterial efficacy of polyhexanide, cold atmospheric argon plasma and saline in the treatment of canine bite wounds].
Topics: Animals; Anti-Bacterial Agents; Argon; Biguanides; Bites and Stings; Dog Diseases; Dogs; Plasma Gase | 2018 |
Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure.
Topics: Bandages; Biguanides; Cellulose; Disinfectants; Humans; Microbial Sensitivity Tests; Spectrophotomet | 2019 |
W.A.R. scores in patients with chronic leg ulcers: results of a multicentre study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biguanides; Child; Chronic Diseas | 2014 |
The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Betaine; Biguanide | 2014 |
Prologue: transformational healing solutions.
Topics: Anti-Infective Agents, Local; Bandages; Biguanides; Humans; Negative-Pressure Wound Therapy; Practic | 2015 |
Interaction and effectiveness of antimicrobials along with healing-promoting agents in a novel biocellulose wound dressing.
Topics: Anti-Bacterial Agents; Bacteria; Bandages; Biguanides; Cellulose; Re-Epithelialization; Wound Healin | 2015 |
Biobrane versus topical agents in the treatment of adult scald burns.
Topics: Administration, Cutaneous; Adult; Age Factors; Aged; Alcohol Drinking; Biguanides; Body Surface Area | 2017 |
The benefits of using polyhexamethylene biguanide in wound care.
Topics: Bandages; Biguanides; Biofilms; Disinfectants; Humans; Wound Infection; Wounds and Injuries | 2017 |
Polihexanide--perspectives on clinical wound antisepsis.
Topics: Anti-Infective Agents, Local; Antisepsis; Biguanides; Drug Resistance, Microbial; Humans; Skin; Woun | 2010 |
Polihexanide for wound treatment--how it began.
Topics: Anti-Infective Agents, Local; Antisepsis; Biguanides; Drug Carriers; Drug Resistance, Microbial; His | 2010 |
Response analysis of stimulating efficacy of polihexanide in an in vitro wound model with respiratory ciliary epithelial cells.
Topics: Anti-Infective Agents, Local; Biguanides; Cell Line; Cell Proliferation; Dose-Response Relationship, | 2010 |
Antimicrobial activity of clinically used antiseptics and wound irrigating agents in combination with wound dressings.
Topics: Anti-Infective Agents, Local; Bandages; Biguanides; Imines; In Vitro Techniques; Microbial Sensitivi | 2011 |
Classification of wounds at risk and their antimicrobial treatment with polihexanide: a practice-oriented expert recommendation.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Biguanides; Humans; Immu | 2011 |
Investigation of lysine acrylate containing poly(N-isopropylacrylamide) hydrogels as wound dressings in normal and infected wounds.
Topics: Acrylamides; Acrylates; Acrylic Resins; Animals; Anti-Bacterial Agents; Bandages; Biguanides; Disinf | 2012 |
Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer.
Topics: Antimicrobial Cationic Peptides; Biguanides; Colony Count, Microbial; Exudates and Transudates; Huma | 2004 |
[Clinical experiences with disinfectant solutions in posttraumatic osteitis].
Topics: Adolescent; Biguanides; Female; Fracture Fixation, Internal; Humans; Male; Middle Aged; Osteitis; Qu | 1979 |
Minor burns.
Topics: Bandages; Biguanides; Burns; Chlorhexidine; Humans; Wound Healing; Wound Infection | 1977 |
[Local management of wounds using the Biotensid wound spray].
Topics: Aerosols; Biguanides; Humans; Wound Infection; Wounds and Injuries | 1975 |