Page last updated: 2024-11-08

biguanides and Fasting Hypoglycemia

biguanides has been researched along with Fasting Hypoglycemia in 68 studies

Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
"The therapeutic effect of short-term buformin (l-butylbiguanide) treatment was investigated in 12 patients with reactive hypoglycemia."7.65Treatment of reactive hypoglycemia with buformin. ( Cabrijan, T; Sekso, M; Solter, M; Zjacić, V, 1975)
" Weight loss was greater in patients with lower baseline HbA1c and in patients taking concomitant biguanides."5.22Subgroup analysis of phase 3 studies of dulaglutide in Japanese patients with type 2 diabetes. ( Iwamoto, N; Nishiyama, H; Ohyama, S; Onishi, Y; Oura, T; Takeuchi, M, 2016)
" As an essential complication provoked by biguanides a lactic acidosis may be elicited which--though seldom occurring--then in most cases takes a fatal course."3.67[Drug-induced harm due to antidiabetics]. ( Verlohren, HJ, 1984)
" The most dangerous side-effect of biguanides is lactic acidosis."3.67Incidence of severe sideeffects during therapy with sulfonylureas and biguanides. ( Berger, W, 1985)
"The therapeutic effect of short-term buformin (l-butylbiguanide) treatment was investigated in 12 patients with reactive hypoglycemia."3.65Treatment of reactive hypoglycemia with buformin. ( Cabrijan, T; Sekso, M; Solter, M; Zjacić, V, 1975)
" The overall incidence of treatment-emergent adverse events (TEAEs) was 75."2.82Long-term safety and efficacy of fasiglifam (TAK-875), a G-protein-coupled receptor 40 agonist, as monotherapy and combination therapy in Japanese patients with type 2 diabetes: a 52-week open-label phase III study. ( Enya, K; Kaku, K; Matsuno, R; Nakaya, R; Ohira, T, 2016)
" The most frequent adverse events with dulaglutide treatment were nasopharyngitis and gastrointestinal symptoms."2.80Efficacy and safety of once-weekly dulaglutide in combination with sulphonylurea and/or biguanide compared with once-daily insulin glargine in Japanese patients with type 2 diabetes: a randomized, open-label, phase III, non-inferiority study. ( Araki, E; Imaoka, T; Inagaki, N; Oura, T; Takeuchi, M; Tanizawa, Y, 2015)
"In the treatment of elderly type 2 diabetes, it is important to detect hypoglycemia correctly, because the elderly patients often exhibit atypical symptoms from hypoglycemia."2.43[Knack of treatment with oral hypoglycemic drugs in the elderly]. ( Hashizume, K; Komatsu, M, 2006)
"Currently available oral agents for the treatment of type 2 diabetes mellitus include a variety of compounds from 5 different pharmacologic classes with differing mechanisms of action, adverse effect profiles, and toxicities."2.41Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment. ( Beattie, P; Harrigan, RA; Nathan, MS, 2001)
"Nocturnal hypoglycemia is a serious complication of insulin-treated diabetes, and it is often asymptomatic."1.56A Novel CGM Metric-Gradient and Combining Mean Sensor Glucose Enable to Improve the Prediction of Nocturnal Hypoglycemic Events in Patients with Diabetes. ( Bao, Y; Kandwal, A; Li, J; Liu, Y; Lu, J; Lu, W; Ma, X; Nie, Z; Tobore, I; Wang, L; Zhou, J, 2020)
" At the same time about 1/3 of these serious adverse drug reactions (ADR) was found to have been reported to the ADR-register."1.27Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden. ( Westerholm, B; Wiholm, BE, 1984)

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-199054 (79.41)18.7374
1990's3 (4.41)18.2507
2000's3 (4.41)29.6817
2010's7 (10.29)24.3611
2020's1 (1.47)2.80

Authors

AuthorsStudies
Li, J1
Ma, X1
Tobore, I1
Liu, Y1
Kandwal, A1
Wang, L1
Lu, J1
Lu, W1
Bao, Y1
Zhou, J1
Nie, Z1
Kopecky, C1
Umetsu, R1
Nishibata, Y1
Abe, J1
Suzuki, Y1
Hara, H1
Nagasawa, H1
Kinosada, Y1
Nakamura, M1
Araki, E2
Tanizawa, Y2
Tanaka, Y1
Taniguchi, A1
Koiwai, K1
Kim, G1
Salsali, A1
Woerle, HJ1
Broedl, UC1
Inagaki, N1
Oura, T2
Takeuchi, M2
Imaoka, T1
Onishi, Y1
Nishiyama, H1
Ohyama, S1
Iwamoto, N1
Kaku, K1
Enya, K1
Nakaya, R1
Ohira, T1
Matsuno, R1
Grunberger, G1
Chen, L1
Rodriguez, A1
Tinahones, FJ1
Jacober, SJ1
Bue-Valleskey, J1
Ben Amara, H1
Kacem, A1
Gaigi, I1
Dakhli, S1
Ben Mami, F1
Achour, A1
STEINER, DF1
WILLIAMS, RH1
FALCONE, AB1
MAO, RL1
SHRAGO, E1
KANEKO, T1
Komatsu, M1
Hashizume, K1
Verlohren, HJ1
Auzepy, P1
Caquet, R1
Lefèbvre, PJ1
Luyckx, AS1
Gérard, J1
Wiholm, BE1
Westerholm, B1
Luk'ianchikov, VS1
Czyzyk, A1
Stryjek-Kamińska, D1
Krentz, AJ1
Ferner, RE1
Bailey, CJ1
Tasaka, Y1
Ishii, J1
Inoue, I1
Harrigan, RA1
Nathan, MS1
Beattie, P1
Gay, G1
Debry, G1
Haslbeck, M1
Permutt, MA1
Sauer, H1
Schneider, B1
Schäfer, G1
Constam, GR1
Sekso, M1
Solter, M1
Zjacić, V1
Cabrijan, T1
Rett, K1
Wicklmayr, M1
Dietze, GJ1
Berger, W3
Solé Violán, J1
Martínez Chuecos, J1
Molinero Somolinos, F1
Marco Moreno, JM1
Wolff, G2
Stowers, JM1
Scoville, AB1
Losert, W4
Loge, O4
Schillinger, E4
Kraaz, W3
Haeckel, R1
De Luca, E1
Pellegrini, M1
Ito, T1
Davidoff, F1
Hermann, LS1
Bäbler, M1
Jahn, P2
Mashimo, K1
Nakagawa, S1
Hanai, N1
Tschudi-Steiner, I1
Mehnert, H1
Breidahl, HD1
Martin, FI1
Semple, B1
Walpole, GR1
Shepherd, DU1
Proust, AJ1
Harcourt, D1
Consiglio, D1
Mantia, G1
Hopps, V1
Ziegelasch, HJ1
Koller, F1
Pirart, J1
Elpern, B1
Lotz, U1
Accettella, U1
Sacra, A1
Gentile, M1
Stötter, G1
Raptis, S1
Rothenbuchner, G1
Pfeiffer, EF1
Rosenbloom, AL1
Jangaard, NO1
Pereira, JN1
Pinson, R1
Böhm, E1
Gutsche, H1
Höpker, W1
Boenicke, G1
Müting, D1
Yoh, YJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A 52-week, Randomised, Multi-centre, Parallel Group Study to Investigate the Safety and Efficacy of BI 10773 (10 mg or 25 mg Administered Orally Once Daily) as add-on Therapy to an Oral Antidiabetic Drug (Sulfonylurea, Biguanide, Thiazolidinedione, Alpha [NCT01368081]Phase 31,162 participants (Actual)Interventional2011-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in HbA1c

Change from baseline in HbA1c after 52 weeks of treatment (NCT01368081)
Timeframe: Baseline and 52 weeks

Interventionpercentage of HbA1c (Least Squares Mean)
Sulfonylurea: Empa 10mg-0.93
Sulfonylurea: Empa 25mg-0.96
Sulfonylurea: Metformin-0.97
Biguanide: Empa 10mg-0.81
Biguanide: Empa 25mg-0.98
Thiazolidinedione: Empa 10mg-0.90
Thiazolidinedione: Empa 25mg-0.96
Alpha Glucosidase Inhibitor: Empa 10mg-0.87
Alpha Glucosidase Inhibitor: Empa 25mg-0.77
DPP-IV Inhibitor: Empa 10mg-1.00
DPP-IV Inhibitor: Empa 25mg-0.83
Glinide: Empa 10mg-0.98
Glinide: Empa 25mg-0.98

Confirmed Hypoglycaemic Adverse Events

Number of patients with confirmed hypoglycaemic adverse events (NCT01368081)
Timeframe: After the first drug intake until 7 days after the last treatment administration, up to 383 days

Interventionparticipants (Number)
Sulfonylurea: Empa 10mg6
Sulfonylurea: Empa 25mg9
Sulfonylurea: Metformin5
Biguanide: Empa 10mg0
Biguanide: Empa 25mg1
Thiazolidinedione: Empa 10mg2
Thiazolidinedione: Empa 25mg1
Alpha Glucosidase Inhibitor: Empa 10mg0
Alpha Glucosidase Inhibitor: Empa 25mg0
DPP-IV Inhibitor: Empa 10mg0
DPP-IV Inhibitor: Empa 25mg1
Glinide: Empa 10mg0
Glinide: Empa 25mg2

Number of Patients With Drug Related Adverse Events

Number of Patients With Drug Related Adverse Events after the first drug intake until 7 days after the last treatment administration, up to 383 days (NCT01368081)
Timeframe: After the first drug intake until 7 days after the last treatment administration, up to 383 days

Interventionparticipants (Number)
Sulfonylurea: Empa 10mg19
Sulfonylurea: Empa 25mg25
Sulfonylurea: Metformin13
Biguanide: Empa 10mg13
Biguanide: Empa 25mg9
Thiazolidinedione: Empa 10mg20
Thiazolidinedione: Empa 25mg19
Alpha Glucosidase Inhibitor: Empa 10mg7
Alpha Glucosidase Inhibitor: Empa 25mg5
DPP-IV Inhibitor: Empa 10mg9
DPP-IV Inhibitor: Empa 25mg18
Glinide: Empa 10mg9
Glinide: Empa 25mg9

Reviews

23 reviews available for biguanides and Fasting Hypoglycemia

ArticleYear
Use of noninsulin antidiabetic medications in hospitalized patients.
    Critical care nursing clinics of North America, 2013, Volume: 25, Issue:1

    Topics: Benzamides; Biguanides; Bromocriptine; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Glycos

2013
[Diabetes mellitus of elderly patients: therapeutic recommendations].
    La Tunisie medicale, 2008, Volume: 86, Issue:11

    Topics: Aged; Aging; Biguanides; Blood Glucose; Cachexia; Diabetes Mellitus, Type 2; Diabetic Neuropathies;

2008
[Knack of treatment with oral hypoglycemic drugs in the elderly].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64, Issue:1

    Topics: Aged; Biguanides; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glyburide; Humans; Hypoglyce

2006
[Severe hypoglycemia due to insulin. Risks and adverse effects of antidiabetic drugs].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Mar-10, Volume: 59, Issue:10

    Topics: Acidosis; Aged; Biguanides; Brain Diseases; Digestive System Diseases; Drug Eruptions; Drug Interact

1983
[Syndrome of reactive hypoglycemia. Myth or reality].
    Journees annuelles de diabetologie de l'Hotel-Dieu, 1983

    Topics: Acarbose; Alcoholic Intoxication; Biguanides; Blood Glucose; Calcium; Dietary Fiber; Drug Synergism;

1983
[Adverse effects and interactions of oral antidiabetics].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1980, Nov-10, Volume: 35, Issue:45

    Topics: Administration, Oral; Biguanides; Diabetes Mellitus; Drug Interactions; Ethanol; Gastrointestinal Di

1980
Comparative tolerability profiles of oral antidiabetic agents.
    Drug safety, 1994, Volume: 11, Issue:4

    Topics: Acarbose; Administration, Oral; Biguanides; Biological Availability; Diabetes Mellitus, Type 2; Drug

1994
[Indication and method of administration of oral antidiabetic agents].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl

    Topics: Administration, Oral; Biguanides; Diabetes Mellitus; Diet, Diabetic; Drug Interactions; Exercise The

1997
[Measures to meet the side effects of the orally administered antihyperglycemic drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl

    Topics: Acarbose; Administration, Oral; Animals; Biguanides; Cardiovascular System; Chromans; Drug Interacti

1997
Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment.
    Annals of emergency medicine, 2001, Volume: 38, Issue:1

    Topics: Administration, Oral; Benzoates; Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Drug Interact

2001
[New aspects of therapy with oral antidiabetic agents].
    Wiener medizinische Wochenschrift (1946), 1979, Dec-30, Volume: 199, Issue:24

    Topics: Acidosis; Biguanides; Blood Proteins; Chlorpropamide; Diabetes Mellitus; Diabetic Nephropathies; Dru

1979
Postprandiol hypoglycemia.
    Diabetes, 1976, Volume: 25, Issue:8

    Topics: Administration, Oral; Adult; Biguanides; Blood Glucose; Diabetes Mellitus; Diet Therapy; Eating; Eva

1976
[What is achieved by the therapy with oral antidiabetics?].
    Der Internist, 1976, Volume: 17, Issue:12

    Topics: Administration, Oral; Adult; Biguanides; Chlorpropamide; Diabetes Mellitus; Diabetic Angiopathies; D

1976
[Hypoglycemia. 3].
    Medizinische Monatsschrift, 1970, Volume: 24, Issue:7

    Topics: Animals; Arginine; Biguanides; Diazoxide; Dicumarol; Drug Synergism; Ethanol; Glucagon; Glucocortico

1970
Oral treatment in diabetes.
    Clinics in endocrinology and metabolism, 1972, Volume: 1, Issue:3

    Topics: Acetohexamide; Acidosis; Administration, Oral; Animals; Biguanides; Cardiovascular Diseases; Chlorpr

1972
[Inhibitors of hepatic gluconeogenesis and their significance in medicine].
    Deutsche medizinische Wochenschrift (1946), 1972, Mar-10, Volume: 97, Issue:10

    Topics: Animals; Biguanides; Chemical Phenomena; Chemistry; Chickens; Columbidae; Cricetinae; Cytoplasm; Dog

1972
[Oral antidiabetics].
    Horumon to rinsho. Clinical endocrinology, 1972, Volume: 20, Issue:10

    Topics: Acidosis; Biguanides; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Gastrointesti

1972
Guanidine derivatives in medicine.
    The New England journal of medicine, 1973, Jul-19, Volume: 289, Issue:3

    Topics: Animals; Axons; Biguanides; Binding Sites; Binding, Competitive; Calcium; Cations, Divalent; Cations

1973
Biguanides and lactate metabolism: a review.
    Danish medical bulletin, 1973, Volume: 20, Issue:3

    Topics: Acidosis; Animals; Biguanides; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus; Gluconeogenes

1973
[Hypoglycemia. 3].
    Medizinische Monatsschrift, 1968, Volume: 22, Issue:3

    Topics: Biguanides; Cyclophosphamide; Diet, Diabetic; Ethanol; Glucagon; Humans; Hypoglycemia; Hypoglycemic

1968
[Evaluation of therapy of diabetes mellitus with oral antidiabetics].
    Nihon rinsho. Japanese journal of clinical medicine, 1969, Volume: 27, Issue:8

    Topics: Adult; Biguanides; Chemical Phenomena; Chemistry; Diabetes Mellitus; Diet, Diabetic; Female; Humans;

1969
[Adverse effects of important long-term-therapeutics].
    Pharmaceutica acta Helvetiae, 1970, Volume: 45, Issue:2

    Topics: Acidosis; Animals; Antidepressive Agents; Antitubercular Agents; Biguanides; Central Nervous System;

1970
Glibenclamide: a review.
    Drugs, 1971, Volume: 1, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Biguanides; Blood Glucose; Carbon Isotopes;

1971

Trials

7 trials available for biguanides and Fasting Hypoglycemia

ArticleYear
Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitus.
    Diabetes, obesity & metabolism, 2015, Volume: 17, Issue:7

    Topics: Adult; Aged; Benzhydryl Compounds; Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-

2015
Efficacy and safety of once-weekly dulaglutide in combination with sulphonylurea and/or biguanide compared with once-daily insulin glargine in Japanese patients with type 2 diabetes: a randomized, open-label, phase III, non-inferiority study.
    Diabetes, obesity & metabolism, 2015, Volume: 17, Issue:10

    Topics: Aged; Biguanides; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Administration Schedul

2015
Subgroup analysis of phase 3 studies of dulaglutide in Japanese patients with type 2 diabetes.
    Endocrine journal, 2016, Volume: 63, Issue:3

    Topics: Aged; Biguanides; Body Mass Index; Combined Modality Therapy; Diabetes Mellitus, Type 2; Double-Blin

2016
Long-term safety and efficacy of fasiglifam (TAK-875), a G-protein-coupled receptor 40 agonist, as monotherapy and combination therapy in Japanese patients with type 2 diabetes: a 52-week open-label phase III study.
    Diabetes, obesity & metabolism, 2016, Volume: 18, Issue:9

    Topics: Benzofurans; Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitor

2016
A randomized clinical trial of basal insulin peglispro vs NPH in insulin-naïve patients with type 2 diabetes: the IMAGINE 6 trial.
    Diabetes, obesity & metabolism, 2016, Volume: 18 Suppl 2

    Topics: Aged; Alanine Transaminase; Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptida

2016
Comparative tolerability profiles of oral antidiabetic agents.
    Drug safety, 1994, Volume: 11, Issue:4

    Topics: Acarbose; Administration, Oral; Biguanides; Biological Availability; Diabetes Mellitus, Type 2; Drug

1994
[On the effect of a new depot biguanide on carbohydrate and protein metabolism in diabetes mellitus].
    Deutsche medizinische Wochenschrift (1946), 1966, May-20, Volume: 91, Issue:20

    Topics: Biguanides; Carbohydrate Metabolism; Diabetes Mellitus; Female; Humans; Hypoglycemia; Insulin; Male;

1966

Other Studies

39 other studies available for biguanides and Fasting Hypoglycemia

ArticleYear
A Novel CGM Metric-Gradient and Combining Mean Sensor Glucose Enable to Improve the Prediction of Nocturnal Hypoglycemic Events in Patients with Diabetes.
    Journal of diabetes research, 2020, Volume: 2020

    Topics: Aged; Biguanides; Blood Glucose; Blood Glucose Self-Monitoring; Circadian Rhythm; Diabetes Mellitus,

2020
[Evaluation of the association between the use of oral anti-hyperglycemic agents and hypoglycemia in Japan by data mining of the Japanese Adverse Drug Event Report (JADER) database].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2014, Volume: 134, Issue:2

    Topics: Acarbose; Administration, Oral; Adverse Drug Reaction Reporting Systems; Benzamides; Biguanides; Dat

2014
Respiratory inhibition and hypoglycemia by biguanides and decamethylenediguanidine.
    Biochimica et biophysica acta, 1958, Volume: 30, Issue:2

    Topics: Antineoplastic Agents; Biguanides; Humans; Hypoglycemia; Hypoglycemic Agents; Metabolism

1958
A study of the action of hypoglycemia-producing biguanide and sulfonylurea compounds on oxidative phosphorylation.
    The Journal of biological chemistry, 1962, Volume: 237

    Topics: Biguanides; Humans; Hypoglycemia; Hypoglycemic Agents; Liver; Mitochondria; Oxidative Phosphorylatio

1962
[STUDIES ON THE MODE OF ACTION OF HYPOGLYCEMIC BIGUANIDES].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1963, Dec-10, Volume: 52

    Topics: Adenosine Triphosphate; Alanine Transaminase; Aspartate Aminotransferases; Biguanides; Carbohydrate

1963
[Drug-induced harm due to antidiabetics].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984, Jan-01, Volume: 39, Issue:1

    Topics: Abnormalities, Drug-Induced; Acidosis; Biguanides; Bone Marrow; Cardiovascular Diseases; Chemical an

1984
Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden.
    Acta medica Scandinavica. Supplementum, 1984, Volume: 683

    Topics: Acidosis; Aged; Anti-Infective Agents, Urinary; Biguanides; Congenital Abnormalities; Contraceptives

1984
[Diagnosis and treatment of hypoglycemia syndrome].
    Terapevticheskii arkhiv, 1982, Volume: 54, Issue:9

    Topics: Biguanides; Blood Glucose; Diagnosis, Differential; Diet; Glucose Tolerance Test; Humans; Hypoglycem

1982
[Drug-induced hypoglycemia in diabetic patients].
    La Nouvelle presse medicale, 1976, Oct-09, Volume: 5, Issue:9 Oct 76

    Topics: Adrenergic beta-Antagonists; Biguanides; Diabetes Mellitus; Hypoglycemia; Hypoglycemic Agents; Insul

1976
Some new aspects on the interaction of hypoglycemia-producing biguanides with biological membranes.
    Biochemical pharmacology, 1976, Sep-15, Volume: 25, Issue:18

    Topics: Animals; Biguanides; Columbidae; Energy Metabolism; Gluconeogenesis; Guinea Pigs; Hypoglycemia; In V

1976
[Therapeutical principles and drug therapy of diabetes in adults].
    Die Medizinische Welt, 1975, Oct-03, Volume: 26, Issue:40

    Topics: Adult; Biguanides; Chemical Phenomena; Chemistry; Diabetes Mellitus; Diabetic Coma; Diet, Diabetic;

1975
Treatment of reactive hypoglycemia with buformin.
    The American journal of clinical nutrition, 1975, Volume: 28, Issue:11

    Topics: Adult; Biguanides; Blood Glucose; Buformin; Female; Glucose Tolerance Test; Humans; Hypoglycemia; In

1975
Hypoglycemia in hypertensive diabetic patients treated with sulfonylureas, biguanides, and captopril.
    The New England journal of medicine, 1988, Dec-15, Volume: 319, Issue:24

    Topics: Biguanides; Captopril; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Female;

1988
[Incidence of severe secondary effects during treatment with sulfonylureas and biguanides].
    Journees annuelles de diabetologie de l'Hotel-Dieu, 1986

    Topics: Adult; Aged; Biguanides; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemia; Inappropriate ADH

1986
Incidence of severe sideeffects during therapy with sulfonylureas and biguanides.
    Hormone and metabolic research. Supplement series, 1985, Volume: 15

    Topics: Acidosis; Biguanides; Chlorpropamide; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemia; Hypog

1985
[Overdose of biguanides].
    Revista clinica espanola, 1985, Volume: 177, Issue:1

    Topics: Acidosis; Adolescent; Biguanides; Buformin; Female; Humans; Hypoglycemia; Lactates; Lactic Acid

1985
Editorial: Oral therapy in diabetes mellitus.
    Southern medical journal, 1974, Volume: 67, Issue:6

    Topics: Acetohexamide; Biguanides; Chlorpropamide; Diabetes Mellitus; Diabetic Ketoacidosis; Diet Therapy; H

1974
[Hypoglycemia induced by N1-(n-butyl)-biguanide (Buformin) in animal experiments].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1969, Volume: 264, Issue:3

    Topics: Animals; Arabinose; Biguanides; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemia; Hypogl

1969
[Enhancement of the hypoglycemic action of insulin by buformin in rats].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4

    Topics: Animals; Biguanides; Carbon Dioxide; Carbon Isotopes; Drug Synergism; Glycogen; Hypoglycemia; Hypogl

1970
[Complications in the therapy of diabetes using oral hypoglycemic agents].
    Minerva medica, 1974, Dec-15, Volume: 65, Issue:90

    Topics: Biguanides; Diabetes Mellitus; Diabetic Coma; Diet, Diabetic; Female; Humans; Hypoglycemia; Hypoglyc

1974
[Oral antidiabetics].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1972, Feb-22, Volume: 61, Issue:8

    Topics: Administration, Oral; Biguanides; Diabetes Mellitus; Gastrointestinal Diseases; Humans; Hypoglycemia

1972
[Studies on the mode of action of biguanides in animals. 4. Studies on gamma-guanidinobutyramide and summary].
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:10

    Topics: Amides; Animals; Biguanides; Blood Glucose; Butyrates; Carbon Isotopes; Diabetes Mellitus, Experimen

1972
[Animal experimental studies on the mode of action of biguanides. 1. Studies with hypoglycemia-inducing doses of biguanide].
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:7

    Topics: Animals; Biguanides; Blood Glucose; Carbon Isotopes; Diaphragm; Dose-Response Relationship, Drug; Fa

1972
[Differential therapy using oral antidiabetics].
    Der Internist, 1971, Volume: 12, Issue:11

    Topics: Administration, Oral; Biguanides; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus; D

1971
Diabetes mellitus: diagnosis and treatment.
    The Medical journal of Australia, 1968, Nov-02, Volume: 2, Issue:18

    Topics: Acetone; Biguanides; Diabetes Complications; Diabetes Mellitus; Diabetic Ketoacidosis; Diet Therapy;

1968
[Synergism between oral diabetics and insulin].
    Bollettino della Societa italiana di biologia sperimentale, 1971, Nov-30, Volume: 47, Issue:22

    Topics: Animals; Biguanides; Blood Glucose; Chlorpropamide; Columbidae; Drug Synergism; Glyburide; Hypoglyce

1971
[Extreme hypoglycemia during combined tolbutamide, n-1-butylbiguanide hydrochloride and chloramphenicol therapy].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Jan-15, Volume: 27, Issue:2

    Topics: Age Factors; Aged; Biguanides; Chloramphenicol; Diabetes Mellitus; Diabetic Angiopathies; Diabetic N

1972
[The risk of hypoglycemia in sulfonylurea therapy].
    Helvetica medica acta, 1972, Volume: 36, Issue:2

    Topics: Age Factors; Aged; Biguanides; Cerebrovascular Disorders; Diabetes Mellitus; Diet Therapy; Glucose T

1972
Failure of the biguanides to improve the control of unstable diabetes treated with insulin.
    Diabetologia, 1971, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Drug Synergism; Female; Glycosuria; Humans;

1971
Chemistry of the biguanides.
    Annals of the New York Academy of Sciences, 1968, Mar-26, Volume: 148, Issue:3

    Topics: Alkylation; Benzene Derivatives; Biguanides; Chemical Phenomena; Chemistry; Chromium; Cobalt; Copper

1968
[Extreme blood sugar depression from combined carbutamide-buformin therapy].
    Das Deutsche Gesundheitswesen, 1969, Jul-17, Volume: 24, Issue:29

    Topics: Aged; Biguanides; Carbutamide; Female; Humans; Hypoglycemia

1969
[Hypoglycemic attacks caused by oral hypoglycemic drugs].
    Il Policlinico. Sezione pratica, 1970, Sep-14, Volume: 77, Issue:37

    Topics: Aged; Biguanides; Chlorpropamide; Diabetes Mellitus; Diabetic Coma; Female; Humans; Hypoglycemia; Hy

1970
[Hypoglycemia after treatment with Glibenclamid (Euglucon 5)].
    Munchener medizinische Wochenschrift (1950), 1970, Nov-27, Volume: 112, Issue:48

    Topics: Aged; Biguanides; Cyclohexanes; Diabetes Mellitus; Humans; Hypoglycemia; Hypoglycemic Agents; Male;

1970
[Progress in the therapy of diabetes].
    Wiener medizinische Wochenschrift (1946), 1971, Apr-03, Volume: 121, Issue:14

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aminocaproates; Animals; Biguanides; Blood Glucose; Child; Dia

1971
The natural history of diabetes mellitus.
    The Journal of the Florida Medical Association, 1971, Volume: 58, Issue:5

    Topics: Biguanides; Child; Child, Preschool; Diabetes Mellitus; Glucose Tolerance Test; Humans; Hypoglycemia

1971
Metabolic effects of the biguanides and possible mechanism of action.
    Diabetes, 1968, Volume: 17, Issue:2

    Topics: Adipose Tissue; Animals; Biguanides; Biological Transport; Columbidae; Gluconeogenesis; Glucose; Gui

1968
[On the forensic evaluation of hypoglycemia during treatment with oral anti-diabetics].
    Deutsche Zeitschrift fur die gesamte gerichtliche Medizin, 1968, Volume: 64, Issue:3

    Topics: Accidents, Traffic; Aged; Biguanides; Blood Glucose; Diabetes Mellitus; Drug Synergism; Humans; Hypo

1968
[Causes and prevention of hypoglycemia due to glibenclamide].
    Die Medizinische Welt, 1969, Aug-30, Volume: 35

    Topics: Aged; Biguanides; Diabetes Mellitus; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle

1969
Pharmacological studies on n-butylbiguanide with special reference to hypoglycemic effect.
    Acta Scholae Medicinalis Universitatis in Kioto, 1966, Volume: 39, Issue:3

    Topics: Animals; Autonomic Nervous System; Biguanides; Blood Glucose; Hypoglycemia; Male; Rabbits; Rats

1966