biguanides has been researched along with Disease Models, Animal in 37 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome." | 7.91 | Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019) |
| "In this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis." | 7.80 | Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. ( Arici, MK; Dursun, A; Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2014) |
| " This study aims to investigate granisetron, a 5-HT( 3) receptor antagonist, in acetic acid-induced rat colitis and probable involvement of 5-HT(3) receptors." | 7.76 | Granisetron ameliorates acetic acid-induced colitis in rats. ( Bahremand, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mousavizadeh, K; Rahimian, R; Rasouli, MR, 2010) |
| "We examined the effects of peritoneal instillation (INST, 5-ml solution) with taurolidine (TAURO) or polihexanide (POLI-LS) on intestinal microcirculation using intravital microscopy (IVM) in experimental endotoxemia (15 mg/kg lipopolysaccharide i." | 7.74 | Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia. ( Frieling, H; Gründling, M; Kanellopoulou, T; Lauer, KS; Lehmann, C; Meissner, K; Pavlovic, D; Usichenko, T; Wendt, M, 2007) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 7.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "2% hexetidine upon plaque and gingivitis." | 7.66 | Influence of hexetidine upon plaque and gingivitis in the beagle dog. ( McDonald, JL; Schemehorn, BR; Stookey, GK, 1978) |
| "Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p<0." | 5.39 | Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. ( Aminian, A; Dehpour, AR; Ghazi-Khansari, M; Hassanzadeh, G; Javadi, S; Kafami, L; Mehr, SE; Noorbakhsh, F; Rahimian, R, 2013) |
| "Miltefosine treatment yielded much higher cure scores than propamidine isetionate plus polyhexanide." | 5.38 | Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. ( Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2012) |
| "Stroke was rendered in rats by introduction of an autologous clot into the middle cerebral artery (MCA)." | 5.37 | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. ( Barzegar-Fallah, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mohammadi-Rick, S; Rahimian, R; Shabanzadeh, AP, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 5.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| "Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome." | 3.91 | Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019) |
| "In this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis." | 3.80 | Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. ( Arici, MK; Dursun, A; Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2014) |
| " This study aims to investigate granisetron, a 5-HT( 3) receptor antagonist, in acetic acid-induced rat colitis and probable involvement of 5-HT(3) receptors." | 3.76 | Granisetron ameliorates acetic acid-induced colitis in rats. ( Bahremand, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mousavizadeh, K; Rahimian, R; Rasouli, MR, 2010) |
| "We examined the effects of peritoneal instillation (INST, 5-ml solution) with taurolidine (TAURO) or polihexanide (POLI-LS) on intestinal microcirculation using intravital microscopy (IVM) in experimental endotoxemia (15 mg/kg lipopolysaccharide i." | 3.74 | Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia. ( Frieling, H; Gründling, M; Kanellopoulou, T; Lauer, KS; Lehmann, C; Meissner, K; Pavlovic, D; Usichenko, T; Wendt, M, 2007) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 3.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| " Smooth muscle relaxation was obtained by salbutamol and l-phenylephrine, whereas contraction was achieved by carbachol and 1-(3-chlorophenyl)-biguanide." | 3.72 | Effect of pharmacologically induced smooth muscle activation on permeability in murine colitis. ( Garrelds, IM; Meijssen, MA; van Meeteren, ME; Zijlstra, FJ, 2003) |
| "2% hexetidine upon plaque and gingivitis." | 3.66 | Influence of hexetidine upon plaque and gingivitis in the beagle dog. ( McDonald, JL; Schemehorn, BR; Stookey, GK, 1978) |
| "Biguanides are a class of antidiabetic drugs that includes phenformin and metformin; however, the former was withdrawn from approval in many countries due to its toxicity." | 2.72 | Therapeutic Repurposing of Biguanides in Cancer. ( Swanson, KD; Zhao, H; Zheng, B, 2021) |
| "In patients with diabetes mellitus, dermatophytosis is more severe and recurrent." | 1.72 | Antifungal activity of alexidine dihydrochloride in a novel diabetic mouse model of dermatophytosis. ( Date, A; Ibrahim, AS; Nabeela, S; Uppuluri, P, 2022) |
| " The increasing incidence of hemangiosarcomas highly probably resulted from increased endothelial proliferation, triggered by the exceedingly high dosage fed, because PHMB is not genotoxic and there is no evidence for epigenetic effects." | 1.51 | Re-evaluation of polihexanide use in wound antisepsis in order to clarify ambiguities of two animal studies. ( Assadian, O; Dissemond, J; Eberlein, T; Kramer, A; Müller, G, 2019) |
| "We show here that breast tumors engage the ShcA pathway to increase their metabolism." | 1.48 | Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. ( Ahn, R; Avizonis, DZ; Chénard, V; Gravel, SP; Hudson, J; Im, YK; McGuirk, S; Najyb, O; Pawson, T; Pollak, M; Sabourin, V; St-Pierre, J; Topisirovic, I; Ursini-Siegel, J, 2018) |
| "Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin." | 1.46 | Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model. ( Davis, SC; Gil, J; Harding, A; Higa, A; Parajon, F; Solis, M; Valdes, J, 2017) |
| "Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p<0." | 1.39 | Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. ( Aminian, A; Dehpour, AR; Ghazi-Khansari, M; Hassanzadeh, G; Javadi, S; Kafami, L; Mehr, SE; Noorbakhsh, F; Rahimian, R, 2013) |
| "Miltefosine treatment yielded much higher cure scores than propamidine isetionate plus polyhexanide." | 1.38 | Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. ( Obwaller, A; Polat, ZA; Vural, A; Walochnik, J, 2012) |
| "Stroke was rendered in rats by introduction of an autologous clot into the middle cerebral artery (MCA)." | 1.37 | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. ( Barzegar-Fallah, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mohammadi-Rick, S; Rahimian, R; Shabanzadeh, AP, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 1.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| " Although formulated NB325 appeared generally safe for application in these studies, the low but observable level of toxicity suggests the need for improvements in the compound and/or formulation." | 1.37 | Cervicovaginal safety of the formulated, biguanide-based human immunodeficiency virus type 1 (HIV-1) inhibitor NB325 in a murine model. ( Kish-Catalone, T; Krebs, FC; Labib, M; Lozenski, K; Pirrone, V; Rando, RF; Wigdahl, B, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.51) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 17 (45.95) | 24.3611 |
| 2020's | 5 (13.51) | 2.80 |
| Authors | Studies |
|---|---|
| Park, CM | 1 |
| Kim, HY | 1 |
| Jeon, D | 1 |
| Shin, YJ | 1 |
| Kim, IH | 1 |
| Choi, SJ | 1 |
| Kim, KC | 1 |
| Lee, K | 1 |
| Kim, SH | 1 |
| Kim, MS | 1 |
| Nabeela, S | 1 |
| Date, A | 1 |
| Ibrahim, AS | 1 |
| Uppuluri, P | 1 |
| McMahon, RE | 1 |
| Salamone, AB | 1 |
| Poleon, S | 1 |
| Bionda, N | 1 |
| Salamone, JC | 1 |
| Zhao, H | 1 |
| Swanson, KD | 1 |
| Zheng, B | 1 |
| Hébert, A | 1 |
| Parisotto, M | 1 |
| Rowell, MC | 1 |
| Doré, A | 1 |
| Fernandez Ruiz, A | 1 |
| Lefrançois, G | 1 |
| Kalegari, P | 1 |
| Ferbeyre, G | 1 |
| Schmitzer, AR | 1 |
| Maddocks, ODK | 1 |
| Athineos, D | 1 |
| Cheung, EC | 1 |
| Lee, P | 1 |
| Zhang, T | 1 |
| van den Broek, NJF | 1 |
| Mackay, GM | 1 |
| Labuschagne, CF | 1 |
| Gay, D | 1 |
| Kruiswijk, F | 1 |
| Blagih, J | 1 |
| Vincent, DF | 1 |
| Campbell, KJ | 1 |
| Ceteci, F | 1 |
| Sansom, OJ | 1 |
| Blyth, K | 1 |
| Vousden, KH | 1 |
| Im, YK | 1 |
| Najyb, O | 1 |
| Gravel, SP | 1 |
| McGuirk, S | 1 |
| Ahn, R | 1 |
| Avizonis, DZ | 1 |
| Chénard, V | 1 |
| Sabourin, V | 1 |
| Hudson, J | 1 |
| Pawson, T | 1 |
| Topisirovic, I | 1 |
| Pollak, M | 1 |
| St-Pierre, J | 1 |
| Ursini-Siegel, J | 1 |
| Diedrich, S | 1 |
| Müller, G | 2 |
| Sandbrink, C | 1 |
| Papke, R | 1 |
| van der Linde, J | 1 |
| Heidecke, CD | 1 |
| Parteke, LI | 1 |
| Assadian, O | 2 |
| Kramer, A | 2 |
| Eberlein, T | 1 |
| Dissemond, J | 1 |
| Zhao, L | 1 |
| Gao, X | 1 |
| Zhuang, J | 1 |
| Wallen, M | 1 |
| Leng, S | 1 |
| Xu, F | 1 |
| Kim, YS | 1 |
| Cha, H | 1 |
| Kim, HJ | 1 |
| Cho, JM | 1 |
| Kim, HR | 1 |
| Polat, ZA | 2 |
| Walochnik, J | 2 |
| Obwaller, A | 2 |
| Vural, A | 2 |
| Dursun, A | 1 |
| Arici, MK | 1 |
| Aminian, A | 1 |
| Noorbakhsh, F | 1 |
| Ghazi-Khansari, M | 1 |
| Kafami, L | 1 |
| Javadi, S | 1 |
| Hassanzadeh, G | 1 |
| Rahimian, R | 4 |
| Dehpour, AR | 4 |
| Mehr, SE | 3 |
| Ahmadi-Mahmoodabadi, N | 1 |
| Nasehi, M | 1 |
| Emam Ghoreishi, M | 1 |
| Zarrindast, MR | 1 |
| Shen, H | 1 |
| Wang, F | 1 |
| Zeng, G | 1 |
| Shen, L | 1 |
| Cheng, H | 1 |
| Huang, D | 1 |
| Wang, R | 1 |
| Rong, L | 1 |
| Chen, ZW | 1 |
| Davis, SC | 1 |
| Harding, A | 1 |
| Gil, J | 1 |
| Parajon, F | 1 |
| Valdes, J | 1 |
| Solis, M | 1 |
| Higa, A | 1 |
| McNamara, DB | 1 |
| Murthy, SN | 1 |
| Fonseca, AN | 1 |
| Desouza, CV | 1 |
| Kadowitz, PJ | 1 |
| Fonseca, VA | 1 |
| Fakhfouri, G | 3 |
| Daneshmand, A | 2 |
| Bahremand, A | 2 |
| Rasouli, MR | 1 |
| Mousavizadeh, K | 1 |
| Zhang, Y | 1 |
| Yang, M | 1 |
| Ji, Q | 1 |
| Fan, D | 1 |
| Peng, H | 1 |
| Yang, C | 1 |
| Xiong, D | 1 |
| Zhou, Y | 1 |
| Barzegar-Fallah, A | 1 |
| Mohammadi-Rick, S | 1 |
| Shabanzadeh, AP | 1 |
| Payandemehr, B | 1 |
| Ziai, P | 1 |
| Pourmand, N | 1 |
| Loloee, S | 1 |
| Ebrahimi, A | 1 |
| Ghasemi, A | 1 |
| Ghasemi, M | 1 |
| Lozenski, K | 1 |
| Kish-Catalone, T | 1 |
| Pirrone, V | 1 |
| Rando, RF | 1 |
| Labib, M | 1 |
| Wigdahl, B | 1 |
| Krebs, FC | 1 |
| Wang, DS | 1 |
| Kusuhara, H | 1 |
| Kato, Y | 1 |
| Jonker, JW | 1 |
| Schinkel, AH | 1 |
| Sugiyama, Y | 1 |
| Zijlstra, FJ | 1 |
| van Meeteren, ME | 1 |
| Garrelds, IM | 1 |
| Meijssen, MA | 1 |
| Talalaenko, AN | 1 |
| Pankrat'ev, DV | 1 |
| Goncharenko, NV | 1 |
| Vasseneix, C | 1 |
| Gargala, G | 1 |
| François, A | 1 |
| Hellot, MF | 1 |
| Duclos, C | 1 |
| Muraine, M | 1 |
| Benichou, J | 1 |
| Ballet, JJ | 1 |
| Brasseur, G | 1 |
| Favennec, L | 1 |
| Frieling, H | 1 |
| Lauer, KS | 1 |
| Gründling, M | 1 |
| Usichenko, T | 1 |
| Meissner, K | 1 |
| Kanellopoulou, T | 1 |
| Lehmann, C | 1 |
| Wendt, M | 1 |
| Pavlovic, D | 1 |
| Ruddell, TJ | 1 |
| Easty, DL | 1 |
| Fiscella, RG | 1 |
| Moshifar, M | 1 |
| Messick, CR | 1 |
| Pendland, SL | 1 |
| Chandler, JW | 1 |
| Viana, M | 1 |
| Wada, Y | 1 |
| Shiraishi, J | 1 |
| Nakamura, M | 1 |
| Koshino, Y | 1 |
| Valluri, S | 1 |
| Fleming, TP | 1 |
| Laycock, KA | 1 |
| Tarle, IS | 1 |
| Goldberg, MA | 1 |
| Garcia-Ferrer, FJ | 1 |
| Essary, LR | 1 |
| Pepose, JS | 1 |
| McDonald, JL | 1 |
| Schemehorn, BR | 1 |
| Stookey, GK | 1 |
| Reed, MJ | 1 |
| Staple, PH | 1 |
| Mashimo, PA | 1 |
| Assan, R | 1 |
| Heuclin, C | 1 |
| Girard, JR | 1 |
| Hull, PS | 1 |
| Davies, RM | 1 |
| Lennon, MA | 1 |
| Denys, A | 1 |
| Machlanński, T | 1 |
| Arnold, Z | 1 |
2 reviews available for biguanides and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic Repurposing of Biguanides in Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biguanides; Cell Line, Tumor; Clinical Tria | 2021 |
Animal models of catheter-induced intimal hyperplasia in type 1 and type 2 diabetes and the effects of pharmacologic intervention.
Topics: Animals; Biguanides; Catheterization; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di | 2009 |
35 other studies available for biguanides and Disease Models, Animal
| Article | Year |
|---|---|
Anti-fibrotic effect of pycnogenol® in a polyhexamethylene guanidine-treated mouse model.
Topics: Animals; Anti-Inflammatory Agents; Biguanides; Disease Models, Animal; Flavonoids; Inflammation; Mal | 2022 |
Antifungal activity of alexidine dihydrochloride in a novel diabetic mouse model of dermatophytosis.
Topics: Animals; Antifungal Agents; Biguanides; Diabetes Mellitus, Experimental; Disease Models, Animal; Mic | 2022 |
Efficacy of Wound Cleansers on Wound-Specific Organisms Using In Vitro and Ex Vivo Biofilm Models.
Topics: Animals; Biguanides; Biofilms; Detergents; Disease Models, Animal; Methicillin-Resistant Staphylococ | 2020 |
Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth.
Topics: AMP-Activated Protein Kinases; Animals; Biguanides; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; | 2021 |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Topics: Animals; Antioxidants; Biguanides; Cell Line, Tumor; Diet; Disease Models, Animal; Female; Food Depr | 2017 |
Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.
Topics: Animals; Biguanides; Breast Neoplasms; Disease Models, Animal; Female; Humans; Mammary Neoplasms, An | 2018 |
Efficiency of Emulsified Particle-Associated Polyhexamethylenbiguanid-Hydrochlorid (Polihexanide) for Peritoneal Lavage in a Murine Sepsis Model.
Topics: Animals; Bacterial Load; Biguanides; Cytokines; Disease Models, Animal; Disinfectants; Female; Mice; | 2018 |
Re-evaluation of polihexanide use in wound antisepsis in order to clarify ambiguities of two animal studies.
Topics: Animals; Anti-Infective Agents, Local; Biguanides; Consensus; Disease Models, Animal; Risk Assessmen | 2019 |
Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT
Topics: Animals; Animals, Newborn; Apnea; Biguanides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; | 2019 |
The Anti-Fibrotic Effects of CG-745, an HDAC Inhibitor, in Bleomycin and PHMG-Induced Mouse Models.
Topics: Animals; Biguanides; Bleomycin; Disease Models, Animal; Epithelial-Mesenchymal Transition; Histone D | 2019 |
Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Animals; Antiprotozoal Agents; Biguanides; Cell Line; Cell Pro | 2014 |
Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis.
Topics: Animals; Biguanides; Cell Proliferation; Demyelinating Diseases; Disease Models, Animal; Dose-Respon | 2013 |
Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague-Dawley rats: An isobologram analysis.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; | 2016 |
Bis-biguanide dihydrochloride inhibits intracellular replication of M. tuberculosis and controls infection in mice.
Topics: Animals; Antitubercular Agents; Biguanides; Disease Models, Animal; DNA Replication; Drug Evaluation | 2016 |
Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model.
Topics: Animals; Betaine; Biguanides; Biofilms; Disease Models, Animal; Disinfectants; Methicillin-Resistant | 2017 |
Granisetron ameliorates acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Biguanides; Colitis; Colon; Dexamethasone; Disease M | 2010 |
Anoikis induction and metastasis suppression by a new integrin αvβ3 inhibitor in human melanoma cell line M21.
Topics: Animals; Anoikis; Antineoplastic Agents; Biguanides; Caspases; Cell Adhesion; Cell Line, Tumor; Dise | 2011 |
Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Topics: Analysis of Variance; Animals; Biguanides; Blood Gas Analysis; Brain Edema; Brain Infarction; Brain | 2011 |
The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Biguanides; Citalopram; Disease Models, Animal; Dose | 2011 |
Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Topical; Animals; Antiprotozoal Agents; Benzam | 2012 |
Cervicovaginal safety of the formulated, biguanide-based human immunodeficiency virus type 1 (HIV-1) inhibitor NB325 in a murine model.
Topics: Administration, Intravaginal; Animals; Anti-HIV Agents; Biguanides; Disease Models, Animal; Drug-Rel | 2011 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Ho | 2003 |
Effect of pharmacologically induced smooth muscle activation on permeability in murine colitis.
Topics: Albuterol; Animals; Biguanides; Carbachol; Colitis; Dextran Sulfate; Disease Models, Animal; Female; | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Topical; Animals; Antiprotozoal Agents; Benzam | 2006 |
Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia.
Topics: Animals; Anti-Infective Agents, Local; Biguanides; Disease Models, Animal; Endotoxemia; Gastrointest | 2007 |
Drug therapy in a murine model of Acanthamoeba keratitis.
Topics: Acanthamoeba Keratitis; Animals; Antiprotozoal Agents; Benzamidines; Biguanides; Disease Models, Ani | 1995 |
Polyhexamethylene biguanide (PHMB) in the treatment of experimental Fusarium keratomycosis.
Topics: Administration, Topical; Animals; Biguanides; Colony Count, Microbial; Cornea; Disease Models, Anima | 1997 |
Effects of the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide in the rat kindling model of epilepsy.
Topics: Amygdala; Animals; Biguanides; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; K | 1997 |
In vitro and in vivo effects of polyhexamethylene biguanide against herpes simplex virus infection.
Topics: Administration, Topical; Animals; Antibodies, Viral; Biguanides; Cattle; Cornea; Disease Models, Ani | 1997 |
Influence of hexetidine upon plaque and gingivitis in the beagle dog.
Topics: Animals; Biguanides; Chlorhexidine; Dental Plaque; Disease Models, Animal; Dogs; Gingivitis; Hexetid | 1978 |
Use of chlorhexidine gluconate to inhibit dental plaque accumulation in Macaca speciosa.
Topics: Animals; Biguanides; Chlorhexidine; Dental Plaque; Disease Models, Animal; Female; Gingivitis; Haplo | 1977 |
An experimental model of phenformin-induced lactic acidosis in rats.
Topics: Acidosis; Animals; Biguanides; Disease Models, Animal; Lactates; Male; Nephrectomy; Phenformin; Rats | 1978 |
The use of the beagle dog as a model system for investigations of anti-plaque agents.
Topics: Animals; Anti-Infective Agents, Local; Biguanides; Dental Plaque; Dental Prophylaxis; Disease Models | 1972 |
Association between chemical structure and antiviral activity of biguanide, sulfonylurethane, and sulfonamide derivatives.
Topics: Animals; Antiviral Agents; Biguanides; Disease Models, Animal; Evaluation Studies as Topic; Mice; Mi | 1973 |