biguanides has been researched along with Diabetic Feet in 9 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Wounds were evenly distributed with respect to etiology and both study groups had a median baseline wound size of 7 cm2." | 2.71 | Impact of antimicrobial gauze on bacterial colonies in wounds that require packing. ( Corbett, LQ; Milne, CT; Motta, GJ, 2004) |
| "A review of Type 2 diabetes mellitus is presented." | 2.44 | Type 2 diabetes: the many facets of care. ( Hall, MA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Gorenstein, SA | 1 |
| Bain, MA | 1 |
| Oropallo, A | 1 |
| Koullias, G | 1 |
| Sabolinski, ML | 1 |
| Lavery, LA | 1 |
| Davis, KE | 1 |
| La Fontaine, J | 1 |
| Farrar, JD | 1 |
| Bhavan, K | 1 |
| Oz, OK | 1 |
| Crisologo, PA | 1 |
| Lintzeris, D | 1 |
| Vernon, K | 1 |
| Percise, H | 1 |
| Strickland, A | 1 |
| Yarrow, K | 1 |
| White, A | 1 |
| Gurganus, M | 1 |
| Sherrod, S | 1 |
| Vergin, K | 1 |
| Johnson, L | 1 |
| Chekmareva, IA | 1 |
| Blatun, LA | 1 |
| Paskhalova, YS | 1 |
| Mitish, VA | 1 |
| Paklina, OV | 1 |
| Terekhova, RP | 1 |
| Sepeda, P | 1 |
| Magomedova, SD | 1 |
| Ushakov, AA | 1 |
| Sokov, SL | 1 |
| Dalla Paola, L | 1 |
| Hunt, S | 1 |
| Hall, MA | 1 |
| Nielsen, AM | 1 |
| Andriessen, A | 1 |
| Motta, GJ | 1 |
| Milne, CT | 1 |
| Corbett, LQ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Negative Pressure Wound Therapy as a Drug Delivery System[NCT02463487] | 150 participants (Actual) | Interventional | 2015-06-02 | Completed | |||
| Kerlix AMD Gauze Study In A Burn Trauma Unit and Its Effect on Healthcare Associated Infections in Burn Patients[NCT00656708] | 108 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
How many wounds fully healed in 16 weeks. Healing defined as fully epithelialized skin with no drainage. (NCT02463487)
Timeframe: 16 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Cardinal Pro (NPWT) Therapy | 44 |
| Cardinal Pro + Irrigation (NPWTi) | 45 |
Dehiscence is defined as any part of a surgically closed wound that failed to heal when sutures were removed. (NCT02463487)
Timeframe: 16 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Cardinal Pro (NPWT) Therapy | 46 |
| Cardinal Pro + Irrigation (NPWTi) | 40 |
Total number of adverse events, including new foot ulcer formation, all-cause hospital readmission, and foot-related hospital readmission. (NCT02463487)
Timeframe: 16 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| New ulcer formation | All-cause readmission | Foot-related readmission | |
| Cardinal Pro (NPWT) Therapy | 12 | 26 | 13 |
| Cardinal Pro + Irrigation (NPWTi) | 18 | 27 | 14 |
2 reviews available for biguanides and Diabetic Feet
| Article | Year |
|---|---|
Diabetic foot wounds: the value of negative pressure wound therapy with instillation.
Topics: Anti-Bacterial Agents; Biguanides; Chondroitin Sulfates; Collagen; Debridement; Diabetic Foot; Granu | 2013 |
Type 2 diabetes: the many facets of care.
Topics: Adult; Amyloid; Biguanides; Community Health Nursing; Diabetes Mellitus, Type 2; Diabetic Foot; Dipe | 2008 |
3 trials available for biguanides and Diabetic Feet
| Article | Year |
|---|---|
Does negative pressure wound therapy with irrigation improve clinical outcomes? A randomized clinical trial in patients with diabetic foot infections.
Topics: Administration, Topical; Adult; Biguanides; Diabetic Foot; Disinfectants; Female; Humans; Male; Midd | 2020 |
Prospective cohort study on surgical wounds comparing a polyhexanide-containing biocellulose dressing with a dialkyl-carbamoyl-chloride-containing hydrophobic dressing.
Topics: Aged; Anti-Infective Agents; Bandages; Biguanides; Biocompatible Materials; Cohort Studies; Diabetic | 2012 |
Impact of antimicrobial gauze on bacterial colonies in wounds that require packing.
Topics: Aged; Aged, 80 and over; Bandages; Biguanides; Colony Count, Microbial; Diabetic Foot; Disinfectants | 2004 |
4 other studies available for biguanides and Diabetic Feet
| Article | Year |
|---|---|
Effectiveness of a purified type I collagen matrix plus the antimicrobial polyhexamethylene biguanide for use in cutaneous wounds: analysis of a population of three combined registries.
Topics: Anti-Infective Agents; Biguanides; Collagen Type I; Diabetic Foot; Female; Humans; Hypoglycemic Agen | 2023 |
Effect of a New Purified Collagen Matrix With Polyhexamethylene Biguanide on Recalcitrant Wounds of Various Etiologies: A Case Series.
Topics: Aged; Anti-Infective Agents, Local; Biguanides; Calciphylaxis; Chronic Disease; Collagen Type I; Dia | 2018 |
[Morphological justification of the effectiveness of ultrasonic cavitation with 0.2].
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Biguanides; D | 2019 |
Case 14: Octenilin Wound Gel versus betadine/PHMB gel.
Topics: Adult; Anti-Infective Agents, Local; Biguanides; Diabetes Mellitus, Type 2; Diabetic Foot; Disinfect | 2016 |