biguanides has been researched along with Chronic Disease in 26 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our aim was to assess the clinical efficacy of a propylbetaine-polihexanide (PP) solution versus normal saline (NS) solution in WBP, assessing inflammatory signs and wound size reduction in patients with pressure ulcers (PUs) or vascular leg ulcers." | 5.22 | Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT. ( Bellingeri, A; Chiari, P; Falciani, F; Moscatelli, A; Peghetti, A; Russo, A; Tino, G; Traspedini, P, 2016) |
| " The effects on plaque and gingivitis of a chlorhexidine paste used for 4 weeks, and of two other experimental products used over 8 weeks, have been investigated." | 5.04 | Testing therapeutic measures for controlling chronic gingivitis in man: the results of two studies. ( Cowell, CR; Saxton, CA; Sheiham, A; Wagg, BJ, 1976) |
| " Studies over the last decade have focused on the design and development of advanced oral delivery dosage forms using bio nano technologies and novel drug carrier systems." | 2.82 | Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions. ( Al-Salami, H; Atlas, MD; Brown, D; Chester, J; Foster, T; Ionescu, CM; Johnston, E; Jones, M; Kovacevic, B; Kuthubutheen, J; Mikov, M; Mooranian, A; Wagle, SR; Walker, D, 2022) |
| " This study is designed to assess the effect of antimicrobial-impregnated dressing (AMD) combined with negative-pressure wound therapy (NPWT) on skin graft survival." | 1.42 | Antimicrobial-impregnated dressing combined with negative-pressure wound therapy increases split-thickness skin graft engraftment: a simple effective technique. ( Chen, CC; Chew, KY; Kuo, YR; Wu, CC, 2015) |
| "The treatment of chronic skin wounds through the use of a polyhexanide/propyl betaine-based gel, in combination with a secondary dressing, showed significant improvements, such as a 30% reduction of pain at dressing change, the reduction in the size and characteristics of the wounds and a reduction in the levels of exudate." | 1.40 | Evaluation of the effectiveness of a polyhexanide and propyl betaine-based gel in the treatment of chronic wounds. ( Ciprandi, G; Durante, CM; Gallarini, A; Greco, A; Maino, C; Sidoli, O, 2014) |
| "Chronic wounds are commonly observed in acute and community settings." | 1.35 | Topical antimicrobial agents for the treatment of chronic wounds. ( McIntosh, C; Ousey, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (30.77) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, M | 1 |
| Ionescu, CM | 1 |
| Walker, D | 1 |
| Wagle, SR | 1 |
| Kovacevic, B | 1 |
| Chester, J | 1 |
| Foster, T | 1 |
| Johnston, E | 1 |
| Kuthubutheen, J | 1 |
| Brown, D | 1 |
| Atlas, MD | 1 |
| Mikov, M | 1 |
| Mooranian, A | 1 |
| Al-Salami, H | 1 |
| Lintzeris, D | 1 |
| Vernon, K | 1 |
| Percise, H | 1 |
| Strickland, A | 1 |
| Yarrow, K | 1 |
| White, A | 1 |
| Gurganus, M | 1 |
| Sherrod, S | 1 |
| Vergin, K | 1 |
| Johnson, L | 1 |
| Jockenhöfer, F | 1 |
| Gollnick, H | 1 |
| Herberger, K | 1 |
| Isbary, G | 1 |
| Renner, R | 1 |
| Stücker, M | 1 |
| Valesky, E | 1 |
| Wollina, U | 1 |
| Weichenthal, M | 1 |
| Karrer, S | 1 |
| Stoffels-Weindorf, M | 1 |
| Dissemond, J | 3 |
| Kim, PJ | 1 |
| Attinger, CE | 1 |
| Steinberg, JS | 1 |
| Evans, KK | 1 |
| Powers, KA | 1 |
| Hung, RW | 1 |
| Smith, JR | 1 |
| Rocha, ZM | 1 |
| Lavery, L | 1 |
| Durante, CM | 1 |
| Greco, A | 1 |
| Sidoli, O | 1 |
| Maino, C | 1 |
| Gallarini, A | 1 |
| Ciprandi, G | 1 |
| Wu, CC | 1 |
| Chew, KY | 1 |
| Chen, CC | 1 |
| Kuo, YR | 1 |
| Bellingeri, A | 1 |
| Falciani, F | 1 |
| Traspedini, P | 1 |
| Moscatelli, A | 1 |
| Russo, A | 1 |
| Tino, G | 1 |
| Chiari, P | 1 |
| Peghetti, A | 1 |
| Moore, M | 1 |
| Dobson, N | 1 |
| Cetnarowski, W | 1 |
| Ousey, K | 1 |
| McIntosh, C | 1 |
| Gerber, V | 1 |
| Kramer, A | 1 |
| Riepe, G | 1 |
| Strohal, R | 1 |
| Vasel-Biergans, A | 1 |
| Eberlein, T | 1 |
| Sibbald, RG | 1 |
| Coutts, P | 1 |
| Woo, KY | 1 |
| Lehner, B | 1 |
| Fleischmann, W | 1 |
| Becker, R | 1 |
| Jukema, GN | 1 |
| Lenselink, E | 1 |
| Andriessen, A | 1 |
| Fleck, CA | 1 |
| Vasseneix, C | 1 |
| Gargala, G | 1 |
| François, A | 1 |
| Hellot, MF | 1 |
| Duclos, C | 1 |
| Muraine, M | 1 |
| Benichou, J | 1 |
| Ballet, JJ | 1 |
| Brasseur, G | 1 |
| Favennec, L | 1 |
| Rietkötter, J | 1 |
| Körber, A | 1 |
| Grabbe, S | 1 |
| Lam, DS | 1 |
| Lyon, D | 1 |
| Poon, AS | 1 |
| Rao, SK | 1 |
| Fan, DS | 1 |
| Sharon, A | 1 |
| Berdicevsky, I | 1 |
| Ben-Aryeh, H | 1 |
| Gutman, D | 1 |
| Bain, MJ | 1 |
| Strahan, JD | 1 |
| Winkler, G | 1 |
| Fövémyi, J | 1 |
| Saxton, CA | 1 |
| Cowell, CR | 1 |
| Sheiham, A | 1 |
| Wagg, BJ | 1 |
| Andreev, D | 1 |
| Pampulov, L | 1 |
| Roth, B | 1 |
| Baltzer, K | 1 |
| Langslet, A | 1 |
| Olsen, I | 1 |
| Lie, SO | 1 |
| Lokken, P | 1 |
| Previato, G | 1 |
| Barbui, T | 1 |
| Guarnieri, GF | 1 |
| Palmari, V | 1 |
| Di Luzio, V | 1 |
| Campanacci, L | 1 |
2 reviews available for biguanides and Chronic Disease
| Article | Year |
|---|---|
Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions.
Topics: Biguanides; Bile Acids and Salts; Chronic Disease; Drug Carriers; Drug Compounding; Drug Delivery Sy | 2022 |
Fighting infection in chronic wounds.
Topics: Acrylic Resins; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Benchmarking; Biguani | 2006 |
7 trials available for biguanides and Chronic Disease
| Article | Year |
|---|---|
Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT.
Topics: Aged; Aged, 80 and over; Bandages; Betaine; Biguanides; Chronic Disease; Female; Humans; Inflammatio | 2016 |
Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Biguanides; Canada; Chro | 2011 |
First experiences with negative pressure wound therapy and instillation in the treatment of infected orthopaedic implants: a clinical observational study.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Biguanides; Chronic Dis | 2011 |
A cohort study on the efficacy of a polyhexanide-containing biocellulose dressing in the treatment of biofilms in wounds.
Topics: Biguanides; Biofilms; Cellulose; Chronic Disease; Disinfectants; Female; Humans; Male; Middle Aged; | 2011 |
The effect of a 1% chlorhexidine gel in the initial therapy of chronic periodontal disease.
Topics: Adolescent; Adult; Biguanides; Chlorhexidine; Chronic Disease; Clinical Trials as Topic; Dental Plaq | 1978 |
Testing therapeutic measures for controlling chronic gingivitis in man: the results of two studies.
Topics: Adolescent; Adult; Biguanides; Chlorhexidine; Chronic Disease; Clinical Trials as Topic; Dental Plaq | 1976 |
[Therapeutic effect of glibenclamide contrasted with other oral antidiabetic agents].
Topics: Administration, Oral; Adult; Biguanides; Chlorpropamide; Chronic Disease; Clinical Trials as Topic; | 1975 |
17 other studies available for biguanides and Chronic Disease
| Article | Year |
|---|---|
Effect of a New Purified Collagen Matrix With Polyhexamethylene Biguanide on Recalcitrant Wounds of Various Etiologies: A Case Series.
Topics: Aged; Anti-Infective Agents, Local; Biguanides; Calciphylaxis; Chronic Disease; Collagen Type I; Dia | 2018 |
W.A.R. scores in patients with chronic leg ulcers: results of a multicentre study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biguanides; Child; Chronic Diseas | 2014 |
The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Betaine; Biguanide | 2014 |
Evaluation of the effectiveness of a polyhexanide and propyl betaine-based gel in the treatment of chronic wounds.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Betaine; Biguanides; Child; C | 2014 |
Antimicrobial-impregnated dressing combined with negative-pressure wound therapy increases split-thickness skin graft engraftment: a simple effective technique.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bandages; Biguanides; Chronic Disease; Female | 2015 |
0.1% Polyhexanide-Betaine Solution as an Adjuvant in a Case-Series of Chronic Wounds.
Topics: Betaine; Biguanides; Chronic Disease; Disinfectants; Humans; Prospective Studies; Retrospective Stud | 2016 |
[Treatment of ulcus cruris and other chronic wounds. Waiting can cost the foot].
Topics: Biguanides; Chronic Disease; Drug Therapy, Combination; Humans; Leg Ulcer; Silver; Wound Healing; Wo | 2008 |
Topical antimicrobial agents for the treatment of chronic wounds.
Topics: Administration, Topical; Anti-Bacterial Agents; Bandages; Biguanides; Chronic Disease; Disinfectants | 2009 |
A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide.
Topics: Acute Disease; Bacterial Infections; Biguanides; Chronic Disease; Contraindications; Disinfectants; | 2010 |
A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Administration, Topical; Animals; Antiprotozoal Agents; Benzam | 2006 |
Eradication of methicillin-resistant Staphylococcus aureus in a chronic wound by a new polyhexanide hydrogel.
Topics: Adult; Biguanides; Chronic Disease; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Methicilli | 2007 |
Polyhexamethylene biguanide (0.02%) alone is not adequate for treating chronic Acanthameoba keratitis.
Topics: Acanthamoeba Keratitis; Biguanides; Chronic Disease; Disinfectants; Humans; Treatment Failure | 2000 |
The effect of chlorhexidine mouth rinses on oral Candida in a group of leukemic patients.
Topics: Biguanides; Candida albicans; Chlorhexidine; Chronic Disease; Humans; Leukemia; Mouth; Mouthwashes; | 1977 |
[Lactic acidosis in diabetes mellitus, caused by butyl biguanide and carbohydrate administration (1st manifestation of latent chronic hapatopathy)].
Topics: Aged; Biguanides; Chronic Disease; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Dietary | 1977 |
[Preliminary treatment of the recipient site and healing of open spongiosa transplant in post-traumatic osteitis].
Topics: Anti-Infective Agents, Local; Biguanides; Bone Transplantation; Chronic Disease; Fracture Fixation, | 1989 |
Chlorhexidine treatment of oral candidiasis in seriously diseased children.
Topics: Administration, Topical; Adolescent; Biguanides; Candidiasis, Oral; Child; Child, Preschool; Chronic | 1974 |
[Effect of the administration of phenyl-ethyl-biguanide on tolerance to oral administration of glucose in chronic uremia].
Topics: Biguanides; Chronic Disease; Glucose; Glucose Tolerance Test; Humans; Insulin; Phenformin; Uremia | 1969 |