biguanides has been researched along with Breast Neoplasms in 7 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We show here that breast tumors engage the ShcA pathway to increase their metabolism." | 1.48 | Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. ( Ahn, R; Avizonis, DZ; Chénard, V; Gravel, SP; Hudson, J; Im, YK; McGuirk, S; Najyb, O; Pawson, T; Pollak, M; Sabourin, V; St-Pierre, J; Topisirovic, I; Ursini-Siegel, J, 2018) |
| "CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport chain/respiration and inhibited AMPKα." | 1.46 | Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. ( Alvarez, J; Ambrose, E; Atkins, WM; Bae, YK; Blair, IA; Cao, Q; Capdevila, JH; Chiu, TL; Chu, H; Cuellar, RAD; Denisov, IG; Falck, JR; Flory, CM; Gallagher, RI; Galván, A; Georg, GI; Grinkova, YV; Guo, Z; Gupta, K; Hanse, EA; Kelekar, A; Langenfeld, VW; Lipscomb, JD; Luna, F; Norris, B; O'Sullivan, MG; Petricoin, EF; Potter, DA; Poulos, TL; Schumacher, RJ; Sevrioukova, IF; Sligar, SG; Stamschror, JD; Swedien, DS; Thomas, DG; Wulfkuhle, JD; Zhang, X, 2017) |
| "Metformin was also effective in significantly enhancing insulin binding in both IM-9 and MCF-7 cells." | 1.26 | Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells. ( Goldfine, ID; Pezzino, V; Vigneri, R; Wong, KY, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Markowicz-Piasecka, M | 1 |
| Sadowski, K | 1 |
| Huttunen, J | 1 |
| Sikora, J | 1 |
| Huttunen, KM | 1 |
| Guo, Z | 1 |
| Sevrioukova, IF | 1 |
| Denisov, IG | 1 |
| Zhang, X | 1 |
| Chiu, TL | 1 |
| Thomas, DG | 1 |
| Hanse, EA | 1 |
| Cuellar, RAD | 1 |
| Grinkova, YV | 1 |
| Langenfeld, VW | 1 |
| Swedien, DS | 1 |
| Stamschror, JD | 1 |
| Alvarez, J | 1 |
| Luna, F | 1 |
| Galván, A | 1 |
| Bae, YK | 1 |
| Wulfkuhle, JD | 1 |
| Gallagher, RI | 1 |
| Petricoin, EF | 1 |
| Norris, B | 1 |
| Flory, CM | 1 |
| Schumacher, RJ | 1 |
| O'Sullivan, MG | 1 |
| Cao, Q | 1 |
| Chu, H | 1 |
| Lipscomb, JD | 1 |
| Atkins, WM | 1 |
| Gupta, K | 1 |
| Kelekar, A | 1 |
| Blair, IA | 1 |
| Capdevila, JH | 1 |
| Falck, JR | 1 |
| Sligar, SG | 1 |
| Poulos, TL | 1 |
| Georg, GI | 1 |
| Ambrose, E | 1 |
| Potter, DA | 1 |
| Im, YK | 1 |
| Najyb, O | 1 |
| Gravel, SP | 1 |
| McGuirk, S | 1 |
| Ahn, R | 1 |
| Avizonis, DZ | 1 |
| Chénard, V | 1 |
| Sabourin, V | 1 |
| Hudson, J | 1 |
| Pawson, T | 1 |
| Topisirovic, I | 1 |
| Pollak, M | 1 |
| St-Pierre, J | 1 |
| Ursini-Siegel, J | 1 |
| Shepard, JB | 1 |
| Wilkinson, RA | 1 |
| Starkey, JR | 1 |
| Teintze, M | 1 |
| Vigneri, R | 1 |
| Pezzino, V | 1 |
| Wong, KY | 1 |
| Goldfine, ID | 1 |
| Dil'man, VM | 1 |
| Bershteĭn, LM | 1 |
| Tsyrlina, EV | 1 |
| Bobrov, IuF | 1 |
| Kovaleva, IG | 2 |
| Revskoy, SY | 1 |
| Poroshina, TE | 1 |
| Berstein, LM | 1 |
| Ostroumova, MN | 1 |
| Dilman, VM | 1 |
7 other studies available for biguanides and Breast Neoplasms
| Article | Year |
|---|---|
Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Biguanides; Breast Neoplasms; Cell Cycle Checkpoints; Female; Huma | 2021 |
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.
Topics: AMP-Activated Protein Kinases; Animals; Biguanides; Breast Neoplasms; Catalytic Domain; Cell Respira | 2017 |
Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.
Topics: Animals; Biguanides; Breast Neoplasms; Disease Models, Animal; Female; Humans; Mammary Neoplasms, An | 2018 |
Novel guanide-substituted compounds bind to CXCR4 and inhibit breast cancer metastasis.
Topics: Animals; Biguanides; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Dogs; Drug Screening Assa | 2014 |
Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells.
Topics: Animals; Biguanides; Breast Neoplasms; Cell Line; Female; Fibroblasts; Humans; Insulin; Liver Neopla | 1982 |
[Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin].
Topics: Adrenal Cortex Hormones; Aged; Biguanides; Blood Glucose; Body Weight; Breast Neoplasms; Buformin; C | 1975 |
Age-dependent metabolic immunodepression and cancer.
Topics: Age Factors; Biguanides; Blood Viscosity; Breast Neoplasms; Cholesterol; Clofibrate; Female; Humans; | 1985 |