Page last updated: 2024-11-08

biguanides and Apnea

biguanides has been researched along with Apnea in 10 studies

Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
"Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome."7.91Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019)
"Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome."3.91Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019)
" Since selective stimulation of PCFs by action on local 5-HT3 receptors could evoke an apnea, this current study addresses whether inhalation of ISO would facilitate the PCF 5-HT3 receptor-mediated apneic response and, if so, how."3.79Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats. ( Xu, F; Zhang, C; Zhang, Z; Zhuang, J, 2013)
" Intravenous (iv) injection of PDG (10 microg/kg), produced hypotension, bradycardia and apnea over a period of time."3.70Phenyldiguanide activates cardiac receptors to produce responses by involving three different efferent pathways in anaesthetized rats. ( Bagchi, S; Deshpande, SB, 2000)
" The response to bolus injection of PDG into the right atrium was qualitatively similar to the one seen in cats under anesthesia, consisting of bradycardia and apnea followed by rapid shallow breathing (RSB)."3.67The respiratory response to stimulation of juxta-pulmonary capillary receptors in the non-anesthetized cat. ( Ginzel, KH; Lucas, EA, 1985)
" Apnea followed by rapid shallow breathing was observed in most animals."3.66Cardiovascular and respiratory responses to right atrial injections of phenyl diguanide in pentobarbital-anesthetized newborn piglets. ( Gootman, N; Gootman, PM; Schleman, M, 1979)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19906 (60.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhao, L1
Gao, X1
Zhuang, J2
Wallen, M1
Leng, S1
Xu, F2
Zhang, Z1
Zhang, C1
Bagchi, S2
Deshpande, SB2
Skofitsch, G1
Saria, A1
Lembeck, F1
Rai, OP1
Aryya, NC1
Schleman, M1
Gootman, N1
Gootman, PM1
Ginzel, KH1
Lucas, EA1
Schmidt, T2
Wellhöner, HH2
Jain, SK1
Subramanian, S1
Julka, DB1
Guz, A1

Trials

1 trial available for biguanides and Apnea

ArticleYear
Search for evidence of lung chemoreflexes in man: study of respiratory and circulatory effects of phenyldiguanide and lobeline.
    Clinical science, 1972, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Apnea; Asthma; Biguanides; Blood Circulation Time; Blood Pressure; Bronchitis; Ca

1972

Other Studies

9 other studies available for biguanides and Apnea

ArticleYear
Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:10

    Topics: Animals; Animals, Newborn; Apnea; Biguanides; Bronchoalveolar Lavage Fluid; Disease Models, Animal;

2019
Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats.
    Neuroscience letters, 2013, Sep-27, Volume: 552

    Topics: Administration, Inhalation; Animals; Apnea; Biguanides; Isoflurane; Lung; Male; Membrane Potentials;

2013
Phenyldiguanide activates cardiac receptors to produce responses by involving three different efferent pathways in anaesthetized rats.
    Indian journal of experimental biology, 2000, Volume: 38, Issue:9

    Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Apnea; Biguanides; Blood Pressure; Bradyc

2000
Phenyldiguanide and capsaicin stimulate functionally different populations of afferent C-fibers.
    Neuroscience letters, 1983, Nov-21, Volume: 42, Issue:1

    Topics: Animals; Apnea; Biguanides; Bradycardia; Capillary Permeability; Capsaicin; Hypotension; Male; Nerve

1983
Pulmonary oedema produced by scorpion venom augments a phenyldiguanide-induced reflex response in anaesthetized rats.
    The Journal of physiology, 1999, Dec-01, Volume: 521 Pt 2

    Topics: Anesthetics, Intravenous; Animals; Apnea; Aprotinin; Biguanides; Bradycardia; Drug Synergism; Female

1999
Cardiovascular and respiratory responses to right atrial injections of phenyl diguanide in pentobarbital-anesthetized newborn piglets.
    Pediatric research, 1979, Volume: 13, Issue:11

    Topics: Anesthesia, Inhalation; Animals; Animals, Newborn; Aorta; Apnea; Biguanides; Blood Pressure; Bradyca

1979
The respiratory response to stimulation of juxta-pulmonary capillary receptors in the non-anesthetized cat.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:1A

    Topics: Anesthesia; Animals; Aorta; Apnea; Arousal; Biguanides; Capillaries; Cats; Dose-Response Relationshi

1985
[Activity in intercostal alpha- and gamma-efferent axons during reflex respiratory arrest by p-chlorophenylbiguanide or 5-hydroxytryptamine].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4

    Topics: Apnea; Axons; Biguanides; Neurons, Efferent; Serotonin; Thoracic Nerves

1970
The reflex influence of a group of slowly conducting vagal afferents on alpha and gamma discharges in cat intercostal nerves.
    Pflugers Archiv : European journal of physiology, 1970, Volume: 318, Issue:4

    Topics: Animals; Apnea; Atropine; Biguanides; Cats; Chemoreceptor Cells; Chlorpromazine; Motor Neurons; Neur

1970