biguanides and Apnea
biguanides has been researched along with Apnea in 10 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Apnea: A transient absence of spontaneous respiration.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome." | 7.91 | Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019) |
| "Prenatal nicotinic exposure (PNE) reportedly sensitizes bronchopulmonary C-fibers (PCFs) and prolongs PCF-mediated apnea in rat pups, contributing to the pathogenesis of sudden infant death syndrome." | 3.91 | Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT ( Gao, X; Leng, S; Wallen, M; Xu, F; Zhao, L; Zhuang, J, 2019) |
| " Since selective stimulation of PCFs by action on local 5-HT3 receptors could evoke an apnea, this current study addresses whether inhalation of ISO would facilitate the PCF 5-HT3 receptor-mediated apneic response and, if so, how." | 3.79 | Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats. ( Xu, F; Zhang, C; Zhang, Z; Zhuang, J, 2013) |
| " Intravenous (iv) injection of PDG (10 microg/kg), produced hypotension, bradycardia and apnea over a period of time." | 3.70 | Phenyldiguanide activates cardiac receptors to produce responses by involving three different efferent pathways in anaesthetized rats. ( Bagchi, S; Deshpande, SB, 2000) |
| " The response to bolus injection of PDG into the right atrium was qualitatively similar to the one seen in cats under anesthesia, consisting of bradycardia and apnea followed by rapid shallow breathing (RSB)." | 3.67 | The respiratory response to stimulation of juxta-pulmonary capillary receptors in the non-anesthetized cat. ( Ginzel, KH; Lucas, EA, 1985) |
| " Apnea followed by rapid shallow breathing was observed in most animals." | 3.66 | Cardiovascular and respiratory responses to right atrial injections of phenyl diguanide in pentobarbital-anesthetized newborn piglets. ( Gootman, N; Gootman, PM; Schleman, M, 1979) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zhao, L | 1 |
| Gao, X | 1 |
| Zhuang, J | 2 |
| Wallen, M | 1 |
| Leng, S | 1 |
| Xu, F | 2 |
| Zhang, Z | 1 |
| Zhang, C | 1 |
| Bagchi, S | 2 |
| Deshpande, SB | 2 |
| Skofitsch, G | 1 |
| Saria, A | 1 |
| Lembeck, F | 1 |
| Rai, OP | 1 |
| Aryya, NC | 1 |
| Schleman, M | 1 |
| Gootman, N | 1 |
| Gootman, PM | 1 |
| Ginzel, KH | 1 |
| Lucas, EA | 1 |
| Schmidt, T | 2 |
| Wellhöner, HH | 2 |
| Jain, SK | 1 |
| Subramanian, S | 1 |
| Julka, DB | 1 |
| Guz, A | 1 |
Trials
1 trial available for biguanides and Apnea
| Article | Year |
|---|---|
Search for evidence of lung chemoreflexes in man: study of respiratory and circulatory effects of phenyldiguanide and lobeline.
Topics: Adolescent; Adult; Apnea; Asthma; Biguanides; Blood Circulation Time; Blood Pressure; Bronchitis; Ca | 1972 |
Other Studies
9 other studies available for biguanides and Apnea
| Article | Year |
|---|---|
Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT
Topics: Animals; Animals, Newborn; Apnea; Biguanides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; | 2019 |
Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats.
Topics: Administration, Inhalation; Animals; Apnea; Biguanides; Isoflurane; Lung; Male; Membrane Potentials; | 2013 |
Phenyldiguanide activates cardiac receptors to produce responses by involving three different efferent pathways in anaesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Apnea; Biguanides; Blood Pressure; Bradyc | 2000 |
Phenyldiguanide and capsaicin stimulate functionally different populations of afferent C-fibers.
Topics: Animals; Apnea; Biguanides; Bradycardia; Capillary Permeability; Capsaicin; Hypotension; Male; Nerve | 1983 |
Pulmonary oedema produced by scorpion venom augments a phenyldiguanide-induced reflex response in anaesthetized rats.
Topics: Anesthetics, Intravenous; Animals; Apnea; Aprotinin; Biguanides; Bradycardia; Drug Synergism; Female | 1999 |
Cardiovascular and respiratory responses to right atrial injections of phenyl diguanide in pentobarbital-anesthetized newborn piglets.
Topics: Anesthesia, Inhalation; Animals; Animals, Newborn; Aorta; Apnea; Biguanides; Blood Pressure; Bradyca | 1979 |
The respiratory response to stimulation of juxta-pulmonary capillary receptors in the non-anesthetized cat.
Topics: Anesthesia; Animals; Aorta; Apnea; Arousal; Biguanides; Capillaries; Cats; Dose-Response Relationshi | 1985 |
[Activity in intercostal alpha- and gamma-efferent axons during reflex respiratory arrest by p-chlorophenylbiguanide or 5-hydroxytryptamine].
Topics: Apnea; Axons; Biguanides; Neurons, Efferent; Serotonin; Thoracic Nerves | 1970 |
The reflex influence of a group of slowly conducting vagal afferents on alpha and gamma discharges in cat intercostal nerves.
Topics: Animals; Apnea; Atropine; Biguanides; Cats; Chemoreceptor Cells; Chlorpromazine; Motor Neurons; Neur | 1970 |