biguanides has been researched along with Aging in 14 studies
Biguanides: Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
biguanides : A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furthermore metformin seems to decrease cancer risk in diabetic patients." | 6.46 | Metformin for aging and cancer prevention. ( Anisimov, VN, 2010) |
| "Ketanserin treatment lowered blood pressure consistently, and the ensuing hypotension was more pronounced in 14- and 24-month than in 4-month-old rats." | 5.29 | Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. ( Buñag, RD; Davidow, LW; Schmitz, TM, 1994) |
| "Furthermore metformin seems to decrease cancer risk in diabetic patients." | 2.46 | Metformin for aging and cancer prevention. ( Anisimov, VN, 2010) |
| "The incidence of cancer increases with age in humans and in laboratory animals alike." | 2.45 | Relationships between cancer and aging: a multilevel approach. ( Anisimov, VN; Pawelec, G; Sikora, E, 2009) |
| "Patients who develop NIDDM at age 65 years may live long enough to develop microvascular complications." | 2.40 | Oral antihyperglycaemics. Considerations in older patients with non-insulin-dependent diabetes mellitus. ( Jennings, PE, 1997) |
| "Periodontal diseases are common, inflammatory infections of the mouth of microbiological etiology." | 2.37 | Chemotherapy and periodontal disease--a review. ( Marder, M; Milgrom, P, 1984) |
| "Ketanserin treatment lowered blood pressure consistently, and the ensuing hypotension was more pronounced in 14- and 24-month than in 4-month-old rats." | 1.29 | Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. ( Buñag, RD; Davidow, LW; Schmitz, TM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cabreiro, F | 1 |
| Au, C | 1 |
| Leung, KY | 1 |
| Vergara-Irigaray, N | 1 |
| Cochemé, HM | 1 |
| Noori, T | 1 |
| Weinkove, D | 1 |
| Schuster, E | 1 |
| Greene, ND | 1 |
| Gems, D | 1 |
| Anisimov, VN | 5 |
| Sikora, E | 1 |
| Pawelec, G | 1 |
| Ben Amara, H | 1 |
| Kacem, A | 1 |
| Gaigi, I | 1 |
| Dakhli, S | 1 |
| Ben Mami, F | 1 |
| Achour, A | 1 |
| Berstein, LM | 1 |
| Popovich, IG | 1 |
| Zabezhinski, MA | 1 |
| Egormin, PA | 1 |
| Tyndyk, ML | 1 |
| Anikin, IV | 1 |
| Semenchenko, AV | 1 |
| Yashin, AI | 1 |
| Levin, PA | 1 |
| McLaughlin, J | 1 |
| Kowarski, AA | 1 |
| Marder, M | 1 |
| Milgrom, P | 1 |
| Davidow, LW | 1 |
| Schmitz, TM | 1 |
| Buñag, RD | 1 |
| Tong, S | 1 |
| Frasier, ID | 1 |
| Ingenito, S | 1 |
| Sica, AL | 1 |
| Gootman, N | 1 |
| Gootman, PM | 1 |
| Jennings, PE | 1 |
| Panzram, G | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Whitaker-Azmitia, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Randomized, Double-blind, Placebo-controlled Study to Assess the Effect of Metformin, an Activator of AMPK, on Cognitive Measures of Progression in Huntington's Disease Patients"[NCT04826692] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-12-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for biguanides and Aging
| Article | Year |
|---|---|
[Role of the growth hormone-insulin-like growth factor-1-insulin system signaling in aging and longevity: evolutional aspect].
Topics: Aging; Animals; Biguanides; Caenorhabditis elegans; Growth Hormone; Hypoglycemic Agents; Insulin; In | 2008 |
Relationships between cancer and aging: a multilevel approach.
Topics: Age Distribution; Age Factors; Aging; Animals; Anticarcinogenic Agents; Biguanides; Carcinogens; Cel | 2009 |
[Diabetes mellitus of elderly patients: therapeutic recommendations].
Topics: Aged; Aging; Biguanides; Blood Glucose; Cachexia; Diabetes Mellitus, Type 2; Diabetic Neuropathies; | 2008 |
Metformin for aging and cancer prevention.
Topics: Aging; Animals; Antineoplastic Agents; Biguanides; Caloric Restriction; Humans; Hyperglycemia; Hypog | 2010 |
Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention.
Topics: Aging; Animals; Biguanides; Cell Transformation, Neoplastic; Humans; Insulin; Insulin-Like Growth Fa | 2003 |
Chemotherapy and periodontal disease--a review.
Topics: Adult; Aging; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Biguanides | 1984 |
Oral antihyperglycaemics. Considerations in older patients with non-insulin-dependent diabetes mellitus.
Topics: Administration, Oral; Aged; Aging; Biguanides; Diabetes Mellitus, Type 2; Drug Therapy, Combination; | 1997 |
7 other studies available for biguanides and Aging
| Article | Year |
|---|---|
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Topics: Adenylate Kinase; Aging; Animals; Biguanides; Caenorhabditis elegans; Caenorhabditis elegans Protein | 2013 |
Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens.
Topics: Aging; Animals; Biguanides; Caenorhabditis elegans Proteins; Caloric Restriction; Humans; Hypoglycem | 2005 |
Diabetes mellitus: customizing management.
Topics: Adult; Aging; Biguanides; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Ty | 1984 |
Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats.
Topics: Aging; Amphetamines; Animals; Biguanides; Blood Pressure; Heart Rate; Ketanserin; Male; Rats; Rats, | 1994 |
Age-related effects of cardiac sympathetic denervation on the responses to cardiopulmonary receptor stimulation in piglets.
Topics: Aging; Animals; Animals, Newborn; Biguanides; Cardiac Catheterization; Cardiovascular System; Electr | 1997 |
[Diabetic coma--epidemiologic aspects].
Topics: Adult; Aged; Aging; Ambulatory Care; Biguanides; Diabetes Complications; Diabetes Mellitus; Diabetes | 1979 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |