bifemelane has been researched along with Brain Ischemia in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 11 (64.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujishima, M; Ishitsuka, T; Omae, T | 1 |
| Egawa, M; Mitsuka, M; Tobe, A; Umezu, K | 1 |
| Hata, R; Kamada, T; Kitagawa, K; Matsumoto, M; Matsuyama, T; Sugita, M; Tagaya, M | 1 |
| Nakamura, T; Ohkawa, I; Ozaki, S; Tajima, T | 1 |
| Arai, Y; Gu, GZ; Matsumoto, K; Mizushima, H; Nakai, Y; Shimazu, M; Shioda, S | 1 |
| Asanuma, M; Chou, HH; Hirata, H; Kondo, Y; Mori, A; Ogawa, N | 1 |
| Kanazawa, A; Kondo, T | 1 |
| Kitagawa, K; Kuwabara, K; Mabuchi, T; Matsumoto, M; Matsushita, K; Ohtsuki, T; Taguchi, A; Yanagihara, T; Yang, GM | 1 |
| Asanuma, M; Iwata, E; Kondo, Y; Matsuura, K; Nishibayashi, K; Ogawa, N | 1 |
| Egashira, T; Takayama, F; Yamanaka, Y | 1 |
| Matsumoto, M; Mori, K; Saito, H; Suda, N; Togashi, H; Yoshioka, M | 1 |
| Asanuma, M; Haba, K; Hirata, H; Mori, A; Ogawa, N | 1 |
| Izuta, M; Kanashiro, M; Maruki, Y; Naritomi, H; Sasaki, M; Sawada, T | 1 |
| Haba, K; Mizukawa, K; Ogawa, N; Ono, T; Yoshikawa, H | 1 |
| Goto, Y; Kikuchi, H; Taki, W | 1 |
| Egawa, M; Hashimoto, N; Tobe, A | 1 |
| Honda, S; Saito, K; Tobe, A; Yanagiya, I | 1 |
17 other study(ies) available for bifemelane and Brain Ischemia
| Article | Year |
|---|---|
[Protective effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on acutely induced cerebral ischemia in Mongolian gerbils and spontaneously hypertensive rats (SHR)].
Topics: Animals; Benzhydryl Compounds; Brain; Brain Ischemia; Disease Models, Animal; Female; Gerbillinae; Glucose; Male; Rats; Rats, Inbred SHR; Time Factors | 1984 |
Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on survival time and brain monoamine levels in bilaterally carotid-artery-ligated gerbils.
Topics: Animals; Arterial Occlusive Diseases; Benzhydryl Compounds; Biogenic Amines; Brain Chemistry; Brain Ischemia; Carotid Artery Diseases; Gerbillinae; Ligation; Male; Norepinephrine; Serotonin | 1984 |
Therapeutic effect of bifemelane on unilateral cerebral ischemia in gerbils.
Topics: Animals; Benzhydryl Compounds; Brain Chemistry; Brain Ischemia; Female; Gerbillinae; Male; Microtubule-Associated Proteins | 1995 |
[Effect of bifemelane hydrochloride in rats on the improvement of the learning and memory impairments and prevention of neuronal damage following transient forebrain ischemia].
Topics: Animals; Avoidance Learning; Benzhydryl Compounds; Brain Ischemia; Dose-Response Relationship, Drug; Male; Memory; Rats; Rats, Wistar | 1994 |
Protective effect of bifemelane on c-Fos-like immunoreactivity in rat cerebral ischemia.
Topics: Animals; Benzhydryl Compounds; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Immunohistochemistry; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 1994 |
Ischemia-induced changes in alpha-tubulin and beta-actin mRNA in the gerbil brain and effects of bifemelane hydrochloride.
Topics: Actins; Animals; Antidepressive Agents; Benzhydryl Compounds; Blotting, Northern; Brain Chemistry; Brain Ischemia; Gerbillinae; Histocytochemistry; In Situ Hybridization; RNA Probes; RNA, Messenger; Sulfur Radioisotopes; Tubulin | 1993 |
[Hydroxyl radical generation and post-ischemic reperfusion brain damage implications for neuroprotection].
Topics: Animals; Benzhydryl Compounds; Brain Ischemia; Cell Survival; Cerebral Cortex; Free Radical Scavengers; Gerbillinae; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Male; Neurons; Reperfusion Injury; Salicylates; Salicylic Acid | 1996 |
Bifemelane hydrochloride enhances 'ischemic tolerance' phenomenon in gerbil hippocampal CA1 neurons.
Topics: Adaptation, Physiological; Animals; Benzhydryl Compounds; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Hippocampus; Male; Neurons; Oxidative Stress | 1996 |
Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Arterial Occlusive Diseases; Benzhydryl Compounds; Blotting, Northern; Brain Ischemia; Chronic Disease; Disease Models, Animal; Frontal Lobe; Gene Expression; Hippocampus; Male; Muscarinic Antagonists; Neostriatum; Nootropic Agents; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; RNA, Messenger; Tritium | 1996 |
Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries.
Topics: Age Factors; Aging; Animals; Benzhydryl Compounds; Binding, Competitive; Brain Ischemia; Choline O-Acetyltransferase; Corpus Striatum; Hippocampus; Kinetics; Male; Muscarinic Antagonists; Nootropic Agents; Prefrontal Cortex; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1996 |
Effects of bifemelane on incomplete cerebral ischaemia-induced reduction of long-term potentiation in rat hippocampal neurones in vivo.
Topics: Animals; Area Under Curve; Benzhydryl Compounds; Brain Ischemia; Carotid Arteries; Electrodes; Electrophysiology; Hippocampus; Long-Term Potentiation; Male; Neurons; Nootropic Agents; Perforant Pathway; Rats; Rats, Wistar; Synapses | 1999 |
Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils.
Topics: Animals; Benzhydryl Compounds; Benzoquinones; Biogenic Monoamines; Brain Chemistry; Brain Ischemia; Dopamine; Gerbillinae; Hydroxyindoleacetic Acid; Morpholines; Nerve Tissue Proteins; Norepinephrine; Serotonin; Ubiquinone | 1992 |
Effect of bifemelane on the intracellular pH and energy state of the ischemic brain.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Benzhydryl Compounds; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Brain Ischemia; Carbon Dioxide; Energy Metabolism; Gerbillinae; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Oxygen; Phosphates; Phosphocreatine | 1990 |
Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced depletion of brain acetylcholine levels in gerbils.
Topics: Acetylcholine; Animals; Benzhydryl Compounds; Benzoquinones; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Gerbillinae; Hippocampus; Humans; Infant, Newborn; Morpholines; Quinones; Ubiquinone | 1988 |
[Effects of bifemelane on the free fatty acid levels during ischemia].
Topics: Animals; Benzhydryl Compounds; Brain; Brain Ischemia; Cerebrovascular Circulation; Fatty Acids, Nonesterified; Rats; Rats, Inbred Strains | 1988 |
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Diseases; Constriction, Pathologic; gamma-Aminobutyric Acid; Gerbillinae; Male; Pantothenic Acid; Piperidines | 1985 |
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and mongolian gerbils.
Topics: Acetylcholine; Animals; Antidepressive Agents; Benzhydryl Compounds; Brain Ischemia; Cerebral Cortex; Gerbillinae; Hippocampus; Hypoxia; Male; Rats; Rats, Inbred Strains; Scopolamine; Time Factors | 1985 |