bicyclol and Neoplasms

To evaluate the efficacy of bicyclol in preventing chemotherapy-induced liver damage.. Patients ≥60 years of age with cancer were equally randomized into control (chemotherapy alone) or prophylactic (chemotherapy supplemented with 75 mg bicyclol, oral, daily) groups. Liver function indices were assessed immediately before treatment, during each therapy cycle and following treatment.. Of 306 patients enrolled, 300 patiets completed the study (n = 147 and n = 153; prophylactic and control groups, respectively). Incidence of grade I-IV elevation of serum transaminase and/or bilirubin was significantly lower in the prophylactic group (17.1%) compared with the control group (47.1%). Incidence of grade II-IV hepatic injury was also significantly lower in the prophylactic group (0.7%) than in the control group (12.4%).. Prophylactic bicyclol (75 mg daily) could significantly reduce the incidence and degree of chemotherapeutic agent-induced liver damage in elderly patients with cancer. Further studies are recommended with larger sample sizes and long-term follow up.

Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Bilirubin; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged; Neoplasms; Pre-Exposure Prophylaxis; Prospective Studies; Transaminases