bicuculline has been researched along with Seizures in 558 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 234 (41.94) | 18.7374 |
| 1990's | 166 (29.75) | 18.2507 |
| 2000's | 101 (18.10) | 29.6817 |
| 2010's | 42 (7.53) | 24.3611 |
| 2020's | 15 (2.69) | 2.80 |
| Authors | Studies |
|---|---|
| Alexandre-Silva, V; Beserra-Filho, JIA; Custódio-Silva, AC; Maria-Macêdo, A; Morera, PMA; Ribeiro, AM; Silva, RH; Silva, SP; Silva-Martins, S; Soares-Silva, B | 1 |
| Beserra-Filho, JIA; Cardoso, GN; da Silva, RH; Dos Santos, JR; Lago, JHG; Prado, CM; Ribeiro, AM; Sarno, TA; Silva, SP; Silva-Freitas, FR; Silva-Martins, S; Soares-Silva, B; Ueno, AK; Vicente-Silva, W | 1 |
| Biagioni, F; Celli, R; Fornai, F; Giorgi, FS; Nicoletti, F; Puglisi-Allegra, S | 1 |
| Higuchi, M; Hirabayashi, T; Hori, Y; Inoue, KI; Kawasaki, K; Matsuo, T; Mimura, K; Minamimoto, T; Miyakawa, N; Nagai, Y; Orihara, A; Oyama, K; Suhara, T; Suzuki, T; Takada, M | 1 |
| Iizuka, M; Izumizaki, M; Lin, ST; Mikami, Y; Onimaru, H; Yoda, S | 1 |
| Bading, H; Bas-Orth, C; Buchthal, B; Koch, M; Lau, D | 1 |
| Kuroda, M; Matsuwaki, T; Nishihara, M; Tanaka, Y; Yamanouchi, K | 1 |
| da Silva Oliveira, GL; da Silva, JCCL; de Castro Almeida, FR; Dos Santos C L da Silva, AP; Feitosa, CM | 1 |
| Aupy, J; Biendon, N; Burbaud, P; Deffains, M; Dovero, S; Guehl, D; Nguyen, TH; Porras, G; Ribot, B | 1 |
| Dambrova, M; Kupats, E; Lauberte, L; Mezapuke, R; Stelfa, G; Svalbe, B; Vavers, E; Vilks, K; Zvejniece, B; Zvejniece, L | 1 |
| An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y | 1 |
| Holmes, GL; Isaev, D; Krishtal, O; Maximyuk, O; Netsyk, O; Oz, M; Romanov, A; Zapukhliak, O | 1 |
| Ayata, C; Chung, DY; de Morais, AL; Endres, M; Loonen, ICM; Misra, A; Qin, T; Schiff, SJ; Schlunk, F; Tamim, I | 1 |
| Aracri, P; de Curtis, M; Forcaia, G; Uva, L | 1 |
| Forcelli, PA; Wicker, E | 1 |
| Dambrova, M; Lauberte, L; Misane, I; Stonans, I; Svalbe, B; Vavers, E; Zvejniece, L | 1 |
| Fedinec, AL; Leffler, CW; Liu, J; Parfenova, H; Pourcyrous, M | 1 |
| Berndt, N; Dreier, JP; Friedman, A; Heinemann, U; Kovács, R; Liotta, A; Rösner, J; Schoknecht, K | 1 |
| Ding, K; Gross, RE; Shiu, FH; Tung, JK | 1 |
| Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G | 1 |
| Bernášková, K; Kubová, H; Mareš, P | 1 |
| Boas, DA; Devor, A; Fu, B; Gómez, CA; Sakadžić, S; Sutin, J; Uhlirova, H; Wu, W; Yaseen, MA | 1 |
| Chuang, SH; Reddy, DS | 1 |
| Allikalt, A; Dzirkale, Z; Jekabsons, K; Klusa, V; Mazina, O; Muceniece, R; Rinken, A; Rumaks, J; Svirskis, S | 1 |
| Carney, PR; Khargonekar, PP; Ratnadurai-Giridharan, S; Stefanescu, RA; Talathi, SS | 1 |
| Bernardeschi, M; Busceti, CL; Cantafora, E; Fornai, F; Frenzilli, G; Giorgi, FS; Nigro, M; Scarcelli, V | 1 |
| Cha, YM; Chen, LF; Frank, CL; West, AE; Wijayatunge, R; Zannas, AS | 1 |
| Buhler, E; Chauvin, Y; Jalabert, M; Malvache, A; Manent, JB; Peret, A; Petit, LF; Represa, A; Watrin, F | 1 |
| Carney, PR; Jiang, H; Yang, H; Zhang, T; Zhou, J | 1 |
| Chang, WP; Lu, HC; Shyu, BC | 1 |
| Breschi, GL; de Curtis, M; Gnatkovsky, V; Taverna, S; Uva, L | 1 |
| López-Pérez, S; Medina-Ceja, L; Morales-Villagrán, A; Ortega-Ibarra, J; Pardo-Peña, K | 1 |
| Guan, LP; Jin, P; Li, FN; Quan, ZS; Wang, SB; Zhang, HJ | 1 |
| Lei, Z; Liang, Y; Xu, ZC; Zhang, H | 1 |
| Basuroy, S; de Jongh Curry, A; Fedinec, AL; Harsono, M; Jolly, EJ; Leffler, CW; Liu, J; Parfenova, H; Pourcyrous, M; Zhuang, D | 1 |
| Araújo, A; Brandão, LE; Cagni, FC; da Silva, RH; de Azevedo, DL; Dos Santos, WF; Miranda, A; Nôga, DA; Ribeiro, AM; Silva, D | 1 |
| Avoli, M; Boido, D; de Curtis, M; Lévesque, M; Uva, L | 1 |
| Breese, GR; Knapp, DJ; Overstreet, DH; Wills, TA | 1 |
| Auta, J; Costa, E; Guidotti, A; Impagnatiello, F; Kadriu, B | 1 |
| Dzirkale, Z; Klusa, V; Krigere, L; Mezhapuke, R; Muceniece, R; Rumaks, J; Saleniece, K; Zharkova, O | 1 |
| Cooper, CE; Cope, M; Delpy, DT; Elwell, CE | 1 |
| Amabeoku, G | 1 |
| Ben-Ari, Y; Khalilov, I; Nardou, R | 1 |
| Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG | 1 |
| Aarabi, A; Grebe, R; Osharina, V; Ponchel, E; Wallois, F | 1 |
| Bai, X; Blumenfeld, H; Danielson, N; DeSalvo, MN; Hyder, F; Mishra, AM; Motelow, JE; Purcaro, MJ; Schridde, U | 1 |
| Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C | 1 |
| Bullis, JB; Jones, TD; Jung, S; Lau, IH; Poolos, NP; Warner, LN | 1 |
| Crespo-Ramírez, M; Flores-Gracia, C; Fuxe, K; Miledi, R; Nuche-Bricaire, A; Pérez de la Mora, M | 1 |
| Bernášková, K; Hrubá, L; Matějovská, I; Rokyta, R; Slamberová, R | 1 |
| Duburs, G; Dzirkale, Z; Fernandes, MA; Klusa, V; Mezhapuke, R; Pupure, J; Rumaks, J; Sile, V; Svirskis, S; Vanina, M | 1 |
| Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM | 1 |
| Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX | 1 |
| de Oliveira, JA; Garcia-Cairasco, N; Rodrigues, MC; Rossetti, F | 1 |
| Mareš, P; Tabashidze, N | 1 |
| Chang, WP; Lee, CM; Shyu, BC; Vogt, BA; Wu, JS | 1 |
| Jiang, H; Yang, H; Yang, J; Zhang, T | 1 |
| de Curtis, M; Librizzi, L; Noè, F; Ravizza, T; Vezzani, A | 1 |
| Bari, F; Busija, DW; Domoki, F; Gáspár, T; Institoris, A; Katakam, PV; Lenti, L; Wappler, E | 1 |
| Boido, D; de Curtis, M; Jesuthasan, N; Uva, L | 1 |
| Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M | 1 |
| Bird, A; Cobb, SR; Ganley, R; McLeod, F; Selfridge, J; Williams, L | 1 |
| Rodríguez de Lores Arnaiz, G; Schneider, PG | 1 |
| Homanics, GE; Korpi, ER; Kralic, JE; Morrow, AL; O'Buckley, TK | 1 |
| Bough, KJ; Eagles, DA; Gudi, K; Han, FT; Rathod, AH | 1 |
| Berkovic, SF; Clark, M; Drago, J; Finkelstein, DI; Horne, MK; Massalas, JS; McColl, C; Powney, E; Ross, SA; Wong, JY | 1 |
| Matsuoka, N; Mochizuki, Y; Mutoh, S; Sugimoto, M; Terai, T; Uchida, I; Yamazaki, S | 1 |
| Kamata, A; Kaneko, S; Murakami, T; Okada, M; Wada, K; Zhu, G | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Dohgu, S; Fujisaki, Y; Kataoka, Y; Oishi, R; Sunada, K; Yamaguchi, C; Yamauchi, A | 1 |
| Rubaj, A; Sieklucka-Dziuba, M; Zgodziński, W | 1 |
| Calabrese, RL; Cymbalyuk, GS; Gaudry, Q; Masino, MA | 1 |
| Schindler, CJ; Slamberová, R; Vathy, I | 3 |
| Browning, RA; Clough, RW; Jobe, PC; Merrill, MA | 1 |
| D'Hooge, R; De Deyn, PP; Marescau, B; Van Bogaert, PP; Van de Vijver, G; Vanholder, R | 1 |
| Clement, AB; Cravatt, BF; Hawkins, EG; Lichtman, AH | 1 |
| Fujiwara-Tsukamoto, Y; Isomura, Y; Nambu, A; Takada, M | 1 |
| Alessandrl, MG; Ferrucci, M; Fornai, F; Giorgi, FS; Lazzeri, G; Lenzi, P; Murri, L; Pizzanelli, C | 1 |
| Bernásková, K; Kaminskij, Y; Mares, P; Zivanović, D | 1 |
| Anschel, DJ; Fisher, RS; Ortega, E | 1 |
| An, SJ; Hwang, IK; Kang, TC; Park, SK; Won, MH | 1 |
| Ben-Ari, Y; Holmes, GL; Khalilov, I; Khazipov, R; Morozova, E; Tyzio, R | 1 |
| Beleboni, Rde O; Coutinho-Netto, J; dos Santos, WF; Garcia-Cairasco, N; Rodrigues, MC | 1 |
| Carratu, P; Daley, ML; Leffler, CW; Parfenova, H | 1 |
| Hu, B; Karnup, S; Stelzer, A; Zhou, L | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M | 1 |
| Behar, KL; de Graaf, RA; Kanamatsu, T; Mason, GF; Patel, AB; Rothman, DL; Shulman, RG | 1 |
| Anderson, AE; Johnston, D; Leung, V; Lin, X; Shah, MM | 1 |
| Anschel, DJ; Fisher, RS; Kraus, AC; Ortega, EL | 1 |
| Herman, P; Hyder, F; Kampmann, C; Novotny, E; Trübel, H | 1 |
| Choi, SY; Hwang, IK; Jung, JY; Kang, TC; Kim, DS; Kwon, OS; Seo, JH; Won, MH; Yoo, KY | 1 |
| Choi, SY; Jung, JY; Kang, TC; Kim, DS; Kim, JE; Kwak, SE; Kwon, OS; Won, MH | 1 |
| Frye, CA; Rhodes, ME | 1 |
| Arisi, GM; Bertti, P; Dal-Cól, ML; Del Vecchio, F; Fernandes, A; Foresti, ML; Furtado, MA; Garcia-Cairasco, N; Rodrigues, MC; Rossetti, F; Santos, FL | 1 |
| Choi, HJ; Choi, KB; Im, BO; Jeong, JH; Ko, SK; Min, YS; Sohn, UD; Song, HJ | 1 |
| Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R | 1 |
| Rokyta, R; Slamberová, R | 2 |
| Gal, A; Hentschke, M; Hentschke, S; Hermans-Borgmeyer, I; Hübner, CA; Jentsch, TJ; Kurth, I; Seidenbecher, T; Wiemann, M | 1 |
| Ojewole, JA | 3 |
| Akada, S; Koda, S; Onimaru, H; Sakamoto, A; Takeda, S | 1 |
| Dehpour, AR; Ebrahimi, F; Homayoun, H; Rafiei-Tabatabaei, N; Riazi, K; Roshanpour, M | 1 |
| Battaglioli, G; Behar, KL; de Graaf, RA; Martin, DL; Patel, AB | 1 |
| Dhir, A; Kulkarni, SK; Naidu, PS | 1 |
| Amabeoku, GJ; Ojewole, JA | 1 |
| Armentero, MT; Blandini, F; Fancellu, R; Fornai, F; Greco, R; Nappi, G; Tassorelli, C | 1 |
| Lesser, RP; Motamedi, GK; Ortinski, PI; Rogawski, MA; Salazar, P; Smith, EL; Vicini, S; Webber, WR | 1 |
| Abarbanel, HD; Haas, JS; Nowotny, T | 1 |
| Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR | 1 |
| Amabeoku, GJ; Green, I; Kabatende, J | 1 |
| Kubová, H; Mares, P; Tchekalarova, J | 1 |
| Cui, GX; Da, TJ; Ge, ZJ; Liu, GJ; Tan, YF; Wang, JK; Zeng, YM; Zhang, LC; Zhao, YP | 1 |
| Fedinec, AL; Leffler, CW; Parfenova, H; Tcheranova, D; Zimmermann, A | 1 |
| Galanopoulou, AS | 1 |
| Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Cowen, PJ; Green, AR; Nutt, DJ | 4 |
| Buckett, WR | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 2 |
| Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E | 1 |
| Chattha, AS; Fromm, GH; Glass, JD | 1 |
| Goitein, KJ; Shohami, E | 1 |
| Prince, DA; Schwartzkroin, PA | 1 |
| Molodavkin, GM; Ostrovskaia, RU | 2 |
| Zetler, G | 1 |
| Csiszar, E; Wasterlain, CG | 1 |
| Kreutzberg, GW; Kuschinsky, W; Schrader, J; Wahl, M | 1 |
| Olsen, RW | 1 |
| Batts, CC; Cowen, PJ; Grahame-Smith, DG; Green, AR; Nutt, DJ | 1 |
| Bowdler, JM; Green, AR | 1 |
| Bichard, AR; Little, HJ | 2 |
| Hablitz, JJ; Johnston, D; Lebeda, FJ | 1 |
| Engel, J; Liljequist, S | 1 |
| Traub, RD; Wong, RK | 1 |
| Atillo, A; Kalimo, H; Olsson, Y; Siesjö, BK; Söderfeldt, B | 1 |
| Aleman, V; de Muñoz, DM | 1 |
| Brinton, RE; Gee, KW; Yamamura, HI | 1 |
| Folbergrová, J; Ingvar, M; Lindvall, O; Siesjö, BK | 1 |
| Gomes, C; Leite, JR; Pagliusi, SR; Trolin, G | 1 |
| Ashton, D | 1 |
| Breese, GR; Frye, GD; McCown, TJ | 1 |
| Maekawa, T; Okuda, Y; Takeshita, H; Yamada, K | 1 |
| Manev, H; Pericić, D | 2 |
| Breese, GR; Frye, GD; McCown, TJ; Mueller, RA | 1 |
| Mauss, EA; Wallenstein, MC | 1 |
| Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G | 1 |
| Dwyer, BE; Wasterlain, CG | 1 |
| Buu, NT; Duhaime, J; Kuchel, O | 1 |
| Paananen, A; Tacke, U; Tuomisto, J | 1 |
| Crider, AM; Hinko, CN; Seibert, K; Tschappat, KD; Wood, JD | 1 |
| Crider, AM; Hinko, CN; Seibert, K | 1 |
| Gale, K; Garant, DS | 2 |
| Evans, MC; Griffiths, T; Meldrum, BS | 1 |
| Ingvar, M; Siesjö, BK | 1 |
| Foote, F; Gale, K | 1 |
| Barris, D; Cordi, A; Roba, J; van Dorsser, W | 1 |
| Bourgeois, BF; Dodson, WE; Ferrendelli, JA | 1 |
| Kiessling, M; Kleihues, P; Xie, Y | 1 |
| Evans, MC; Meldrum, BS | 1 |
| Leniger-Follert, E | 1 |
| Colombo, R; Ossi, C; Pinelli, A; Spazzi, L; Tofanetti, O | 1 |
| Clark, CR; Dockens, RC; Norris, GN; Ravis, WR; Sansom, RT; Wells, MJ | 1 |
| Horton, RW; McWilliam, JR; Meldrum, BS; Pedley, TA | 1 |
| Berne, RM; Rubio, R; Welsh, JE; Winn, HR | 1 |
| Bazan, NG; Morelli de Liberti, SA; Rodriguez de Turco, EB | 1 |
| Crill, WE; Schwindt, PC; Tribble, GL | 1 |
| Chapman, AG; Evans, MC | 1 |
| Chodkowska, A; Kleinrok, Z; Sieklucka-Dziuba, M | 1 |
| Betin, C; Blavet, N; Clostre, F; DeFeudis, FV | 1 |
| Ingvar, M; Siesjö, BK; Westerberg, E | 1 |
| Gale, K; Iadarola, MJ | 1 |
| Costa, LG; Doctor, SV; Murphy, SD | 1 |
| Connors, BW; Gutnick, MJ; Prince, DA | 1 |
| Collins, RC | 1 |
| Molodavkin, GM | 1 |
| Ben-Ari, Y; Ghilini, G; Naquet, R; Riche, D; Tremblay, E | 1 |
| Pizzi, WJ; Unnerstall, JR | 1 |
| Ingvar, M; Nilsson, B; Siesjö, BK | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Enna, SJ; Fox, DA; Kendall, DA | 1 |
| Hossmann, KA; Kiessling, M; Kleihues, P | 1 |
| Folbergrová, J; Ingvar, M; Siesjö, BK | 1 |
| Burnham, WM; Kalichman, MW; Livingston, KE | 1 |
| Bayne, LL; Simon, RP | 1 |
| Suga, S; Wasterlain, CG | 1 |
| Javid, MJ; Stone, WE | 1 |
| Babb, TL; Brown, WJ; Crandall, PH; Mitchell, AG | 1 |
| Grahame-Smith, DG; Green, AR; Nutt, DJ | 1 |
| Bowdler, JM; Green, AR; Rawle, F | 1 |
| Bourn, WM; Reigel, CE | 1 |
| Bading, H; Gass, P; Kiessling, M | 1 |
| Davis, W; Penix, LP; Subramaniam, S | 1 |
| Albrecht, RF; Baughman, VL; Cwik, M; Hoffman, WE; Lassen, NA; Paulson, OB; Pelligrino, DA; Theard, MA; Wang, Q | 1 |
| Baldwin, RA; Pereira de Vasconcelos, A; Wasterlain, CG | 1 |
| Albrecht, RF; Baughman, VL; Pelligrino, DA; Theard, MA; Wang, Q | 1 |
| Bailleux, V; Hamoir, G; Nuyts, JP; Poupaert, JH; Stables, JP; Vallée, L; Vamecq, J | 1 |
| Kubota, K; Mikami, A; Oishi, T | 1 |
| de Feo, MR; Mecarelli, O; Ricci, GF | 1 |
| de Feo, MR; Del Priore, D; Mecarelli, O | 1 |
| Barron, TF; Cataltepe, O; Heitjan, DF; Towfighi, J; Vannucci, RC | 1 |
| Dean, P; Redgrave, P; Shehab, S; Simkins, M | 2 |
| Devaud, LL; Morrow, AL; Purdy, RH | 1 |
| Dunham, L; Guillet, R | 1 |
| McCormick, DA; Ramoa, AS; Trent, F | 1 |
| Lemaire, S; Shukla, VK | 1 |
| Ahmad, I; Pleuvry, BJ | 1 |
| Greenberg, DA; Lowry, T; Sasahira, M; Simon, RP | 1 |
| Obara, N | 1 |
| DeJoseph, MR; Hawkins, PA; Hawkins, RA; Mans, AM; Viña, JR | 1 |
| Evans, MS; Faingold, CL; Li, Y | 1 |
| Shimosaka, S; Simon, RP; So, YT | 1 |
| Amabeoku, G; Chikuni, O | 1 |
| Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B | 1 |
| Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q | 1 |
| Ahmad, I; Lauretti, GR; Pleuvry, BJ | 1 |
| Franklin, PH; Murray, TF; Zhang, G | 2 |
| Getova, DP; Maslarova, JE; Nikolov, RK; Semkova, IS | 1 |
| Fonia, O; Gavish, M; Katz, Y; Liu, L; Pasternak, GW; Pick, CG; Weizman, A | 1 |
| Dubur, GIa; Germane, OK; Karpova, MN; Klusha, VE; Pankov, OIu | 1 |
| Folbergrová, J; Gidö, G; Katsura, K; Siesjö, BK | 1 |
| Camurcu, S; Kaya, M; Oztaş, B | 2 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Blisard, KS; Fagin, K; Falivena, P; Harrington, DA; Olejniczak, P; Privitera, MD; Scremin, OU; Taylor, KL | 1 |
| Greene, GM; Heistad, DD; Loftus, CM; Muhonen, MG | 1 |
| Brown, J; Butterworth, AR; Little, HJ; Rabbani, M | 1 |
| Finch, DM; Handforth, A; Peters, R; Tan, AM; Treiman, DM | 1 |
| Garant, DS; Moshé, SL; Sperber, EF; Xu, SG | 1 |
| Fiakpui, CY; Knaus, EE | 1 |
| Stringer, JL | 1 |
| Amabeoku, GJ; Chikuni, O | 2 |
| Bele, S; Bravo, R; Gass, P; Herdegen, T; Kiessling, M; Zimmermann, M | 1 |
| Franklin, PH; Murray, TF; Roth, JE | 1 |
| Gale, K; Japikse, K; Maggio, R; Pazos, A; Pritchard, P | 1 |
| Inagaki, M; Tamura, M | 1 |
| Gale, K; Grayson, DR; Lanaud, P; Maggio, R | 1 |
| Guiol, C; Ledoussal, C; Surgé, JM | 1 |
| Costa, E; Mocchetti, I; Sun, FY | 1 |
| Herbst, C; Shams, H; Simmet, T; Tippler, B | 1 |
| Belluardo, N; Condorelli, DF; Dell'Albani, P; Funakoshi, H; Jiang, XH; Metsis, M; Mudò, G; Salin, T; Timmusk, T | 1 |
| Chiba, S; Kamata, S; Matsumoto, M; Miyagishi, T; Mutoh, F; Nunomura, A; Wada, JA | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Mariot, R; Zanotti, A | 1 |
| Chen, SS; Chen, SW; Chiang, CS; Lai, SL; Yang, RC; Yang, SL | 1 |
| Bartsch, R; Engel, J; Hönack, D; Kutscher, B; Löscher, W; Polymeropoulos, EE; Rostock, A; Rundfeldt, C; Tober, C; White, HS; Wolf, HH | 1 |
| Barrett, JA; Dixon, KD; Gietzen, DW; Jones, AC; Truong, BG; Washburn, DS | 1 |
| Gale, K; Pasini, A; Tortorella, A | 2 |
| Cataltepe, O; Towfighi, J; Vannucci, RC | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T | 1 |
| Moshé, SL; Nunes, ML; Velísek, L; Velísková, J | 1 |
| Czuczwar, SJ; Dzieciuch, J; Kleinrok, Z; Klonowski, P; Tutka, P | 1 |
| Federico, P; MacVicar, BA | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A | 2 |
| Miyakawa, T; Niki, H; Tateishi, K; Yagi, T | 1 |
| Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T | 1 |
| Afshar, JK; Fornai, F; Gale, K; Proctor, MR | 1 |
| Fueta, Y; Janjua, NA; Mita, T; Murai, Y; Ohmori, O; Ohno, K; Ono, T | 1 |
| Ben-Ari, Y; Esclapez, M; Khalilov, I; Khazipov, R | 1 |
| Bujas, M; Pericić, D | 1 |
| Iwata, N; Kaneko, T; Tanabe, M; Tonohiro, T | 1 |
| Almond, HR; Carmosin, RJ; Carson, JR; Pitis, PM; Stables, JP; Swinyard, EA; Vaught, JL; White, HS; Wolf, HH | 1 |
| Bujas, M; Jazvinsćak, M; Pericić, D | 1 |
| Asanuma, A; Iga, T; Kawakami, J; Sawada, Y; Yamamoto, K; Yanagisawa, K | 1 |
| Józwiak, L; Kleinrok, Z; Sieklucka-Dziuba, M; Tokarski, R | 1 |
| Chunngam, T; Patarapanich, C; Sooksawate, T; Tantisira, B; Tantisira, MH | 1 |
| Margineanu, DG; Wülfert, E | 1 |
| Fukuda, M; Kida, K; Morimoto, T; Nagao, H | 1 |
| Bonsignori, A; Colombo, M; Dostert, P; Fariello, RG; Heidempergher, F; McArthur, RA; Pevarello, P; Pinciroli, V; Post, C; Salvati, P; Varasi, M | 1 |
| Cortey, A; Daval, JL; Doriat, JF | 1 |
| Köhling, R; Lücke, A; Mayer, T; Musshoff, U; Osterfeld, M; Schütte, W; Speckmann, EJ; Wolf, P | 1 |
| Abolhassan, A; Mohammad, S; Pourgholami, MH | 1 |
| Daval, JL; Doriat, JF; Humbert, AC; Koziel, V | 2 |
| Devaud, LL; Fritschy, JM; Morrow, AL | 1 |
| Golovko, AI; Ivanov, MB; Shilov, VV; Sofronov, GA; Sviderskiĭ, OA | 1 |
| Kaya, M; Oztaş, B | 2 |
| Cassidy, RM; Gale, K | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Armand, V; Heinemann, U; Rundfeldt, C | 1 |
| Greene, JR; McMath, H; Mellanby, J; Mudher, AK; Perry, VH | 1 |
| Amabeoku, GJ | 1 |
| Fukuda, T; Minami, E; Nomoto, M; Nunoura, Y; Shibata, H | 1 |
| Easton, A; Gale, K; Walker, BR | 1 |
| Fujisaki, K; Fujiwara, M; Kataoka, Y; Miura, I; Nakao, T; Oishi, R; Shuto, H; Sueyasu, M; Watanabe, Y | 1 |
| Borck, C; Jefferys, JG | 1 |
| Bujas, M; Jazvinsćak, M; Mirković, K; Pericić, D | 1 |
| Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M | 1 |
| Aizenman, E; Gardner, G; Jensen, FE; Orlando, L; Rosenberg, PA; Sanchez, RM; Tauck, DL; Wang, C | 1 |
| Amzica, F; Neckelmann, D; Steriade, M | 1 |
| Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Chae, WG; Choi, H; Choi, J; Jahng, Y; Je, SM; Kim, EK; Kim, TH; Kim, YC; Lee, ES; Park, M; Zhao, LX | 1 |
| Gause, L; Kampov-Polevoy, AB; Matthews, DB; Morrow, AL; Overstreet, DH | 1 |
| Misawa, M; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Takahashi-Nakano, Y; Tseng, LF; Yajima, Y | 1 |
| Schindler, CJ; Slamberová, R; Vathy, I; Velísková, J | 1 |
| Stringer, JL; Xiong, ZQ | 2 |
| Dohi, T; Irifune, M; Kamata, Y; Kawahara, M; Nishikawa, T; Sato, T | 1 |
| Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y | 1 |
| Jimbo, Y; Robinson, HP | 1 |
| Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT | 1 |
| Dybdal, D; Gale, K | 1 |
| Kanie, S; Kodama, K; Komatsu, K; Miyamoto, KI; Nagasaka, Y; Namiki, M; Niikura, S; Yokoyama, O; Yotsuyanagi, S | 1 |
| Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M | 1 |
| Chino, M; Kubová, H; Mares, P; Mathern, P; Veliký, M | 1 |
| Bazan, NG; Folbergrová, J; Katsura, K; Kristián, T; Rodriguez de Turco, EB; Siesjö, BK | 1 |
| Ebert, U; Löscher, W; Wlaź, P | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M | 1 |
| Grieb, P; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z | 1 |
| Devaud, LL; Matthews, DB; Morrow, AL; Overstreet, DH; Rezvani, AH | 1 |
| Potier, S; Psarropoulou, C | 1 |
| Golovenko, NY; Zhuk, OV; Zinkovsky, VG | 1 |
| Pape, HC; Seidenbecher, T | 1 |
| Ariano, MA; Bunzow, JR; Cepeda, C; Falzone, TL; Flores-Hernandez, J; Grandy, DK; Hurst, RS; Kozell, LB; Levine, MS; Low, MJ; Meshul, CK; Rubinstein, M | 1 |
| Anderson, KJ; Carney, PR; Chaves, AH; Garcia, J; Grimes, JR; Lee, N; MacLennan, AJ; Roper, SN; Zhu, WJ | 1 |
| Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K | 1 |
| Burnashev, N; Bushell, TJ; Clarke, VR; Collett, VJ; Collingridge, GL; Duvoisin, RM; Flor, PJ; Gasparini, F; Hampson, DR; Klebs, K; Knoepfel, T; Kuhn, R; Portet, C; Rozov, A; Sansig, G; Schmutz, M; Schroeder, M; Shigemoto, R; van Der Putten, H; Zhang, C | 1 |
| Chadda, R; Devaud, LL | 1 |
| Little, HJ; Watson, WP | 1 |
| Barton, ME; Bennett, GD; Bialer, M; Finnell, RH; Isoherranen, N; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B | 1 |
| Ito, M; Katoh, M; Kishikawa, M; Kitajima, S; Seto-Ohshima, A | 1 |
| Bada, HS; Daley, ML; Korones, SB; Leffler, CW; Parfenova, H; Pourcyrous, M | 1 |
| Amabeoku, GJ; Bienvenu, E; Eagles, PK; Scott, G; Springfield, EP | 1 |
| Bazhenov, M; Sejnowski, T; Steriade, M; Timofeev, I | 1 |
| Chapman, AG; Meldrum, BS; Siesjö, BK | 1 |
| Astrup, J; Heuser, D; Lassen, NA; Nilsson, B; Norberg, K; Siesjö, BK | 1 |
| Heuser, D | 1 |
| Lloyd, KG; Worms, P | 1 |
| Kuschinsky, W; Wahl, M | 1 |
| Bloom, SR; Butler, J; Horton, RW; Keenan, J; Meldrum, BS | 1 |
| Meldrum, BS | 1 |
| Caston, TV; Collins, RC | 1 |
| Matthews, WD; McCafferty, GP | 1 |
| Nordström, CH; Rehncrona, S; Siesjö, BK; Westerberg, E | 1 |
| Blennow, G; Folbergrová, J; Nilsson, B; Siesjö, BK | 2 |
| Calderini, G; Carlsson, A; Nordström, CH | 1 |
| Stone, WE | 1 |
| Rose, D | 1 |
| Ciesielski, L; Kempf, E; Mack, G; Maitre, M; Mandel, P; Simler, S | 1 |
| Maxson, SC; Sze, PY; Towle, AC | 1 |
| Creutzfeldt, OD; Eckart, W; Tsumoto, T | 1 |
| Conn, M; Fando, JL; Wasterlain, CG | 1 |
| Drucker-Colín, RR; Durán, L; Levi, G; Meza-Ruíz, G; Tapia, R | 1 |
| Heistad, DD; Marcus, ML; Mueller, SM | 1 |
| Astrup, J; Blennow, G; Nilsson, B | 1 |
| Folbergrova, J; Nilsson, B; Nordström, CH; Siesjö, BK | 1 |
| Bigler, ED | 1 |
| Gartside, IB; Hayes, AG; Straughan, DW | 1 |
| Lippa, AS; Regan, B | 1 |
| Johansson, BB; Lund, S | 1 |
| Bianchi, M; Galzigna, L; Garbin, L; Marzotto, A | 1 |
| Blennow, G; Brierley, JB; Meldrum, BS; Siesjö, BK | 1 |
| Frey, HH; Löscher, W | 1 |
| Gardner, CR; Webster, RA | 1 |
| Alpern, HP; Greer, CA | 1 |
| Blennow, G; Nilsson, B; Siesjö, BK | 2 |
| Brand, SJ; Curtis, DR; Johnston, GA; Lodge, D | 1 |
| Borgström, L; Chapman, AG; Siesjö, BK | 1 |
| Wasterlain, CG | 1 |
| Mulas, A; Pedata, F; Pepeu, G; Pepeu, IM | 1 |
| Meldrum, BS; Nilsson, B | 1 |
| Ban, M; Miller, T; Olsen, RW | 1 |
| Burchfiel, JL; Conway, JL; Duffy, FH | 1 |
| Curtis, DR; Game, CJ; Lodge, D | 1 |
| Corbett, R; Dunn, RW | 1 |
| Auta, J; Costa, E; Guidotti, A; Kozikowski, AP; Ma, D; Papadopoulos, V; Puia, G; Romeo, E | 1 |
| Golovko, AI; Sofronov, GA | 1 |
| Bauknight, GC; Kontos, HA; Wei, EP | 1 |
| Brown, LL; Moshé, SL; Sperber, EF; Tempel, A | 1 |
| Gale, K; Mocchetti, I; Riva, MA | 1 |
| Garcia-Cairasco, N; Terra, VC | 1 |
| Garcia-Cairasco, N; Oliveira, JA; Terra, VC; Tsutsui, J | 1 |
| Godlevskiĭ, LS; Oleĭnik, AA; Shandra, AA; Vikhrestiuk, SL | 1 |
| Daval, JL; el Hamdi, G; Nehlig, A; Pereira de Vasconcelos, A; Werck, MC | 1 |
| Dasheiff, RM; Sacks, DS | 2 |
| Aquila, WJ; During, MJ; Ley, E; Tendler, D; Young, RS | 1 |
| Churchill, L; Cross, RS; Heimer, L; Kalivas, PW; Nelson, SR; Pazdernik, TL; Zahm, DS | 1 |
| Mizuki, Y; Sekimoto, M; Ushijima, I; Yamada, M | 1 |
| Habibuddin, M; Pal, M; Pal, SP | 1 |
| Dudek, FE; Meier, CL; Obenaus, A | 1 |
| Cavalheiro, EA; de Feo, MR; Mecarelli, O; Ricci, G | 1 |
| Rosenberg, HC; Weng, X | 1 |
| Dean, P; overton, P; Redgrave, P; Simkins, M | 1 |
| Bravo, R; Gass, P; Herdegen, T; Kiessling, M | 1 |
| Block, F; Heim, C; Sieklucka, M; Sontag, KH | 1 |
| Bada, HS; Busija, DW; Korones, SB; Leffler, CW; Pourcyrous, M; Stidham, GL | 1 |
| Dolin, SJ; Morris, PJ; Smith, MB; Soar, J | 1 |
| Moshé, SL; Sperber, EF; Xu, SG | 1 |
| Gallager, DW; Heninger, C; Hernandez, TD; Marley, RJ | 1 |
| Gale, K; Maggio, R; Sohn, E | 1 |
| Aley, KO; Kulkarni, SK | 1 |
| Bitran, D; Kellogg, CK; Primus, RJ | 1 |
| Diamantis, W; Gels, M; Gordon, R; Sofia, RD | 1 |
| Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V | 1 |
| Lothman, EW; Stringer, JL | 1 |
| Liljequist, S | 1 |
| Dickinson, SL; Jackson, HC; Nutt, DJ; Ripley, TL | 1 |
| Lok, SY; Meldrum, BS; Millan, MH; Obrenovitch, TP; Sarna, GS; Symon, L | 1 |
| Faktorová, M; Kubová, H; Mares, P | 1 |
| Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Siarey, RJ; Whittington, MA | 1 |
| Jope, RS; Ormandy, GC; Song, L | 1 |
| Block, F; Bortolotto, Z; Heim, C; Sieklucka, M; Sontag, KH | 1 |
| Petersen, EN | 1 |
| Evinger, C; Jones, KJ | 1 |
| Daval, J; Werck, M | 1 |
| Bardgett, ME; Gray, BC; Miller, JW | 1 |
| Avoli, M; Brancati, A; Hwa, GG; Tancredi, V; Zona, C | 1 |
| Bastide, J; Bastide, P; Coudert, P; Couquelet, JM; Rubat, C; Tronche, P | 1 |
| Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Diedrichs, S; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA | 1 |
| Mutoh, F | 1 |
| Simmet, T; Tippler, B | 1 |
| Baram, TZ; Snead, OC | 1 |
| Mares, P; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Bohuslav, T; Kubová, H; Mares, P | 1 |
| Crabbe, JC; Diggs, HE; Farrell, E; Feller, DJ; Merrill, C | 1 |
| Jones, RS; Lambert, JD | 1 |
| Dziki, M; Ikonomidou, C; Parada-Turska, J; Turski, WA; Urbanska, E | 1 |
| Pericić, D; Tvrdeić, A | 1 |
| Gale, K; Graham, J; Wardas, J | 1 |
| Gennings, C; Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Campbell, JA; Greenwood, TD; Rathman, TL; Sleevi, MC; Wolfe, JF | 1 |
| Ferrendelli, JA; Miller, JW | 1 |
| Bingmann, D; Speckmann, EJ; Straub, H; Walden, J | 1 |
| Gallager, DW; Hernandez, TD; Rosen, JB | 1 |
| Depaulis, A; Liu, Z; Marescaux, C; Micheletti, G; Vergnes, M; Warter, JM | 1 |
| Gale, K; Garant, DS; Iadarola, MJ | 1 |
| Smith, GK; Suzuki, SS | 1 |
| Alpern, HP; McIntyre, TD | 2 |
| Dudek, BC; Kim, D; Phillips, TJ | 1 |
| Dudek, BC; Phillips, TJ | 1 |
| Gallager, DW; Heninger, C; Hernandez, TD; Wilson, MA | 1 |
| Dean, P; Gale, K | 1 |
| Moshé, SL; Sperber, EF; Wurpel, JN; Zhao, DY | 1 |
| Folbergrová, J; Mares, P | 1 |
| Peris, J; Wehner, JM; Zahniser, NR | 1 |
| Pierson, MG; Smith, KL; Swann, JW | 1 |
| Baldino, F; Gutnick, MJ; Wolfson, B | 1 |
| Gale, K; Maggio, R | 1 |
| Franklin, PH; Murray, TF; Tripp, ED; Zhang, G | 1 |
| Hascoet, JM; Monin, P; Vert, P | 1 |
| Bagri, A; Brandão, ML; Carrive, P; Tomaz, C | 1 |
| Dasheiff, RM | 1 |
| Clifford, DB; Olney, JW; Zorumski, CF | 1 |
| Nagaya, H; Negishi, N; Okada, R | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| Bhadra, S; Idemudia, SO; Lal, H | 1 |
| Georgieva, J | 1 |
| Lister, RG; Nutt, DJ | 2 |
| Arienti, G; Corazzi, L; Piccinin, GL; Ramacci, MT | 1 |
| Murray, TF; Sanders, RC | 1 |
| Halsey, MJ; Little, HJ; Wardley-Smith, B | 2 |
| Hodin, RA; Kreisman, NR; Rosenthal, M; Sick, TJ | 1 |
| Daval, JL; Sarfati, A | 1 |
| Miñano, FJ; Sancibrián, M; Serrano, JS; Serrano, MI | 1 |
| Gale, RG; Little, HJ; Nutt, DJ; Standing, BL; Taylor, SC | 1 |
| Mehta, AK; Ticku, MK | 2 |
| Chapman, AG | 1 |
| Gale, K; Piredda, S | 2 |
| Kent, AP; Webster, RA | 1 |
| Faraci, FM; Heistad, DD; Motley, MG | 1 |
| Anderson, MC; Chung, EY; Van Woert, MH | 1 |
| Clarke, RJ; de Azeredo, FA; Guedes, RC; Hicks, TP; Tashiro, T | 1 |
| Fletcher, A; Forster, EA | 1 |
| Hara, T; Kawazawa, S; Mizuki, Y; Ushijima, I; Yamada, M | 1 |
| Busija, DW; Leffler, CW | 1 |
| Dowell, RT; Eldridge, FL; Paydarfar, D; Scott, SC | 1 |
| Kano, M; Kontos, HA; Moskowitz, MA; Ogilvy, CS; Sakas, DE; Wei, EP | 1 |
| Armstead, WM; Busija, DW; Leffler, CW; Mirro, R | 1 |
| Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Ikonomidou, C; Klockgether, T; Turski, L; Turski, WA | 1 |
| Bagri, A; Di Scala, G; Sandner, G | 1 |
| Rastogi, SK; Ticku, MK | 2 |
| Beutler, JA; Brubaker, AN; Curtis, DR; Enna, SJ; Karbon, EW; Malik, R | 1 |
| Gale, K | 1 |
| Battaini, F; Caimi, BR; Govoni, S; Ossi, C; Pinelli, A; Trivulzio, S | 1 |
| Koryntová, H; Marĕs, J; Marĕs, P; Rokyta, R; Zouhar, A | 1 |
| Anderson, SA; Gallager, DW; Gonsalves, SF; Malcolm, AB | 1 |
| Beitz, AJ; Larson, AA | 1 |
| Lee, RJ; Lomax, P; McCabe, RT; Olsen, RW; Wamsley, JK | 1 |
| Folbergrová, J | 1 |
| Krivánek, J | 1 |
| Breese, GR; Frye, GD; McCown, TJ; Peterson, SL | 1 |
| Little, H; Nutt, DJ | 1 |
| Little, HJ; Nutt, DJ; Taylor, SC | 1 |
| Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A | 1 |
| Saano, V | 1 |
| Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B | 1 |
| Busto, R; Ginsberg, MD; Ikeda, M; Martinez, E; Santiso, M; Yoshida, S | 1 |
| Dwyer, BE; Fujikawa, DG; Wasterlain, CG | 1 |
| Anić-Stojiljković, S; Manev, H; Pericić, D | 1 |
| Gallager, DW; Gonsalves, SF | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Naquet, R; Pinard, E; Riche, D; Rigaud, AS; Seylaz, J | 1 |
| Dwyer, BE; Fujikawa, DG; Vannucci, RC; Wasterlain, CG | 1 |
| Brioni, JD; McGaugh, JL | 1 |
| de Feo, MR; Mecarelli, O; Ricci, GF; Rina, MF | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Agopyan, N; Avoli, M | 1 |
| Arienti, G; Corazzi, L; Marku, N; Piccinin, GL | 3 |
| Bryan, RM; Dundore, RL; Keil, LC; Severs, WB; Wurpel, JN | 1 |
| Crider, AM; Hinko, CN; Wood, JD | 1 |
| Briggs, RW; Cowan, BE; Dunham, SL; Novotny, E; Petroff, OA; Young, RS | 1 |
| Georgiev, V; Getova, D | 1 |
| Moshé, SL; Sperber, EF; Wong, BY; Wurpel, JN | 1 |
| Gale, K; Pavlick, M; Piredda, S | 1 |
| Hossmann, KA; Paschen, W; van den Kerchhoff, W | 1 |
| Faingold, CL; Meldrum, BS; Millan, MH | 1 |
| Ferrendelli, JA; Mirski, MA | 1 |
| Brizzee, BL; Busto, R; Ginsberg, MD; Hodin, RA; Kreisman, NR; Rosenthal, M; Sick, TJ | 1 |
| Evans, D; Smith, JC | 1 |
| Dworsky, S; McCandless, DW | 1 |
| Freund, RK; Marley, RJ; Wehner, JM | 1 |
| Berne, RM; Park, TS; Rubio, R; Van Wylen, DG | 1 |
| Gale, K; Garant, D | 1 |
| Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV | 1 |
| Caspary, DM; Faingold, CL; Gehlbach, G; Travis, MA | 1 |
| Goping, G; Klatzo, I; Nitsch, C | 1 |
| Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV; Okazaki, MM | 1 |
| Caspary, DM; Faingold, CL; Hoffmann, WE | 1 |
| Piredda, SG; Swinyard, EA; Woodhead, JH | 1 |
| Little, HJ; Wardley-Smith, B | 1 |
| Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Mello, LE; Turski, L; Turski, WA | 1 |
| Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J | 1 |
| Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM | 1 |
| Calderazzo-Filho, LS; Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, WA | 1 |
| Gale, K; Lim, CR; Piredda, S | 1 |
| Clozel, M; Daval, JL; Dubruc, C; Monin, P; Morselli, PL; Vert, P | 1 |
| Kupferberg, HJ; Swinyard, EA | 1 |
| Mori, K; Oshima, E; Shingu, K; Urabe, N | 1 |
| Alpern, HP; Drugan, RC; Maier, SF; McIntyre, TD | 1 |
4 review(s) available for bicuculline and Seizures
| Article | Year |
|---|---|
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Picrotoxin; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Synaptic Membranes | 1981 |
Epilepsy and gamma-aminobutyric acid-mediated inhibition.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Bicuculline; Brain; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Infant; Mice; Neural Inhibition; Receptors, Drug; Seizures; Structure-Activity Relationship; Synaptic Transmission | 1975 |
Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.
Topics: Animals; Bicuculline; Cell Compartmentation; Epilepsy; gamma-Aminobutyric Acid; Microinjections; Morphine; Muscimol; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Seizures; Substantia Nigra | 1985 |
Mechanisms of sensory seizures: brain-stem neuronal response changes and convulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Bicuculline; Convulsants; Neurons; Reticular Formation; Seizures; Strychnine | 1985 |
554 other study(ies) available for bicuculline and Seizures
| Article | Year |
|---|---|
The bee venom active compound melittin protects against bicuculline-induced seizures and hippocampal astrocyte activation in rats.
Topics: Animals; Anticonvulsants; Astrocytes; Bee Venoms; Behavior, Animal; Bicuculline; Hippocampus; Male; Melitten; Rats; Rats, Wistar; Seizures | 2022 |
Sakuranetin exerts anticonvulsant effect in bicuculline-induced seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Biological Products; Flavonoids; Male; Mice; Seizures | 2022 |
Noradrenaline and Seizures: A Perspective on the Role of Adrenergic Receptors in Limbic Seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Humans; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Seizures | 2023 |
Chemogenetic attenuation of cortical seizures in nonhuman primates.
Topics: Animals; Bicuculline; Body Fluids; Brain; GABA-A Receptor Antagonists; Macaca; Male; Seizures | 2023 |
Cannabinoid receptors involved in descending inhibition on spinal seizure-like activity in the phrenic output.
Topics: Animals; Animals, Newborn; Bicuculline; Phrenic Nerve; Rats; Receptors, Cannabinoid; Receptors, Glycine; Seizures; Spinal Cord; Strychnine | 2023 |
A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.
Topics: Animals; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Neurotoxins; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ribonuclease III; Seizures; Signal Transduction; Specific Pathogen-Free Organisms; Subcellular Fractions; Transcriptome; Up-Regulation | 2020 |
Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice.
Topics: Animals; Bicuculline; Cerebral Cortex; Convulsants; Hippocampus; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Progranulins; Receptors, N-Methyl-D-Aspartate; Seizures | 2020 |
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Arginine; Behavior, Animal; Benzodiazepines; Bicuculline; Female; Flumazenil; GABA-A Receptor Antagonists; Humans; Maze Learning; Mice; Nitric Oxide; Polycyclic Sesquiterpenes; Receptors, GABA-A; Seizures; Signal Transduction | 2021 |
Acute Striato-Cortical Synchronization Induces Focal Motor Seizures in Primates.
Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Synchronization; Female; GABA-A Receptor Antagonists; Macaca fascicularis; Male; Neural Pathways; Putamen; Rats, Sprague-Dawley; Seizures | 2020 |
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures.
Topics: Animals; Anisoles; Bicuculline; Convulsants; Gene Expression; Genetic Predisposition to Disease; Habenula; Hippocampus; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Pentylenetetrazole; Propylamines; Receptors, GABA-A; Receptors, GABA-B; Receptors, sigma; Seizures; Sigma-1 Receptor | 2021 |
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Mice; Muscarinic Agonists; Pentylenetetrazole; Phenols; Pilocarpine; Propofol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus | 2021 |
Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors.
Topics: Animals; Bicuculline; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Mecamylamine; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Nicotinic; Seizures; Synaptic Transmission | 2021 |
Spreading depression as an innate antiseizure mechanism.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Stem; Cortical Spreading Depression; Depression; Female; Gene Knock-In Techniques; Kainic Acid; Male; Mice; Nervous System; Optogenetics; Penicillins; Potassium Channel Blockers; Seizures; Tetrodotoxin | 2021 |
Mapping region-specific seizure-like patterns in the in vitro isolated guinea pig brain.
Topics: Animals; Bicuculline; Brain; Brain Mapping; Electroencephalography; Female; Guinea Pigs; Organ Culture Techniques; Seizures | 2021 |
Optogenetic activation of the reticular nucleus of the thalamus attenuates limbic seizures via inhibition of the midline thalamus.
Topics: Bicuculline; Epilepsy, Absence; Humans; Optogenetics; Seizures; Thalamus | 2021 |
The activity of selective sigma-1 receptor ligands in seizure models in vivo.
Topics: Acetamides; Analysis of Variance; Animals; Anisoles; Anticonvulsants; Bicuculline; Convulsants; Male; Mice; Morpholines; Pentylenetetrazole; Propylamines; Pyrrolidinones; Receptors, sigma; Seizures; Sigma-1 Receptor; Survival Analysis | 2017 |
Preventing harmful effects of epileptic seizures on cerebrovascular functions in newborn pigs: does sex matter?
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Bicuculline; Boranes; Carbonates; Cerebral Arteries; Cerebrovascular Disorders; Disease Models, Animal; Endothelial Cells; Female; Humans; Male; Pia Mater; Seizures; Sex Factors; Sus scrofa; Time Factors; Vasodilation; Vasodilator Agents | 2017 |
Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anthracenes; Bicuculline; Electrophysiology; Flavin-Adenine Dinucleotide; Male; Oxygen Consumption; Rats; Rats, Wistar; Seizures | 2017 |
Chemically activated luminopsins allow optogenetic inhibition of distributed nodes in an epileptic network for non-invasive and multi-site suppression of seizure activity.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Dentate Gyrus; Epilepsy; Imidazoles; Luminescent Agents; Male; Neural Inhibition; Neural Pathways; Opsins; Optogenetics; Pyrazines; Rats, Sprague-Dawley; Seizures | 2018 |
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pentylenetetrazole; Pilocarpine; Plant Extracts; Plant Leaves; Plants, Medicinal; Random Allocation; Seizures; Senna Plant | 2018 |
Ontogenetic development of sensitivity of the cerebral cortex to an antagonist of GABA(A) receptor bicuculline.
Topics: Age Factors; Animals; Bicuculline; Electroencephalography; GABA-A Receptor Antagonists; Male; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Somatosensory Cortex | 2018 |
Phasor analysis of NADH FLIM identifies pharmacological disruptions to mitochondrial metabolic processes in the rodent cerebral cortex.
Topics: Animals; Bicuculline; Biomarkers; Cerebral Cortex; Disease Models, Animal; Humans; Intravital Microscopy; Microscopy, Fluorescence, Multiphoton; Mitochondria; Models, Biological; NAD; Nonlinear Dynamics; Rats, Sprague-Dawley; Rodentia; Seizures | 2018 |
Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hippocampus; Kindling, Neurologic; Male; Mice; Microinjections; Neural Inhibition; Neurosteroids; Pregnanolone; Pyridazines; Receptors, GABA-A; Seizures; Zinc | 2019 |
Lunasin-induced behavioural effects in mice: focus on the dopaminergic system.
Topics: Amphetamine; Animals; Apomorphine; Bicuculline; Brain; Catalepsy; Central Nervous System Agents; Cyclic AMP; Dopamine Agents; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; HEK293 Cells; Humans; Ketamine; Male; Mice, Inbred C57BL; Motor Activity; Receptors, Dopamine D1; Receptors, Dopamine D2; Seizures; Soybean Proteins | 2013 |
Genesis of interictal spikes in the CA1: a computational investigation.
Topics: Action Potentials; Animals; Bicuculline; CA1 Region, Hippocampal; Computer Simulation; Male; Models, Neurological; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2014 |
Region-specific DNA alterations in focally induced seizures.
Topics: Animals; Bicuculline; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Electroencephalography; Male; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Seizures | 2014 |
The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
Topics: 4-Aminopyridine; Animals; Astrocytes; Bicuculline; Cell Survival; Cells, Cultured; Disease Models, Animal; GABA-A Receptor Antagonists; Gene Expression Regulation; Hippocampus; Jumonji Domain-Containing Histone Demethylases; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Neurons; Pilocarpine; Potassium Channel Blockers; RNA Interference; Seizures | 2014 |
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Classical Lissencephalies and Subcortical Band Heterotopias; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electroencephalography; Electrophysiological Phenomena; Epilepsy; Gene Knockdown Techniques; Microtubule-Associated Proteins; Neocortex; Nerve Net; Neuropeptides; Pentylenetetrazole; Rats; Rats, Transgenic; Seizures; Somatosensory Cortex | 2014 |
In vivo imaging of epileptic foci in rats using a miniature probe integrating diffuse optical tomography and electroencephalographic source localization.
Topics: Animals; Bicuculline; Brain; Brain Mapping; Convulsants; Electroencephalography; Epilepsies, Partial; Image Processing, Computer-Assisted; Rats; Rats, Sprague-Dawley; Seizures; Tomography, Optical | 2015 |
Treatment with direct-current stimulation against cingulate seizure-like activity induced by 4-aminopyridine and bicuculline in an in vitro mouse model.
Topics: 4-Aminopyridine; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Seizures; Treatment Outcome | 2015 |
Synchronous inhibitory potentials precede seizure-like events in acute models of focal limbic seizures.
Topics: 4-Aminopyridine; Action Potentials; Animals; Bicuculline; Computer Simulation; Convulsants; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; In Vitro Techniques; Models, Biological; Neural Inhibition; Potassium Channel Blockers; Quinoxalines; Seizures | 2015 |
Increase in the extracellular glutamate level during seizures and electrical stimulation determined using a high temporal resolution technique.
Topics: 4-Aminopyridine; Animals; Bicuculline; Calibration; Catheters, Indwelling; Convulsants; Dialysis; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Equipment Design; Extracellular Space; Fluorescence; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Lasers; Male; Rats, Wistar; Seizures | 2015 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Quinazolinones; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2015 |
Reduced expression of IA channels is associated with post-ischemic seizures.
Topics: Animals; Bicuculline; Blotting, Western; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; Disease Susceptibility; Gene Expression; Immunohistochemistry; Kv Channel-Interacting Proteins; Male; Neurons; Rats, Wistar; Seizures; Severity of Illness Index; Shal Potassium Channels | 2016 |
Selective head cooling during neonatal seizures prevents postictal cerebral vascular dysfunction without reducing epileptiform activity.
Topics: Animals; Animals, Newborn; Arterioles; Bicuculline; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular Disorders; Convulsants; Electroencephalography; Endothelial Cells; Female; Head; Hypothermia, Induced; In Situ Nick-End Labeling; Male; Seizures; Swine; Vasodilation | 2016 |
Anticonvulsant Effects of Fractions Isolated from Dinoponera quadriceps (Kempt) Ant Venom (Formicidae: Ponerinae).
Topics: Animals; Ant Venoms; Anticonvulsants; Ants; Bicuculline; Disease Models, Animal; Male; Mice; Seizures | 2016 |
High-frequency oscillations and seizure-like discharges in the entorhinal cortex of the in vitro isolated guinea pig brain.
Topics: 4-Aminopyridine; Animals; Bicuculline; Convulsants; Entorhinal Cortex; Female; Guinea Pigs; In Vitro Techniques; Microelectrodes; Periodicity; Seizures | 2017 |
Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds.
Topics: Aging; Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Anxiety; Behavior, Animal; Bicuculline; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Ethanol; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Seizures; Social Behavior | 2008 |
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Bicuculline; Diazepam; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; GABA Modulators; Imidazoles; Male; Pyridines; Rats; Rats, Inbred F344; Seizures; Zolpidem | 2008 |
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Betulinic Acid; Bicuculline; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Muscle Tonus; Pentacyclic Triterpenes; Postural Balance; Receptors, GABA; Seizures; Triterpenes | 2008 |
Bicuculline-induced seizures: a challenge for optical and biochemical modeling of the cytochrome oxidase CuA NIRS signal.
Topics: Animals; Bicuculline; Copper; Electron Transport Complex IV; Male; Models, Biological; Rats; Rats, Wistar; Seizures; Spectroscopy, Near-Infrared | 2009 |
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Generalized; Lethal Dose 50; Male; Methanol; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Leaves; Polygalaceae; Seizures; Solvents; Water | 2008 |
Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Bicuculline; Biophysics; Bumetanide; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agents; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Spectrum Analysis | 2009 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Local haemodynamic changes preceding interictal spikes: a simultaneous electrocorticography (ECoG) and near-infrared spectroscopy (NIRS) analysis in rats.
Topics: Animals; Bicuculline; Brain; Brain Mapping; Cerebrovascular Circulation; Convulsants; Cortical Synchronization; Electroencephalography; Hemodynamics; Male; Rats; Rats, Sprague-Dawley; Seizures; Spectroscopy, Near-Infrared | 2010 |
Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat.
Topics: Animals; Bicuculline; Brain; Brain Mapping; Electroencephalography; Female; Magnetic Resonance Imaging; Oxygen; Rats; Rats, Wistar; Seizures; Signal Processing, Computer-Assisted; Time Factors | 2010 |
Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Electroencephalography; GABA Agents; Humans; Male; Microinjections; Muscimol; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2010 |
Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling.
Topics: Animals; Bicuculline; CA1 Region, Hippocampal; Calcineurin; Calcineurin Inhibitors; Chronic Disease; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Disease Models, Animal; Down-Regulation; Epilepsy; In Vitro Techniques; Magnesium Compounds; Male; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 2010 |
GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Bicuculline; Corticosterone; Dose-Response Relationship, Drug; Exploratory Behavior; Fear; GABA-A Receptor Antagonists; Male; Microdialysis; Motor Activity; Phosphinic Acids; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 2010 |
Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering.
Topics: Animals; Bicuculline; Disease Susceptibility; Female; Maternal Behavior; Methamphetamine; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures | 2011 |
Comparative study of taurine and tauropyrone: GABA receptor binding, mitochondrial processes and behaviour.
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; Dihydropyridines; Energy Metabolism; Ethanol; Hydrophobic and Hydrophilic Interactions; Male; Mice; Mice, Inbred ICR; Mitochondria; Motor Activity; Muscle Tonus; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Taurine | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles | 2011 |
Behavioral and EEG effects of GABAergic manipulation of the nigrotectal pathway in the Wistar audiogenic rat strain.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Bicuculline; Corpus Striatum; Electroencephalography; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Muscimol; Neural Pathways; Rats; Rats, Wistar; Seizures; Substantia Nigra; Superior Colliculi; Video Recording | 2011 |
GABA-A receptors play a minor role in cortical epileptic afterdischarges in immature rats.
Topics: Animals; Bicuculline; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Evoked Potentials; GABA Antagonists; Male; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 2011 |
Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Biological Clocks; Calcium; Corpus Callosum; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes; Gyrus Cinguli; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscimol; Neural Pathways; Seizures; Thalamus | 2011 |
Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics.
Topics: Animals; Bicuculline; Calibration; Diffusion; Imaging, Three-Dimensional; Male; Phantoms, Imaging; Rats; Rats, Sprague-Dawley; Seizures; Spectrophotometry; Tomography, Optical | 2012 |
Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage.
Topics: Animals; Astrocytes; Bicuculline; Blood-Brain Barrier; Brain; Encephalitis; Epilepsy; GABA-A Receptor Antagonists; Guinea Pigs; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Recurrence; Seizures | 2012 |
Cerebral microcirculatory responses of insulin-resistant rats are preserved to physiological and pharmacological stimuli.
Topics: Animals; Bicuculline; Cerebrovascular Circulation; Convulsants; Diabetes Mellitus, Type 2; Hypercapnia; Insulin Resistance; Male; Microcirculation; Rats; Seizures | 2012 |
Network dynamics during the progression of seizure-like events in the hippocampal-parahippocampal regions.
Topics: Algorithms; Animals; Bicuculline; Disease Progression; Electrodes, Implanted; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; GABA Antagonists; Guinea Pigs; Hippocampus; Nerve Net; Parahippocampal Gyrus; Seizures | 2014 |
Anticonvulsant action of indazole.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Indazoles; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures; Strychnine | 2013 |
Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Waves; Disease Models, Animal; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Hippocampus; Kainic Acid; Methyl-CpG-Binding Protein 2; Mice; Nerve Net; Neurons; Potassium Channel Blockers; Rett Syndrome; Seizures | 2013 |
Ketamine prevents seizures and reverses changes in muscarinic receptor induced by bicuculline in rats.
Topics: Animals; Bicuculline; Convulsants; Excitatory Amino Acid Antagonists; Ketamine; Male; Rats; Rats, Wistar; Receptors, Muscarinic; Seizures | 2013 |
Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.
Topics: Animals; Autoradiography; Bicuculline; Blotting, Western; Cerebral Cortex; Chlorides; Convulsants; Female; GABA Agonists; GABA Antagonists; Kinetics; Ligands; Male; Mice; Mice, Knockout; Muscimol; Pyridazines; Radioligand Assay; Receptors, GABA-A; Seizures | 2002 |
An anticonvulsant profile of the ketogenic diet in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Bicuculline; Convulsants; Dietary Fats; Disease Models, Animal; Electroencephalography; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Strychnine; Survival Rate; Time Factors | 2002 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Genotype; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Potassium Channel Blockers; Receptors, GABA-A; Receptors, Nicotinic; Seizures; Strychnine | 2002 |
Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Bicuculline; Carbamazepine; Ceftizoxime; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Phenobarbital; Phenytoin; Receptors, GABA; Seizures; Sodium Channel Blockers | 2002 |
Impaired M-current and neuronal excitability.
Topics: Age Factors; Animals; Bicuculline; Central Nervous System; Data Interpretation, Statistical; Electroencephalography; Epilepsy, Benign Neonatal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Humans; Indoles; Infant, Newborn; Male; Mice; Mice, Knockout; Microdialysis; Mutation; Neurons; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinoxalines; Rats; Rats, Wistar; Seizures; Synaptic Transmission | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
Cyclosporine A-increased nitric oxide production in the rat dorsal hippocampus mediates convulsions.
Topics: Animals; Bicuculline; Convulsants; Cyclosporine; Enzyme Inhibitors; Hippocampus; Immunosuppressive Agents; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Seizures | 2002 |
The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists.
Topics: Animals; Avoidance Learning; Bicuculline; Brain Chemistry; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hypoxia; Mice; N-Methylaspartate; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 2003 |
Bursting in leech heart interneurons: cell-autonomous and network-based mechanisms.
Topics: Action Potentials; Animals; Bicuculline; Cells, Cultured; Electric Conductivity; Ganglia; Heart; Interneurons; Leeches; Models, Neurological; Myocardial Contraction; Nerve Net; Patch-Clamp Techniques; Periodicity; Seizures | 2002 |
Bicuculline seizure susceptibility and nigral GABAA alpha1 receptor mRNA is altered in adult prenatally morphine-exposed females.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Susceptibility; Estradiol; Female; Hormone Replacement Therapy; Morphine; Ovariectomy; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Substantia Nigra | 2003 |
Role of the superior colliculus and the intercollicular nucleus in the brainstem seizure circuitry of the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Bicuculline; Brain Stem; Disease Models, Animal; Epilepsy; Female; Inferior Colliculi; Male; Rats; Rats, Mutant Strains; Seizures; Superior Colliculi | 2003 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Channels; Cells, Cultured; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Guanidines; Membrane Potentials; Mice; Neurons; Nickel; Piperidines; Potassium Channel Blockers; Seizures; Spermine; Spinal Cord; Succinates; Synapses; Tetraethylammonium; Tetrodotoxin; Uremia | 2003 |
Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Modulators; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; GABA Antagonists; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Limbic System; Mice; Mice, Knockout; Neurons; Neurotoxins; Polyunsaturated Alkamides; Seizures | 2003 |
Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetazolamide; Animals; Animals, Newborn; Anti-Ulcer Agents; Atropine; Bicuculline; Carbenoxolone; Carbonic Anhydrase Inhibitors; Chlorides; Drug Interactions; Electric Conductivity; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Fluorides; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Valine | 2003 |
A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus.
Topics: Animals; Benzylamines; Bicuculline; Biogenic Monoamines; Cerebellum; Dopamine beta-Hydroxylase; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Extracellular Space; Frontal Lobe; GABA Antagonists; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Locus Coeruleus; Male; Neurons; Neurotoxins; Norepinephrine; Olfactory Pathways; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Staining and Labeling; Status Epilepticus; Time Factors | 2003 |
Action of GABA-B antagonist on cortical epileptic afterdischarges in rats is similar to that of GABA-A antagonist.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Electric Stimulation; Electroencephalography; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Motor Activity; Organophosphorus Compounds; Rats; Rats, Wistar; Seizures; Sensory Thresholds; Signal Processing, Computer-Assisted | 2003 |
Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model.
Topics: Action Potentials; Animals; Bicuculline; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Seizures | 2004 |
GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus.
Topics: Analysis of Variance; Animals; Baclofen; Bicuculline; Cell Count; GABA Agonists; GABA Antagonists; Gerbillinae; Hippocampus; Immunohistochemistry; Mossy Fibers, Hippocampal; Muscimol; Receptors, GABA-B; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Seizures; Severity of Illness Index | 2004 |
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Disease Susceptibility; Excitatory Postsynaptic Potentials; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isonicotinic Acids; Male; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Potassium; Pyramidal Cells; Rats; Seizures; Time Factors | 2004 |
Cholera toxin B decreases bicuculline seizures in prenatally morphine- and saline-exposed male rats.
Topics: Animals; Bicuculline; Cholera Toxin; Female; Male; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures; Sodium Chloride | 2004 |
Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol.
Topics: Animals; Bicuculline; Electroencephalography; Hippocampus; Male; Microinjections; Muscimol; Rats; Rats, Wistar; Seizures; Substantia Nigra | 2004 |
Heme oxygenase inhibition reduces neuronal activation evoked by bicuculline in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Bicuculline; Brain; Carbon Monoxide; Electroencephalography; GABA Antagonists; Heme Oxygenase (Decyclizing); Hemin; Metalloporphyrins; Neurons; Protoporphyrins; Seizures; Swine; Vasodilation | 2004 |
Reversal of hippocampal LTP by spontaneous seizure-like activity: role of group I mGluR and cell depolarization.
Topics: Animals; Bicuculline; Calcium; Dendrites; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Models, Neurological; Neurons; Picrotoxin; Receptors, Metabotropic Glutamate; Seizures; Synaptic Transmission; Time Factors | 2005 |
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.
Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Male; Mice; Microinjections; N-Methylaspartate; Picrotoxin; Pregnenolone; Seizures | 2004 |
Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation.
Topics: Animals; Bicuculline; Cerebral Cortex; Convulsants; Glucose; Glutamic Acid; Glutamine; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; Models, Neurological; Neurons; Oxidation-Reduction; Rats; Seizures | 2004 |
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.
Topics: Analysis of Variance; Animals; Bicuculline; Blotting, Western; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Electroencephalography; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Vitro Techniques; Ion Channels; Kainic Acid; Male; Membrane Potentials; Muscle Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Seizures; Valine | 2004 |
Focally injected adenosine prevents seizures in the rat.
Topics: Adenosine; Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Seizures | 2004 |
[Duration of induced seizures during selective pharyngeal brain cooling].
Topics: Animals; Bicuculline; Body Temperature; Body Temperature Regulation; Cerebral Cortex; Cold Temperature; Cryotherapy; Hypothermia, Induced; Pharynx; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome | 2004 |
Elevated voltage gated Cl- channel expression enhances fast paired-pulse inhibition in the dentate gyrus of seizure sensitive gerbil.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Action Potentials; Animals; Bicuculline; Blotting, Western; Chloride Channels; CLC-2 Chloride Channels; Convulsants; Dentate Gyrus; Drug Synergism; Gerbillinae; Immunohistochemistry; Neural Inhibition; Seizures | 2005 |
Effects of GABAergic transmissions on the immunoreactivities of calcium binding proteins in the gerbil hippocampus.
Topics: Animals; Baclofen; Bicuculline; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cell Count; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Gerbillinae; Hippocampus; Immunohistochemistry; Muscimol; Neurons; Parvalbumins; S100 Calcium Binding Protein G; Seizures; Synaptic Transmission | 2005 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; gamma-Aminobutyric Acid; Hippocampus; Isotopes; Ovariectomy; Pentylenetetrazole; Progestins; Rats; Rats, Long-Evans; Reaction Time; Receptors, GABA-A; Seizures; Tissue Distribution | 2005 |
Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Disease Models, Animal; Electric Stimulation; Electroencephalography; Functional Laterality; GABA Antagonists; Hippocampus; Kindling, Neurologic; Male; Microscopy, Interference; Muscarinic Agonists; Muscarinic Antagonists; Pilocarpine; Rats; Rats, Wistar; Scopolamine; Seizures; Stereotaxic Techniques; Time Factors | 2005 |
Extremely low frequency magnetic fields modulate bicuculline-induced-convulsion in rats.
Topics: Animals; Bicuculline; Brain Chemistry; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Magnetics; Male; Rats; Rats, Sprague-Dawley; Seizures | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isonicotinic Acids; Lipoproteins; Magnesium; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium; Pyridazines; Rats; Seizures | 2005 |
Seizure susceptibility in prenatally methamphetamine-exposed adult female rats.
Topics: Animals; Bicuculline; Central Nervous System Stimulants; Disease Susceptibility; Estrous Cycle; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Methamphetamine; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures | 2005 |
Occurrence of bicuculline-, NMDA- and kainic acid-induced seizures in prenatally methamphetamine-exposed adult male rats.
Topics: Animals; Bicuculline; Central Nervous System Stimulants; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Kainic Acid; Male; Methamphetamine; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures | 2005 |
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Topics: Animals; Antiporters; Bicuculline; Brain; Chloride-Bicarbonate Antiporters; Convulsants; Dentate Gyrus; Gene Targeting; Hydrogen-Ion Concentration; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; Seizures; Sensory Thresholds | 2006 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura | 2005 |
Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats.
Topics: Animals; Animals, Newborn; Benzoxazines; Bicuculline; Brain Stem; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Morpholines; Naphthalenes; Organ Culture Techniques; Rats; Rats, Wistar; Respiration; Respiratory Insufficiency; Seizures; Signal Transduction; Spinal Cord | 2005 |
The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway.
Topics: Animals; Arginine; Bicuculline; Cyclic GMP; Dose-Response Relationship, Drug; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pentylenetetrazole; Phosphodiesterase Inhibitors; Piperazines; Purines; Seizures; Signal Transduction; Sildenafil Citrate; Sulfones | 2006 |
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Bicuculline; Blotting, Western; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Protein Isoforms; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Vigabatrin | 2006 |
Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.
Topics: Animals; Bicuculline; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Muscimol; Picrotoxin; Seizures | 2006 |
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Persea; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2006 |
Unilateral lesion of the subthalamic nucleus enhances cortical fos expression associated with focally evoked seizures in the rat.
Topics: Animals; Bicuculline; Cerebral Cortex; Convulsants; Gene Expression Regulation; Immunohistochemistry; Male; N-Methylaspartate; Oncogene Proteins v-fos; Rats; Rats, Sprague-Dawley; Seizures; Subthalamic Nucleus | 2006 |
Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models.
Topics: 4-Aminopyridine; Animals; Bicuculline; Cerebrospinal Fluid; Cryotherapy; Disease Models, Animal; Electrodes; Electroencephalography; Evoked Potentials; Hippocampus; Limbic System; Male; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission | 2006 |
Spike-timing-dependent plasticity of inhibitory synapses in the entorhinal cortex.
Topics: Animals; Bicuculline; Calcium Channel Blockers; Calcium Channels, L-Type; Chelating Agents; Egtazic Acid; Electrophysiology; Entorhinal Cortex; Excitatory Postsynaptic Potentials; GABA Antagonists; Models, Neurological; Nerve Net; Neuronal Plasticity; Nimodipine; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses | 2006 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behavior; Diazepam; Disease Models, Animal; Drug Interactions; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Spiders; Substantia Nigra; Urea | 2006 |
Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Crassulaceae; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2007 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Disease Susceptibility; Drug Interactions; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Severity of Illness Index | 2007 |
Involvement of NMDA receptors in thiopental-induced loss of righting reflex, antinociception and anticonvulsion effects in mice.
Topics: Analgesics; Anesthetics, Intravenous; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Dizocilpine Maleate; Female; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Movement; Muscimol; N-Methylaspartate; Pain Measurement; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reflex, Abnormal; Seizures; Thiopental | 2007 |
Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury.
Topics: Administration, Topical; Animals; Animals, Newborn; Bicuculline; Blood Pressure; Boranes; Bradykinin; Carbon Monoxide; Carbonates; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Hemin; Injections, Intraperitoneal; Injections, Intravenous; Isoproterenol; Nitroprusside; Protective Agents; Seizures; Swine; Vasodilation; Vasodilator Agents | 2007 |
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Hypoxis; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Mice; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors.
Topics: Animals; Animals, Newborn; Bicuculline; Electroencephalography; Female; Kainic Acid; Male; Mother-Child Relations; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recurrence; Seizures; Sex Characteristics; Sex Factors; Signal Transduction | 2008 |
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Electrodes, Implanted; Electroencephalography; GABA Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Studies on the post-ictal rise in seizure threshold.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Electroshock; GABA Antagonists; Halothane; Lidocaine; Male; Maximum Allowable Concentration; Neurotransmitter Agents; Pentylenetetrazole; Propranolol; Prostaglandins; Rats; Seizures | 1981 |
Intravenous bicuculline test in mice: characterization with GABAergic drugs.
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Female; gamma-Aminobutyric Acid; Injections, Intravenous; Mice; Myoclonus; Seizures; Time Factors | 1981 |
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Chlordiazepoxide; Clonazepam; Dose-Response Relationship, Drug; Male; Muridae; Nitrazepam; Pentylenetetrazole; Phenytoin; Seizures | 1982 |
Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid.
Topics: Allylglycine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Male; Neurotransmitter Agents; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Taurine | 1984 |
Bicuculline and neuronal activity in motor cortex.
Topics: Animals; Bicuculline; Cats; Evoked Potentials; Motor Cortex; Neural Inhibition; Neurons; Pyramidal Tracts; Seizures; Synapses | 1980 |
Intracranial pressure during prolonged experimental convulsions in cats.
Topics: Animals; Bicuculline; Blood Pressure; Cats; Intracranial Pressure; Pentylenetetrazole; Seizures | 1983 |
Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity.
Topics: Animals; Bicuculline; Culture Techniques; Dendrites; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; Neural Inhibition; Penicillin G; Seizures; Synapses; Synaptic Transmission | 1980 |
[Participation of GABA-ergic structures in producing the effects of haloperidol].
Topics: Animals; Bicuculline; Chlorpromazine; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Rats; Receptors, Neurotransmitter; Seizures; Semicarbazides; Sulfhydryl Compounds | 1980 |
Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Ceruletide; Cholecystokinin; Diazepam; Kinetics; Male; Mice; Pentylenetetrazole; Seizures; Sincalide; Strychnine; Time Factors | 1980 |
Cyclic nucleotide metabolism in mouse brain during seizures induced by bicuculline or dibutyryl cyclic guanosine monophosphate.
Topics: Animals; Bicuculline; Brain; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Male; Mice; Mice, Inbred C57BL; Seizures | 1980 |
Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure.
Topics: Adenosine; Animals; Bicuculline; Cats; Cerebral Cortex; Female; Hypoxanthines; Inosine; Lactates; Male; Nucleotidases; Seizures | 1980 |
Ethyl beta-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats.
Topics: Animals; Bicuculline; Carbolines; Dose-Response Relationship, Drug; Flurazepam; Indoles; Rats; Receptors, Drug; Receptors, GABA-A; Seizures | 1981 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
Topics: Animals; Bicuculline; Electroshock; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures | 1982 |
Regional rat brain benzodiazepine receptor number and gamma-aminobutyric acid concentration following a convulsion.
Topics: Anesthesia; Animals; Bicuculline; Brain; Electroshock; gamma-Aminobutyric Acid; Male; Nerve Tissue Proteins; Propranolol; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Seizures; Synaptosomes | 1982 |
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome.
Topics: Anesthetics; Animals; Bicuculline; Body Temperature; Flurazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Pressure; Seizures; Synaptic Transmission; Tremor; Valproic Acid | 1982 |
Antagonism of GABA-mediated responses by d-tubocurarine in hippocampal neurons.
Topics: Animals; Bicuculline; Culture Techniques; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Picrotoxin; Receptors, Adrenergic, beta; Seizures; Synapses; Synaptic Transmission; Tetrodotoxin; Tubocurarine | 1982 |
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Drug; Ethanol; Female; Motor Activity; Muridae; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Sleep Stages; Strychnine | 1982 |
Synchronized burst discharge in disinhibited hippocampal slice. I. Initiation in CA2-CA3 region.
Topics: Animals; Bicuculline; Calcium; Culture Techniques; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Penicillin G; Potassium; Reaction Time; Seizures; Synaptic Transmission | 1983 |
Pathogenesis of brain lesions caused by experimental epilepsy. Light- and electron-microscopic changes in the rat hippocampus following bicuculline-induced status epilepticus.
Topics: Animals; Astrocytes; Bicuculline; Brain Edema; Hippocampus; Inclusion Bodies; Male; Microscopy, Electron; Neurons; Rats; Rats, Inbred Strains; Seizures; Synapses | 1983 |
Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice.
Topics: 3-Mercaptopropionic Acid; 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Brain; Convulsants; Humans; Mice; Morphine Dependence; Pentylenetetrazole; Receptors, Opioid; Seizures; Strychnine | 1983 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Influence of lesions of the noradrenergic locus coeruleus system on the cerebral metabolic response to bicuculline-induced seizures.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Cyclic AMP; Cyclic GMP; Fatty Acids, Nonesterified; Glycolysis; Locus Coeruleus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Seizures | 1983 |
Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.
Topics: 3-Mercaptopropionic Acid; Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Brain; Cell Compartmentation; Cell Fractionation; Cerebellum; Drug Interactions; Female; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Synaptosomes | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Ethanol; GABA Antagonists; Humans; Inferior Colliculi; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures; Septum Pellucidum; Substance Withdrawal Syndrome; Substantia Nigra | 1983 |
Cyclic nucleotides in rat brain during lidocaine infusion.
Topics: Animals; Bicuculline; Cerebellar Cortex; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Electroencephalography; Lidocaine; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Effect of dihydroergotoxine on the susceptibility of rats to convulsions produced by different convulsant agents.
Topics: Animals; Bicuculline; Convulsants; Dihydroergotoxine; Drug Synergism; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1983 |
Comparison of the CNS effects induced by TRH and bicuculline after microinjection into medial septum, substantia nigra and inferior colliculus: absence of support for a GABA antagonist action for TRH.
Topics: Animals; Bicuculline; Body Temperature; Brain; Ethanol; GABA Antagonists; Inferior Colliculi; Male; Microinjections; Motor Activity; Psychomotor Performance; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Thyrotropin-Releasing Hormone | 1984 |
Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cyclooxygenase Inhibitors; Electroshock; Female; Hindlimb; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Papio; Pentylenetetrazole; Photic Stimulation; Seizures; Strychnine; Valproic Acid | 1984 |
Selective focal inhibition of brain protein synthesis during generalized bicuculline seizures in newborn marmoset monkeys.
Topics: Amino Acids; Animals; Animals, Newborn; Autoradiography; Bicuculline; Brain; Callithrix; Organ Specificity; Protein Biosynthesis; Seizures; Tritium; Valine | 1984 |
The bicuculline-like properties of dopamine sulfate in rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Rats, Inbred Strains; Seizures; Strychnine; Synaptic Membranes | 1984 |
Seizure thresholds and their postictal changes in audiogenic seizure (AGS)-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bicuculline; Electroshock; Female; Male; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1984 |
gamma-Aminobutyric acid uptake inhibition and anticonvulsant activity of nipecotic acid esters.
Topics: Alanine; Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry, Physical; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Nipecotic Acids; Seizures; Solubility; Structure-Activity Relationship | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Lesions of substantia nigra protect against experimentally induced seizures.
Topics: Animals; Bicuculline; Electroshock; Male; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Tegmentum Mesencephali | 1983 |
Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline or L-allylglycine.
Topics: Allylglycine; Animals; Bicuculline; Calcium; Hippocampus; Intracellular Membranes; Male; Neurons; Rats; Rats, Inbred Strains; Seizures | 1983 |
Local blood flow and glucose consumption in the rat brain during sustained bicuculline-induced seizures.
Topics: Animals; Bicuculline; Brain; Brain Mapping; Cerebrovascular Circulation; Glucose; Male; Rats; Rats, Inbred Strains; Seizures | 1983 |
Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat.
Topics: Animals; Bicuculline; Drug Synergism; Electroshock; GABA Antagonists; Isoniazid; Male; Morphine; Naloxone; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1983 |
Anticonvulsant activity of milacemide.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1983 |
Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Electroshock; Female; Malonates; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures | 1983 |
Regional impairment of protein synthesis in the rat brain during bicuculline-induced seizures.
Topics: Animals; Autoradiography; Bicuculline; Brain; Epilepsy; Female; Kinetics; Nerve Tissue Proteins; Polyribosomes; Rats; Rats, Inbred Strains; Seizures; Tritium | 1984 |
Regional brain glucose metabolism in chemically-induced seizures in the rat.
Topics: Allylglycine; Animals; Bicuculline; Blood Glucose; Brain; Convulsants; Deoxyglucose; Energy Metabolism; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Mechanisms of regulation of cerebral microflow during bicuculline-induced seizures in anaesthetized cats.
Topics: Anesthesia, Intravenous; Animals; Bicuculline; Brain; Calcium; Cats; Cerebrovascular Circulation; Electroencephalography; Hydrogen; Microcirculation; Oxygen; Potassium; Seizures | 1984 |
Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds.
Topics: Animals; Bicuculline; Injections, Intraventricular; Isomerism; Kynurenine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1984 |
Anticonvulsant activity of some 4-aminobenzamides.
Topics: Animals; Anticonvulsants; Benzamides; Bicuculline; Electroshock; Male; Mice; Pentylenetetrazole; Seizures | 1984 |
Regional cerebral blood flow in the rat during prolonged seizure activity.
Topics: Animals; Bicuculline; Carbon Dioxide; Cerebrovascular Circulation; Electroencephalography; Evoked Potentials; Male; Oxygen; Rats; Seizures | 1980 |
Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure.
Topics: Adenosine; Animals; Bicuculline; Blood Pressure; Brain Chemistry; Carbon Dioxide; Hydrogen-Ion Concentration; Hypoxanthines; Hypoxia; Inosine; Oxygen; Rats; Seizures | 1980 |
Arachidonic acid and arachidonoyl-diglycerols increase in rat cerebrum during bicuculline-induced status epilepticus.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bicuculline; Cerebral Cortex; Diglycerides; Fatty Acids; Glycerides; Male; Rats; Rats, Inbred Strains; Seizures | 1982 |
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome.
Topics: Animals; Benzodiazepinones; Bicuculline; Flumazenil; Flurazepam; Male; Mice; Nervous System Diseases; Pressure; Seizures; Tremor | 1982 |
Reduction of postsynaptic inhibition tolerated before seizure initiation: brain stem.
Topics: Animals; Bicuculline; Brain Stem; Cats; gamma-Aminobutyric Acid; Motor Neurons; Neural Inhibition; Seizures | 1983 |
Cortical GABA turnover during bicuculline seizures in rats.
Topics: Aminocaproates; Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Seizures; Vigabatrin | 1983 |
[Comparison of the anticonvulsant and central effects of 3-bromophenylsuccinimide and N-methylimide of 3,5-dibromophenylsuccinic acid].
Topics: Animals; Anticonvulsants; Bicuculline; Bromosuccinimide; Depression, Chemical; Female; Humans; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Seizures; Stereotyped Behavior; Succinimides | 1982 |
Further characterization of the behavioral despair test in mice: positive effects of convulsants.
Topics: Animals; Antidepressive Agents; Bicuculline; Brain; Convulsants; Dextroamphetamine; Escape Reaction; Male; Mice; Motivation; Motor Activity; Muridae; Picrotoxin; Seizures; Sleep, REM; Strychnine | 1982 |
The influence of bicuculline-induced seizures on free fatty acid concentrations in cerebral cortex, hippocampus, and cerebellum.
Topics: Animals; Bicuculline; Cerebellum; Cerebral Cortex; Fatty Acids, Nonesterified; Hippocampus; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred Strains; Seizures | 1982 |
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Seizures; Substantia Nigra | 1982 |
Effect of trimethyltin on chemically-induced seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Isoniazid; Male; Mice; Pentylenetetrazole; Seizures; Strychnine; Time Factors; Trialkyltin Compounds; Trimethyltin Compounds | 1982 |
Mechanisms of neocortical epileptogenesis in vitro.
Topics: Animals; Bicuculline; Cerebral Cortex; Electric Stimulation; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Penicillins; Reaction Time; Seizures; Synapses | 1982 |
Anticonvulsant effects of muscimol.
Topics: Animals; Bicuculline; GABA Antagonists; Muscimol; Neurons; Oxazoles; Penicillins; Picrotoxin; Rats; Receptors, Drug; Seizures; Strychnine | 1980 |
[Study of the activating effect of small doses of haloperidol].
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Haloperidol; Mice; Motor Activity; Motor Cortex; Rats; Seizures; Somatosensory Cortex | 1981 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1981 |
Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy.
Topics: Animals; Bicuculline; Brain; Deoxy Sugars; Deoxyglucose; Electric Conductivity; Glucose; Kainic Acid; Male; Organ Specificity; Pentylenetetrazole; Pyrrolidines; Rats; Seizures | 1981 |
Muscimol and gamma-hydroxybutyrate: similar interactions with convulsant agents.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Hydroxybutyrates; Male; Mice; Muscimol; Oxazoles; Pentylenetetrazole; Seizures; Sodium Oxybate; Strychnine; Sulfhydryl Compounds | 1981 |
Local cerebral blood flow in the brain during bicuculline-induced seizures and the modulating influence of inhibition of prostaglandin synthesis.
Topics: Animals; Autoradiography; Bicuculline; Cerebrovascular Circulation; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Inbred Strains; Seizures | 1981 |
Behavioural effects of GABA-agonists and antagonists infused in the mesencephalic reticular formation - deep layers of superior colliculus.
Topics: Animals; Behavior, Animal; Bicuculline; Dominance, Cerebral; gamma-Aminobutyric Acid; Mesencephalon; Motor Activity; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Reticular Formation; Seizures; Superior Colliculi | 1981 |
Effect of gamma-vinyl GABA on bicuculline-induced seizures.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Seizures; Strychnine; Transaminases; Vigabatrin | 1981 |
Pulmonary edema during bicuculline-induced seizures in rats.
Topics: Animals; Bicuculline; Blood Pressure; Lung; Pulmonary Edema; Rats; Respiration; Seizures; Trachea | 1981 |
Metabolic changes in cerebral cortex, hippocampus, and cerebellum during sustained bicuculline-induced seizures.
Topics: Animals; Bicuculline; Blood Pressure; Body Temperature; Cerebellum; Cerebral Cortex; Energy Metabolism; Glucose; Hippocampus; Male; Rats; Rats, Inbred Strains; Seizures | 1981 |
Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Amygdala; Animals; Bicuculline; gamma-Aminobutyric Acid; Imidazoles; Kindling, Neurologic; Male; Pentobarbital; Picrotoxin; Rats; Seizures; Vigabatrin | 1981 |
Systemic and pulmonary vascular pressures during generalized seizures in sheep.
Topics: Animals; Aorta; Bicuculline; Blood Pressure; Cardiac Output; Electroencephalography; Female; Heart Atria; Pulmonary Circulation; Pulmonary Edema; Pulmonary Wedge Pressure; Seizures; Spinal Cord | 1981 |
Effects of neonatal seizures or anoxia on cerebellar mitotic activity in the rat.
Topics: Animals; Animals, Newborn; Bicuculline; Cerebellum; DNA; Hypoxia, Brain; Mitosis; Rats; Seizures | 1980 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures | 1980 |
Structural and physiologic studies in experimentally induced epilepsy.
Topics: Animals; Bicuculline; Cats; Cobalt; Dendrites; Dominance, Cerebral; Evoked Potentials; Female; Hippocampus; Homeostasis; Male; Seizures; Synapses | 1980 |
On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock.
Topics: Animals; Bicuculline; Convulsants; Electroshock; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intravenous; Male; Pentylenetetrazole; Rats; Seizures | 1980 |
Enhanced 5-hydroxytryptamine and dopamine-mediated behavioural responses following convulsions--I. The effects of single and repeated bicuculline-induced seizures.
Topics: Animals; Behavior, Animal; Bicuculline; Dopamine; Levodopa; Male; Rats; Seizures; Serotonin; Time Factors; Tranylcypromine | 1980 |
Enhanced 5-hydroxytryptamine and dopamine-mediated behavioural responses following convulsions--II. The effects of anaesthesia and current conditions on the appearance of enhanced responses following electroconvulsive shock.
Topics: Anesthesia; Animals; Behavior, Animal; Bicuculline; Dopamine; Electroshock; Male; Methohexital; Rats; Seizures; Serotonin; Tryptophan | 1980 |
Brain and serum calcium concentrations following electroconvulsive shock or bicuculline-induced convulsions in rats.
Topics: Animals; Bicuculline; Brain Chemistry; Calcium; Electroshock; In Vitro Techniques; Male; Rats; Seizures | 1980 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 1995 |
Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain.
Topics: Animals; Bicuculline; Brain; Brain Ischemia; Dizocilpine Maleate; Enzyme Activation; Hippocampus; Immunoblotting; Mitogens; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Seizures; Somatosensory Cortex; Tyrosine | 1993 |
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhibitors; Indazoles; Kainic Acid; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Nitric oxide (NO) is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats.
Topics: Amino Acid Oxidoreductases; Animals; Anticonvulsants; Arginine; Bicuculline; Cerebrovascular Circulation; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Seizures; Stereoisomerism | 1994 |
Nitric oxide mediates the increase in local cerebral blood flow during focal seizures.
Topics: Amino Acid Oxidoreductases; Animals; Antipyrine; Arginine; Autoradiography; Bicuculline; Cerebrovascular Circulation; Frontal Lobe; Guanylate Cyclase; Male; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Seizures; Skull; Vasodilation | 1995 |
The role of nitric oxide in modulating brain activity and blood flow during seizure.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Brain; Cerebrovascular Circulation; Electroencephalography; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Seizures | 1995 |
Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 1995 |
Local injection of bicuculline into area 8 and area 6 of the rhesus monkey induces deficits in performance of a visual discrimination GO/NO-GO task.
Topics: Animals; Behavior, Animal; Bicuculline; Convulsants; Eye Movements; Macaca mulatta; Motor Cortex; Neural Inhibition; Prefrontal Cortex; Psychomotor Performance; Seizures | 1995 |
Seizure susceptibility in immature rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate.
Topics: Age Factors; Animals; Bicuculline; Body Weight; Brain; Disease Models, Animal; Female; Humans; Infant, Newborn; Kainic Acid; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Wistar; Seizures | 1995 |
Prenatal cocaine: seizure susceptibility in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Body Weight; Brain; Cocaine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pentylenetetrazole; Pregnancy; Rats; Rats, Wistar; Seizures | 1995 |
Effect of hypoxia/ischemia on bicuculline-induced seizures in immature rats: behavioral and electrocortical phenomena.
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Brain Ischemia; Electrodes, Implanted; Electroencephalography; Hypoxia, Brain; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
The dorsal midbrain anticonvulsant zone--I. Effects of locally administered excitatory amino acids or bicuculline on maximal electroshock seizures.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Mapping; Electroshock; Excitatory Amino Acids; Female; Hindlimb; Male; Mesencephalon; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerve Roots | 1995 |
The dorsal midbrain anticonvulsant zone--III. Effects of efferent pathway transections on suppression of electroshock seizures and defence-like reactions produced by local injections of bicuculline.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Mapping; Efferent Pathways; Electroshock; Hindlimb; Male; Mesencephalon; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerve Roots | 1995 |
The neurosteroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Bicuculline; Brain; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine | 1995 |
Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Female; Ferrets; GABA Antagonists; Geniculate Bodies; Male; Nerve Net; Oscillometry; Seizures | 1995 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Binding, Competitive; Brain; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Naltrexone; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Epileptic tolerance: prior seizures protect against seizure-induced neuronal injury.
Topics: Animals; Bicuculline; Epilepsy; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
[Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channels; Chloride Channels; Male; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Optimizing the measurement of regional cerebral glucose consumption with [6-14C]glucose.
Topics: Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Carbon Dioxide; Carbon Radioisotopes; Glucose; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Seizures; Time Factors; Tissue Distribution | 1994 |
Inferior colliculus neuronal membrane and synaptic properties in genetically epilepsy-prone rats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Bicuculline; Cell Membrane; Disease Susceptibility; Electric Stimulation; Epilepsy; In Vitro Techniques; Inferior Colliculi; Male; Membrane Potentials; Neurons; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Seizures; Species Specificity; Synapses; Synaptic Transmission | 1994 |
Deep prepiriform cortex modulates kainate-induced hippocampal injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Electroencephalography; Excitatory Amino Acids; GABA Antagonists; Hippocampus; Kainic Acid; Male; Neural Pathways; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission | 1994 |
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.
Topics: Animals; Bicuculline; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Levodopa; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Pyrimethamine; Seizures | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Imidazoles; Isoniazid; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; Hippocampus; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1994 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680.
Topics: Adenosine; Animals; Anticonvulsants; Antihypertensive Agents; Behavior, Animal; Bicuculline; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Membranes; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Xanthines | 1994 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1994 |
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Injections, Spinal; Isoquinolines; Kinetics; Male; Mice; Mice, Inbred Strains; Muscimol; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
[The effect of the new amino acid-containing 1,4-dihydropyridine glutapyrone on penicillin-induced focal epileptic activity and convulsions induced by bicuculline and thiosemicarbazide].
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dihydropyridines; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsies, Partial; Glutamates; Male; Mice; Mice, Inbred ICR; Penicillins; Rats; Rats, Wistar; Seizures; Semicarbazides | 1993 |
Functional, metabolic, and circulatory changes associated with seizure activity in the postischemic brain.
Topics: Animals; Bicuculline; Cerebrovascular Circulation; Creatine; Energy Metabolism; Glucose; Glycogen; Ischemic Attack, Transient; Kinetics; Male; Oxygen; Phosphocreatine; Prosencephalon; Rats; Rats, Wistar; Seizures | 1994 |
Influence of pregnancy on blood-brain barrier integrity during seizures in rats.
Topics: Animals; Bicuculline; Blood-Brain Barrier; Evans Blue; Female; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar; Seizures | 1993 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Experimental seizures in the frog (Rana pipiens).
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Cisplatin; Convulsants; Electroencephalography; Kainic Acid; Pentylenetetrazole; Rana pipiens; Seizures; Strychnine | 1994 |
Mechanism of redistribution of cerebral blood flow during hypercarbia and seizures.
Topics: Animals; Bicuculline; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Collateral Circulation; Dogs; Microspheres; Regional Blood Flow; Seizures; Vascular Resistance | 1994 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihydropyridines; Drug Tolerance; Male; Mice; Mice, Inbred Strains; Nitrendipine; Pentobarbital; Seizures; Substance Withdrawal Syndrome | 1994 |
Interictal spiking increases 2-deoxy[14C]glucose uptake and c-fos-like reactivity.
Topics: Animals; Autoradiography; Bicuculline; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Genes, fos; Immunohistochemistry; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reference Values; Seizures | 1994 |
The influence of thalamic GABA transmission on the susceptibility of adult rats to flurothyl induced seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Bicuculline; Flurothyl; gamma-Aminobutyric Acid; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission; Thalamic Nuclei; Vigabatrin | 1993 |
Synthesis and anticonvulsant activity of 1,3-dihydro-5-phenyl-2H-pyrido[3,2-e]-1,4-diazepin-2-ones.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Evaluation, Preclinical; Mice; Pentylenetetrazole; Pyridones; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 1993 |
Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Electric Stimulation; Evoked Potentials; Hippocampus; Ketamine; Kindling, Neurologic; Limbic System; Male; Neurons; Phenobarbital; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques; Synapses | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine | 1993 |
The KROX-20 transcription factor in the rat central and peripheral nervous systems: novel expression pattern of an immediate early gene-encoded protein.
Topics: Animals; Bicuculline; Central Nervous System; Denervation; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth Response Protein 2; Formaldehyde; Gene Expression; Genes, Immediate-Early; Imidazoles; Male; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution; Transcription Factors; Zinc Fingers | 1993 |
The sigma receptor ligand 1,3-di(2-tolyl)guanidine is anticonvulsant in the rat prepiriform cortex.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Drug Interactions; Guanidines; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, sigma; Seizures | 1993 |
Blockade of GABA receptors in superior colliculus protects against focally evoked limbic motor seizures.
Topics: Animals; Bicuculline; Electroshock; Epilepsies, Partial; GABA-A Receptor Antagonists; Limbic System; Male; Microinjections; Rats; Rats, Sprague-Dawley; Reference Values; Seizures; Superior Colliculi | 1993 |
Preparation and optical characteristics of hemoglobin-free isolated perfused rat head in situ.
Topics: Animals; Bicuculline; Blood Substitutes; Brain; Copper; Electroencephalography; Electron Transport Complex IV; Fluorocarbons; Glucose; Head; Heme; Hypoxia, Brain; In Vitro Techniques; Male; Oxidation-Reduction; Oxygen Consumption; Perfusion; Photic Stimulation; Rats; Rats, Wistar; Seizures; Spectrophotometry; Temperature | 1993 |
Expression of c-fos mRNA following seizures evoked from an epileptogenic site in the deep prepiriform cortex: regional distribution in brain as shown by in situ hybridization.
Topics: Animals; Bicuculline; Brain; In Situ Hybridization; Male; Microinjections; Olfactory Pathways; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Tissue Distribution | 1993 |
Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents.
Topics: Animals; Anti-Infective Agents; Behavior, Animal; Bicuculline; Body Temperature; Central Nervous System; Drug Interactions; Female; Fluoroquinolones; Male; Mice; Motor Activity; Naphthyridines; Pentylenetetrazole; Phenylbutyrates; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Kinase; Animals; Bicuculline; Cerebral Cortex; Male; Pentostatin; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Seizures; Theophylline; Thioinosine | 1993 |
Adrenal steroids mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsions.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Bicuculline; Blotting, Northern; Corticosterone; Dexamethasone; Diazepam; Hippocampus; Immunoenzyme Techniques; Male; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1993 |
A role for endothelin in bicuculline-induced neurogenic pulmonary oedema in rats.
Topics: Acidosis; Animals; Aspartic Acid Endopeptidases; Bicuculline; Blood Gas Analysis; Blood Pressure; Bronchoalveolar Lavage Fluid; Convulsants; Electroencephalography; Endothelin-Converting Enzymes; Endothelins; Glycopeptides; In Vitro Techniques; Male; Metalloendopeptidases; Peptides, Cyclic; Protease Inhibitors; Pulmonary Edema; Rats; Rats, Wistar; Seizures | 1995 |
Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus. Role of glutamate receptor activation.
Topics: Animals; Behavior, Animal; Bicuculline; Cells, Cultured; Dentate Gyrus; Excitatory Amino Acid Agonists; Fetus; GABA-A Receptor Antagonists; Gene Expression; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, trkC; Receptors, Nerve Growth Factor; Ribonucleases; RNA, Messenger; Seizures | 1995 |
Convulsive seizures induced by micro-injection of bicuculline methiodide into the interpeduncular nucleus in rats.
Topics: Animals; Behavior, Animal; Bicuculline; Convulsants; Electrodes, Implanted; Male; Mesencephalon; Microinjections; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Diazepam; Down-Regulation; Drug Tolerance; Flumazenil; GABA Modulators; Imidazoles; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Tritium | 1996 |
Previous heat shock treatment attenuates bicuculline-induced convulsions in rats.
Topics: Animals; Bicuculline; Brain; Electroencephalography; Heat-Shock Proteins; Hot Temperature; HSP72 Heat-Shock Proteins; Immunoblotting; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Seizures; Shock; Tissue Distribution | 1996 |
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamates; Dyskinesia, Drug-Induced; Electroshock; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Phenylenediamines; Postural Balance; Rats; Rats, Wistar; Seizures; Strychnine | 1996 |
Indispensable amino acid deficiency and increased seizure susceptibility in rats.
Topics: Amino Acids; Animals; Bicuculline; Differential Threshold; Disease Susceptibility; Drug Administration Schedule; Histidine; Injections; Injections, Intraperitoneal; Isoleucine; Limbic System; Male; Olfactory Pathways; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Threonine | 1996 |
The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Bicuculline; Convulsants; Fenclonine; Fluoxetine; gamma-Aminobutyric Acid; Male; Microinjections; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Substantia Nigra | 1996 |
Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures.
Topics: Animals; Animals, Newborn; Bicuculline; Brain Ischemia; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hypoxia; Osmolar Concentration; Rats; Seizures; Time Factors | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.
Topics: Animals; Arginine; Bicuculline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Time Factors | 1996 |
Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.
Topics: Acrylates; Animals; Bicuculline; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Substantia Nigra; Vigabatrin | 1996 |
NG-nitro-L-arginine differentially affects glutamate- or kainate-induced seizures.
Topics: Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nitroarginine; Seizures | 1996 |
Imaging the induction and spread of seizure activity in the isolated brain of the guinea pig: the roles of GABA and glutamate receptors.
Topics: Animals; Bicuculline; Brain; Electric Stimulation; Guinea Pigs; Image Processing, Computer-Assisted; Receptors, GABA-A; Seizures | 1996 |
Abecarnil, a beta-carboline derivative, does not exhibit anticonvulsant tolerance or withdrawal effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Binding Sites; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Seizures; Substance Withdrawal Syndrome | 1996 |
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
Topics: Animals; Bicuculline; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Protein-Tyrosine Kinases; Seizures | 1996 |
Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding.
Topics: Animals; Autoradiography; Behavior, Animal; Bicuculline; Brain; Caffeine; Disease Susceptibility; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Receptors, GABA-A; Receptors, Purinergic P1; RNA, Messenger; Seizures; Time Factors; Xanthines | 1996 |
The role of nitric oxide in focally-evoked limbic seizures.
Topics: Animals; Arginine; Bicuculline; Enzyme Inhibitors; GABA Antagonists; Limbic System; Male; Myoclonus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; Electrophysiology; Flunitrazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Phenobarbital; Seizures | 1997 |
Bicuculline induces ictal seizures in the intact hippocampus recorded in vitro.
Topics: Animals; Animals, Newborn; Bicuculline; Electric Stimulation; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Male; Pyramidal Cells; Rats; Rats, Wistar; Seizures | 1997 |
Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites.
Topics: Animals; Benzodiazepines; Bicuculline; Binding Sites; Cold Temperature; Diazepam; Differential Threshold; Dose-Response Relationship, Drug; Female; Flumazenil; Handling, Psychological; Ligands; Male; Rats; Rats, Wistar; Seizures; Sex Characteristics; Stress, Physiological; Swimming | 1997 |
Picolinic acid and indole-2-carboxylic acid: two types of glycinergic compounds modulate motor function differentially.
Topics: Animals; Anticonvulsants; Bicuculline; Carboxylic Acids; Cats; Decerebrate State; Female; Glycine Agents; Indoles; Male; Mice; Muscle Relaxation; Muscle, Skeletal; Picolinic Acids; Rats; Rats, Wistar; Reflex; Seizures; Strychnine | 1997 |
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Topics: Anesthesia; Animals; Anticonvulsants; Bicuculline; Calcium; Cerebellum; Electroshock; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Piperidines; Potassium; Pyrroles; Rats; Seizures; Structure-Activity Relationship; Veratridine | 1997 |
Influence of gender and gonadectomy on bicuculline-induced convulsions and on GABAA receptors.
Topics: Animals; Bicuculline; Brain; Female; Male; Orchiectomy; Ovariectomy; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Sex Characteristics | 1997 |
Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bicuculline; Brain Chemistry; Cells, Cultured; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Synergism; Enoxacin; Female; GABA-A Receptor Antagonists; Injections, Intraventricular; Male; Membrane Potentials; Mice; Microinjections; Norfloxacin; Oocytes; Phenylacetates; Receptors, GABA-A; RNA, Messenger; Seizures; Xenopus laevis | 1997 |
Influence of bilateral clamping of carotid arteries on the seizures susceptibility and central action of AOAA in mice.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Carotid Arteries; Female; GABA Agents; gamma-Aminobutyric Acid; Mice; Motor Activity; Seizures | 1996 |
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Sleep; Strychnine; Time Factors; Urea; Valproic Acid | 1997 |
Inhibition by levetiracetam of a non-GABAA receptor-associated epileptiform effect of bicuculline in rat hippocampus.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Flunarizine; GABA Antagonists; Hippocampus; Levetiracetam; Male; Piracetam; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 1997 |
The effect of GABAergic system activity on hyperthermia-induced seizures in rats.
Topics: Analysis of Variance; Animals; Bicuculline; Body Temperature Regulation; Electroencephalography; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hot Temperature; Male; Muscimol; Rats; Rats, Inbred Lew; Seizures; Semicarbazides | 1997 |
Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Bicuculline; Drug Design; Electroshock; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Structure; Motor Activity; Picrotoxin; Postural Balance; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine | 1998 |
Selective alterations in binding kinetic parameters and allosteric regulation of N-methyl-D-aspartate receptors after prolonged seizures in the developing rat brain.
Topics: Allosteric Regulation; Animals; Bicuculline; Binding Sites; Brain; Dizocilpine Maleate; Female; Glutamic Acid; Glycine; Kinetics; Ligands; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Animals; Anticonvulsants; Bicuculline; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Epilepsy; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Polypharmacy; Seizures; Vigabatrin | 1998 |
Evaluation of the anticonvulsant profile of progesterone in male amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Hormone Antagonists; Hypnotics and Sedatives; Kindling, Neurologic; Male; Mifepristone; Progesterone; Rats; Seizures | 1998 |
Medium- and long-term effects of repeated bicuculline-induced seizures in developing rats on local cerebral energy metabolism.
Topics: Aging; Animals; Auditory Pathways; Autoradiography; Bicuculline; Body Weight; Brain; Carbon Dioxide; Carbon Radioisotopes; Deoxyglucose; Energy Metabolism; Olfactory Pathways; Organ Size; Organ Specificity; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Seizures; Visual Pathways | 1998 |
Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Desoxycorticosterone; Diazepam; Differential Threshold; Drug Resistance; Ethanol; Female; Gene Expression; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Time Factors | 1998 |
[Mechanisms of development of elevated seizure readiness during norbornene intoxication].
Topics: Animals; Bicuculline; Chloride Channels; Convulsants; Dopamine Antagonists; GABA Agonists; GABA Antagonists; Kindling, Neurologic; Lethal Dose 50; Male; Mice; Muscarinic Agonists; Norbornanes; Picrotoxin; Receptors, GABA-A; Seizures | 1998 |
Influence of orchidectomy and ovariectomy on the blood-brain barrier permeability during bicuculline-induced seizures.
Topics: Animals; Bicuculline; Blood-Brain Barrier; Evans Blue; Female; Male; Orchiectomy; Ovariectomy; Rats; Rats, Wistar; Seizures; Serum Albumin | 1998 |
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Muscimol; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Time Factors; Vigabatrin | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Carbamates; Convulsants; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Phenylenediamines; Rats; Rats, Wistar; Seizures | 1999 |
Heparin injection into the adult rat hippocampus induces seizures in the absence of macroscopic abnormalities.
Topics: Animals; Bicuculline; Drug Combinations; Electrophysiology; Heparin; Hippocampus; In Vitro Techniques; Male; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, Neurotransmitter; Seizures; Swine; Synapses | 1999 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Clonidine; Dextromethorphan; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ketamine; Mice; Muscimol; N-Methylaspartate; Picrotoxin; Receptors, GABA; Receptors, Glutamate; Seizures; Theophylline | 1999 |
Efficacy of shitei-to, a traditional Chinese medicine formulation, against convulsions in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Drugs, Chinese Herbal; Electroshock; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Strychnine | 1999 |
Medium- and long-term alterations of brain A1 and A2A adenosine receptor characteristics following repeated seizures in developing rats.
Topics: Adenosine; Animals; Animals, Newborn; Bicuculline; Brain Chemistry; Convulsants; Female; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Membranes; Phenethylamines; Pregnancy; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Seizures | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamates; Humans; Kynurenic Acid; Lidocaine; Limbic System; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Solitary Nucleus; Synaptic Transmission; Vagus Nerve | 1999 |
Inhibition of GABA system involved in cyclosporine-induced convulsions.
Topics: Animals; Anticonvulsants; Bicuculline; Binding Sites; Brain; Cells, Cultured; Cerebellum; Cyclosporine; Drug Synergism; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Male; Mice; Mice, Inbred Strains; Muscimol; Neurons; Rats; Rats, Wistar; Seizures; Strychnine; Tacrolimus | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; Clonazepam; Diazepam; Drug Interactions; Drug Tolerance; Flumazenil; Imidazoles; Ligands; Male; Mice; Receptors, GABA-A; Seizures; Tritium | 1999 |
Seizure-like events in disinhibited ventral slices of adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Potassium Chloride; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1999 |
Effects of adrenalectomy and gonadectomy on sex and stress-induced differences in bicuculline-induced convulsions.
Topics: Adrenalectomy; Animals; Bicuculline; Castration; Convulsants; Female; Male; Rats; Rats, Wistar; Seizures; Sex Factors; Stress, Physiological | 1999 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epilepsy, Absence; Frontal Lobe; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Kainic Acid; Limbic System; Male; Parietal Lobe; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Strychnine | 2000 |
Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Chemotactic Factors; Convulsants; Dithionitrobenzoic Acid; Epilepsy; Hippocampus; Indicators and Reagents; Long-Term Potentiation; Membrane Potentials; Oxidation-Reduction; Patch-Clamp Techniques; Pentylenetetrazole; Phosphines; PQQ Cofactor; Quinolones; Quinones; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Seizures; Sulfhydryl Reagents | 2000 |
Changes in neuronal conductance during different components of cortically generated spike-wave seizures.
Topics: Action Potentials; Animals; Bicuculline; Cats; Cell Membrane; Convulsants; Electric Conductivity; Electric Stimulation; Electroencephalography; Electrophysiology; Neocortex; Neurons; Oscillometry; Seizures; Sleep Stages | 2000 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Flurothyl; Genetic Predisposition to Disease; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Metallothionein 3; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Seizures; Synapses; Synaptic Vesicles; Zinc | 2000 |
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; Seizures; Vigabatrin | 2000 |
P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Bicuculline; Convulsants; Disease Models, Animal; Rats; Seizures; Substance Withdrawal Syndrome | 2000 |
Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Brain Chemistry; Convulsants; Enkephalin, D-Penicillamine (2,5)-; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Quinolines; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Synaptic Transmission | 2000 |
Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner.
Topics: Age Factors; Analgesics, Opioid; Animals; Bicuculline; Convulsants; Disease Susceptibility; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors | 2000 |
Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression.
Topics: Animals; Barium; Bicuculline; Cortical Spreading Depression; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Hippocampus; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Male; Microelectrodes; Neuroglia; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Evidence for GABA(A) receptor agonistic properties of ketamine: convulsive and anesthetic behavioral models in mice.
Topics: Allylglycine; Anesthesia; Anesthetics, Dissociative; Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; Ketamine; Male; Mice; Muscimol; Receptors, GABA-A; Reflex; Seizures | 2000 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, Neurologic; Male; Muscimol; Rats; Rats, Wistar; Seizures; Thiourea; Valproic Acid | 2000 |
Propagation of spontaneous synchronized activity in cortical slice cultures recorded by planar electrode arrays.
Topics: Animals; Bicuculline; Cerebral Cortex; Culture Media; Culture Techniques; Electrodes; Kainic Acid; Rats; Seizures | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus.
Topics: Animals; Anticonvulsants; Bicuculline; Functional Laterality; GABA-A Receptor Agonists; Kynurenic Acid; Male; Microinjections; Motor Activity; Muscimol; Posture; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Subthalamic Nucleus | 2000 |
GABAergic contribution to rat bladder hyperactivity after middle cerebral artery occlusion.
Topics: Animals; Baclofen; Bicuculline; Cerebral Infarction; Cerebral Ventricles; Dose-Response Relationship, Drug; Female; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Injections, Intraventricular; Middle Cerebral Artery; Muscimol; Pressure; Rats; Rats, Sprague-Dawley; Seizures; Urinary Bladder; Urination | 2000 |
The influence of MK-801 on bicuculline evoked seizures in adult mice exposed to transient episode of brain ischemia.
Topics: Age Factors; Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Convulsants; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Ischemic Attack, Transient; Ischemic Preconditioning; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Rate | 2000 |
Convulsant action of systemically administered glutamate and bicuculline methiodide in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Convulsants; Glutamic Acid; Male; Rats; Rats, Wistar; Seizures | 2000 |
Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain.
Topics: Animals; Bicuculline; Brain Ischemia; Calcium; Cyclic AMP; Cyclic GMP; Diglycerides; Electroencephalography; Fatty Acids, Nonesterified; Male; Phospholipids; Rats; Rats, Wistar; Seizures | 2000 |
High susceptibility of the anterior and posterior piriform cortex to induction of convulsions by bicuculline.
Topics: Amygdala; Animals; Axonal Transport; Bicuculline; Female; Male; Mediodorsal Thalamic Nucleus; Microinjections; Olfactory Bulb; Olfactory Pathways; Organ Specificity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Disease Susceptibility; Excitatory Amino Acid Antagonists; Ischemic Attack, Transient; Ischemic Preconditioning; Mice; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors | 2000 |
2-deoxyglucose enhances epileptic tolerance evoked by transient incomplete brain ischemia in mice.
Topics: Animals; Antimetabolites; Bicuculline; Brain Ischemia; Convulsants; Cycloheximide; Deoxyglucose; Male; Mice; Protein Synthesis Inhibitors; Seizures | 2001 |
Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels.
Topics: Alcohol Drinking; Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dose-Response Relationship, Drug; Ethanol; Male; Rats; Rats, Sprague-Dawley; Seizures; Self Administration; Taste | 2001 |
Endogenous acetylcholine facilitates epileptogenesis in immature rat neocortex.
Topics: Acetylcholine; Animals; Animals, Newborn; Bicuculline; Cholinesterase Inhibitors; Evoked Potentials; Neocortex; Physostigmine; Rats; Rats, Sprague-Dawley; Seizures | 2001 |
The pharmacodynamics of anticonvulsant and subconvulsant effects of ethanol in CBA and C57BL/6 mice.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System Depressants; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Seizures | 2001 |
Contribution of intralaminar thalamic nuclei to spike-and-wave-discharges during spontaneous seizures in a genetic rat model of absence epilepsy.
Topics: Action Potentials; Animals; Bicuculline; Electroencephalography; Electrophysiology; Epilepsy, Absence; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Intralaminar Thalamic Nuclei; Male; Neurons; Rats; Rats, Mutant Strains; Reaction Time; Recruitment, Neurophysiological; Seizures | 2001 |
Dopamine D4 receptor-deficient mice display cortical hyperexcitability.
Topics: 4-Aminopyridine; Animals; Bicuculline; Cerebral Cortex; Convulsants; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Mice; Mice, Neurologic Mutants; Motor Cortex; Neural Inhibition; Patch-Clamp Techniques; Piperazines; Presynaptic Terminals; Pyramidal Cells; Receptors, Dopamine D2; Receptors, Dopamine D4; Seizures; Sulfonamides | 2001 |
An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability.
Topics: Action Potentials; Animals; Axons; Bicuculline; Cerebral Cortex; Electroencephalography; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Mice; Mice, Knockout; Mice, Neurologic Mutants; Nervous System Malformations; Neurologic Examination; Peripheral Nervous System; Pyramidal Cells; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; RNA, Messenger; Seizures; Signal Transduction | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid | 2001 |
Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium; Convulsants; Electrophysiology; Excitatory Amino Acid Antagonists; Extracellular Space; Female; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Reference Values; Seizures; Synaptic Transmission | 2001 |
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Drug Resistance; Electroencephalography; Excitatory Amino Acid Agonists; Gene Targeting; Genetic Predisposition to Disease; Glycine; Hippocampus; Homozygote; In Vitro Techniques; Mice; Mice, Knockout; Pentylenetetrazole; Phenotype; Physical Chromosome Mapping; Receptors, Metabotropic Glutamate; Seizures | 2001 |
Sex differences in rats in the development of and recovery from ethanol dependence assessed by changes in seizure susceptibility.
Topics: Alcoholism; Animals; Anticonvulsants; Bicuculline; Ethanol; Female; GABA Antagonists; Male; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Substance Withdrawal Syndrome | 2001 |
Prenatal morphine exposure decreases susceptibility of adult male rat offspring to bicuculline seizures.
Topics: Animals; Bicuculline; Brain; Disease Susceptibility; Epilepsy; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Morphine; Orchiectomy; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Sex Factors; Testosterone | 2001 |
Selectivity of the protective effects of dihydropyridine calcium channel antagonists against the ethanol withdrawal syndrome.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Bicuculline; Body Temperature; Calcium Channel Blockers; Central Nervous System Depressants; Convulsants; Dihydropyridines; Ethanol; GABA Antagonists; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome | 2002 |
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.
Topics: Acoustic Stimulation; Administration, Oral; Amides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Cyclopropanes; Electrophysiology; Electroshock; Epilepsy; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Mutagenicity Tests; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 2002 |
Manipulation of the somatosensory cortex modulates stimulus-induced repetitive ear movements in a seizure-sensitive strain of gerbil.
Topics: Animals; Bicuculline; Disease Models, Animal; Ear; Evoked Potentials, Somatosensory; Female; GABA Antagonists; Gerbillinae; Male; Seizures; Somatosensory Cortex | 2001 |
Cerebrovasodilatory contribution of endogenous carbon monoxide during seizures in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Bicuculline; Carbon Monoxide; Cerebral Arteries; Cerebrovascular Circulation; Convulsants; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; GABA Antagonists; Glutamates; Heme; Heme Oxygenase (Decyclizing); Membrane Potentials; Mesoporphyrins; Metalloporphyrins; Nerve Tissue Proteins; Neurons; Pia Mater; Protoporphyrins; Seizures; Status Epilepticus; Swine; Vasodilation | 2002 |
Anticonvulsant activity of aqueous extract of Leonotis leonurus.
Topics: Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Lamiaceae; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2002 |
Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities.
Topics: Animals; Bicuculline; Cats; Convulsants; Electroencephalography; Electrophysiology; Evoked Potentials; Neocortex; Neuroglia; Neurons; Potassium; Seizures; Sodium | 2002 |
Cerebral metabolic changes during prolonged epileptic seizures in rats.
Topics: Adenine Nucleotides; Amino Acids; Ammonia; Animals; Bicuculline; Biological Transport; Brain; Citric Acid Cycle; Creatine; Energy Metabolism; Glucose; Glycolysis; Hydrogen-Ion Concentration; Male; NAD; Oxidation-Reduction; Phosphocreatine; Rats; Seizures | 1977 |
Evidence against H+ and K+ as main factors for the control of cerebral blood flow: a microelectrode study.
Topics: Amphetamines; Animals; Bicuculline; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Extracellular Space; Hydrogen; Hydrogen-Ion Concentration; Hyperemia; Hypoglycemia; Hypoxia; Insulin; Microelectrodes; Potassium; Rats; Seizures | 1978 |
The significance of cortical extracellular H+, K+ and Ca2+ activities for regulation of local cerebral blood flow under conditions of enhanced neuronal activity.
Topics: Animals; Bicuculline; Brain; Calcium; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Electric Stimulation; Extracellular Space; Hydrogen-Ion Concentration; Muscle, Smooth; Neurons; Potassium; Regional Blood Flow; Seizures; Vascular Resistance | 1978 |
Differential blockade of bicuculline convulsions by neuroleptics.
Topics: Animals; Antipsychotic Agents; Bicuculline; Isoquinolines; Male; Mice; Photic Stimulation; Seizures | 1978 |
Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats.
Topics: Acid-Base Equilibrium; Animals; Arteries; Bicuculline; Cats; Chloralose; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Male; Pentobarbital; Phentolamine; Pia Mater; Seizures; Vasodilation | 1979 |
Endocrine factors and glucose metabolism during prolonged seizures in baboons.
Topics: Animals; Bicuculline; Blood Glucose; Fatty Acids, Nonesterified; Glucagon; Growth Hormone; Haplorhini; Hormones; Hydrocortisone; Insulin; Papio; Prolactin; Seizures | 1979 |
[Participation of cholinergic mechanisms in realizing the effects of bicuculline].
Topics: Animals; Benactyzine; Bicuculline; Cerebral Cortex; GABA Antagonists; Isoquinolines; Mice; Parasympatholytics; Rats; Receptors, Neurotransmitter; Seizures | 1978 |
Activation of cortical circuits during interictal spikes.
Topics: Animals; Bicuculline; Cerebral Cortex; Deoxyglucose; Electroencephalography; Female; Male; Penicillins; Rats; Seizures; Strychnine; Synaptic Transmission | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Synaptic Transmission | 1979 |
Adenosine in rat cerebral cortex during hypoxia and bicuculline-induced seizures.
Topics: Adenosine; Animals; Bicuculline; Brain; Hypoxia; Rats; Seizures | 1977 |
Cerebral blood flow and oxygen utilization in rats during bicuculline-induced seizures. Effects of substrate depletion.
Topics: Animals; Bicuculline; Cerebrovascular Circulation; Male; Oxygen Consumption; Rats; Seizures | 1977 |
Monoamine metabolism during bicuculline-induced epileptic seizures in the rat.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Bicuculline; Brain; Catecholamines; Cerebellum; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hydroxyindoleacetic Acid; Limbic System; Male; Norepinephrine; Rats; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Seizures; Serotonin; Tryptophan; Tyrosine | 1978 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
Facilitation of bicuculline- and picrotoxin-induced seizures by sodium valproate in rats.
Topics: Animals; Bicuculline; Drug Synergism; Male; Picrotoxin; Rats; Seizures; Valproic Acid | 1979 |
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Muscimol; Picrotoxin; Rats; Seizures; Structure-Activity Relationship; Valproic Acid | 1979 |
Brain gamma-aminobutyric acid and acoustic priming in C57BL/6Bg mice.
Topics: Acoustic Stimulation; Alanine; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Brain Chemistry; gamma-Aminobutyric Acid; Glutamates; Hydrazines; Hydroxylamines; Mice; Mice, Inbred C57BL; Seizures; Time Factors | 1977 |
Modification of orientation sensitivity of cat visual cortex neurons by removal of GABA-mediated inhibition.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Cats; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Neural Inhibition; Neurons; Orientation; Seizures; Synapses; Visual Cortex | 1979 |
Effects of bicuculline-induced seizures on cerebral metabolism and circulation of rats rendered hypoglycemic by starvation.
Topics: Animals; Bicuculline; Brain; Cerebrovascular Circulation; Electroencephalography; Energy Metabolism; Hypoglycemia; Male; Rats; Seizures; Starvation | 1979 |
Brain protein synthesis during neonatal seizures: an experimental study.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Electroencephalography; Evoked Potentials; Flurothyl; Lysine; Nerve Tissue Proteins; Polyribosomes; Rats; Seizures; Status Epilepticus | 1979 |
Neurophysiological and neurochemical studies on the action of the anticonvulsant gamma-hydroxy, gamma-ethyl, gamma-phenyl-butyramide.
Topics: Amygdala; Animals; Anticonvulsants; Bicuculline; Brain; Cats; Cerebral Cortex; Drug Synergism; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Mice; Phenylbutyrates; Phenytoin; Potassium; Seizures; Strychnine; Substantia Nigra | 1979 |
Effect of sympathetic nerves on cerebral vessels during seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cats; Cerebrovascular Circulation; Denervation; Female; Male; Masticatory Muscles; Permeability; Regional Blood Flow; Seizures; Sympathetic Nervous System | 1979 |
Effects of reduced cerebral blood flow upon EEG pattern, cerebral extracellular potassium, and energy metabolism in the rat cortex during bicuculline-induced seizures.
Topics: Animals; Bicuculline; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Energy Metabolism; Evoked Potentials; Extracellular Space; Lactates; Male; Oxygen; Potassium; Rats; Seizures | 1979 |
Energy flux and lactate production in rat cerebral cortex during the first 5-10 s of bicuculline-induced seizures.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bicuculline; Cerebral Cortex; Energy Metabolism; Kinetics; Lactates; Male; Phosphocreatine; Rats; Seizures | 1978 |
Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Light; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Visual Cortex | 1977 |
Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity.
Topics: Animals; Bemegride; Bicuculline; Cerebral Cortex; Convulsants; Instinct; Male; Medulla Oblongata; Neural Inhibition; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Mice; Pentylenetetrazole; Seizures; Strychnine | 1977 |
Effect of sympathetic stimulation on the blood brain barrier dysfunction induced by amphetamine and by epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Dextroamphetamine; Electric Stimulation; Hypertension; Male; Rats; Seizures; Sympathetic Nervous System | 1978 |
Properties of two derivatives of gamma-aminobutyric acid (GABA) capable of abolishing Cardiazol- and bicuculline-induced convulsions in the rat.
Topics: Animals; Bicuculline; Brain; Chemical Phenomena; Chemistry, Physical; Female; gamma-Aminobutyric Acid; Isoquinolines; Male; Mitochondria; Pentylenetetrazole; Rats; Seizures | 1978 |
Epileptic brain damage: the role of systemic factors that modify cerebral energy metabolism.
Topics: Animals; Bicuculline; Blood Glucose; Blood Pressure; Body Temperature; Brain; Brain Damage, Chronic; Brain Ischemia; Carbon Dioxide; Electroencephalography; Energy Metabolism; Male; Oxygen; Rats; Seizures | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; Drug Interactions; Electroencephalography; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Time Factors; Trimethadione | 1977 |
Mediation of myoclonic seizures by dopamine and clonic seizures by acetylcholine and GABA.
Topics: Animals; Apomorphine; Bicuculline; Dose-Response Relationship, Drug; Flurothyl; Haloperidol; Isoquinolines; Mice; Myoclonus; Pilocarpine; Scopolamine; Seizures | 1977 |
Sustained epileptic seizures complicated by hypoxia, arterial hypotension or hyperthermia: effects on celebral energy state.
Topics: Animals; Bicuculline; Brain; Energy Metabolism; Fever; Hypotension; Hypoxia; Male; Rats; Seizures | 1977 |
Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system.
Topics: Action Potentials; Alanine; Aminobutyrates; Animals; Areca; Arecoline; Bicuculline; Cats; Cerebellum; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Mice; Neural Inhibition; Nicotinic Acids; Nipecotic Acids; Plant Extracts; Plants, Medicinal; Purkinje Cells; Reflex, Monosynaptic; Seizures; Spinal Cord | 1977 |
Glucose consumption in the cerebral cortex of rat during bicuculline-induced status epilipticus.
Topics: Animals; Bicuculline; Cerebral Cortex; Glucose; Male; Oxygen Consumption; Rats; Seizures | 1976 |
Effects of neonatal status epilepticus on rat brain development.
Topics: Animals; Animals, Newborn; Bicuculline; Body Weight; Brain; Brain Chemistry; Cerebellum; Cholesterol; DNA; Electroencephalography; Female; Flurothyl; Male; Nerve Tissue Proteins; Organ Size; Rats; RNA; Seizures | 1976 |
Changes in regional brain acetylcholine levels during drug-induced convulsions.
Topics: Acetylcholine; Animals; Bicuculline; Brain Chemistry; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine | 1976 |
Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline.
Topics: Animals; Bicuculline; Brain; Cerebrovascular Circulation; Electroencephalography; Male; Oxygen Consumption; Rats; Seizures; Time Factors | 1976 |
Studies on the neuropharmacological activity of bicuculline and related compounds.
Topics: Acetylcholinesterase; Acetylthiocholine; Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Insecta; Isoquinolines; Kinetics; Mice; Muscles; Neuromuscular Junction; Seizures; Synapses; Tail | 1976 |
Bicuculline reversal of deprivation amblyopia in the cat.
Topics: Amblyopia; Animals; Bicuculline; Cats; GABA Antagonists; Isoquinolines; Neural Pathways; Seizures; Visual Cortex; Visual Pathways | 1976 |
Benzodiazepines and central glycine receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Chlordiazepoxide; Diazepam; Glycine; Mice; Receptors, Drug; Seizures; Species Specificity; Spinal Cord; Strychnine; Time Factors | 1976 |
Effects of some GABAergic agents on quinine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; Male; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Phenytoin; Quinine; Receptors, GABA-A; Seizures | 1992 |
Yohimbine-induced seizures involve NMDA and GABAergic transmission.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Dioxanes; gamma-Aminobutyric Acid; Idazoxan; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Adrenergic, alpha; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Synaptic Transmission; Yohimbine | 1992 |
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
Topics: Acetamides; Animals; Bicuculline; Binding, Competitive; Brain; Diazepam Binding Inhibitor; Indoleacetic Acids; Isoniazid; Ligands; Mitochondria; Motor Activity; Neuropeptides; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1992 |
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Tritium | 1992 |
Superoxide production in experimental seizures in cats.
Topics: Animals; Bicuculline; Blood Pressure; Brain; Cats; Female; Male; Models, Biological; Nitroblue Tetrazolium; Seizures; Superoxides | 1992 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flurothyl; gamma-Aminobutyric Acid; Muscimol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission | 1992 |
Basic fibroblast growth factor mRNA increases in specific brain regions following convulsive seizures.
Topics: Animals; Bicuculline; Brain; Brain Injuries; Catheterization; Fibroblast Growth Factor 2; Male; Microinjections; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Ribonucleases; RNA Probes; RNA, Messenger; Seizures | 1992 |
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Arousal; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Mapping; Clobazam; Dominance, Cerebral; Epilepsy, Tonic-Clonic; Escape Reaction; gamma-Aminobutyric Acid; Inferior Colliculi; Male; Motor Activity; Neural Inhibition; Neural Pathways; Rats; Rats, Wistar; Seizures; Substantia Nigra; Superior Colliculi; Synaptic Transmission | 1992 |
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts.
Topics: Acoustic Stimulation; Animals; Arousal; Behavior, Animal; Bicuculline; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Escape Reaction; gamma-Aminobutyric Acid; Inferior Colliculi; Male; Neural Inhibition; Neural Pathways; Rats; Rats, Wistar; Seizures; Superior Colliculi; Synaptic Transmission | 1992 |
[The effect of activation of the superior colliculus on the convulsive activity during picrotoxin-induced kindling].
Topics: Animals; Bicuculline; Electroencephalography; Kindling, Neurologic; Male; Microinjections; Penicillin G; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Superior Colliculi | 1992 |
Quantitative autoradiographic measurements of functional changes induced by generalized seizures in the developing rat brain: central adenosine and benzodiazepine receptors and local cerebral glucose utilization.
Topics: Age Factors; Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Brain Mapping; Epilepsy, Generalized; gamma-Aminobutyric Acid; Hippocampus; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Purinergic; Seizures; Status Epilepticus | 1992 |
Seizure circuit analysis with voltage sensitive dye.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Brain; Brain Mapping; Disease Models, Animal; Fluorescent Dyes; Kainic Acid; Limbic System; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit.
Topics: Animals; Aspartic Acid; Bicuculline; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypoxia; Kinetics; Rabbits; Reference Values; Seizures; Taurine; Time Factors | 1992 |
Patterns of glucose use after bicuculline-induced convulsions in relationship to gamma-aminobutyric acid and mu-opioid receptors in the ventral pallidum--functional markers for the ventral pallidum.
Topics: Animals; Autoradiography; Bicuculline; Biomarkers; Globus Pallidus; Glucose; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, mu; Seizures; Substance P | 1992 |
[The threshold lowering effects of chronic treatment with haloperidol on beta-carboline derivative-induced tonic convulsion].
Topics: Animals; Bicuculline; Carbolines; Drug Administration Schedule; Drug Interactions; Haloperidol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Seizures | 1992 |
Anticonvulsant effect of intranigral fluoxetine.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Fluoxetine; Male; Microinjections; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1992 |
Neuropharmacology of amide derivatives of P-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Brain; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Muscle Relaxation; Nervous System; Picrotoxin; Seizures | 1992 |
In vivo mapping of drug-induced seizures with voltage-sensitive dye.
Topics: Animals; Autoradiography; Bicuculline; Blood Pressure; Brain; Brain Mapping; Coloring Agents; Deoxyglucose; Electric Stimulation; Kainic Acid; Male; Membrane Potentials; Models, Neurological; Neural Pathways; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Persistent hyperexcitability in isolated hippocampal CA1 of kainate-lesioned rats.
Topics: Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Evoked Potentials; Hippocampus; In Vitro Techniques; Injections; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Age-related anticonvulsant activity of NMDA in the rat caudate-putamen.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Caudate Nucleus; Female; Male; N-Methylaspartate; Putamen; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques | 1992 |
Infusion of bicuculline methiodide into the tectum: model specificity of pro- and anticonvulsant actions.
Topics: Animals; Behavior, Animal; Bicuculline; Electroshock; Male; Microinjections; Models, Neurological; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi | 1992 |
Anticonvulsant role of nigrotectal projection in the maximal electroshock model of epilepsy--I. Mapping of dorsal midbrain with bicuculline.
Topics: Animals; Bicuculline; Brain Mapping; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mesencephalon; Neural Pathways; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Superior Colliculi | 1992 |
Induction of immediate early gene encoded proteins in the rat hippocampus after bicuculline-induced seizures: differential expression of KROX-24, FOS and JUN proteins.
Topics: Animals; Bicuculline; DNA-Binding Proteins; Early Growth Response Protein 1; Female; Gene Expression Regulation; Hippocampus; Immediate-Early Proteins; Immunohistochemistry; Organ Specificity; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Rats; Rats, Inbred Strains; Seizures; Transcription Factors; Zinc Fingers | 1992 |
Transient reduction of cerebral blood flow leads to longlasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures.
Topics: Animals; Bicuculline; Brain Chemistry; Carotid Arteries; Cerebrovascular Circulation; gamma-Aminobutyric Acid; Rats; Rats, Inbred Strains; Seizures | 1992 |
Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs.
Topics: Animals; Animals, Newborn; Bicuculline; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Female; Hydrogen-Ion Concentration; Hyperemia; Male; Muscle Contraction; Oxygen; Pancuronium; Seizures; Swine | 1992 |
Does glycine antagonism underlie the excitatory effects of methohexitone and propofol?
Topics: Anesthesia, General; Animals; Bicuculline; Central Nervous System; Electroencephalography; Ethanol; Glycine; Male; Methohexital; Mice; Mice, Inbred Strains; Pentobarbital; Propofol; Seizures; Strychnine | 1992 |
Is the anticonvulsant effect of substantia nigra infusion of gamma-vinyl-GABA (GVG) mediated by the GABAA receptor in rat pups?
Topics: Aminocaproates; Animals; Anticonvulsants; Bicuculline; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Substantia Nigra; Vigabatrin | 1991 |
Chronic administration of beta-carboline-3-carboxylic acid methylamide by continuous intraventricular infusion increases GABAergic function.
Topics: Animals; Bicuculline; Carbolines; Cerebral Cortex; Cerebral Ventricles; Chlorine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Infusion Pumps; Injections, Intraperitoneal; Male; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1991 |
Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models.
Topics: Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Isoniazid; Kainic Acid; Male; Microinjections; Muscimol; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Synaptic Transmission | 1991 |
Altered response to GABAergic agents following electro and chemo convulsions in mice.
Topics: Animals; Bicuculline; Electroshock; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A Receptor Antagonists; Isoniazid; Male; Mice; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Seizures | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Kidney; Male; Medetomidine; Muscimol; Myocardium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stimulation, Chemical; Stress, Physiological; Tritium | 1991 |
Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures.
Topics: Animals; Baclofen; Bicuculline; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Ion Channels; Limbic System; Male; Membrane Proteins; Muscimol; Neural Inhibition; Picrotoxin; Rats; Seizures | 1990 |
Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice.
Topics: Animals; Avoidance Learning; Bicuculline; Body Temperature; Brain; Drug Tolerance; Environment; Ethanol; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Motor Activity; Picrotoxin; Postural Balance; Seizures; Sleep; Species Specificity | 1991 |
Anticonvulsant activity of the imidazoline 6,7-benzoidazoxan.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Dioxanes; Electroshock; Imidazoles; Male; Mice; Phenytoin; Postural Balance; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1991 |
Changes in rat brain extracellular glutamate concentration during seizures induced by systemic picrotoxin or focal bicuculline injection: an in vivo dialysis study with on-line enzymatic detection.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicuculline; Brain Chemistry; Cerebral Cortex; Dialysis; Electroencephalography; Electroshock; Extracellular Space; Glutamates; Hippocampus; Injections; Kainic Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Blood-brain barrier permeability in experimental induced seizure: variations during the estrous cycle.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Brain; Diestrus; Estrus; Female; Metestrus; Proestrus; Rats; Rats, Inbred Strains; Reference Values; Seizures; Vagina | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment.
Topics: Adaptation, Psychological; Administration, Inhalation; Animals; Behavior, Animal; Bicuculline; Brain; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ethanol; Isradipine; Male; Mice; Mice, Inbred C57BL; Nimodipine; Nitrendipine; Seizures; Substance Withdrawal Syndrome | 1991 |
Analysis of the convulsant-potentiating effects of lithium in rats.
Topics: Animals; Bicuculline; Chlorides; Convulsants; Drug Synergism; Hippocampus; Kainic Acid; Lithium; Lithium Chloride; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1991 |
Decreased susceptibility to seizures induced by bicuculline after transient bilateral clamping of the carotid arteries in rats.
Topics: Animals; Bicuculline; Brain Chemistry; Carotid Arteries; Constriction; Disease Susceptibility; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Male; Rats; Receptors, GABA-A; Seizures; Status Epilepticus | 1991 |
Selective protection by adenosine receptor agonists against DMCM-induced seizures.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Female; Mice; Pentylenetetrazole; Phenylisopropyladenosine; Receptors, Purinergic; Seizures; Theophylline | 1991 |
Differential neuronal expression of c-fos proto-oncogene following peripheral nerve injury or chemically-induced seizure.
Topics: Animals; Bicuculline; Blotting, Northern; Brain; Cricetinae; DNA-Binding Proteins; Immunohistochemistry; Mesocricetus; Motor Neurons; Neurons; Peripheral Nerve Injuries; Peripheral Nerves; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Seizures | 1991 |
Autoradiographic changes in brain adenosine A1 receptors and their coupling to G proteins following seizures in the developing rat.
Topics: Adenosine; Animals; Autoradiography; Bicuculline; Brain; Brain Chemistry; Female; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Seizures | 1991 |
The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.
Topics: Alcian Blue; Animals; Baclofen; Bicuculline; Female; Histocytochemistry; In Vitro Techniques; Microinjections; Pentylenetetrazole; Piperidines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Tegmentum Mesencephali; Thalamic Nuclei | 1991 |
Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azoles; Behavior, Animal; Bicuculline; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Pyridazines; Seizures; Tetrazoles; Triazoles | 1990 |
Paradoxical anticonvulsant activity of the gamma-aminobutyrate antagonist bicuculline methiodide in the rat striatum.
Topics: Animals; Anticonvulsants; Bicuculline; Corpus Striatum; Electroencephalography; GABA Antagonists; Male; Microinjections; Models, Neurological; Neurons; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Synapses | 1991 |
Effect of postnatal anoxia on seizure susceptibility in rats: bicuculline-induced seizures and pretreatment with iproniazid.
Topics: Animals; Bicuculline; Brain; Disease Susceptibility; Electroencephalography; Hypoxia; Iproniazid; Male; Rats; Rats, Inbred Strains; Seizures | 1991 |
The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures.
Topics: Acute Disease; Albumins; Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Evans Blue; Female; Hypertension; Male; Mesencephalon; Pentylenetetrazole; Permeability; Rats; Rats, Inbred Strains; Seizures; Thalamus | 1991 |
On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
Topics: Animals; Bicuculline; Brain; Dinoprost; Epilepsy; Gerbillinae; Handling, Psychological; Kinetics; Pentylenetetrazole; Seizures; SRS-A | 1991 |
Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Female; Pregnancy; Rats; Seizures | 1990 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Anticonvulsant effects of clonazepam on chemically induced convulsions.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Clonazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1990 |
Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.
Topics: Animals; Antidepressive Agents; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Ergotamines; Female; Male; Mice; Mice, Inbred CBA; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Species Specificity | 1990 |
Effect of chronic ivermectin treatment on GABA receptor function in ethanol withdrawal-seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain Chemistry; Ethanol; Flunitrazepam; Ivermectin; Mice; Ovum; Oxyuroidea; Receptors, GABA-A; Seizures | 1990 |
Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Cerebral Cortex; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1990 |
Excitatory amino acid antagonists protect mice against seizures induced by bicuculline.
Topics: Animals; Bicuculline; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Muscimol; Pipecolic Acids; Piperazines; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1990 |
Species dependent dual modulation of the benzodiazepine/GABA receptor chloride channel by dihydroergosine.
Topics: Animals; Bicuculline; Brain; Chloride Channels; Diazepam; Ergotamines; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Proteins; Mice; Mice, Inbred CBA; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Species Specificity | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Antagonism between intracerebroventricularly administered N-methyl-D-aspartate and bicuculline methiodide in induction of clonic seizures in mice.
Topics: Animals; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Seizures | 1990 |
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Lethal Dose 50; Male; Methaqualone; Mice; Molecular Structure; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine | 1990 |
The central medial nucleus: thalamic site of seizure regulation.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Female; Muscimol; Rats; Rats, Inbred Strains; Seizures; Thalamic Nuclei | 1990 |
Paroxysmal depolarization shifts induced by bicuculline in CA3 neurons of hippocampal slices: suppression by the organic calcium antagonist verapamil.
Topics: Animals; Bicuculline; Guinea Pigs; Hippocampus; In Vitro Techniques; Seizures; Verapamil | 1990 |
Long-term changes in sensitivity to GABA in dorsal raphe neurons following amygdala kindling.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Convulsants; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1990 |
Suppression of spontaneous generalized non-convulsive seizures in the rat by microinjection of GABA antagonists into the superior colliculus.
Topics: Animals; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi | 1990 |
Substance P antagonists in substantia nigra are anticonvulsant.
Topics: Animals; Bicuculline; Male; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Substance P; Substantia Nigra | 1986 |
Spontaneous EEG spikes in the normal hippocampus. V. Effects of ether, urethane, pentobarbital, atropine, diazepam and bicuculline.
Topics: Anesthetics; Animals; Atropine; Behavior, Animal; Bicuculline; Diazepam; Electroencephalography; Ether; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Pentobarbital; Rats; Reference Values; Seizures; Urethane | 1988 |
Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Female; Flumazenil; Male; Mice; Pentylenetetrazole; Phenobarbital; Reaction Time; Seizures; Sleep | 1989 |
Convulsant properties of GABA antagonists and anticonvulsant properties of ethanol in selectively bred long- and short-sleep mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Mice; Picrotoxin; Seizures | 1989 |
Modification of ethanol effects by bicuculline: genotype-dependent responses and inheritance.
Topics: Animals; Bicuculline; Body Temperature; Ethanol; Genetics, Behavioral; Genotype; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Postural Balance; Seizures; Sleep | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Chemistry; Diazepam; Drug Tolerance; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1989 |
Anticonvulsant action of GABA receptor blockade in the nigrotectal target region.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Seizures; Substantia Nigra; Superior Colliculi | 1989 |
Evidence for the involvement of nigral GABAA receptors in seizures of adult rats.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Substantia Nigra | 1989 |
Cortical Na+,K+-ATPase of immature rats following bicuculline-induced seizures.
Topics: Aging; Animals; Bicuculline; Cerebral Cortex; Enzyme Activation; Male; Potassium; Rats; Rats, Inbred Strains; Seizures; Sodium-Potassium-Exchanging ATPase | 1989 |
[35S]TBPS binding sites are decreased in the colliculi of mice with a genetic predisposition to bicuculline-induced seizures.
Topics: Animals; Autoradiography; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Female; Inferior Colliculi; Mice; Receptors, GABA-A; Seizures; Superior Colliculi | 1989 |
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Colliculi; N-Methylaspartate; Picrotoxin; Rats; Seizures; Valine | 1989 |
Synchronized neuronal activities in neocortical explant cultures.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Magnesium; Membrane Potentials; Neural Conduction; Organ Culture Techniques; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1989 |
Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Glutamates; Male; Morphine; Muscimol; Olfactory Bulb; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures; Substantia Nigra; Valine | 1989 |
Adenosine A1 receptor activation mediates suppression of (-) bicuculline methiodide-induced seizures in rat prepiriform cortex.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autoradiography; Bicuculline; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Seizures | 1989 |
Autoregulation of cerebral blood flow. Effect of phenobarbital and pancuronium in the newborn piglet.
Topics: Animals; Animals, Newborn; Bicuculline; Blood Gas Analysis; Cardiac Output; Cerebrovascular Circulation; Pancuronium; Phenobarbital; Seizures; Swine | 1989 |
Increased susceptibility of detelencephalated rats to audiogenic seizures induced by microinjection of bicuculline into the inferior colliculus.
Topics: Acoustic Stimulation; Animals; Bicuculline; Cerebral Cortex; Cerebral Decortication; Inferior Colliculi; Male; Rats; Rats, Inbred Strains; Seizures; Telencephalon | 1989 |
Regional voltage map of the hippocampus during seizures.
Topics: Animals; Bicuculline; Diagnosis, Computer-Assisted; Electroencephalography; Electrophysiology; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures; Trypan Blue | 1989 |
Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; Ketamine; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains; Seizures; Thalamus | 1989 |
The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Pons; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Superior Colliculi | 1989 |
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Ethanol; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Sesterterpenes; Substance Withdrawal Syndrome | 1989 |
Effects of the diterpene sclareol glycol on convulsive seizures.
Topics: Animals; Bicuculline; Colforsin; Convulsants; Diterpenes; Drug Synergism; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1989 |
3-(Methoxycarbonyl)-amino-beta-carboline reduces both the sedative and anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Carbolines; Diazepam; Hypnotics and Sedatives; Male; Mice; Seizures; Time Factors | 1989 |
Effect of subconvulsive doses of bicuculline on the incorporation of radioactive precursors into glycerolipids in rat brain areas.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamines; Female; Glycerol; Glycolipids; Injections, Intraventricular; Phospholipids; Rats; Rats, Inbred Strains; Seizures | 1989 |
Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Seizures; Theophylline; Time Factors | 1989 |
Systemically administered glycine protects against strychnine convulsions, but not the behavioural effects of high pressure, in mice.
Topics: Animals; Atmospheric Pressure; Bicuculline; Dose-Response Relationship, Drug; Glycine; High Pressure Neurological Syndrome; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Strychnine; Time Factors | 1989 |
Role of pulmonary edema in phasic changes of cerebral oxygenation during serial seizures.
Topics: Animals; Bicuculline; Brain; Electron Transport Complex IV; Hemodynamics; Hydrogen-Ion Concentration; Male; Oxygen Consumption; Pentylenetetrazole; Pulmonary Edema; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1987 |
Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Female; Male; Rats; Receptors, GABA-A; Receptors, Purinergic; Seizures | 1987 |
Effect of peptidyl-dipeptidase inhibitors in experimental convulsions in mice.
Topics: Animals; Bicuculline; Captopril; Dipeptidases; Enalapril; Enzyme Inhibitors; Female; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Seizures; Strychnine | 1987 |
Changes in benzodiazepine/GABA receptor complex function in benzodiazepine-tolerant mice.
Topics: Animals; Anticonvulsants; Bicuculline; Body Temperature; Drug Tolerance; Flurazepam; gamma-Aminobutyric Acid; Infusions, Intravenous; Male; Mice; Motor Activity; Pentobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
Regional changes in transmitter amino acids during focal and generalized seizures in rats.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Brain; Glucose; Hippocampus; Kainic Acid; Lactates; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Seizures | 1985 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Activation of a cranial vasodilator pathway during seizures in rats.
Topics: Animals; Atropine; Bicuculline; Cerebrovascular Circulation; Hexamethonium; Hexamethonium Compounds; Male; Microspheres; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Spinal Cord; Sympathetic Nervous System; Vasodilation | 1986 |
Effect of inferior olive lesion on seizure threshold in the rat.
Topics: Animals; Bicuculline; Cerebellum; Convulsants; Male; Motor Activity; Neural Pathways; Olivary Nucleus; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Strychnine | 1987 |
Opioid mechanisms involved in the slow potential change and neuronal refractoriness during cortical spreading depression.
Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Electroshock; gamma-Aminobutyric Acid; Gerbillinae; Glutamates; Glutamic Acid; Injections, Intravenous; Iontophoresis; Naloxone; Rats; Rats, Inbred Strains; Reaction Time; Seizures | 1987 |
A proconvulsant action of selective alpha 2-adrenoceptor antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Carbolines; Convulsants; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1988 |
Benzodiazepines increase tonic component of postdecapitation convulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Decerebrate State; Flumazenil; Male; Mice; Mice, Inbred Strains; Picrotoxin; Receptors, GABA-A; Seizures | 1988 |
Role of prostanoids in cerebrovascular responses during seizures in piglets.
Topics: Animals; Animals, Newborn; Bicuculline; Cerebrovascular Circulation; Fatty Acids; Female; Indomethacin; Male; Microspheres; Prostanoic Acids; Seizures; Swine | 1989 |
Role of endogenous adenosine in recurrent generalized seizures.
Topics: Adenosine; Animals; Bicuculline; Blood Pressure; Cats; Cerebral Cortex; Dipyridamole; Doxapram; Naloxone; Penicillins; Receptors, Purinergic; Reference Values; Seizures; Theophylline | 1989 |
Trigeminovascular fibers increase blood flow in cortical gray matter by axon reflex-like mechanisms during acute severe hypertension or seizures.
Topics: Angiotensin II; Animals; Axons; Bicuculline; Blood Pressure; Cats; Cerebrovascular Circulation; Female; Ganglionectomy; Hypercapnia; Hypertension; Male; Organ Specificity; Periaqueductal Gray; Reference Values; Reflex; Seizures; Trigeminal Nerve | 1989 |
Cerebral superoxide anion generation during seizures in newborn pigs.
Topics: Animals; Animals, Newborn; Bicuculline; Nitroblue Tetrazolium; Seizures; Superoxide Dismutase; Swine; Tetrazolium Salts | 1989 |
The basal ganglia, the deep prepyriform cortex, and seizure spread: bicuculline is anticonvulsant in the rat striatum.
Topics: Animals; Basal Ganglia; Bicuculline; Brain; Corpus Striatum; Male; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sleep | 1985 |
Securinine alkaloids: a new class of GABA receptor antagonist.
Topics: Alkaloids; Animals; Azepines; Bicuculline; Cats; Central Nervous System; Convulsants; Female; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Lactones; Mice; Mice, Inbred ICR; Piperidines; Receptors, GABA-A; Seizures; Stimulation, Chemical | 1985 |
Kynurenine may directly interact with GABA receptors in rat brain.
Topics: Animals; Bicuculline; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Injections, Intraventricular; Kynurenine; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tryptophan | 1985 |
Infusion of opiates into substantia nigra protects against maximal electroshock seizures in rats.
Topics: Animals; Bicuculline; Electroshock; Enkephalin, Methionine; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Substantia Nigra | 1985 |
EEG changes induced by convulsants interfering with GABAergic inhibition in rats. I. Cortical recordings.
Topics: 3-Mercaptopropionic Acid; Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Cerebral Cortex; Electroencephalography; GABA Antagonists; Male; Rats; Seizures; Sulfhydryl Compounds; Synaptic Transmission | 1985 |
Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences.
Topics: Animals; Bicuculline; Brain; Delayed-Action Preparations; Diazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Serotonin | 1985 |
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picrotoxin; Pipecolic Acids; Proline; Receptors, GABA-A; Seizures; Strychnine | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; Muscimol; Pentobarbital; Receptors, GABA-A; Seizures | 1985 |
A possible role of a GABAergic mechanism in the convulsant action of RO5-4864.
Topics: Animals; Benzodiazepinones; Bicuculline; Convulsants; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1985 |
The effect of vanadate on Na+,K+-ATPase activity of mouse cerebral cortex during bicuculline-induced seizures.
Topics: Animals; Bicuculline; Cerebral Cortex; Freezing; Male; Mice; Mice, Inbred ICR; Seizures; Sodium-Potassium-Exchanging ATPase; Tissue Preservation; Vanadates; Vanadium | 1986 |
What is the correct value for Na, K-ATPase activity in homogenates of cerebral cortex?
Topics: Adenosine Triphosphatases; Animals; Bicuculline; Cerebral Cortex; Drug Resistance; Drug Stability; Freezing; Histological Techniques; Male; Membranes; Ouabain; Rats; Rats, Inbred Strains; Seizures; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 1986 |
GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Baclofen; Benzodiazepinones; Bicuculline; Ethanol; Geniculate Bodies; Inferior Colliculi; Kainic Acid; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stereoisomerism; Substance Withdrawal Syndrome | 1986 |
Benzodiazepine-receptor mediated convulsions in infant rats: effects of beta-carbolines.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Flurazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1986 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; Harmaline; Male; Mice; Mice, Inbred DBA; Ouabain; Papio; Pentylenetetrazole; Picrotoxin; Rats; Riluzole; Seizures; Synaptic Transmission; Thiazoles | 1985 |
Tofizopam selectively increases the action of anticonvulsants.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Bicuculline; Drug Synergism; Electroshock; Male; Mice; Receptors, GABA-A; Seizures | 1986 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscimol; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Clomipramine; Depressive Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; Imipramine; Male; Olfactory Bulb; Rats; Receptors, GABA-A; Seizures; Sleep | 1987 |
Cerebral phosphoinositide, triacylglycerol and energy metabolism during sustained seizures induced by bicuculline.
Topics: Animals; Bicuculline; Brain; Electroencephalography; Energy Metabolism; Glycolysis; Lipid Metabolism; Male; Phosphatidylinositols; Rats; Rats, Inbred Strains; Seizures; Triglycerides | 1987 |
Metabolic anatomy of generalized bicuculline seizures in the newborn marmoset monkey.
Topics: Animals; Animals, Newborn; Autoradiography; Bicuculline; Brain; Callitrichinae; Carbon Radioisotopes; Deoxy Sugars; Deoxyglucose; Seizures; Tissue Distribution | 1986 |
Sex differences in the sensitivity of CBA mice to convulsions induced by GABA antagonists are age-dependent.
Topics: Aging; Animals; Bicuculline; Female; GABA Antagonists; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Sex Factors; Strychnine | 1987 |
Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration.
Topics: Animals; Behavior, Animal; Benzodiazepines; Bicuculline; Drug Tolerance; Flumazenil; gamma-Aminobutyric Acid; Iontophoresis; Male; Neurons; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1988 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
Continuous determination of the cerebrovascular changes induced by bicuculline and kainic acid in unanaesthetized spontaneously breathing rats.
Topics: Action Potentials; Animals; Bicuculline; Blood Pressure; Brain; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Evoked Potentials; Hippocampus; Kainic Acid; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Seizures | 1987 |
Generalized seizures deplete brain energy reserves in normoxemic newborn monkeys.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Bicuculline; Brain; Callitrichinae; Energy Metabolism; Glucose; Lactates; Lactic Acid; NAD; Phosphocreatine; Seizures | 1988 |
Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks.
Topics: Animals; Bicuculline; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Electroshock; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Picrotoxin; Reinforcement, Psychology; Seizures | 1988 |
Effects of progabide on bicuculline-induced epileptic seizures in developing rats.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Seizures; Status Epilepticus | 1988 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Synaptic and non-synaptic mechanisms underlying low calcium bursts in the in vitro hippocampal slice.
Topics: Action Potentials; Animals; Bicuculline; Calcium; Chlorides; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Seizures; Synapses | 1988 |
Incorporation of glycerol and ethanolamine into glycerophospholipid in rat brain areas during bicuculline-induced convulsive seizures.
Topics: Animals; Bicuculline; Brain Stem; Carbon Radioisotopes; Cerebellum; Cerebral Cortex; Ethanolamine; Ethanolamines; Female; Glycerol; Hippocampus; Phosphatidic Acids; Rats; Rats, Inbred Strains; Seizures; Tritium | 1988 |
Regional cerebral glucose utilization during vasopressin-induced barrel rotations or bicuculline-induced seizures in rats.
Topics: Animals; Arginine Vasopressin; Bicuculline; Brain; Glucose; Male; Motor Activity; Rats; Rats, Inbred Strains; Seizures; Tissue Distribution | 1988 |
Lack of correlation between the anaesthetic and anti-convulsant potencies of althesin, ketamine and methohexitone.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Anticonvulsants; Bicuculline; Female; Ketamine; Methohexital; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1988 |
A comparison of prodrug esters of nipecotic acid.
Topics: Animals; Anticonvulsants; Bicuculline; Esters; GABA Antagonists; Male; Mice; Nipecotic Acids; Parasympathomimetics; Pentylenetetrazole; Pharmaceutical Preparations; Prodrugs; Proline; Seizures; Strychnine | 1988 |
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Cerebrovascular Circulation; Dogs; Glucose; Hemodynamics; Hydrogen; Hypoglycemia; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Phosphorus; Seizures | 1987 |
GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists.
Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Anticonvulsants; Barbiturates; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Picrotoxin; Rats; Seizures; Semicarbazides | 1987 |
Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Muscimol; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra | 1987 |
Anticonvulsant effects of GABA elevation in the deep prepiriform cortex.
Topics: Aminocaproates; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Seizures; Vigabatrin | 1987 |
Glycerol as an indicator of lipid degradation in bicuculline-induced seizures and experimental cerebral ischemia.
Topics: Adenosine Triphosphate; Animals; Bicuculline; Cats; Female; Fluorometry; Glycerol; Ischemic Attack, Transient; Lactates; Lactic Acid; Male; Phospholipids; Seizures | 1986 |
Induction of audiogenic seizure susceptibility by focal infusion of excitant amino acid or bicuculline into the inferior colliculus of normal rats.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Bicuculline; Inferior Colliculi; Male; Microinjections; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi | 1986 |
Anterior thalamic mediation of generalized pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Female; Guinea Pigs; Kainic Acid; Microinjections; Muscimol; Pentylenetetrazole; Seizures; Stereotaxic Techniques; Thalamic Nuclei; Vigabatrin | 1986 |
Seizure-associated pulmonary edema and cerebral oxygenation in the rat.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Male; Oxygen Consumption; Pulmonary Edema; Rats; Rats, Inbred Strains; Seizures | 1987 |
Differential convulsive susceptibility of high-activity and low-activity selected mice in response to GABA antagonists.
Topics: Animals; Behavior, Animal; Bicuculline; Female; Flurothyl; GABA Antagonists; Male; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1987 |
Seizure activity and cortical spreading depression monitored by an extrinsic potential-sensitive molecular probe.
Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Female; Gerbillinae; Male; Mitochondria; Picrotoxin; Potassium Chloride; Seizures | 1987 |
Regional cerebral energy metabolism in bicuculline induced seizures.
Topics: Adenosine Triphosphate; Animals; Bicuculline; Cerebellum; Energy Metabolism; Female; Glucose; Mice; Motor Cortex; Phosphocreatine; Seizures | 1987 |
Cerebellar metabolism of phosphatidylethanolamine and its water-soluble precursors during bicuculline-induced convulsive seizures.
Topics: Animals; Bicuculline; Cerebellum; Cytidine Diphosphate; Ethanolamines; Female; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; Seizures | 1987 |
Differential sensitivity to bicuculline in three inbred mouse strains.
Topics: Action Potentials; Animals; Bicuculline; Electric Stimulation; Epilepsy; Female; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Seizures; Species Specificity | 1987 |
Interstitial fluid adenosine and sagittal sinus blood flow during bicuculline-seizures in newborn piglets.
Topics: Adenosine; Animals; Animals, Newborn; Bicuculline; Cerebrovascular Circulation; Cranial Sinuses; Extracellular Space; Hemodynamics; Hypoxanthine; Hypoxanthines; Inosine; Seizures; Swine | 1987 |
Cerebellar metabolism of phosphatidylcholine and its hydrosoluble precursors during bicuculline-induced convulsive seizures.
Topics: Animals; Bicuculline; Cerebellum; Choline; Female; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Inbred Strains; Seizures; Solubility; Time Factors | 1986 |
Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Electroencephalography; Injections; Male; Muscimol; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra | 1986 |
Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.
Topics: Animals; Bicuculline; Brain Diseases; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1986 |
Inferior colliculus neuronal response abnormalities in genetically epilepsy-prone rats: evidence for a deficit of inhibition.
Topics: Acoustic Stimulation; Animals; Bicuculline; gamma-Aminobutyric Acid; Inferior Colliculi; Neurons; Rats; Rats, Mutant Strains; Seizures | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; Epilepsy; Kainic Acid; Methionine Sulfoximine; Pentylenetetrazole; Pyridoxine; Rabbits; Seizures | 1986 |
Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Hippocampus; Kainic Acid; Limbic System; Male; Nerve Degeneration; Neural Inhibition; Neural Pathways; Phenobarbital; Rats; Seizures; Time Factors | 1986 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid | 1985 |
In vivo interactions between the benzodiazepine antagonist Ro 15-1788 and the steroid anaesthetic althesin in rats.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Benzodiazepinones; Bicuculline; Drug Synergism; Drug Therapy, Combination; Female; Flumazenil; Pregnanediones; Rats; Rats, Inbred Strains; Seizures | 1985 |
Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates.
Topics: 2-Chloroadenosine; Adenosine; Aminophylline; Animals; Benzodiazepinones; Bicuculline; Brain; Carbolines; Convulsants; Electroencephalography; Flumazenil; Male; Motor Activity; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1985 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Male; Microinjections; Muscimol; Rats; Rats, Inbred Strains; Seizures | 1986 |
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Hypnotics and Sedatives; Kindling, Neurologic; Male; Mice; Motor Skills; Papio; Pentylenetetrazole; Photic Stimulation; Pyridazines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1986 |
Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channel Blockers; Central Nervous System; Convulsants; Drug Evaluation, Preclinical; Electroencephalography; Ischemia; Nicotinic Acids; Nimodipine; Pentylenetetrazole; Perfusion; Rabbits; Seizures; Verapamil | 1986 |
Injections of picrotoxin and bicuculline into the amygdaloid complex of the rat: an electroencephalographic, behavioural and morphological analysis.
Topics: Amygdala; Animals; Behavior, Animal; Bicuculline; Drug Interactions; Electroencephalography; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1985 |
Intracerebral site of convulsant action of bicuculline.
Topics: Animals; Bicuculline; Brain; Electroencephalography; Male; Rats; Rats, Inbred Strains; Seizures | 1985 |
Regional cerebral blood flow during bicuculline-induced seizures in the newborn piglet: effect of phenobarbital.
Topics: Acid-Base Equilibrium; Animals; Animals, Newborn; Bicuculline; Blood Gas Analysis; Blood Pressure; Cerebrovascular Circulation; Microspheres; Phenobarbital; Potassium Chloride; Seizures; Swine; Time Factors | 1985 |
Antiepileptic drugs: detection, quantification, and evaluation.
Topics: Age Factors; Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1985 |
Anticonvulsant actions of enflurane on epilepsy models in cats.
Topics: Amygdala; Animals; Anticonvulsants; Bicuculline; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Enflurane; Epilepsy; Female; Kindling, Neurologic; Male; Penicillin G; Seizures | 1985 |
Influence of reduced oxygen availability on cerebral metabolic changes during bicuculline-induced seizures in rats.
Topics: Animals; Bicuculline; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Hypoxia, Brain; Male; Oxygen; Rats; Rats, Inbred Strains; Seizures | 1985 |
Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures.
Topics: Adaptation, Psychological; Animals; Bicuculline; Electroshock; Escape Reaction; gamma-Aminobutyric Acid; Male; Myoclonus; Rats; Seizures | 1985 |