bicuculline has been researched along with Aura in 274 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (17.15) | 18.7374 |
| 1990's | 102 (37.23) | 18.2507 |
| 2000's | 95 (34.67) | 29.6817 |
| 2010's | 29 (10.58) | 24.3611 |
| 2020's | 1 (0.36) | 2.80 |
| Authors | Studies |
|---|---|
| Estin, J; Li, D; Li, J; Lin, W; Liou, JY; Luo, P; Ma, H; Niemeyer, JE; Schwartz, TH; Yang, F; Zhan, F; Zhao, M | 1 |
| Bagó, AG; Entz, L; Erőss, L; Fabó, D; Hofer, KT; Jordán, Z; Kandrács, Á; Nagy, G; Tóth, EZ; Tóth, K; Ulbert, I; Wittner, L | 1 |
| Ding, K; Gross, RE; Shiu, FH; Tung, JK | 1 |
| Pan, YZ; Rutecki, PA; Sutula, TP | 1 |
| Bazan, N; Lu, Y; Pei, L; Shang, Y; Tian, Q; Wang, X; Wen, R; Yang, Y; Zhao, K; Zhu, LQ | 1 |
| Albertson, AJ; Hablitz, JJ; Williams, SB | 1 |
| Buhler, E; Chauvin, Y; Jalabert, M; Malvache, A; Manent, JB; Peret, A; Petit, LF; Represa, A; Watrin, F | 1 |
| Kubová, H; Mareš, P | 1 |
| Bernard, C; Ivanov, AI; Turner, DA | 1 |
| Hasegawa, M; Hongo, Y; Ikegaya, Y; Ogawa, K; Sakaguchi, G; Takasu, K | 1 |
| Grandjean, J; Rudin, M; Schroeter, A; Seuwen, A | 1 |
| Dudek, FE; Kadam, SD | 1 |
| Bénar, CG; Bernard, C; Ghestem, A; Giusiano, B; Hitziger, S; Ivanov, AI; Quilichini, PP; Saillet, S; Vanzetta, I | 1 |
| Fujiwara, A; Kamei, C; Takechi, K; Watanabe, Y | 1 |
| Ma, H; Schwartz, TH; Suh, M; Zhao, M | 1 |
| Ben-Ari, Y; Khalilov, I; Nardou, R | 1 |
| Deisz, RA; Lehmann, TN; Meencke, HJ; Nitsch, R; Teichgräber, LA; Weiss, T | 1 |
| Godukhin, OV; Levin, SG; Parnyshkova, EY | 1 |
| Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG | 1 |
| Khan, RS; Mathew, J; Paulose, CS; Peeyush Kumar, T | 1 |
| Basuroy, S; Leffler, CW; Parfenova, H; Tcheranova, D; Zimmermann, A | 1 |
| Bénar, CG; Bernard, C; Flynn, C; Ivanov, AI; Vanzetta, I | 1 |
| Bullis, JB; Jones, TD; Jung, S; Lau, IH; Poolos, NP; Warner, LN | 1 |
| Paz, C; Retana-Márquez, S; Rubio, C; Rubio-Osornio, M; Verónica Custodio, ML | 1 |
| Behrens, CJ; Caliskan, G; Heinemann, U; Hollnagel, JO; Liotta, A; Rösler, A; ul Haq, R | 1 |
| Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J | 1 |
| Chevalier, M; Doren, EL; Frim, DM; Koch, H; Kohrman, MH; Lasky, RE; Lew, SM; Marcuccilli, CJ; Mrejeru, A; Peña-Ortega, F; Pytel, P; Ramirez, JM; Tryba, AK; van Drongelen, W; Viemari, JC | 1 |
| Alania, M; Doreulee, N; Kapanadze, Ts; Skhirtladze, E; Vashalomidze, G | 1 |
| Becker, AJ; Friedman, A; Gitler, D; Kahn, J; Ketzef, M; Weissberg, I | 1 |
| Feuerstein, TJ; Freiman, I; Freiman, TM; Knop, T; Kovacs, FE; Szabo, B; Urbanski, MJ; Zentner, J | 1 |
| Aaron, G; Quach-Wong, B; Sonnenfeld, J; Storch, G; Walker, J | 1 |
| Bernášková, K; Kubová, H; Mareš, P | 1 |
| Haglund, MM | 1 |
| Krogh, KA; Li, Y; Thayer, SA | 1 |
| de Curtis, M; Librizzi, L; Noè, F; Ravizza, T; Vezzani, A | 1 |
| Banczerowski-Pelyhe, I; Détári, L; Dóczi, J; Gulyás-Kovács, A; Tarnawa, I; Világi, I | 1 |
| Benardete, EA; Kriegstein, AR | 1 |
| Hanaya, R; Kiura, Y; Kurisu, K; Sasa, M; Serikawa, T | 1 |
| Bianchi, R; Chuang, SC; Lee, AC; Shin, HS; Wong, RK | 1 |
| Choudhary, MI; DeLorenzo, RJ; Rahman, AU; Raza, M; Shaheen, F; Sombati, S | 1 |
| Behne, F; Ebner, A; Gorji, A; Höhling, JM; Köhling, R; Lahl, R; Madeja, M; Panneck, HW; Speckmann, EJ; Straub, H; Tuxhorn, I; Wolf, P | 1 |
| Rubaj, A; Sieklucka-Dziuba, M; Zgodziński, W | 1 |
| Misgeld, U; Yanovsky, Y | 1 |
| de Curtis, M; Librizzi, L | 1 |
| Browning, RA; Clough, RW; Jobe, PC; Merrill, MA | 1 |
| Conquet, F; Pralong, E; Stoop, R | 1 |
| Miyakawa, N; Momose-Sato, Y; Sasaki, S; Sato, K; Yazawa, I | 1 |
| Rutecki, PA; Sayin, U | 1 |
| Hagemann, G; Koch, UR; Köhling, R; Redecker, C; Speckmann, EJ; Straub, H | 1 |
| Maiorov, VI | 1 |
| Gorji, A; Scheller, D; Speckmann, EJ | 1 |
| Aker, R; Gören, MZ; Onat, FY; Yananli, HR | 1 |
| Adamchik, Y; Carlen, PL; Li, J; Naus, CC; Pelletier, MR; Samoilova, M; Wentlandt, K | 1 |
| Perez Velazquez, JL | 1 |
| Musshoff, U; Speckmann, EJ | 1 |
| Cobb, SR; Davies, CH; Ferrigan, L; Khoshnood, MJ; Roshan-Milani, S | 1 |
| Ma, HT; Wu, CH; Wu, JY | 1 |
| Bernásková, K; Kaminskij, Y; Mares, P; Zivanović, D | 1 |
| Albrecht, D; Klueva, J; Munsch, T; Pape, HC | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Albensi, BC; Ata, G; Janigro, D; Schmidt, E; Waterman, JD | 1 |
| Castro-Alamancos, MA; Rigas, P | 1 |
| Crowley, JC; Katz, LC; Mizrahi, A; Shtoyerman, E | 1 |
| Blumenfeld, H; Hyder, F; Nersesyan, H; Rothman, DL | 1 |
| Bernardi, G; Bonsi, P; Calabresi, P; Costa, C; De Persis, C; Martella, G; Pisani, A; Pisani, F | 1 |
| Bae, YC; Cho, JH; Choi, BJ; Choi, IS; Jung, SC; Kim, JH; Lee, MG | 1 |
| Campbell, SL; Hablitz, JJ | 1 |
| Namiki, A; Ohmori, H; Sato, Y | 1 |
| Buzsáki, G; Creso, J; Hirase, H | 1 |
| Patel, LS; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Bahar, S; Mehta, AD; Schwartz, TH; Suh, M | 1 |
| Broberger, C; McCormick, DA | 1 |
| Katleba, K; Schwartzkroin, PA; Tschuluun, N; Wenzel, JH | 1 |
| Brown, JT; Calver, AR; Collingridge, GL; Davies, CH; Randall, A; Thuault, SJ | 1 |
| Campbell, S; Hablitz, JJ | 1 |
| de Curtis, M; Librizzi, L; Uva, L; Wendling, F | 1 |
| Brown, JT; Cobb, SR; Davies, CH; Farmer, C; Gill, CH; Lappin, SC; McNaughton, NC; Randall, A; Shivji, N | 1 |
| Debanne, D; Gähwiler, BH; Thompson, SM | 1 |
| Browning, RA; Cranick, S; Patrylo, PR | 1 |
| Borbély, S; Détári, L; Halasy, K; Somogyvári, Z; Világi, I | 1 |
| de Curtis, M; Labyt, E; Uva, L; Wendling, F | 1 |
| Guan, X; Li, X; Li, Y; Ouyang, G | 1 |
| Bankirer, Y; Schiller, Y | 1 |
| de Curtis, M; Frassoni, C; Frigerio, S; Librizzi, L; Pastori, C; Regondi, MC | 1 |
| Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS | 1 |
| Addae, JI; Ali, N; Stone, TW; Youssef, FF | 1 |
| Jiruska, P; Mares, P; Otáhal, J; Proks, J | 1 |
| Bertram, EH; Williamson, JM; Zhang, D | 1 |
| Carney, P; Jiang, H; Liang, X; Liu, Z; Wang, Q; Zhang, Q | 1 |
| Butuzova, MV; Kitchigina, VF | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Carney, PR; Chen, H; Jiang, H; Liu, Z; Roper, SN; Yuan, Z; Zhang, Q | 1 |
| Iyengar, SS; Mott, DD | 1 |
| Campbell, AM; Holmes, O | 1 |
| Brady, RJ; Swann, JW | 1 |
| Kostopoulos, G | 1 |
| Campbell, BG; Chow, KL; Crabtree, JW; Ostrach, LH | 2 |
| Al-Sayegh, A; Ebadi, M; Hammad, HM; Swanson, S | 1 |
| Fujiwara, K; Klatzo, I; Nitsch, C; Suzuki, R | 2 |
| Kiessling, M; Kleihues, P; Xie, Y | 1 |
| Haglund, MM; Schwartzkroin, PA | 1 |
| Fujiwara, K; Klatzo, I; Kuroiwa, T; Nitsch, C | 1 |
| Kiessling, M; Kleihues, P | 1 |
| Albowitz, B; Kuhnt, U | 2 |
| Alkadhi, KA; Salgado, D | 1 |
| Greenberg, DA; Lowry, T; Sasahira, M; Simon, RP | 1 |
| Avoli, M; Drapeau, C; Kurcewicz, I; Louvel, J; Pumain, R | 1 |
| Pencek, TL; Verma-Ahuja, S | 1 |
| Evans, MS; Faingold, CL; Li, Y | 1 |
| Hablitz, JJ; Rucker, F; Sutor, B; ten Bruggencate, G | 1 |
| Debanne, D; Gähwiler, BH; Müller, M; Scanziani, M; Thompson, SM | 1 |
| Piguet, P | 1 |
| Dudek, FE; Kim, YI; Peacock, WJ | 1 |
| Ben-Ari, Y; Gaiarsa, JL; Zagrean, L | 1 |
| Caspary, DM; Evans, MS; Faingold, CL; Viola-McCabe, KE | 1 |
| Dudek, FE; Patrylo, PR; Schweitzer, JS | 2 |
| Burke, JP; Hablitz, JJ | 1 |
| Scharfman, HE | 1 |
| Sowell, KL; Stringer, JL | 1 |
| Gähwiler, BH; Müller, M; Rietschin, L; Thompson, SM | 1 |
| Avoli, M; Fueta, Y | 1 |
| Chang, FC; Gean, PW; Hung, CR | 1 |
| Jefferys, JG; Watts, AE; Whittington, MA | 1 |
| Bloms-Funke, P; Madeja, M; Musshoff, U; Speckmann, EJ | 1 |
| Bravo, R; Gass, P; Herdegen, T; Kiessling, M; Sandkühler, J; Zimmermann, M | 1 |
| Bingmann, D; Bonnet, U | 1 |
| Müller, M | 1 |
| Fried, I; Isokawa, M | 1 |
| Higashima, M; Kinoshita, H; Koshino, Y; Yamaguchi, N | 1 |
| Borck, C; Colling, SB; Jefferys, JG; Traub, RD | 1 |
| Dudek, FE; Meier, CL | 1 |
| Rasmussen, PA; Rutecki, PA; Yang, Y | 1 |
| Jefferys, JG; Whittington, MA | 1 |
| Biella, G; de Curtis, M; Forti, M | 1 |
| Alkadhi, KA; Salgado-Commissariat, D | 1 |
| Biella, G; Caccia, S; de Curtis, M; Forti, M | 1 |
| Albowitz, B; König, P; Kuhnt, U | 1 |
| Abraham, LA; Boillot, MA; King, MA; Roper, SN | 1 |
| Eder, HG; Fisher, RS; Jones, DB | 1 |
| Ameri, A; Gleitz, J; Peters, T | 1 |
| Avoli, M; Hwa, G; Kurcewicz, I; Lacaille, JC; Louvel, J; Pumain, R | 1 |
| Costa da Costa, J; Russo, RE; Velluti, JC | 1 |
| Ameri, A | 2 |
| Akimitsu, T; Amano, T; Arita, K; Hanaya, R; Iida, K; Ishihara, K; Kurisu, K; Sasa, M; Serikawa, T | 1 |
| Rutecki, PA; Yang, Y | 1 |
| deBeer Zeiger, J | 1 |
| Herreras, O; Lerma, J; Rodríguez-Moreno, A | 1 |
| Haberly, LB; Kapur, A; Lytton, WW; Pearce, RA | 1 |
| Beck, SG; Birnstiel, S; Wülfert, E | 1 |
| Dudek, FE; Patrylo, PR | 1 |
| Niemi-Junkola, U; Redgrave, P; Shehab, S | 1 |
| Dallaire, F; Psarropoulou, C | 1 |
| Cody, C; Jones, RS; Maubach, KA | 1 |
| Behr, J; Lyson, KJ; Mody, I | 1 |
| Beaucher, J; Harnois, C; Psarropoulou, C | 1 |
| Köhling, R; Lücke, A; Mayer, T; Musshoff, U; Osterfeld, M; Schütte, W; Speckmann, EJ; Wolf, P | 1 |
| Higashi, H; Maeda, H; Shoji, Y; Tanaka, E; Yamamoto, S | 1 |
| Guan, L; Tsau, Y; Wu, JY | 1 |
| Contreras, D; Steriade, M | 1 |
| Amzica, F; Neckelmann, D; Steriade, M | 1 |
| Amzica, F; Neckelmann, D; Steriade, M; Timofeev, I | 1 |
| Jefferys, JG; Traub, RD | 1 |
| Luhmann, HJ; Sutor, B | 1 |
| Matejovská, I; Velísek, L; Velísková, J | 1 |
| D'Ambrosio, R; Hochman, DW; Janigro, D; Schwartzkroin, PA | 1 |
| Armand, V; Heinemann, U; Rundfeldt, C | 1 |
| Cheng, JS; Liu, J | 1 |
| Siggins, GR; Tallent, MK | 1 |
| Conti, M; De Luigi, A; De Simoni, MG; Marchesi, F; Moneta, D; Ravizza, T; Vezzani, A | 1 |
| Brückner, C; Heinemann, U; Meierkord, H; Stenkamp, K | 1 |
| Descombes, S; Gruslin, E; Psarropoulou, C | 1 |
| Bernásková, K; Mares, P; Slamberová, R | 1 |
| Descombes, S; Psarropoulou, C | 1 |
| Borck, C; Jefferys, JG | 1 |
| Alkadhi, KA; Otoom, SA | 1 |
| Hochman, DW; Schwartzkroin, PA | 1 |
| Margineanu, DG; Wülfert, E | 1 |
| Lynch, M; Sutula, T | 1 |
| Devaud, LL; Grobin, AC; Janis, GC; Matthews, DB; Morrow, AL; VanDoren, MJ | 1 |
| Aizenman, E; Gardner, G; Jensen, FE; Orlando, L; Rosenberg, PA; Sanchez, RM; Tauck, DL; Wang, C | 1 |
| Baraban, SC; Hochman, DW; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Carlen, PL; Frantseva, MV; Hwang, PA; Velazquez, JL | 1 |
| Lukasiuk, K; Pitkänen, A | 1 |
| Schindler, CJ; Slamberová, R; Vathy, I; Velísková, J | 1 |
| Epiney, S; Meier, E; Pralong, E; Stoop, R | 1 |
| Asprodini, E; Cope, DW; Crunelli, V; Emri, Z; Leresche, N | 1 |
| Chiou, LC; Gean, PW; Shen, YZ; Young, C | 1 |
| Mason, R; Parker, TL; Sokal, DM | 1 |
| Pralong, E; Stoop, R | 1 |
| Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M | 1 |
| Empson, RM; Gee, VJ; Newberry, NR; Sheardown, MJ | 1 |
| Ebner, A; Höhling, JM; Köhling, R; Lücke, A; Oppel, F; Pannek, H; Speckmann, EJ; Straub, H; Tuxhorn, I; Wolf, P | 1 |
| Karnup, S; Stelzer, A | 1 |
| Badea, T; Goldberg, J; Mao, B; Yuste, R | 1 |
| Biella, G; de Curtis, M; Librizzi, L | 1 |
| Cvitanović, P; Mogul, DJ; Slutzky, MW | 1 |
| Carlen, PL; Li, J; Naus, CC; Shen, H; Zhang, L | 1 |
| Anderson, KJ; Carney, PR; Chaves, AH; Garcia, J; Grimes, JR; Lee, N; MacLennan, AJ; Roper, SN; Zhu, WJ | 1 |
| Araque, A; Buño, W; Martín, ED | 1 |
| Schindler, CJ; Slamberová, R; Vathy, I | 1 |
| Higashima, M; Ohno, K | 1 |
| Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W | 1 |
| Dudek, FE; Smith, BN | 1 |
| Barton, ME; Bennett, GD; Bialer, M; Finnell, RH; Isoherranen, N; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B | 1 |
| Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S | 1 |
| Deisz, RA | 1 |
| Menendez de la Prida, L; Pozo, MA | 1 |
| Alpern, HP; Greer, CA | 1 |
| Bartholini, G | 1 |
| Meldrum, BS | 1 |
| Johansson, B; Nilsson, B | 1 |
| Brierley, JB; Meldrum, BS; Papy, JJ; Toure, MF | 1 |
| Dudek, FE; Peacock, WJ; Wuarin, JP | 1 |
| Cook, CJ; Devine, CE; Gilbert, KV; Tavener, A | 1 |
| Gean, PW | 1 |
| Wheal, HV; Williamson, R | 1 |
| Gale, K; Miller, LP; Murray, TF; Zhong, P | 1 |
| Ducić, I; Polc, P | 1 |
| Avoli, M; Hwa, GG; Oliver, A; Villemure, JG | 1 |
| Higashi, H; Nishi, S; Tanaka, E | 1 |
| Webster, RA; Zia-Gharib, F | 1 |
| Simpson, LH; Wheal, HV; Williamson, R | 1 |
| Avoli, M; Hwa, GG | 2 |
| de Feo, MR; Mecarelli, O; Ricci, G; Rina, MF | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Shandra, AA; Vikhrestiuk, SL | 1 |
| Budko, KP; Mares, P; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Avoli, M | 1 |
| Jones, RS; Lambert, JD | 1 |
| Buchwald, NA; Cepeda, C; Dudek, FE; Kim, YI; Peacock, WJ; Tasker, JG; Walsh, JP; Wuarin, JP | 1 |
| Simmet, T; Tippler, B | 1 |
| Bosy, TZ; Bowers, BJ; Wehner, JM | 1 |
| Kimura, H; Uemura, S | 1 |
| Ferrendelli, JA; Miller, JW | 1 |
| Furshpan, EJ; Segal, MM | 1 |
| Löscher, W; Wahnschaffe, U | 1 |
| Araki, N; Greenberg, JH; Reivich, M; Uematsu, D | 1 |
| Arezzo, JC; Givre, SJ; Schroeder, CE; Tenke, CE; Vaughan, HG | 1 |
| Ives, AE; Jefferys, JG | 1 |
| Albowitz, B; Ehrenreich, L; Kuhnt, U | 1 |
| Avoli, M; Tancredi, V | 1 |
| Kriegstein, AR; Shen, JM | 1 |
| Karlsson, G; Olpe, HR | 1 |
| Chagnac-Amitai, Y; Connors, BW | 1 |
| Johansson, BB; Kalimo, H; Sokrab, TE | 1 |
| Alzheimer, C; Sutor, B; ten Bruggencate, G | 1 |
| Higashima, M; Kim, JH; Masukawa, LM; Spencer, DD | 1 |
| Coenen, AM; Peeters, BW; van Rijn, CM; Vossen, JM | 1 |
| Collingridge, GL; Herron, CE; Williamson, R | 1 |
| Baldino, F; Gutnick, MJ; Heinemann, U; Wolfson, B | 1 |
| Meldrum, BS; Ottersen, OP; Storm-Mathisen, J; Swan, JH | 1 |
| Jones, RS | 1 |
| Ackerman, R; Engel, J; Yan, HJ | 1 |
| Gale, K | 1 |
| Lloyd, KG | 1 |
| Bazan, NG; Dobard, P; Vadnal, R; Van Rooijen, LA | 1 |
| Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV; Wang, CM | 1 |
| Koga, K; Miura, I | 1 |
| Larson-Prior, LJ; Slater, NT | 1 |
| Hagberg, H; Hamberger, A; Jacobson, I; Lazarewicz, JW; Lehmann, A | 1 |
| Chamberlin, NL; Dingledine, R; Giacchino, JL; Korn, SJ | 1 |
| Freund, RK; Marley, RJ; Wehner, JM | 1 |
| Chatt, AB; Ebersole, JS | 1 |
| Caspary, DM; Faingold, CL; Gehlbach, G | 1 |
| Sutch, CP; Swartzwelder, HS; Wilson, WA | 1 |
| Goping, G; Klatzo, I; Nitsch, C | 1 |
| Goping, G; Klatzo, I; Laursen, H; Nitsch, C | 1 |
| Mori, K; Oshima, E; Shingu, K; Urabe, N | 1 |
| de Feo, MR; Mecarelli, O; Ricci, GF | 1 |
5 review(s) available for bicuculline and Aura
| Article | Year |
|---|---|
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds | 2010 |
Functional and pharmacological properties of GABA-mediated inhibition in the human neocortex.
Topics: Bicuculline; Calcium; Cerebral Cortex; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Neural Inhibition; Potassium; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission | 1997 |
Epilepsy and gamma-aminobutyric acid-mediated inhibition.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Bicuculline; Brain; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Infant; Mice; Neural Inhibition; Receptors, Drug; Seizures; Structure-Activity Relationship; Synaptic Transmission | 1975 |
Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.
Topics: Animals; Bicuculline; Cell Compartmentation; Epilepsy; gamma-Aminobutyric Acid; Microinjections; Morphine; Muscimol; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Seizures; Substantia Nigra | 1985 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
269 other study(ies) available for bicuculline and Aura
| Article | Year |
|---|---|
Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain; Brain Mapping; Epilepsy | 2023 |
Presence of synchrony-generating hubs in the human epileptic neocortex.
Topics: Adult; Aged; Bicuculline; Epilepsy; Female; GABA-A Receptor Antagonists; Humans; Male; Middle Aged; Neocortex; Neurons; Receptors, GABA-A; Young Adult | 2019 |
Chemically activated luminopsins allow optogenetic inhibition of distributed nodes in an epileptic network for non-invasive and multi-site suppression of seizure activity.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Dentate Gyrus; Epilepsy; Imidazoles; Luminescent Agents; Male; Neural Inhibition; Neural Pathways; Opsins; Optogenetics; Pyrazines; Rats, Sprague-Dawley; Seizures | 2018 |
2-Deoxy-d-glucose reduces epileptiform activity by presynaptic mechanisms.
Topics: Animals; Bicuculline; CA3 Region, Hippocampal; Deoxyglucose; Epilepsy; Glycolysis; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Synaptic Potentials; Tetrodotoxin | 2019 |
EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability.
Topics: Animals; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Glutamic Acid; Guanine Nucleotide Exchange Factors; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kainic Acid; KATP Channels; Male; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Probability; Protein Binding; Quinoxalines; Synaptosomes; Transduction, Genetic | 2013 |
Regulation of epileptiform discharges in rat neocortex by HCN channels.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Cyclic Nucleotide-Gated Cation Channels; Epilepsy; GABAergic Neurons; Interneurons; Membrane Potentials; Neocortex; Pyramidal Cells; Pyrimidines; Rats; Synaptic Transmission | 2013 |
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Classical Lissencephalies and Subcortical Band Heterotopias; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electroencephalography; Electrophysiological Phenomena; Epilepsy; Gene Knockdown Techniques; Microtubule-Associated Proteins; Neocortex; Nerve Net; Neuropeptides; Pentylenetetrazole; Rats; Rats, Transgenic; Seizures; Somatosensory Cortex | 2014 |
GABAB, not GABAA receptors play a role in cortical postictal refractoriness.
Topics: Animals; Azepines; Bicuculline; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Epilepsy; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Pentylenetetrazole; Picrotoxin; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B | 2015 |
Metabolic responses differentiate between interictal, ictal and persistent epileptiform activity in intact, immature hippocampus in vitro.
Topics: Animals; Animals, Newborn; Bicuculline; Convulsants; Epilepsy; Flavin-Adenine Dinucleotide; GABA-A Receptor Antagonists; Hippocampus; Ions; Magnesium; Mice; Microelectrodes; NAD; Oxygen; Receptors, GABA-A; Tissue Culture Techniques | 2015 |
Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model--a functional multineuron calcium imaging study.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Calcium; Convulsants; Disease Models, Animal; Epilepsy; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Wistar; Statistics, Nonparametric | 2015 |
Metabolic changes assessed by MRS accurately reflect brain function during drug-induced epilepsy in mice in contrast to fMRI-based hemodynamic readouts.
Topics: Animals; Bicuculline; Brain; Epilepsy; Female; GABA-A Receptor Antagonists; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Neurovascular Coupling; Oxidative Stress; Proton Magnetic Resonance Spectroscopy | 2015 |
Temporal progression of evoked field potentials in neocortical slices after unilateral hypoxia-ischemia in perinatal rats: Correlation with cortical epileptogenesis.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; Functional Laterality; GABA Antagonists; Hypoxia-Ischemia, Brain; In Vitro Techniques; Neocortex; Rats; Rats, Sprague-Dawley | 2016 |
Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges.
Topics: Animals; Bicuculline; Cerebrovascular Circulation; Epilepsy; Evoked Potentials, Somatosensory; Interneurons; Male; Oxygen Consumption; Rats; Rats, Wistar; Somatosensory Cortex | 2016 |
Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice.
Topics: Animals; Anti-Bacterial Agents; Bicuculline; Brain; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electroencephalography; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Oximes; Phosphinic Acids; Pyridines; Teicoplanin | 2009 |
Hemodynamic surrogates for excitatory membrane potential change during interictal epileptiform events in rat neocortex.
Topics: Anesthetics, Inhalation; Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Evoked Potentials, Somatosensory; Hemodynamics; Hemoglobins; Isoflurane; Male; Membrane Potentials; Neocortex; Optics and Photonics; Photic Stimulation; Rats; Rats, Sprague-Dawley; Spectrum Analysis; Statistics as Topic | 2009 |
Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Bicuculline; Biophysics; Bumetanide; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agents; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Spectrum Analysis | 2009 |
Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; Drug Resistance; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Mice; Neurons; Phosphinic Acids; Propanolamines; Rats; Rats, Wistar; Receptors, GABA-B; Synaptic Transmission | 2009 |
The effects of interleukin-10 on the development of epileptiform activity in the hippocampus induced by transient hypoxia, bicuculline, and electrical kindling.
Topics: Animals; Bicuculline; Epilepsy; Hippocampus; Hypoxia, Brain; Interleukin-10; Kindling, Neurologic; Male; Rats; Rats, Wistar | 2009 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A.
Topics: Animals; Anticonvulsants; Behavioral Symptoms; Bicuculline; Carbamazepine; Cerebellum; Disease Models, Animal; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Male; Maze Learning; Phytotherapy; Pilocarpine; Plant Preparations; Protein Binding; Rats; Rats, Wistar; Receptors, GABA; Saponins; Triterpenes; Tritium | 2010 |
Epileptic seizures increase circulating endothelial cells in peripheral blood as early indicators of cerebral vascular damage.
Topics: Animals; Apoptosis; Bicuculline; CD146 Antigen; Cell Communication; Cell Proliferation; Cells, Cultured; Cerebral Arteries; Cerebrovascular Disorders; Convulsants; Disease Models, Animal; Endothelium, Vascular; Epilepsy; Female; Immunophenotyping; Male; Microvessels; Predictive Value of Tests; Swine | 2010 |
Investigation of linear coupling between single-event blood flow responses and interictal discharges in a model of experimental epilepsy.
Topics: Animals; Bicuculline; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Evoked Potentials; GABA Antagonists; Image Processing, Computer-Assisted; Laser-Doppler Flowmetry; Linear Models; Magnetic Resonance Imaging; Male; Oxygen; Rats; Rats, Wistar | 2010 |
Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling.
Topics: Animals; Bicuculline; CA1 Region, Hippocampal; Calcineurin; Calcineurin Inhibitors; Chronic Disease; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Disease Models, Animal; Down-Regulation; Epilepsy; In Vitro Techniques; Magnesium Compounds; Male; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 2010 |
Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Female; Hippocampus; Long-Term Potentiation; Male; Models, Animal; Nicotine; Phenobarbital; Potassium; Pyramidal Cells; Rats; Rats, Wistar | 2011 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology.
Topics: Action Potentials; Adolescent; Bicuculline; Child; Child, Preschool; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Male; N-Methylaspartate; Neocortex; Neurons; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Piperazines | 2010 |
Orexinergic system and pathophysiology of epilepsy.
Topics: Animals; Bicuculline; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy; Intracellular Signaling Peptides and Proteins; Male; Neuropeptides; Orexin Receptors; Orexins; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide | 2010 |
Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.
Topics: 4-Aminopyridine; Age Factors; Animals; Bicuculline; Brain; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy; GABA-A Receptor Antagonists; Glutamate Decarboxylase; In Vitro Techniques; Mice; Mice, Knockout; Receptors, N-Methyl-D-Aspartate; Synapsins; Synaptic Transmission; Valine | 2011 |
Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex.
Topics: Adolescent; Adult; Benzoxazines; Bicuculline; Biophysics; Cannabinoid Receptor Modulators; Cannabinoids; Carbachol; Child; Child, Preschool; Cholinergic Agonists; Electric Stimulation; Epilepsy; Female; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Middle Aged; Morpholines; Naphthalenes; Neocortex; Neurons; Patch-Clamp Techniques; Sodium Channel Blockers; Statistics, Nonparametric; Synaptic Transmission; Tetrodotoxin; Young Adult | 2012 |
Propagation of epileptiform events across the corpus callosum in a cingulate cortical slice preparation.
Topics: Animals; Axons; Bicuculline; Calcium; Corpus Callosum; Diagnostic Imaging; Dizocilpine Maleate; Epilepsy; Extracellular Space; Female; Gyrus Cinguli; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Magnesium; Male; Mice; Microinjections; Models, Neurological; Perfusion; Solutions | 2012 |
An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci.
Topics: Animals; Bicuculline; Brain Waves; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-B; Time Factors | 2012 |
Optical imaging of visual cortex epileptic foci and propagation pathways.
Topics: Acute Disease; Animals; Bicuculline; Brain Mapping; Dominance, Ocular; Electroencephalography; Epilepsy; Evoked Potentials, Visual; Functional Laterality; GABA Antagonists; Macaca fascicularis; Neural Pathways; Photic Stimulation; Visual Cortex | 2012 |
Epileptic stimulus increases Homer 1a expression to modulate endocannabinoid signaling in cultured hippocampal neurons.
Topics: 4-Aminopyridine; Animals; Bicuculline; Calcium; Carrier Proteins; Cells, Cultured; Convulsants; DNA; Endocannabinoids; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; Homer Scaffolding Proteins; Neuroimaging; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridines; Rats; Real-Time Polymerase Chain Reaction; Signal Transduction; Transfection | 2012 |
Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage.
Topics: Animals; Astrocytes; Bicuculline; Blood-Brain Barrier; Brain; Encephalitis; Epilepsy; GABA-A Receptor Antagonists; Guinea Pigs; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Recurrence; Seizures | 2012 |
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Convulsants; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Female; Magnesium Deficiency; Male; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 2002 |
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.
Topics: Animals; Bicuculline; Carmustine; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Litter Size; Patch-Clamp Techniques; Pregnancy; Pyramidal Cells; Rats; Receptors, GABA | 2002 |
Effects of vigabatrin on epileptiform abnormal discharges in hippocampal CA3 neurons of spontaneously epileptic rats (SER).
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Membrane Potentials; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Receptors, GABA-A; Vigabatrin | 2002 |
Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzoates; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Hippocampus; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Phospholipase C beta; Potassium Channel Blockers; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synapses; Type C Phospholipases | 2002 |
In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cells, Cultured; Delphinium; Epilepsy; GABA Antagonists; Patch-Clamp Techniques; Pentylenetetrazole; Plant Extracts; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2002 |
Effect of levetiracetam on epileptiform discharges in human neocortical slices.
Topics: Adolescent; Adult; Anticonvulsants; Bicuculline; Child; Child, Preschool; Culture Media; Culture Techniques; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Female; Humans; Infant; Levetiracetam; Magnesium; Male; Middle Aged; Neocortex; Piracetam | 2002 |
The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists.
Topics: Animals; Avoidance Learning; Bicuculline; Brain Chemistry; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hypoxia; Mice; N-Methylaspartate; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 2003 |
Suppression of epileptiform activity by GABA(B) receptors in wild type and weaver hippocampus 'in vitro'.
Topics: Animals; Baclofen; Bicuculline; Crosses, Genetic; Disease Models, Animal; Epilepsy; Female; GABA Agonists; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Neurologic Mutants; Neurons; Pyramidal Cells; Receptors, GABA-B | 2003 |
Epileptiform ictal discharges are prevented by periodic interictal spiking in the olfactory cortex.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Epilepsy; Guinea Pigs; In Vitro Techniques; Olfactory Pathways | 2003 |
Role of the superior colliculus and the intercollicular nucleus in the brainstem seizure circuitry of the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Bicuculline; Brain Stem; Disease Models, Animal; Epilepsy; Female; Inferior Colliculi; Male; Rats; Rats, Mutant Strains; Seizures; Superior Colliculi | 2003 |
Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice.
Topics: Action Potentials; Animals; Benzoates; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glycine; Hippocampus; In Vitro Techniques; Indans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2003 |
Optical analysis of acute spontaneous epileptiform discharges in the in vivo rat cerebral cortex.
Topics: Animals; Bicuculline; Brain Mapping; Cerebral Cortex; Diagnostic Imaging; Electroencephalography; Epilepsy; Fluorescent Dyes; GABA-A Receptor Antagonists; Image Interpretation, Computer-Assisted; Male; Membrane Potentials; Pyridinium Compounds; Rats; Rats, Wistar | 2003 |
Group I metabotropic glutamate receptor activation produces prolonged epileptiform neuronal synchronization and alters evoked population responses in the hippocampus.
Topics: 4-Aminopyridine; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Neurons; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2003 |
Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chronic Disease; Cortical Spreading Depression; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; GABA Antagonists; Humans; In Vitro Techniques; Membrane Potentials; Microelectrodes; Neocortex; Neuroglia; Neurons; Parasympathomimetics; Pilocarpine; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2003 |
NMDA-dependent and NMDA-independent neural processes in the bicucculline-disinhibited motor cortex of the cat during the acquisition and reproduction of a conditioned paw-on-support placing reflex.
Topics: Animals; Bicuculline; Cats; Conditioning, Operant; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Motor Cortex; N-Methylaspartate; Neurons | 2003 |
The lateral spread of epileptiform discharges in rat neocortical slices: effect of focal phencyclidine application.
Topics: Animals; Bicuculline; Cerebral Cortex; Convulsants; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Microelectrodes; Neural Conduction; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate | 2003 |
Extracellular concentrations of catecholamines and amino acids in the dorsomedial hypothalamus of kindled rats. A microdialysis study.
Topics: Animals; Bicuculline; Blood Pressure; Chromatography, High Pressure Liquid; Dopamine; Dorsomedial Hypothalamic Nucleus; Epilepsy; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Kindling, Neurologic; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Epileptiform activity in hippocampal slice cultures exposed chronically to bicuculline: increased gap junctional function and expression.
Topics: Animals; Bicuculline; Carbenoxolone; Connexin 26; Connexin 43; Connexins; Cyclic AMP Response Element-Binding Protein; Electric Stimulation; Epilepsy; Fluorescence Recovery After Photobleaching; GABA Antagonists; Gap Junction beta-1 Protein; Gap Junctions; Gene Expression; Hippocampus; In Vitro Techniques; Male; Nerve Tissue Proteins; Octanols; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Time Factors | 2003 |
Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity.
Topics: Animals; Animals, Newborn; Bicarbonates; Bicuculline; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Electric Stimulation; Epilepsy; Ethoxzolamide; Evoked Potentials; GABA Antagonists; In Vitro Techniques; Interneurons; Magnesium; Male; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar | 2003 |
Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats.
Topics: Animals; Bicuculline; Circadian Rhythm; Electroencephalography; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Melatonin; Membrane Potentials; Pyramidal Cells; Rats; Rats, Wistar; Tryptamines | 2003 |
Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Analysis of Variance; Animals; Bicuculline; Choline; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Regression Analysis | 2003 |
Initiation of spontaneous epileptiform events in the rat neocortex in vivo.
Topics: Animals; Bicuculline; Epilepsy; Evoked Potentials; GABA-B Receptor Antagonists; Male; Neocortex; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-B | 2004 |
Action of GABA-B antagonist on cortical epileptic afterdischarges in rats is similar to that of GABA-A antagonist.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Electric Stimulation; Electroencephalography; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Motor Activity; Organophosphorus Compounds; Rats; Rats, Wistar; Seizures; Sensory Thresholds; Signal Processing, Computer-Assisted | 2003 |
Synaptic and non-synaptic mechanisms of amygdala recruitment into temporolimbic epileptiform activities.
Topics: 4-Aminopyridine; Action Potentials; Amygdala; Anesthetics, Local; Animals; Anti-Ulcer Agents; Bicuculline; Carbenoxolone; Dissection; Electric Stimulation; Entorhinal Cortex; Epilepsy; Evoked Potentials; Extracellular Space; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Neurons; Phosphinic Acids; Potassium; Propanolamines; Rats; Rats, Wistar; Reaction Time; Synapses; Tetrodotoxin; Time Factors | 2003 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Activation of long-term synaptic plasticity causes suppression of epileptiform activity in rat hippocampal slices.
Topics: Animals; Bicuculline; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neural Inhibition; Neuronal Plasticity; Rats; Synaptic Transmission; Time Factors; Valine | 2004 |
Leading role of the piriform cortex over the neocortex in the generation of spontaneous interictal spikes during block of GABA(A) receptors.
Topics: Animals; Bicuculline; Brain Mapping; Cerebral Cortex; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Mice; Mice, Inbred BALB C; Neocortex; Time Factors | 2004 |
High-resolution in vivo imaging of hippocampal dendrites and spines.
Topics: Animals; Bicuculline; Dendrites; Electroencephalography; Epilepsy; GABA Antagonists; Green Fluorescent Proteins; Hippocampus; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Confocal; Pilocarpine; Pyramidal Cells; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 2004 |
Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats.
Topics: Animals; Bicuculline; Brain Mapping; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Droperidol; Electroencephalography; Epilepsy; Epilepsy, Generalized; Female; Fentanyl; Humans; Magnetic Resonance Imaging; Oxygen; Rats; Rats, Inbred Strains; Rats, Wistar; Regional Blood Flow | 2004 |
Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, N-Type; Dose-Response Relationship, Drug; Epilepsy; Lamotrigine; Levetiracetam; Male; Membrane Potentials; Neocortex; Patch-Clamp Techniques; Piracetam; Pyramidal Cells; Rats; Rats, Wistar; Triazines | 2004 |
Excitability of CA1 neurons in the model of malformation-associated epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Epilepsy; Evoked Potentials; Female; GABA Antagonists; Hippocampus; Male; Methylazoxymethanol Acetate; Neurons; Potassium Acetate; Pregnancy; Rats; Rats, Sprague-Dawley | 2004 |
Glutamate transporters regulate excitability in local networks in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Neocortex; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Temperature | 2004 |
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aminophylline; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theobromine; Xanthines | 2004 |
Capillary level imaging of local cerebral blood flow in bicuculline-induced epileptic foci.
Topics: Animals; Bicuculline; Capillaries; Cerebrovascular Circulation; Convulsants; Dextrans; Electrophysiology; Epilepsy; Female; Fluorescein-5-isothiocyanate; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Regional Blood Flow | 2004 |
Physiological and morphological characterization of dentate granule cells in the p35 knock-out mouse hippocampus: evidence for an epileptic circuit.
Topics: Animals; Bicuculline; Dendrites; Dentate Gyrus; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Postsynaptic Potentials; Feedback, Physiological; Genetic Predisposition to Disease; Hippocampus; In Vitro Techniques; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Neurons | 2004 |
Temporal dependence in uncoupling of blood volume and oxygenation during interictal epileptiform events in rat neocortex.
Topics: Action Potentials; Animals; Bicuculline; Blood Volume; Brain Mapping; Convulsants; Electrophysiology; Epilepsy; Image Processing, Computer-Assisted; Iontophoresis; Male; Neocortex; Optics and Photonics; Oxygen Consumption; Oxyhemoglobins; Rats; Rats, Sprague-Dawley; Signal Processing, Computer-Assisted; Time Factors | 2005 |
Excitatory effects of thyrotropin-releasing hormone in the thalamus.
Topics: Action Potentials; Animals; Bicuculline; Calcium Signaling; Epilepsy; Female; Ferrets; GABA Antagonists; gamma-Aminobutyric Acid; Geniculate Bodies; In Vitro Techniques; Interneurons; Ion Transport; Male; Methacholine Chloride; Muscarinic Agonists; Patch-Clamp Techniques; Potassium; Potassium Channels; Receptors, GABA-A; Thalamus; Thyrotropin-Releasing Hormone; Wakefulness | 2005 |
Initiation and spread of epileptiform discharges in the methylazoxymethanol acetate rat model of cortical dysplasia: functional and structural connectivity between CA1 heterotopia and hippocampus/neocortex.
Topics: Abnormalities, Drug-Induced; Animals; Bicuculline; Biotin; Brain Diseases; Dextrans; Electrophysiology; Epilepsy; Female; Fluorescent Dyes; GABA Antagonists; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Neocortex; Neural Pathways; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 2005 |
Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit.
Topics: 4-Aminopyridine; Animals; Bicuculline; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Deletion; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; Mice; Mice, Knockout; Phosphinic Acids; Potassium Channel Blockers; Propanolamines; Pyramidal Cells; Quinolinium Compounds; Receptors, GABA-B; Time Factors; Valine | 2005 |
Modification of epileptiform discharges in neocortical neurons following glutamate uptake inhibition.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Freezing; Glutamates; Hippocampus; In Vitro Techniques; Neocortex; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2005 |
Propagation dynamics of epileptiform activity acutely induced by bicuculline in the hippocampal-parahippocampal region of the isolated Guinea pig brain.
Topics: Action Potentials; Acute Disease; Animals; Bicuculline; Brain Mapping; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electrophysiology; Epilepsy; Evoked Potentials; Guinea Pigs; Hippocampus; Humans; In Vitro Techniques; Neural Pathways; Parahippocampal Gyrus | 2005 |
Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Ion Channels; Male; Neural Inhibition; Patch-Clamp Techniques; Pyrimidines; Rats; Time Factors | 2006 |
A brief period of epileptiform activity strengthens excitatory synapses in the rat hippocampus in vitro.
Topics: Animals; Bicuculline; Cells, Cultured; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Humans; In Vitro Techniques; Interneurons; Long-Term Potentiation; Memory Disorders; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2006 |
Reeler homozygous mice exhibit enhanced susceptibility to epileptiform activity.
Topics: Animals; Bicuculline; Disease Models, Animal; Electroshock; Epilepsy; Genetic Predisposition to Disease; Hippocampus; Homozygote; Humans; In Vitro Techniques; Kindling, Neurologic; Male; Mice; Mice, Neurologic Mutants; Neocortex; Nervous System Malformations; Phenotype | 2006 |
Laminar analysis of initiation and spread of epileptiform discharges in three in vitro models.
Topics: 4-Aminopyridine; Action Potentials; Animals; Bicuculline; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; GABA Antagonists; Interneurons; Magnesium; Male; Neocortex; Nerve Net; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats; Rats, Wistar; Synaptic Transmission | 2006 |
Realistic modeling of entorhinal cortex field potentials and interpretation of epileptic activity in the guinea pig isolated brain preparation.
Topics: Action Potentials; Animals; Bicuculline; Computer Simulation; Electrophysiology; Entorhinal Cortex; Epilepsy; GABA Antagonists; Guinea Pigs; Interneurons; Models, Theoretical; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission | 2006 |
Application of wavelet-based similarity analysis to epileptic seizures prediction.
Topics: Algorithms; Animals; Bicuculline; Electroencephalography; Epilepsies, Partial; Epilepsy; Humans; Neocortex; Nerve Net; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Signal Processing, Computer-Assisted; Temporal Lobe | 2007 |
Cellular mechanisms underlying antiepileptic effects of low- and high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Radiation; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Neocortex; Rats; Rats, Wistar; Time Factors | 2007 |
Expression of adhesion factors induced by epileptiform activity in the endothelium of the isolated guinea pig brain in vitro.
Topics: Animals; Bicuculline; Brain; Cell Adhesion Molecules; Electrophysiology; Encephalitis; Endothelium, Vascular; Epilepsy; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Intercellular Adhesion Molecule-1; Limbic System; Neocortex; Neurons; P-Selectin; Proto-Oncogene Proteins c-fos; Tissue Distribution; Up-Regulation | 2007 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epilepsy, Reflex; Excitatory Amino Acid Agonists; GABA Antagonists; Homocysteine; Kindling, Neurologic; Lacosamide; Male; Mice; N-Methylaspartate; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzothiadiazines; Bicuculline; Chlormethiazole; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials, Somatosensory; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Neocortex; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2007 |
Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Data Interpretation, Statistical; Electrodes, Implanted; Electroencephalography; Electrophysiology; Epilepsy; Functional Laterality; Male; Movement; Posture; Rats; Rats, Wistar; Valproic Acid | 2007 |
Multiple roles of midline dorsal thalamic nuclei in induction and spread of limbic seizures.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Mapping; Electrodes, Implanted; Epilepsy; Glutamates; Hippocampus; Kindling, Neurologic; Limbic System; Male; Mediodorsal Thalamic Nucleus; Muscimol; Rats; Rats, Sprague-Dawley | 2008 |
Visualizing localized dynamic changes during epileptic seizure onset in vivo with diffuse optical tomography.
Topics: Animals; Bicuculline; Brain; Electroencephalography; Epilepsy; GABA Antagonists; Hemoglobins; Humans; Optics and Photonics; Oxyhemoglobins; Rats; Time Factors; Tomography | 2008 |
Repeated blockade of GABAA receptors in the medial septal region induces epileptiform activity in the hippocampus.
Topics: Action Potentials; Animals; Bicuculline; Biological Clocks; Electroencephalography; Epilepsy; Fornix, Brain; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Muscimol; Neural Inhibition; Neural Pathways; Neurons; Rabbits; Receptors, GABA-A; Septal Nuclei; Synaptic Transmission; Theta Rhythm | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.
Topics: Acoustics; Animals; Bicuculline; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Image Processing, Computer-Assisted; Male; Rats; Rats, Sprague-Dawley; Tomography, Optical; Ultrasonography | 2008 |
Neuregulin blocks synaptic strengthening after epileptiform activity in the rat hippocampus.
Topics: Animals; Animals, Newborn; Bicuculline; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Neuregulins; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2008 |
Bicuculline epileptogenesis in the rat.
Topics: Animals; Bicuculline; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Neural Inhibition; Penicillins; Rats; Somatosensory Cortex; Synaptic Transmission | 1984 |
Postsynaptic actions of baclofen associated with its antagonism of bicuculline-induced epileptogenesis in hippocampus.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; In Vitro Techniques; Membrane Potentials; Neural Conduction; Rats; Synaptic Transmission | 1984 |
The mechanisms underlying potentiation of recruiting responses may include GABA-disinhibition.
Topics: Animals; Bicuculline; Cats; Cerebral Cortex; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid | 1984 |
Effects of bicuculline-induced epileptiform activity on development of receptive field properties in striate cortex and lateral geniculate nucleus of the rabbit.
Topics: Animals; Bicuculline; Electroencephalography; Epilepsy; Geniculate Bodies; Neural Pathways; Penicillins; Rabbits; Visual Cortex; Visual Fields | 1984 |
Characterization of penicillin- and bicuculline-induced epileptiform discharges during development of striate cortex in rabbits.
Topics: Animals; Bicuculline; Electroencephalography; Epilepsy; Penicillins; Rabbits; Visual Cortex | 1984 |
Dissociation between epileptic seizures induced by convulsant drugs and alteration in the concentrations of pyridoxal phosphate in rat brain regions.
Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Bicuculline; Brain; Convulsants; Epilepsy; Male; Picrotoxin; Pyridoxal Kinase; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Strychnine | 1983 |
Regional changes in cerebral blood flow and blood-brain barrier permeability during epileptiform seizures and in acute hypertension in rabbits.
Topics: Acute Disease; Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Electrocardiography; Electroencephalography; Epilepsy; Epinephrine; Evans Blue; Hypertension; Metaraminol; Nicotine; Rabbits | 1984 |
Regional impairment of protein synthesis in the rat brain during bicuculline-induced seizures.
Topics: Animals; Autoradiography; Bicuculline; Brain; Epilepsy; Female; Kinetics; Nerve Tissue Proteins; Polyribosomes; Rats; Rats, Inbred Strains; Seizures; Tritium | 1984 |
Seizure-like spreading depression in immature rabbit hippocampus in vitro.
Topics: Animals; Bicuculline; Disease Models, Animal; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Membrane Potentials; Neuroglia; Penicillin G; Potassium Chloride; Rabbits | 1984 |
Specific gravity increases and brain water content decreases during short epileptiform seizures in discrete rabbit brain areas.
Topics: Animals; Bicuculline; Blood; Blood-Brain Barrier; Body Water; Brain; Epilepsy; Epinephrine; Hypertension; Male; Pentylenetetrazole; Rabbits; Specific Gravity; Time Factors; Tissue Distribution | 1984 |
Regional protein synthesis in the rat brain during bicuculline-induced epileptic seizures.
Topics: Animals; Autoradiography; Bicuculline; Brain Stem; Cerebellum; Epilepsy; Female; Protein Biosynthesis; Rats; Status Epilepticus | 1981 |
Epileptiform activity in the guinea-pig neocortical slice spreads preferentially along supragranular layers--recordings with voltage-sensitive dyes.
Topics: Animals; Bicuculline; Cerebral Cortex; Denervation; Electric Stimulation; Electrophysiology; Epilepsy; Guinea Pigs; Neural Pathways; Optics and Photonics; Styrenes | 1995 |
Inhibition of epileptiform activity by serotonin in rat CA1 neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Male; Membrane Potentials; Neurons; Rats; Rats, Sprague-Dawley; Serotonin | 1995 |
Epileptic tolerance: prior seizures protect against seizure-induced neuronal injury.
Topics: Animals; Bicuculline; Epilepsy; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
GABAA-mediated inhibition and in vitro epileptogenesis in the human neocortex.
Topics: Bicuculline; Calcium; Cerebral Cortex; Cerebrospinal Fluid; Culture Media; Electric Stimulation; Epilepsy; GABA Antagonists; Humans; In Vitro Techniques; Magnesium; Neural Inhibition; Potassium; Receptors, GABA; Synapses; Synaptic Transmission | 1995 |
Hippocampal CA1 neuronal properties in genetically epilepsy-prone rats: evidence for increased excitation.
Topics: Acoustic Stimulation; Animals; Bicuculline; Cell Membrane; Electrophysiology; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synapses | 1994 |
Inferior colliculus neuronal membrane and synaptic properties in genetically epilepsy-prone rats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Bicuculline; Cell Membrane; Disease Susceptibility; Electric Stimulation; Epilepsy; In Vitro Techniques; Inferior Colliculi; Male; Membrane Potentials; Neurons; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Seizures; Species Specificity; Synapses; Synaptic Transmission | 1994 |
Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy.
Topics: Age Factors; Animals; Bicuculline; Culture Techniques; Epilepsy; Frontal Lobe; Membrane Potentials; Microscopy; Picrotoxin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Role of excitatory amino acid and GABAB receptors in the generation of epileptiform activity in disinhibited hippocampal slice cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; GABA-B Receptor Antagonists; Hippocampus; In Situ Hybridization; Organ Culture Techniques; Pyramidal Cells; Rats; Receptors, GABA-B; Receptors, Glutamate; Synapses | 1994 |
GABAA- and GABAB-mediated inhibition in the rat dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Pyramidal Tracts; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Synapses | 1993 |
Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Cerebral Cortex; Child; Child, Preschool; Culture Techniques; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Female; Humans; Infant; Male; Neurons; Psychosurgery; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Spasms, Infantile; Synaptic Transmission | 1993 |
Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Electric Stimulation; Electrophysiology; Epilepsy; Gamma Rays; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; Nerve Fibers; Neurons, Afferent; Potassium; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar | 1994 |
Loss of synaptic inhibition during repetitive stimulation in genetically epilepsy-prone rats (GEPR).
Topics: Acoustic Stimulation; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred Strains; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Synapses | 1994 |
Potassium-dependent prolonged field bursts in the dentate gyrus: effects of extracellular calcium and amino acid receptor antagonists.
Topics: Animals; Bicuculline; Calcium; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Hippocampus; In Vitro Techniques; Male; Nerve Fibers; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Synaptic Transmission | 1994 |
Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex.
Topics: Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Cycloleucine; Epilepsy; Evoked Potentials; Female; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1994 |
Synchronization of area CA3 hippocampal pyramidal cells and non-granule cells of the dentate gyrus in bicuculline-treated rat hippocampal slices.
Topics: Action Potentials; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Membrane Potentials; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley | 1994 |
Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Dendrites; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Membrane Potentials; Organ Culture Techniques; Organophosphorus Compounds; Pyramidal Tracts; Quinoxalines; Rats; Synapses | 1993 |
Tetraethylammonium-induced epileptiform activity in young and adult rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Bicuculline; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Male; Piperazines; Pyramidal Tracts; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetraethylammonium; Tetraethylammonium Compounds | 1993 |
Use-dependent modification of a slow NMDA receptor-mediated synaptic potential in rat amygdalar slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Animals; Bicuculline; Electrophysiology; Epilepsy; Evoked Potentials; In Vitro Techniques; Ketamine; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Epileptic focus induced in rat by intrahippocampal cholera toxin: neuronal properties in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclofen; Bicuculline; Cholera Toxin; Chronic Disease; Epilepsy; Hippocampus; Injections; Male; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 1993 |
Spread of epileptiform potentials in the neocortical slice: recordings with voltage-sensitive dyes.
Topics: Animals; Bicuculline; Cerebral Cortex; Coloring Agents; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Guinea Pigs; Histocytochemistry; In Vitro Techniques | 1993 |
Effects of the epileptogenic agent bicuculline methiodide on membrane currents induced by N-methyl-D-aspartate and kainate (oocyte; Xenopus laevis).
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electric Conductivity; Epilepsy; Kainic Acid; N-Methylaspartate; Oocytes; Xenopus laevis | 1994 |
JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures.
Topics: Activating Transcription Factor 1; Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depression; DNA-Binding Proteins; Early Growth Response Protein 1; Epilepsy; Gene Expression; Genes, fos; Genes, jun; Immediate-Early Proteins; Immunohistochemistry; Male; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Transcription Factors | 1993 |
GABA-responses of CA3 neurones at epileptogenic threshold concentrations of convulsants.
Topics: Action Potentials; Animals; Bicarbonates; Bicuculline; Caffeine; Chlorides; Convulsants; Epilepsy; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Penicillins; Pentylenetetrazole; Synapses | 1993 |
Morphological and functional consequences of chronic epilepsy in rat hippocampal slice cultures.
Topics: Animals; Bicuculline; Chronic Disease; Culture Techniques; Disease Models, Animal; Electrophysiology; Epilepsy; Hippocampus; Neurons; Picrotoxin; Rats | 1993 |
Extracellular slow negative transient in the dentate gyrus of human epileptic hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Adult; Bicuculline; Dentate Gyrus; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Extracellular Space; GABA Antagonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Nerve Fibers; Receptors, N-Methyl-D-Aspartate | 1996 |
Activation of GABAergic function necessary for afterdischarge generation in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Bicuculline; Electric Stimulation; Epilepsy; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors | 1996 |
On the structure of ictal events in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Axons; Bicuculline; Brain; Computer Simulation; Dendrites; Electroencephalography; Epilepsy; Hippocampus; Humans; In Vitro Techniques; Male; Microelectrodes; Models, Neurological; Neural Networks, Computer; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Spontaneous and stimulation-induced synchronized burst afterdischarges in the isolated CA1 of kainate-treated rats.
Topics: Action Potentials; Animals; Behavior, Animal; Bicuculline; Cell Count; Convulsants; Dentate Gyrus; Epilepsy; Injections; Kainic Acid; Male; Neurons; Perfusion; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1996 |
Propofol inhibits epileptiform activity in rat hippocampal slices.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Convulsants; Drug Evaluation, Preclinical; Epilepsy; GABA Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley | 1996 |
Review of the role of inhibitory neurons in chronic epileptic foci induced by intracerebral tetanus toxin.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cerebral Cortex; Disease Models, Animal; Epilepsy; Functional Laterality; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Neural Inhibition; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetanus Toxin | 1996 |
Epileptiform activity in the piriform cortex of the in vitro isolated guinea pig brain preparation.
Topics: Animals; Bicuculline; Brain; Cerebral Cortex; Disease Models, Animal; Epilepsy; Guinea Pigs; Neural Pathways; Olfactory Pathways; Receptors, GABA; Synaptic Transmission | 1996 |
Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Convulsants; Drug Evaluation, Preclinical; Electric Stimulation; Epilepsy; Evoked Potentials; Genetic Predisposition to Disease; In Vitro Techniques; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists | 1996 |
Persistent excitability changes in the piriform cortex of the isolated guinea-pig brain after transient exposure to bicuculline.
Topics: Animals; Bicuculline; Cerebral Cortex; Epilepsy; Guinea Pigs; Synaptic Transmission; Time Factors | 1997 |
Spatiotemporal distribution of intracellular calcium transients during epileptiform activity in guinea pig hippocampal slices.
Topics: Animals; Bicuculline; Calcium Channels; Electric Stimulation; Electrophysiology; Epilepsy; GABA Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Micromanipulation; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
Disinhibited in vitro neocortical slices containing experimentally induced cortical dysplasia demonstrate hyperexcitability.
Topics: Action Potentials; Animals; Bicuculline; Brain; Cerebral Cortex; Epilepsy; GABA Antagonists; In Vitro Techniques; Neural Inhibition; Rats; Rats, Sprague-Dawley | 1997 |
Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats.
Topics: Administration, Topical; Animals; Bicuculline; Cerebral Cortex; Diazepam; Disease Models, Animal; Double-Blind Method; Drug Delivery Systems; Electroencephalography; Epidural Space; Epilepsies, Partial; Epilepsy; Functional Laterality; Hippocampus; Male; Motor Cortex; Random Allocation; Rats | 1997 |
Bicuculline-induced epileptiform activity in rat hippocampal slices: suppression by Aconitum alkaloids.
Topics: Aconitine; Alkaloids; Animals; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; Medicine, Chinese Traditional; Plants, Medicinal; Rats; Rats, Wistar | 1997 |
The cerebral hemisphere of the turtle in vitro. An experimental model with spontaneous interictal-like spikes for the study of epilepsy.
Topics: Animals; Bicuculline; Convulsants; Disease Models, Animal; Epilepsy; In Vitro Techniques; Membrane Potentials; Pyramidal Cells; Turtles | 1997 |
Effects of the alkaloids 6-benzoylheteratisine and heteratisine on neuronal activity in rat hippocampal slices.
Topics: Aconitine; Action Potentials; Alkaloids; Analgesics; Animals; Bicuculline; Convulsants; Depression, Chemical; Drugs, Chinese Herbal; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Neurons; Rats; Rats, Wistar; Sodium Channels | 1997 |
Antiepileptic effects of 20-hydroxyecdysone on convulsive seizures in spontaneously epileptic rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Ecdysterone; Epilepsy; Female; Male; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Metabotropic glutamate receptor activation modulates epileptiform activity in the hippocampus.
Topics: 4-Aminopyridine; Adrenergic Antagonists; Animals; Bicuculline; Cholinergic Antagonists; Cycloleucine; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1997 |
Comparison of fluorescent voltage-sensitive dyes for multisite optical recording in hamster cerebral cortex by measurement of bicuculline-induced epileptiform events.
Topics: Animals; Bicuculline; Brain Mapping; Cerebral Cortex; Convulsants; Cricetinae; Electronic Data Processing; Epilepsy; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mesocricetus | 1997 |
Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cells, Cultured; Electric Stimulation; Electroencephalography; Embryo, Mammalian; Epilepsy; Evoked Potentials; Female; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Synaptic Transmission; Tetrodotoxin | 1997 |
GABAA-mediated IPSCs in piriform cortex have fast and slow components with different properties and locations on pyramidal cells.
Topics: Animals; Bicuculline; Cerebral Cortex; Dendrites; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; In Vitro Techniques; Male; Models, Neurological; Neuronal Plasticity; Olfactory Pathways; Organophosphorus Compounds; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A | 1997 |
Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Interactions; Electric Stimulation; Epilepsy; GABA Antagonists; Levetiracetam; Male; Membrane Potentials; Models, Biological; Piracetam; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Kainic Acid; Male; Motor Activity; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Values | 1998 |
Anticonvulsant and behavioural effects of bicuculline injected into the mesencephalic locomoter region of rats.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Electroshock; Epilepsy; Female; GABA Antagonists; Locomotion; Male; Mesencephalon; Microinjections; Movement; Muscle, Skeletal; Rats; Rats, Sprague-Dawley | 1997 |
Activation of muscarinic receptors during blockade of GABA(A)-mediated inhibition induces synchronous epileptiform activity in immature rat hippocampus.
Topics: Animals; Bicuculline; Carbachol; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1998 |
Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition.
Topics: Animals; Baclofen; Bicuculline; Entorhinal Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Phosphinic Acids; Propanolamines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Receptors, GABA-B; Substance P; Synapses; Tachykinins | 1998 |
Enhanced propagation of epileptiform activity through the kindled dentate gyrus.
Topics: Animals; Bicuculline; Chronic Disease; Dentate Gyrus; Entorhinal Cortex; Epilepsy; Evoked Potentials; GABA Antagonists; In Vitro Techniques; Kindling, Neurologic; Rats; Rats, Wistar | 1998 |
Inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices by the Aconitum alkaloid mesaconitine.
Topics: Aconitine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Male; Potassium Chloride; Rats; Rats, Wistar; Timolol; Yohimbine | 1998 |
Comparison of the effects of M1 and M2 muscarinic receptor activation in the absence of GABAergic inhibition in immature rat hippocampal CA3 area.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Carbachol; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Muscarinic Agonists; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1998 |
Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Animals; Anticonvulsants; Bicuculline; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Epilepsy; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Polypharmacy; Seizures; Vigabatrin | 1998 |
Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Baclofen; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 1998 |
Initiation of spontaneous epileptiform activity in the neocortical slice.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Image Processing, Computer-Assisted; Magnesium; Neocortex; Organ Culture Techniques; Rats; Rats, Sprague-Dawley | 1998 |
Spike-wave complexes and fast components of cortically generated seizures. I. Role of neocortex and thalamus.
Topics: Animals; Bicuculline; Cats; Convulsants; Cortical Synchronization; Denervation; Epilepsy; Microinjections; Neocortex; Neural Pathways; Thalamus | 1998 |
Spike-wave complexes and fast components of cortically generated seizures. III. Synchronizing mechanisms.
Topics: Anesthesia; Animals; Bicuculline; Cats; Cerebral Cortex; Convulsants; Cortical Synchronization; Epilepsy; Excitatory Postsynaptic Potentials; Membrane Potentials; Neural Pathways; Periodicity; Sleep; Synapses; Thalamus | 1998 |
Spike-wave complexes and fast components of cortically generated seizures. II. Extra- and intracellular patterns.
Topics: Anesthesia; Animals; Bicuculline; Cats; Cerebral Cortex; Cognition; Convulsants; Cortical Synchronization; Electric Stimulation; Epilepsy; Neurons; Periodicity; Sleep; Thalamus | 1998 |
'Dormant' inhibitory neurons: do they exist and what is their functional impact?
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Computer Simulation; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Male; Models, Neurological; Neurons; Pyramidal Cells; Rats; Tetanus Toxin | 1998 |
Involvement of GABA(B) receptors in convulsant-induced epileptiform activity in rat neocortex in vitro.
Topics: Animals; Bicuculline; Convulsants; Epilepsy; GABA Antagonists; In Vitro Techniques; Membrane Potentials; Microelectrodes; Neocortex; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Synaptic Transmission | 1998 |
Bicuculline-induced rhythmic EEG episodes: gender differences and the effects of ethosuximide and baclofen treatment.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; Epilepsy, Absence; Estradiol; Ethosuximide; Female; Incidence; Male; Ovariectomy; Rats; Rats, Wistar; Sex Factors | 1998 |
Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Bicuculline; Chlorides; Diuretics; Epilepsy; Furosemide; GABA Antagonists; Hippocampus; In Vitro Techniques; Microelectrodes; Rats; Rats, Sprague-Dawley | 1999 |
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Carbamates; Convulsants; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Phenylenediamines; Rats; Rats, Wistar; Seizures | 1999 |
[Hippocampal non-NMDA and GABA-A receptors in benzylpenicillin-induced epilepsy and electro-acupuncture antiepilepsy].
Topics: Animals; Anticonvulsants; Bicuculline; Electroacupuncture; Electroencephalography; Epilepsy; Female; GABA Antagonists; Hippocampus; Male; Penicillin G; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Somatostatin acts in CA1 and CA3 to reduce hippocampal epileptiform activity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Dendrites; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Hormone Antagonists; Male; Mossy Fibers, Hippocampal; Organ Culture Techniques; Phosphinic Acids; Propanolamines; Rats; Rats, Sprague-Dawley; Somatostatin | 1999 |
Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures.
Topics: Animals; Antibodies; Anticonvulsants; Antirheumatic Agents; Bicuculline; Cell Count; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Epilepsy; Excitatory Amino Acid Agonists; GABA Antagonists; Glutamic Acid; Hippocampus; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Male; Microglia; Nerve Degeneration; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Sialoglycoproteins | 1999 |
Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of rats.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Convulsants; Entorhinal Cortex; Epilepsy; Evoked Potentials; Hippocampus; Rats | 1999 |
Epileptiform activity generated by endogenous acetylcholine during blockade of GABAergic inhibition in immature and adult rat hippocampus.
Topics: Acetylcholine; Age of Onset; Analysis of Variance; Animals; Bicuculline; Cholinesterase Inhibitors; Epilepsy; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Physostigmine; Rats; Rats, Sprague-Dawley | 1999 |
Abnormal responses to perforant path stimulation in the dentate gyrus of slices from rats with kainate-induced epilepsy and mossy fiber reorganization.
Topics: Action Potentials; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neuronal Plasticity; Perforant Pathway; Rats; Rats, Sprague-Dawley; Staining and Labeling | 1999 |
GABA uptake blocker NNC-711 exhibits marked anticonvulsant action in two cortical epileptic models in immature rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Electric Stimulation; Epilepsy; GABA Antagonists; Male; Nipecotic Acids; Oximes; Rats; Rats, Wistar | 1999 |
Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; N-Methylaspartate; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1999 |
Seizure-like events in disinhibited ventral slices of adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Potassium Chloride; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1999 |
Valproic acid intensifies epileptiform activity in the hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Epilepsy; GABA Antagonists; Hippocampus; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Valproic Acid | 1999 |
Chloride-cotransport blockade desynchronizes neuronal discharge in the "epileptic" hippocampal slice.
Topics: 4-Aminopyridine; Animals; Axons; Bicuculline; Carrier Proteins; Chlorides; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Postsynaptic Potentials; Furosemide; Hippocampus; In Vitro Techniques; Neurons; Potassium; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters; Synapses; Synaptic Transmission | 2000 |
Differential paired-pulse effects of gabazine and bicuculline in rat hippocampal CA3 area.
Topics: Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Functional Laterality; GABA Antagonists; Hippocampus; Male; Pyridazines; Rats; Rats, Sprague-Dawley | 2000 |
Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats.
Topics: Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Magnesium; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2000 |
Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Central Nervous System Depressants; Cerebral Cortex; Convulsants; Cyclooxygenase Inhibitors; Dihydrotestosterone; Electrophysiology; Enzyme Inhibitors; Epilepsy; Ethanol; Finasteride; Indomethacin; Male; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2000 |
Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Chemotactic Factors; Convulsants; Dithionitrobenzoic Acid; Epilepsy; Hippocampus; Indicators and Reagents; Long-Term Potentiation; Membrane Potentials; Oxidation-Reduction; Patch-Clamp Techniques; Pentylenetetrazole; Phosphines; PQQ Cofactor; Quinolones; Quinones; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Seizures; Sulfhydryl Reagents | 2000 |
Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Diseases; Choristoma; Convulsants; Electrophysiology; Epilepsy; Female; Hippocampus; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synapses | 2000 |
Free radical production correlates with cell death in an in vitro model of epilepsy.
Topics: Action Potentials; Aniline Compounds; Animals; Antioxidants; Bicuculline; Calcium; Cell Death; Disease Models, Animal; Epilepsy; Fluorescent Dyes; Free Radicals; GABA Antagonists; Glutathione; Hippocampus; Microscopy, Fluorescence; Nerve Degeneration; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Rhodamines; Vitamin E; Xanthenes | 2000 |
GABA(A)-mediated toxicity of hippocampal neurons in vitro.
Topics: Animals; Anticonvulsants; Bicuculline; Cell Survival; Cells, Cultured; Epilepsy; Female; Fetus; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Vigabatrin | 2000 |
Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner.
Topics: Age Factors; Analgesics, Opioid; Animals; Bicuculline; Convulsants; Disease Susceptibility; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors | 2000 |
Modulation of epileptiform discharges in the rat limbic system in vitro by noradrenergic agents.
Topics: Adrenergic Agonists; Animals; Bicuculline; Epilepsy; Female; Limbic System; Male; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 2000 |
Somatostatin inhibits GABAergic transmission in the sensory thalamus via presynaptic receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Cats; Cell Membrane; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Geniculate Bodies; Hormones; Male; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Sleep; Somatostatin; Synaptic Transmission; Tetrodotoxin; Ventral Thalamic Nuclei | 2000 |
Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Docosahexaenoic Acids; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Magnesium; Male; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2000 |
Multi-neuronal recordings reveal a differential effect of thapsigargin on bicuculline- or gabazine-induced epileptiform excitability in rat hippocampal neuronal networks.
Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Convulsants; Electrophysiology; Enzyme Inhibitors; Epilepsy; GABA Antagonists; Hippocampus; Immunohistochemistry; Microelectrodes; Nerve Net; Neurons; Pyridazines; Rats; Rats, Wistar; Thapsigargin | 2000 |
Functional connections and epileptic spread between hippocampus, entorhinal cortex and amygdala in a modified horizontal slice preparation of the rat brain.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Denervation; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Female; Hippocampus; Male; Neural Pathways; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 2000 |
The influence of MK-801 on bicuculline evoked seizures in adult mice exposed to transient episode of brain ischemia.
Topics: Age Factors; Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Convulsants; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Ischemic Attack, Transient; Ischemic Preconditioning; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Rate | 2000 |
Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function.
Topics: Action Potentials; Animals; Bicuculline; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Valine | 2000 |
Effects of nifedipine on rhythmic synchronous activity of human neocortical slices.
Topics: Adolescent; Bicuculline; Calcium Channel Blockers; Child; Child, Preschool; Convulsants; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; Humans; In Vitro Techniques; Infant; Infant, Newborn; Magnesium; Neocortex; Nifedipine; Periodicity | 2000 |
Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons, Afferent; Organ Culture Techniques; Picrotoxin; Pyridazines; Receptors, AMPA; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2001 |
Calcium imaging of epileptiform events with single-cell resolution.
Topics: Action Potentials; Animals; Bicuculline; Calcium; Cerebral Cortex; Convulsants; Electrophysiology; Epilepsy; Fura-2; Intracellular Membranes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Fluorescence; Neurons; Reaction Time; Tetrodotoxin | 2001 |
Discharge threshold is enhanced for several seconds after a single interictal spike in a model of focal epileptogenesis.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy; GABA Antagonists; Guinea Pigs; Neurons; Olfactory Pathways; Penicillins; Reaction Time | 2001 |
Deterministic chaos and noise in three in vitro hippocampal models of epilepsy.
Topics: Animals; Bicuculline; Biomedical Engineering; Computer Simulation; Electrophysiology; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Male; Models, Neurological; Nonlinear Dynamics; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Stochastic Processes | 2001 |
Upregulation of gap junction connexin 32 with epileptiform activity in the isolated mouse hippocampus.
Topics: Action Potentials; Animals; Anti-Ulcer Agents; Bicuculline; Carbenoxolone; Cell Membrane; Connexins; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Epilepsy; GABA Antagonists; Gap Junction beta-1 Protein; Gap Junctions; Hippocampus; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Models, Animal; Neurons; Organ Culture Techniques; Proto-Oncogene Proteins c-fos; RNA, Messenger; Transcription, Genetic; Up-Regulation | 2001 |
An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability.
Topics: Action Potentials; Animals; Axons; Bicuculline; Cerebral Cortex; Electroencephalography; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Mice; Mice, Knockout; Mice, Neurologic Mutants; Nervous System Malformations; Neurologic Examination; Peripheral Nervous System; Pyramidal Cells; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; RNA, Messenger; Seizures; Signal Transduction | 2001 |
Synaptic regulation of the slow Ca2+-activated K+ current in hippocampal CA1 pyramidal neurons: implication in epileptogenesis.
Topics: 4-Aminopyridine; Animals; Bicuculline; Calcium; Convulsants; Electric Stimulation; Epilepsy; Hippocampus; Magnesium; Male; Potassium Channels, Calcium-Activated; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glutamate; Synapses | 2001 |
Prenatal morphine exposure decreases susceptibility of adult male rat offspring to bicuculline seizures.
Topics: Animals; Bicuculline; Brain; Disease Susceptibility; Epilepsy; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Morphine; Orchiectomy; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Sex Factors; Testosterone | 2001 |
Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Epilepsy, Temporal Lobe; Ethosuximide; GABA Antagonists; Hippocampus; Male; Neurons; Phenytoin; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley | 2002 |
Nociceptin, OP4 receptor ligand in different models of experimental epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy; Female; Mice; N-Methylaspartate; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pentylenetetrazole; Receptors, Opioid | 2002 |
Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy.
Topics: Action Potentials; Animals; Bicuculline; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neural Pathways; Patch-Clamp Techniques; Periodicity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 2002 |
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.
Topics: Acoustic Stimulation; Administration, Oral; Amides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Cyclopropanes; Electrophysiology; Electroshock; Epilepsy; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Mutagenicity Tests; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 2002 |
Inhibitory role of the zona incerta in the pilocarpine model of epilepsy.
Topics: Animals; Bicuculline; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Male; Muscimol; Pilocarpine; Rats; Rats, Wistar; Subthalamus | 2002 |
Cellular mechanisms of pharmacoresistance in slices from epilepsy surgery.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Bicuculline; Drug Resistance; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Guinea Pigs; Humans; Neocortex; Nerve Tissue Proteins; Neurons; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Species Specificity; Synaptic Transmission | 2002 |
Excitatory and inhibitory control of epileptiform discharges in combined hippocampal/entorhinal cortical slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Rats; Rats, Wistar | 2002 |
Differential neurohumoral modulation of myoclonic and clonic seizures.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Dopamine; Epilepsies, Myoclonic; Epilepsy; Fenclonine; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Neurotransmitter Agents; Norepinephrine; Parasympathetic Nervous System; Scopolamine; Time Factors | 1978 |
[Potential therapeutic activity of GABA-mimetic drugs in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Basal Ganglia Diseases; Bicuculline; Dopamine; Dyskinesia, Drug-Induced; Epilepsy; Extrapyramidal Tracts; gamma-Aminobutyric Acid; Humans; Huntington Disease; Levodopa; Limbic System; Neural Pathways; Neurons; Neurotransmitter Agents; Parkinson Disease; Psychopharmacology | 1979 |
The pathophysiology of the blood-brain barrier dysfunction induced by severe hypercapnia and by epileptic brain activity.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Epilepsy; Homocysteine; Hypercapnia; Hypertension; Male; Permeability; Phentolamine; Proteins; Rats | 1977 |
Four models for studying cerebral lesions secondary to epileptic seizures.
Topics: Animals; Astrocytes; Bicuculline; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperature; Cerebellum; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Gallamine Triethiodide; Gliosis; Glycine; Hippocampus; Ischemia; Papio; Pentylenetetrazole; Purkinje Cells | 1975 |
Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Aging; Bicuculline; Cerebral Cortex; Child; Child, Preschool; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Female; Humans; Infant; Male; Membrane Potentials; Microelectrodes; N-Methylaspartate; Neurons; Quinoxalines; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1992 |
Contribution of amino acid transmitters to epileptiform activity and reflex suppression in electrically head stunned sheep.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Baclofen; Bicuculline; Blinking; Electric Stimulation; Electrocardiography; Electroencephalography; Epilepsy; Heart Rate; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, GABA-A; Reflex, Pupillary; Sheep; Sheep Diseases; Tiletamine; Zolazepam | 1992 |
Ethanol inhibits epileptiform activity and NMDA receptor-mediated synaptic transmission in rat amygdaloid slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Anticonvulsants; Bicuculline; Depression, Chemical; Epilepsy; Ethanol; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1992 |
The contribution of AMPA and NMDA receptors to graded bursting activity in the hippocampal CA1 region in an acute in vitro model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Amygdala; Animals; Bicuculline; Brain Mapping; Carbachol; Dominance, Cerebral; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Ibotenic Acid; Kainic Acid; Limbic System; Muscimol; Quisqualic Acid; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1992 |
Benzodiazepine antagonist flumazenil reduces bicuculline-induced enhancement of neuronal activity in the spinal cord.
Topics: Animals; Bicuculline; Cats; Epilepsy; Evoked Potentials; Flumazenil; Male; Motor Neurons; Receptors, GABA-A; Spinal Cord | 1991 |
Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Potentials; Humans; In Vitro Techniques; Membrane Potentials; Piperazines; Receptors, N-Methyl-D-Aspartate; Synapses | 1991 |
Synaptic responses of guinea pig cingulate cortical neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Gyrus Cinguli; Magnesium; Neurons; Quinoxalines; Synapses | 1991 |
Effect of compounds modulating amino acid neurotransmission on the development and control of bicuculline-induced epileptogenic spiking in the rat.
Topics: Amino Acids; Animals; Bicuculline; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Male; Neurotransmitter Agents; Perfusion; Rats; Rats, Inbred Strains | 1991 |
The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Chronic Disease; Electric Stimulation; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; Electric Stimulation; Epilepsy; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of carbamazepine on bicuculline- and pentylenetetrazol-induced seizures in developing rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Carbamazepine; Epilepsy; Female; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1991 |
[Effects of activation and lesions of the superior colliculi of the lamina quadrigemina on epileptic activity in rats].
Topics: Animals; Bicuculline; Electrophysiology; Epilepsy; Kindling, Neurologic; Male; Penicillins; Picrotoxin; Rats; Rats, Inbred Strains; Superior Colliculi | 1991 |
Bicuculline-induced neocortical epileptiform foci and the effects of 6-hydroxydopamine in developing rats.
Topics: Animals; Bicuculline; Catecholamines; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lobe; Male; Occipital Lobe; Oxidopamine; Rats; Rats, Inbred Strains | 1991 |
Epileptiform discharges and a synchronous GABAergic potential induced by 4-aminopyridine in the rat immature hippocampus.
Topics: Animals; Bicuculline; Epilepsy; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Models, Biological; Perfusion; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
The role of excitatory amino acid receptors in the propagation of epileptiform discharges from the entorhinal cortex to the dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GABA Antagonists; Humans; Infant; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Psychosurgery; Pyramidal Tracts; Spasms, Infantile; Synapses; Synaptic Transmission | 1990 |
On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
Topics: Animals; Bicuculline; Brain; Dinoprost; Epilepsy; Gerbillinae; Handling, Psychological; Kinetics; Pentylenetetrazole; Seizures; SRS-A | 1991 |
Adrenalectomy increases bicuculline-induced seizure sensitivity in long-sleep and short-sleep mice.
Topics: Adrenal Glands; Adrenalectomy; Animals; Bicuculline; Body Weight; Corticosterone; Epilepsy; Ethanol; Genetic Predisposition to Disease; Genotype; Mice; Mice, Inbred Strains; Reaction Time; Sleep; Time Factors | 1991 |
Common epileptic pathway in amygdaloid bicuculline and electrical kindling demonstrated by transferability.
Topics: Amygdala; Animals; Bicuculline; Electric Stimulation; Epilepsy; Kindling, Neurologic; Male; Neural Pathways; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1990 |
Characterization of GABAergic seizure regulation in the midline thalamus.
Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobutyric Acid; Pentobarbital; Pentylenetetrazole; Piperidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamic Nuclei | 1990 |
Epileptiform activity in microcultures containing small numbers of hippocampal neurons.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Cells, Cultured; Epilepsy; Evoked Potentials; Hippocampus; Kynurenic Acid; Neurons; Rats; Synapses | 1990 |
Lesions of the deep prepiriform cortex ('area tempestas') in rats do not affect the convulsant action of systemically administered bicuculline.
Topics: Animals; Bicuculline; Cerebral Cortex; Convulsants; Epilepsy; Female; Rats; Rats, Inbred Strains | 1990 |
Alterations in cytosolic free calcium in the cat cortex during bicuculline-induced epilepsy.
Topics: Animals; Bicuculline; Calcium; Cats; Cerebral Cortex; Cytosol; Epilepsy; Fluorescent Dyes; Indoles; Male | 1990 |
Laminar analysis of bicuculline-induced epileptiform activity in area 17 of the awake macaque.
Topics: Animals; Bicuculline; Epilepsy; Evoked Potentials, Visual; Macaca; Macaca fascicularis; Visual Cortex | 1990 |
Synchronization of epileptiform bursts induced by 4-aminopyridine in the in vitro hippocampal slice preparation.
Topics: 4-Aminopyridine; Animals; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; Neural Conduction; Rats; Rats, Inbred Strains; Recruitment, Neurophysiological | 1990 |
Optical recording of epileptiform voltage changes in the neocortical slice.
Topics: 4-Aminopyridine; Amifampridine; Animals; Bicuculline; Cerebral Cortex; Convulsants; Electrophysiology; Epilepsy; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Membrane Potentials | 1990 |
Control of spontaneous epileptiform discharges by extracellular potassium: an "in vitro" study in the CA1 subfield of the hippocampal slice.
Topics: Animals; Bicuculline; Epilepsy; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channels; Male; Penicillins; Potassium; Rats; Synapses; Synaptic Transmission | 1987 |
The development of bicuculline-induced epileptiform discharges in embryonic turtle cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Epilepsy; Receptors, GABA-A; Turtles | 1989 |
NMDA receptor antagonists CPP and MK-801 partially suppress the epileptiform discharges induced by the convulsant drug bicuculline in the rat neocortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Inhibitory processes in normal and epileptic-like rat hippocampal slices: the role of GABAB receptors.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; Penicillins; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibition.
Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Synchronization; Electric Stimulation; Electroencephalography; Electrophysiology; Epilepsy; Evoked Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Rats | 1989 |
Endogenous serum albumin content in brain after short-lasting epileptic seizures.
Topics: Animals; Bicuculline; Blood-Brain Barrier; Brain; Epilepsy; Male; Rats; Rats, Inbred Strains; Serum Albumin | 1989 |
Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs.
Topics: Action Potentials; Animals; Bicuculline; Convulsants; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Receptors, Purinergic; Xanthines | 1989 |
Epileptiform discharges evoked in hippocampal brain slices from epileptic patients.
Topics: Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Humans; Membrane Potentials; Rats | 1989 |
Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/RIJ inbred strain of rats.
Topics: Animals; Behavior, Animal; Bicuculline; Electroencephalography; Epilepsy; Female; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Muscimol; Rats; Rats, Inbred Strains | 1989 |
A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Epilepsy; Evoked Potentials; Female; Folic Acid Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Pentylenetetrazole; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1985 |
An N-methyl-D-aspartate (NMDA) receptor antagonist reduces bicuculline-induced depolarization shifts in neocortical explant cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cerebral Cortex; Culture Techniques; Epilepsy; Membrane Potentials; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1986 |
Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate.
Topics: Allylglycine; Animals; Aspartic Acid; Bicuculline; Cerebellum; Epilepsy; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Immunoenzyme Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Synaptic Transmission | 1987 |
Epileptiform events induced by GABA-antagonists in entorhinal cortical cells in vitro are partly mediated by N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Epilepsy; In Vitro Techniques; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
[Studies on glucose metabolism and local cerebral blood flow in bicuculline-induced rat epilepsy].
Topics: Animals; Autoradiography; Bicuculline; Brain; Cerebrovascular Circulation; Epilepsy; Glucose; Hippocampus; Male; Rats | 1987 |
Enhanced inositide turnover in brain during bicuculline-induced status epilepticus.
Topics: Animals; Bicuculline; Brain; Diglycerides; Epilepsy; Fatty Acids, Nonesterified; Male; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution | 1986 |
Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments.
Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Epilepsy; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Potassium; Rats; Receptors, GABA-A | 1986 |
A measurement of cerebral glucose uptake rate by 31P MRS.
Topics: Analgesia; Animals; Bicuculline; Blood Pressure; Brain; Deoxy Sugars; Deoxyglucose; Epilepsy; Glucose-6-Phosphate; Glucosephosphates; Heart Rate; Kinetics; Magnetic Resonance Spectroscopy; Male; Nitrous Oxide; Pentobarbital; Rats; Rats, Inbred WKY | 1988 |
GABAergic inhibition and epileptiform discharges in the turtle hippocampus in vitro.
Topics: Afferent Pathways; Animals; Bicuculline; Electric Stimulation; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Picrotoxin; Pipecolic Acids; Pyramidal Tracts; Reference Values; Synapses; Turtles | 1988 |
Alterations in extracellular amino acids and Ca2+ following excitotoxin administration and during status epilepticus.
Topics: Amino Acids; Animals; Aspartic Acid; Bicuculline; Calcium; Epilepsy; Ethanolamines; Extracellular Space; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Rabbits; Synaptic Membranes; Synaptosomes; Taurine; Tetrodotoxin | 1986 |
Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition.
Topics: Action Potentials; Animals; Bicuculline; Electrophysiology; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Models, Neurological; Neurons; Potassium; Rats; Temperature | 1987 |
Differential sensitivity to bicuculline in three inbred mouse strains.
Topics: Action Potentials; Animals; Bicuculline; Electric Stimulation; Epilepsy; Female; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Seizures; Species Specificity | 1987 |
Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Biomechanical Phenomena; Cats; Cerebral Cortex; Disease Susceptibility; Epilepsy; Models, Neurological; Neural Pathways; Neurons; Penicillins; Phenobarbital; Phenytoin; Reaction Time | 1986 |
Decreased effectiveness of GABA-mediated inhibition in the inferior colliculus of the genetically epilepsy-prone rat.
Topics: Animals; Bicuculline; Epilepsy; Flurazepam; GABA Antagonists; gamma-Aminobutyric Acid; Inferior Colliculi; Rats; Rats, Inbred Strains | 1986 |
Attenuation of epileptiform bursting by baclofen: reduced potency in elevated potassium.
Topics: Action Potentials; Animals; Baclofen; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Potassium; Rats; Rats, Inbred Strains | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; Epilepsy; Kainic Acid; Methionine Sulfoximine; Pentylenetetrazole; Pyridoxine; Rabbits; Seizures | 1986 |
The blood-brain barrier to horseradish peroxidase at the onset of bicuculline-induced seizures in hypothalamus, pallidum, hippocampus, and other selected regions of the rabbit.
Topics: Animals; Bicuculline; Blood-Brain Barrier; Brain; Epilepsy; Horseradish Peroxidase; Male; Microscopy, Electron; Pinocytosis; Rabbits | 1986 |
Incongruence of regional cerebral blood flow increase and blood-brain barrier opening in rabbits at the onset of seizures induced by bicuculline, methoxypyridoxine, and kainic acid.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Brain; Epilepsy; Kainic Acid; Male; Nicotine; Pyridoxine; Rabbits; Regional Blood Flow | 1985 |
Anticonvulsant actions of enflurane on epilepsy models in cats.
Topics: Amygdala; Animals; Anticonvulsants; Bicuculline; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Enflurane; Epilepsy; Female; Kindling, Neurologic; Male; Penicillin G; Seizures | 1985 |
Bicuculline- and allylglycine-induced epilepsy in developing rats.
Topics: Allylglycine; Animals; Behavior, Animal; Bicuculline; Brain; Electroencephalography; Epilepsy; Female; gamma-Aminobutyric Acid; Glycine; Hippocampus; Male; Rats; Somatosensory Cortex; Time Factors | 1985 |