bibw-2992 and Colorectal-Neoplasms

bibw-2992 has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for bibw-2992 and Colorectal-Neoplasms

Article	Year
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS. Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10 KRAS, the most common oncogenic driver in human cancers, is controlled and signals primarily through protein-protein interactions (PPIs). The interaction between KRAS and SOS1, crucial for the activation of KRAS, is a typical, challenging PPI with a large contact surface area and high affinity. Here, we report that the addition of only one atom placed between Y884 Topics: Afatinib; Allosteric Regulation; Binding Sites; Catalytic Domain; Colorectal Neoplasms; ErbB Receptors; Humans; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Interaction Maps; Proto-Oncogene Proteins p21(ras); Quinazolines; SOS1 Protein	2021

Article

Year

One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.

Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10

KRAS, the most common oncogenic driver in human cancers, is controlled and signals primarily through protein-protein interactions (PPIs). The interaction between KRAS and SOS1, crucial for the activation of KRAS, is a typical, challenging PPI with a large contact surface area and high affinity. Here, we report that the addition of only one atom placed between Y884

Topics: Afatinib; Allosteric Regulation; Binding Sites; Catalytic Domain; Colorectal Neoplasms; ErbB Receptors; Humans; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Interaction Maps; Proto-Oncogene Proteins p21(ras); Quinazolines; SOS1 Protein

2021