bibp-3226 and Leukemia--Erythroblastic--Acute

bibp-3226 has been researched along with Leukemia--Erythroblastic--Acute* in 1 studies

Other Studies

1 other study(ies) available for bibp-3226 and Leukemia--Erythroblastic--Acute

Article	Year
Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226. Bioorganic & medicinal chemistry letters, 2000, Jul-17, Volume: 10, Issue:14 Analogues of BIBP 3226, (R)-N(alpha)-diphenylacetyl-N-(4-hydroxybenzyl)argininamide, were synthesized and investigated for Y1 antagonism (Ca2+-assay, HEL cells) and binding on Y1, Y2 and Y5 receptors. Replacing the benzylamino by a tetrahydrobenzazepinyl group preserves most of the Y1 activity. Combination with a N(G)-phenylpropyl arginine and a N(alpha)-p-biphenylylacetyl moiety shifted the NPY receptor selectivity towards Y5. Topics: Animals; Arginine; Drug Design; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Molecular Conformation; Molecular Structure; Neuropeptide Y; Receptors, Neuropeptide Y; Structure-Activity Relationship; Swine; Tumor Cells, Cultured	2000

Article

Year

Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226.

Bioorganic & medicinal chemistry letters, 2000, Jul-17, Volume: 10, Issue:14

Analogues of BIBP 3226, (R)-N(alpha)-diphenylacetyl-N-(4-hydroxybenzyl)argininamide, were synthesized and investigated for Y1 antagonism (Ca2+-assay, HEL cells) and binding on Y1, Y2 and Y5 receptors. Replacing the benzylamino by a tetrahydrobenzazepinyl group preserves most of the Y1 activity. Combination with a N(G)-phenylpropyl arginine and a N(alpha)-p-biphenylylacetyl moiety shifted the NPY receptor selectivity towards Y5.

Topics: Animals; Arginine; Drug Design; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Molecular Conformation; Molecular Structure; Neuropeptide Y; Receptors, Neuropeptide Y; Structure-Activity Relationship; Swine; Tumor Cells, Cultured

2000