bialaphos and Seizures

bialaphos has been researched along with Seizures* in 2 studies

Other Studies

2 other study(ies) available for bialaphos and Seizures

Article	Year
Decreased plasma and cerebrospinal fluid glutamine concentrations in a patient with bialaphos poisoning. Human & experimental toxicology, 2001, Volume: 20, Issue:8 A 47-year-old Japanese woman undergoing maintenance hemodialysis (HD) was admitted to our hospital because of poisoning with the herbicide bialaphos. Respiratory arrest and loss of consciousness ensued rapidly, accompanied by convulsions and nystagmus. Treatment with HD and direct hemoperfusion, followed by HD alone, effectively removed bialaphos and its chief toxic metabolite (L-AMPB) from the circulation (bialaphos decreased from 0.33 to < 0.05 microg/ml and L-AMPB from 14 to 0.86 microg/ml). The glutamate concentration improved gradually after the removal of bialaphos and L-AMPB from plasma (plasma glutamate concentration: 250.4 nmol/l on day 5 to 120.6 nmol/l on day 26). Decreased glutamine concentration in cerebrospinal fluid was demonstrated for the first time as well as in plasma, indicating glutamine synthetase inhibition not only in plants but also in humans by bialaphos poisoning. Topics: Adult; Female; Glutamic Acid; Glutamine; Herbicides; Humans; Japan; Organophosphate Poisoning; Organophosphorus Compounds; Renal Dialysis; Respiratory Distress Syndrome; Seizures; Unconsciousness	2001
Bialaphos poisoning with apnea and metabolic acidosis. Journal of toxicology. Clinical toxicology, 1991, Volume: 29, Issue:1 A 64-year-old man with ethanol intoxication, ingested a bottle of Herbiace (100 ml, 32 w/v% of bialaphos, CAS #35597-43-4, Meiji Seika Kaisha, Tokyo, Japan). He had severe metabolic acidosis and was treated with infusions of sodium bicarbonate and furosemide, plus gastric lavage and enema. The metabolic acidosis improved 15 hours after treatment but nystagmus, apnea and convulsions were progressive. Although his sensorium was clear, spontaneous respirations were not observed for 64 hours. The electroencephalographic findings of atypical triphasic waves and slow waves suggest a unique response to bialaphos poisoning. His clinical course indicates that the management of apnea is critically important to recovery from bialaphos poisoning. Topics: Acidosis; Alcoholic Intoxication; Apnea; Electroencephalography; Herbicides; Humans; Male; Middle Aged; Nystagmus, Pathologic; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Seizures	1991

Article

Year

Decreased plasma and cerebrospinal fluid glutamine concentrations in a patient with bialaphos poisoning.

Human & experimental toxicology, 2001, Volume: 20, Issue:8

A 47-year-old Japanese woman undergoing maintenance hemodialysis (HD) was admitted to our hospital because of poisoning with the herbicide bialaphos. Respiratory arrest and loss of consciousness ensued rapidly, accompanied by convulsions and nystagmus. Treatment with HD and direct hemoperfusion, followed by HD alone, effectively removed bialaphos and its chief toxic metabolite (L-AMPB) from the circulation (bialaphos decreased from 0.33 to < 0.05 microg/ml and L-AMPB from 14 to 0.86 microg/ml). The glutamate concentration improved gradually after the removal of bialaphos and L-AMPB from plasma (plasma glutamate concentration: 250.4 nmol/l on day 5 to 120.6 nmol/l on day 26). Decreased glutamine concentration in cerebrospinal fluid was demonstrated for the first time as well as in plasma, indicating glutamine synthetase inhibition not only in plants but also in humans by bialaphos poisoning.

Topics: Adult; Female; Glutamic Acid; Glutamine; Herbicides; Humans; Japan; Organophosphate Poisoning; Organophosphorus Compounds; Renal Dialysis; Respiratory Distress Syndrome; Seizures; Unconsciousness

2001

Bialaphos poisoning with apnea and metabolic acidosis.

Journal of toxicology. Clinical toxicology, 1991, Volume: 29, Issue:1

A 64-year-old man with ethanol intoxication, ingested a bottle of Herbiace (100 ml, 32 w/v% of bialaphos, CAS #35597-43-4, Meiji Seika Kaisha, Tokyo, Japan). He had severe metabolic acidosis and was treated with infusions of sodium bicarbonate and furosemide, plus gastric lavage and enema. The metabolic acidosis improved 15 hours after treatment but nystagmus, apnea and convulsions were progressive. Although his sensorium was clear, spontaneous respirations were not observed for 64 hours. The electroencephalographic findings of atypical triphasic waves and slow waves suggest a unique response to bialaphos poisoning. His clinical course indicates that the management of apnea is critically important to recovery from bialaphos poisoning.

Topics: Acidosis; Alcoholic Intoxication; Apnea; Electroencephalography; Herbicides; Humans; Male; Middle Aged; Nystagmus, Pathologic; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Seizures

1991