bi-d1870 has been researched along with Esophageal-Neoplasms* in 1 studies
1 other study(ies) available for bi-d1870 and Esophageal-Neoplasms
| Article | Year |
|---|---|
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Ribosomal S6 protein kinase 4 (RSK4) was identified to be a promising target for the treatment of esophageal squamous cell carcinoma (ESCC) in our previous research, whose current treatments are primarily chemotherapy and radiotherapy due to the lack of targeted therapy. However, few potent and specific RSK4 inhibitors are reported. In this study, a series of 1,4-dihydro- Topics: Animals; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Male; Mice, Nude; Molecular Docking Simulation; Molecular Structure; Oxazines; Protein Kinase Inhibitors; Pyrimidines; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 90-kDa; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2021 |