bexarotene has been researched along with Amyloid Deposits in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (92.31) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Karki, P; Mafimoghaddam, S; Orlova, EV; Orman, MA; Sherman, MB; Vekilov, PG; Xu, Y | 1 |
| Bednarikova, Z; Gazova, Z; Huy, PDQ; Li, MS; Linh, HQ; Phuc, LH; Thai, NQ | 1 |
| Casali, BT; Landreth, GE; Reed-Geaghan, EG | 1 |
| Bednarikova, Z; Gazova, Z; Li, MS; Linh, HQ; Pham, HDQ; Thai, NQ | 1 |
| Allard, JS; LaClair, KD; Lee, DL; Manaye, KF; Savonenko, AV; Troncoso, JC; Wong, PC | 1 |
| Goduni, E; Jay, T; Lamb, BT; Landreth, GE; Malm, T; Mariani, MM; Quigley, C; Ransohoff, RM; Savage, JC | 1 |
| Blanco-Gandía, M; Bonet-Costa, V; Borras, C; Garcia-Tarraga, P; Garcia-Verdugo, JM; Herranz-Pérez, V; Inglés, M; Mas-Bargues, C; Miñarro, J; Rodriguez-Arias, M; Viña, J | 1 |
| Casali, B; Jay, TR; Lamb, R; Landreth, GE; Malm, T; Mariani, MM; Medarametla, L; Neilson, L | 1 |
| Brunden, KR; Casali, BT; Cirrito, JR; Cramer, PE; Goebel, WD; James, MJ; Karlo, JC; Landreth, GE; Lee, CY; Restivo, JL; Wesson, DW; Wilson, DA; Zinn, AE | 1 |
| Nau, JY | 1 |
| Gross, M | 1 |
| LaFerla, FM | 1 |
13 other study(ies) available for bexarotene and Amyloid Deposits
| Article | Year |
|---|---|
Suppression of amyloid-β fibril growth by drug-engineered polymorph transformation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Bexarotene; Peptide Fragments; Plaque, Amyloid; Rats | 2022 |
Bexarotene Does Not Clear Amyloid Beta Plaques but Delays Fibril Growth: Molecular Mechanisms.
Topics: Amyloid beta-Peptides; Benzothiazoles; Bexarotene; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Atomic Force; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Neuroprotective Agents; Plaque, Amyloid; Protein Multimerization; Protein Structure, Secondary; Tetrahydronaphthalenes; Thiazoles; Water | 2017 |
Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Bexarotene; Cells, Cultured; Cognition; Cognition Disorders; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Peptide Fragments; Plaque, Amyloid; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors | 2018 |
Bexarotene cannot reduce amyloid beta plaques through inhibition of production of amyloid beta peptides: in silico and in vitro study.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Bexarotene; Computer Simulation; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Plaque, Amyloid; PPAR gamma; Protein Binding; Protein Conformation; Retinoid X Receptors | 2018 |
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice.
Topics: Alzheimer Disease; Animals; Anticarcinogenic Agents; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Behavior, Animal; Bexarotene; Blotting, Western; Disease Models, Animal; Female; Male; Memory; Mice; Mice, Mutant Strains; Plaque, Amyloid; Tetrahydronaphthalenes | 2013 |
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Axl Receptor Tyrosine Kinase; Benzoates; Benzylamines; Bexarotene; c-Mer Tyrosine Kinase; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Leukocyte Common Antigens; Macrophages; Male; Membrane Glycoproteins; Mice; Microglia; Myeloid Cells; Phagocytosis; Pioglitazone; Plaque, Amyloid; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2015 |
Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Avoidance Learning; Bexarotene; Brain; Cells, Cultured; Disease Models, Animal; Female; Genistein; Habituation, Psychophysiologic; Maze Learning; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Nootropic Agents; Olfactory Perception; Plaque, Amyloid; PPAR gamma; Recognition, Psychology; Tetrahydronaphthalenes | 2016 |
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Bexarotene; Biomarkers; Cell Survival; Cytokines; Disease Models, Animal; Female; Gliosis; Glutamic Acid; Habituation, Psychophysiologic; Hippocampus; Inflammation; Male; Membrane Transport Proteins; Memory; Mice, Transgenic; Neurons; Neurotoxins; Olfactory Bulb; Plaque, Amyloid; Receptors, LDL; Retinoid X Receptors; Synapses; Tetrahydronaphthalenes | 2017 |
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Apolipoproteins E; Astrocytes; Behavior, Animal; Bexarotene; Brain; Disease Models, Animal; Extracellular Fluid; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Molecular Targeted Therapy; Odorants; Olfactory Pathways; Orphan Nuclear Receptors; Phagocytosis; Plaque, Amyloid; PPAR gamma; Retinoid X Receptors; Tetrahydronaphthalenes | 2012 |
[Alzheimer disease: the temptation coming from off-label use].
Topics: Alzheimer Disease; Animals; Antineoplastic Agents; Bexarotene; Drug Approval; Drug Repositioning; Exploratory Behavior; Guideline Adherence; Humans; Mass Media; Mice; Off-Label Use; Plaque, Amyloid; Tetrahydronaphthalenes; Treatment Outcome | 2012 |
Latest Alzheimer's research: some rays of hope.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Bexarotene; Biomedical Research; Cognition; Health Status; Humans; Patient Education as Topic; Plaque, Amyloid; Tetrahydronaphthalenes; United States | 2012 |
Understanding amyloid and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Bexarotene; Brain; Central Nervous System Agents; Humans; Plaque, Amyloid; Tetrahydronaphthalenes | 2012 |
Preclinical success against Alzheimer's disease with an old drug.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Bexarotene; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Retinoid X Receptors; Tetrahydronaphthalenes | 2012 |