Compounds > betulinic acid

betulinic acid and Neoplasms

betulinic acid has been researched along with Neoplasms in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.22)18.2507
2000's11 (24.44)29.6817
2010's25 (55.56)24.3611
2020's8 (17.78)2.80

Authors

AuthorsStudies
Fujii, N; Mahindroo, N; Punchihewa, C1
Barthel, A; Csuk, R; Kluge, R; Kommera, H; Paschke, R; Ströhl, D1
Eiznhamer, DA; Flavin, MT; Flavin, WP; Koohang, A; Mar, AA; Szotek, EL; Xu, ZQ1
Han, J; He, WJ; Ji, CJ; Tan, NH; Zeng, GZ; Zhang, YM1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS1
Csuk, R; Fischer, L; Rohmer, M; Wiemann, J1
Kishore, N; Kumar, P; Shanker, K; Verma, AK1
Borkova, L; Hodon, J; Kazakova, A; Pokorny, J; Urban, M1
Miao, Z; Wang, C; Wang, Y; Wu, Y; Ye, S; Zhang, H; Zhang, Y; Zhu, Y1
Abzaliyeva, S; Bazarbayeva, A; Farooqi, AA; Kapanova, G; Tashenova, G; Tulebayeva, A; Turgambayeva, A1
Abdullin, TI; Idrisova, LR; Ishkaeva, RA; Kundina, AV; Laikov, AV; Mironov, VF; Nemtarev, AV; Salikhova, TI; Tikhomirova, MV; Tsepaeva, OV1
Chen, H; Dai, Z; Gao, F; Gu, Y; Han, N; Huo, S; Lei, H; Li, W; Liu, X; Qi, J; Tian, X; Wang, P; Wu, Q; Xie, T; Yang, Y1
Cheng, J; Han, Y; Li, X; Wang, S; Yang, X; Zhao, H1
Akinyelu, J; Daniels, A; Oladimeji, O; Singh, M1
Haeri, HH; Hinderberger, D; Hussain, H; Kaluđerović, GN; Morgan, I; Roos, AH; Sultani, HN; Westermann, B1
Dong, S; Jiang, W; Li, X; Zhou, W1
Bhadauria, AS; Kumar, P; Saha, S; Singh, AK1
Bori, ID; Hung, HY; Iida, A; Lee, KH; Nakagawa-Goto, K; Qian, K; Suzuki, N; Tokuda, H1
Baratto, LC; Emmerich, D; Paschke, R; Schmidt, H; Vanchanagiri, K1
Dehelean, C; Duicu, O; Gheorgheosu, D; Muntean, D; Soica, C1
Csuk, R1
Chinthakindi, PK; Hamid, A; Koul, S; Majeed, R; Mintoo, MJ; Mondhe, DM; Rath, SK; Rayees, S; Sangwan, PL; Saxena, AK; Singh, G; Singh, SK1
Airoldi, FP; Araújo, BQ; Citó, AM; Ferreira, PM; Lima, DJ; Monção, NB; Pessoa, C; Silva, Jdo N1
Chinthakindi, PK; Hamid, A; Hussain, A; Khan, I; Koul, S; Majeed, R; Sangwan, PL; Saxena, AK; Sharma, PR1
Aleshunin, PA; Chytil, P; Etrych, T; Filippov, SK; Janoušková, O; Lomkova, EA; Lucas, H; Mueller, T; Skorik, YA; Trhlíková, O; Ulbrich, K1
Günther, G; Morales, J; Rodríguez, L; Valdés, K1
Bramucci, M; Dall'Acqua, S; Ferrari, S; Gandin, V; Maggi, F; Mártonfi, P; Peron, G; Quassinti, L1
Chang, FR; Chen, IH; Chen, SL; Chiang, MY; Du, YC; Hwang, TL; Lin, AS; Lin, CR; Lübken, T; Wu, CC; Wu, YC; Yen, MH1
Fulda, S; Kroemer, G1
Chan, KL; Majid, AM; Ng, KW; Salhimi, SM1
Fulda, S1
Barthel, A; Csuk, R; Schwarz, S; Sczepek, R; Siewert, B1
Fang, X; Guo, X; He, K; Jin, YH; Li, Q; Li, Y; Sun, C; Wang, X; Zhan, Z1
Chen, CH; Huang, L; Hung, HY; Kim, SY; Lee, KH; Qian, K1
Ahmad, FJ; Awasthi, A; Jaggi, M; Mishra, G; Singh, AT; Singh, MK1
Cichewicz, RH; Kouzi, SA1
Eiznhamer, DA; Xu, ZQ1
Debatin, KM; Fulda, S1
Dzubak, P; Hajduch, M; Klinotova, E; Kvasnica, M; Sarek, J1
Behrend, L; Debatin, KM; Fulda, S; Kasperczyk, H; La Ferla-Brühl, K; Westhoff, MA; Zwacka, RM1
Kaczor, J; Kandefer-Szerszeń, M; Rzeski, W; Sifringer, M; Stepulak, A; Szymański, M; Wejksza, K; Zdzisińska, B1
de Roo, GM; Kessler, JH; Medema, JP; Mullauer, FB1
Cmoch, P; Pakulski, Z; Strnad, M; Swaczynová, J1
Cho, KH; Chung, SM; Das Gupta, TK; Graham, J; Pezzuto, JM; Shin, YG1

Reviews

15 review(s) available for betulinic acid and Neoplasms

ArticleYear
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
    Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13

    Topics: Antineoplastic Agents; Drug Discovery; Hedgehog Proteins; Humans; Neoplasms; Signal Transduction; Transcription Factors; Zinc Finger Protein GLI1

2009
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
    European journal of medicinal chemistry, 2017, Dec-15, Volume: 142

    Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes

2017
Human disorders associated with inflammation and the evolving role of natural products to overcome.
    European journal of medicinal chemistry, 2019, Oct-01, Volume: 179

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Humans; Inflammation; Neoplasms; Skin Diseases

2019
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.
    European journal of medicinal chemistry, 2019, Nov-15, Volume: 182

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferation; Drug Design; Humans; Neoplasms; Triterpenes; Viruses

2019
Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis.
    Molecules (Basel, Switzerland), 2022, Dec-21, Volume: 28, Issue:1

    Topics: Animals; Antineoplastic Agents; Betulinic Acid; Carcinogenesis; Epidermal Growth Factor; ErbB Receptors; Neoplasms; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

2022
Betulinic acid in the treatment of tumour diseases: Application and research progress.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 142

    Topics: Animals; Antineoplastic Agents, Phytogenic; Betula; Betulinic Acid; Humans; Neoplasms; Oxidative Stress; Pentacyclic Triterpenes; Signal Transduction

2021
Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications.
    Life sciences, 2018, Sep-15, Volume: 209

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Humans; Mitochondria; Models, Theoretical; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2018
Betulinic acid as a potent and complex antitumor phytochemical: a minireview.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Humans; Neoplasm Metastasis; Neoplasms; Pentacyclic Triterpenes; Phytochemicals; Triterpenes

2014
Betulinic acid and its derivatives: a patent review (2008-2013).
    Expert opinion on therapeutic patents, 2014, Volume: 24, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Cell Line, Tumor; Drug Design; Humans; Neoplasms; Patents as Topic; Pentacyclic Triterpenes; Solubility; Structure-Activity Relationship; Triterpenes

2014
Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments.
    Nanomedicine (London, England), 2016, Volume: 11, Issue:23

    Topics: Animals; Antineoplastic Agents; Betulinic Acid; Biological Availability; Drug Delivery Systems; Drug Liberation; Humans; Nanocapsules; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Triterpenes; Unilamellar Liposomes; Ursolic Acid; Water

2016
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
    Drug discovery today, 2009, Volume: 14, Issue:17-18

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Drug Resistance, Neoplasm; Humans; Mitochondrial Membranes; Models, Biological; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2009
Modulation of apoptosis by natural products for cancer therapy.
    Planta medica, 2010, Volume: 76, Issue:11

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Clinical Trials as Topic; Gossypol; Humans; Mitochondria; Neoplasms; Pentacyclic Triterpenes; Reactive Oxygen Species; Resveratrol; Signal Transduction; Stilbenes; Triterpenes; Vitamin E

2010
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection.
    Medicinal research reviews, 2004, Volume: 24, Issue:1

    Topics: Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Betulinic Acid; HIV Infections; Humans; Mass Spectrometry; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2004
Betulinic acid: a promising anticancer candidate.
    IDrugs : the investigational drugs journal, 2004, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Agents; Betulinic Acid; Drugs, Investigational; Humans; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2004

Other Studies

30 other study(ies) available for betulinic acid and Neoplasms

ArticleYear
Synthesis and biological evaluation of antitumour-active betulin derivatives.
    Bioorganic & medicinal chemistry, 2010, Volume: 18, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triterpenes

2010
Synthesis, proapoptotic screening, and structure-activity relationships of novel aza-lupane triterpenoids.
    Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18

    Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes

2010
Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana.
    Bioorganic & medicinal chemistry letters, 2012, Oct-15, Volume: 22, Issue:20

    Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Neoplasms; Plant Roots; Staphylococcal Infections; Staphylococcus aureus; Triterpenes; Ziziphus

2012
Syntheses of C-ring modified dehydroabietylamides and their cytotoxic activity.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Abietanes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Neoplasms; Structure-Activity Relationship

2018
Discovery and optimization of betulinic acid derivatives as novel potent CD73 inhibitors.
    Bioorganic & medicinal chemistry, 2022, 04-01, Volume: 59

    Topics: 5'-Nucleotidase; Adenosine; Betulinic Acid; Humans; Immunotherapy; Neoplasms; Pentacyclic Triterpenes

2022
Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability.
    Journal of natural products, 2023, 08-25, Volume: 86, Issue:8

    Topics: Betulinic Acid; Chromatography, Liquid; Glycosides; Humans; Male; Mannose; Neoplasms; Rhamnose; Tandem Mass Spectrometry; Triterpenes

2023
Betulinic Acid-Nitrogen Heterocyclic Derivatives: Design, Synthesis, and Antitumor Evaluation
    Molecules (Basel, Switzerland), 2020, Feb-20, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Betulinic Acid; Cytotoxins; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes

2020
Carrier-Free Triterpene Prodrugs with Glutathione Response and Biosafety for Synergistically Enhanced Photochemotherapy.
    ACS applied materials & interfaces, 2021, Jan-13, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Agents; Betulinic Acid; Chlorophyllides; Density Functional Theory; Drug Synergism; Female; Glutathione; Light; Mice, Inbred BALB C; Models, Chemical; Molecular Dynamics Simulation; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Photochemotherapy; Photosensitizing Agents; Porphyrins; Prodrugs; Singlet Oxygen; Stigmasterol

2021
Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria.
    International journal of molecular sciences, 2021, May-11, Volume: 22, Issue:10

    Topics: Apoptosis; Betulinic Acid; Caco-2 Cells; Cell Cycle; Cell Proliferation; Drug Delivery Systems; Gold; HeLa Cells; Humans; MCF-7 Cells; Metal Nanoparticles; Mitochondria; Neoplasms; Pentacyclic Triterpenes

2021
Access to New Cytotoxic Triterpene and Steroidal Acid-TEMPO Conjugates by Ugi Multicomponent-Reactions.
    International journal of molecular sciences, 2021, Jul-01, Volume: 22, Issue:13

    Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cholic Acid; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fusidic Acid; Humans; Neoplasms; Pentacyclic Triterpenes; Small Molecule Libraries; Spin Labels; Steroids; Triterpenes

2021
A-ring modified betulinic acid derivatives as potent cancer preventive agents.
    Bioorganic & medicinal chemistry letters, 2014, Feb-01, Volume: 24, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Betulinic Acid; Cell Line; Herpesvirus 4, Human; Humans; Mice; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2014
Synthesis and studies of anticancer properties of lupane-type triterpenoid derivatives containing a cisplatin fragment.
    European journal of medicinal chemistry, 2014, Mar-21, Volume: 75

    Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cisplatin; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes

2014
Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.
    Cell death & disease, 2014, Oct-09, Volume: 5

    Topics: Animals; Apoptosis; Betulinic Acid; Cell Cycle Checkpoints; Cell Line, Tumor; Enzyme Inhibitors; Female; Humans; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Triterpenes

2014
Assessing chemical constituents of Mimosa caesalpiniifolia stem bark: possible bioactive components accountable for the cytotoxic effect of M. caesalpiniifolia on human tumour cell lines.
    Molecules (Basel, Switzerland), 2015, Mar-05, Volume: 20, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Survival; Flavonoids; Humans; Mimosa; Neoplasms; Pentacyclic Triterpenes; Phenols; Plant Bark; Plant Extracts; Triterpenes; Tumor Cells, Cultured

2015
PI3K target based novel cyano derivative of betulinic acid induces its signalling inhibition by down-regulation of pGSK3β and cyclin D1 and potentially checks cancer cell proliferation.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:5

    Topics: Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HL-60 Cells; Humans; MCF-7 Cells; Neoplasms; Pentacyclic Triterpenes; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Signal Transduction; Triazoles; Triterpenes

2016
Biodegradable Micellar HPMA-Based Polymer-Drug Conjugates with Betulinic Acid for Passive Tumor Targeting.
    Biomacromolecules, 2016, 11-14, Volume: 17, Issue:11

    Topics: Animals; Betulinic Acid; Biodegradable Plastics; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Carriers; Humans; Methacrylates; Mice; Micelles; Neoplasms; Pentacyclic Triterpenes; Polymers; Triterpenes

2016
Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Proliferation; Chromatography, High Pressure Liquid; Cisplatin; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; HCT116 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Neoplasms; Oils, Volatile; Pentacyclic Triterpenes; Phytochemicals; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plant Oils; Plants, Medicinal; Slovakia; Thymus Plant; Triterpenes

2017
Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana.
    Planta medica, 2009, Volume: 75, Issue:3

    Topics: Acacia; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Line, Tumor; Diterpenes; Flavonoids; Humans; Leukocyte Elastase; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Plant Extracts; Plant Roots; Superoxides; Triterpenes

2009
Anti-angiogenic and cytotoxicity studies of some medicinal plants.
    Planta medica, 2010, Volume: 76, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Aorta; Betulinic Acid; Cell Line, Tumor; Endothelial Cells; Humans; Lignans; Neoplasms; Pentacyclic Triterpenes; Plant Extracts; Plants, Medicinal; Rats; Triterpenes; Umbilical Veins

2010
Synthesis, encapsulation and antitumor activity of new betulin derivatives.
    Archiv der Pharmazie, 2011, Volume: 344, Issue:1

    Topics: Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Colorimetry; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Liposomes; Neoplasms; Pentacyclic Triterpenes; Pyrazoles; Rhodamines; Structure-Activity Relationship; Triazoles; Triterpenes

2011
Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.
    Molecular carcinogenesis, 2011, Volume: 50, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Betulinic Acid; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Flow Cytometry; Ginsenosides; HeLa Cells; Hep G2 Cells; Humans; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Poly(ADP-ribose) Polymerases; Protein Transport; RNA Interference; Triterpenes

2011
New betulinic acid derivatives as potent proteasome inhibitors.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Antineoplastic Agents; Betulinic Acid; Chymotrypsin; Cysteine Proteinase Inhibitors; Drug Design; Inflammation; Molecular Structure; Molecular Targeted Therapy; Neoplasms; Pentacyclic Triterpenes; Proteasome Inhibitors; Signal Transduction; Structure-Activity Relationship; Triterpenes

2011
Application of a liquid chromatography-electrospray mass spectrometry (LC/MS) method to the biodistribution and excretion studies of novel 5'-chloro-2, 3-didehydroindolo (2', 3': 2, 3) betulinic acid (DRF-4012) in tumour-bearing mice.
    Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:6

    Topics: Animals; Betulinic Acid; Calibration; Cell Line, Tumor; Chromatography, Liquid; Drug Stability; Humans; Indoles; Injections, Intravenous; Male; Mice; Mice, Nude; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution; Triterpenes; Xenograft Model Antitumor Assays

2013
Sensitization for anticancer drug-induced apoptosis by betulinic Acid.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Betulinic Acid; Caspases; Cells, Cultured; Cisplatin; Complement Membrane Attack Complex; Complement System Proteins; Cytochromes c; Dactinomycin; Doxorubicin; Drug Synergism; Enzyme Activation; Etoposide; Fibroblasts; Glycoproteins; Humans; Membrane Potentials; Mitochondria; Mutation; Neoplasms; Paclitaxel; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Triterpenes; Tumor Stem Cell Assay; Tumor Suppressor Protein p53

2005
Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity.
    Bioorganic & medicinal chemistry, 2005, May-16, Volume: 13, Issue:10

    Topics: Acylation; Antineoplastic Agents; Betulinic Acid; Cell Survival; Drug Screening Assays, Antitumor; Esters; Humans; Neoplasms; Pentacyclic Triterpenes; Phthalic Acids; Triterpenes; Tumor Cells, Cultured

2005
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.
    Oncogene, 2005, Oct-20, Volume: 24, Issue:46

    Topics: Apoptosis; Base Sequence; Betulinic Acid; Cell Line, Tumor; DNA Primers; Humans; Hydrolysis; I-kappa B Proteins; Neoplasms; NF-kappa B; NF-KappaB Inhibitor alpha; Pentacyclic Triterpenes; Triterpenes

2005
Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 374, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Humans; Neoplasms; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Triterpenes

2006
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.
    Cancer letters, 2007, Jun-18, Volume: 251, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cells, Cultured; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Jurkat Cells; Lung Neoplasms; Male; Neoplasms; Pentacyclic Triterpenes; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Triterpenes; Uterine Cervical Neoplasms

2007
Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents.
    Carbohydrate research, 2008, May-05, Volume: 343, Issue:6

    Topics: Antineoplastic Agents; Betulinic Acid; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Mannose; Mannosides; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Saponins; Triterpenes

2008
Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatography-electrospray mass spectrometry.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Sep-24, Volume: 732, Issue:2

    Topics: Animals; Betulinic Acid; Calibration; Chromatography, High Pressure Liquid; Humans; Kidney; Liver; Lung; Mass Spectrometry; Mice; Mice, Nude; Neoplasms; Pentacyclic Triterpenes; Triterpenes

1999