betulinic acid has been researched along with Melanoma in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, DS; Pezzuto, JM; Pisha, E | 1 |
| Chai, HB; Jeong, HJ; Kim, DS; Park, SY | 1 |
| Chatterjee, P; Kouzi, SA; Pezzuto, JM | 1 |
| Assefa, H; Nimrod, A; Sindelar, R; Walker, L | 1 |
| Chatterjee, P; Hamann, MT; Kouzi, SA; Pezzuto, JM | 2 |
| Kim, DS; Kim, JY; Koo, HM | 1 |
| Bąk, W; Bargieł, J; Cabaj, J; Góralczyk, A; Grabarska, A; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
| Cavalleri, JV; Delarocque, J; Feige, K; Kalbitz, J; Kietzmann, M; Meißner, J; Michael, J; Michaelis, A; Paschke, R; Pratscher, B; Weber, LA | 1 |
| Choromańska, A; Kotulska, M; Kulbacka, J; Kutkowska, J; Mączyńska, J; Saczko, J; Zalewski, J; Zalewski, M | 1 |
| Ambrus, R; Avram, S; Bojin, F; Borcan, F; Ciurlea, S; Coricovac, D; Danciu, C; Dehelean, CA; Matusz, P; Olariu, T; Savoiu-Balint, G; Soica, C; Zupko, I | 1 |
| Dutta, SK; Ghosh, M; Saha, S | 1 |
| Cavalleri, JM; Feige, K; Liebscher, G; Mueller, T; Paschke, R; Vanchangiri, K | 1 |
| Brüne, B; Dehelean, C; Gheorgheosu, D; Jung, M; Muntean, D; Ören, B; Schmid, T | 1 |
| Hoeller, C; Jansen, B; Oberkleiner, P; Pehamberger, H; Selzer, E; Thallinger, C; Wacheck, V | 1 |
| Pezzuto, JM; Tan, Y; Yu, R | 1 |
| Arimochi, H; Fujino, H; Kataoka, K; Kondo, K; Kuwahara, T; Miyoshi, T; Monden, Y; Ohnishi, Y; Sawada, N; Takahashi, Y | 1 |
| Debatin, KM; Fulda, S; Jeremias, I | 1 |
| Derby, S; Di, W; Jiang, Q; Qiu, L; Schefeller, E; Wan, Y; Wanebo, H; Wang, Q; Yan, B | 1 |
| Rieber, M; Rieber, MS | 2 |
| Dräger, B; Galgon, T; Wohlrab, W | 1 |
| Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E | 1 |
| Rieber, M; Strasberg Rieber, M | 1 |
| Jansen, B; Kodym, R; Pehamberger, H; Pimentel, E; Schlegel, W; Selzer, E; Wacheck, V | 1 |
| El-Deiry, WS; Meng, RD | 1 |
| Daniel, PT; Eberle, J; Geilen, CC; Hossini, AM; Orfanos, CE; Raisova, M; Riebeling, C; Sturm, I; Wieder, T | 1 |
27 other study(ies) available for betulinic acid and Melanoma
| Article | Year |
|---|---|
Synthesis of betulinic acid derivatives with activity against human melanoma.
Topics: Antineoplastic Agents; Betulinic Acid; Carcinoma, Squamous Cell; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Melanoma; Mouth Neoplasms; Pentacyclic Triterpenes; Triterpenes | 1998 |
Preparation of amino acid conjugates of betulinic acid with activity against human melanoma.
Topics: Antineoplastic Agents; Betulinic Acid; Fibrosarcoma; Humans; Hydrolysis; Melanoma; Pentacyclic Triterpenes; Triterpenes; Tumor Cells, Cultured | 1999 |
Glucosidation of betulinic acid by Cunninghamella species.
Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Biotransformation; Cell Survival; Cunninghamella; Drug Screening Assays, Antitumor; Fermentation; Glucosides; Humans; Hydrolysis; Melanoma; Pentacyclic Triterpenes; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes; Tumor Cells, Cultured | 1999 |
Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
Topics: Antineoplastic Agents; Apoptosis; Complement Inactivator Proteins; DNA Fragmentation; Drug Evaluation, Preclinical; Humans; Melanoma; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Microbial transformations of the antimelanoma agent betulinic acid.
Topics: Antineoplastic Agents; Bacillus megaterium; Betulinic Acid; Biotransformation; Cunninghamella; Melanoma; Pentacyclic Triterpenes; Spectrum Analysis; Triterpenes | 2000 |
Development of C-20 modified betulinic acid derivatives as antitumor agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Betulinic Acid; Drug Screening Assays, Antitumor; Humans; Male; Melanoma; Oleanolic Acid; Pentacyclic Triterpenes; Prostatic Neoplasms; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 2001 |
Additive Interactions between Betulinic Acid and Two Taxanes in In Vitro Tests against Four Human Malignant Melanoma Cell Lines.
Topics: Antineoplastic Agents; Betulinic Acid; Cell Line; Docetaxel; Humans; In Vitro Techniques; Melanoma; Melanoma, Cutaneous Malignant; Paclitaxel; Pentacyclic Triterpenes; Skin Neoplasms; Taxoids | 2022 |
Betulinic acid shows anticancer activity against equine melanoma cells and permeates isolated equine skin in vitro.
Topics: Animals; Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Fibroblasts; Horse Diseases; Horses; Melanoma; Melanoma, Cutaneous Malignant; Pentacyclic Triterpenes; Skin; Skin Neoplasms; Triterpenes | 2020 |
Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro.
Topics: Betulinic Acid; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Delivery Systems; Electrochemotherapy; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Melanoma; Neoplasm Metastasis; Pentacyclic Triterpenes; Triterpenes | 2019 |
Betulinic acid in complex with a gamma-cyclodextrin derivative decreases proliferation and in vivo tumor development of non-metastatic and metastatic B164A5 cells.
Topics: Animals; Antineoplastic Agents; Betulinic Acid; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Female; gamma-Cyclodextrins; Melanoma; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Solubility; Triterpenes; X-Ray Diffraction | 2014 |
A potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Disease Models, Animal; Drug Synergism; Esters; Female; Humans; Inhibitory Concentration 50; Lung Neoplasms; Melanoma; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mitochondria; NIH 3T3 Cells; Oxidative Stress; Pentacyclic Triterpenes; Reactive Oxygen Species; Triterpenes | 2015 |
In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses.
Topics: Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Caspases; Cell Cycle; Cell Line, Tumor; Enzyme Activation; Female; Horses; Humans; Melanoma; Pentacyclic Triterpenes; Propanolamines; Safety; Triterpenes; Xenograft Model Antitumor Assays | 2016 |
Betulinic acid suppresses NGAL-induced epithelial-to-mesenchymal transition in melanoma.
Topics: Acute-Phase Proteins; Betulinic Acid; Cell Line, Tumor; Cell Movement; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Lipocalin-2; Lipocalins; Melanoma; Neoplasm Invasiveness; Pentacyclic Triterpenes; Phenotype; Proto-Oncogene Proteins; Triterpenes | 2013 |
Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.
Topics: Androstadienes; Betulinic Acid; Cell Culture Techniques; Chromones; Enzyme Inhibitors; Humans; Melanoma; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Pentacyclic Triterpenes; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Triterpenes; Wortmannin | 2002 |
Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Betulinic Acid; Blotting, Western; Caspase 3; Caspases; Cell Line, Tumor; Enzyme Activation; Flow Cytometry; Humans; Intracellular Membranes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Melanoma; Membrane Potentials; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Phosphorylation; Reactive Oxygen Species; Time Factors; Triterpenes | 2003 |
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Cycle; Female; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Skin Neoplasms; Triterpenes; Tumor Cells, Cultured; Vincristine | 2004 |
Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Betulinic Acid; Cell Division; Cell Line, Tumor; Cell Survival; Humans; Intracellular Membranes; Kidney Neoplasms; Medulloblastoma; Melanoma; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Neuroblastoma; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; TNF-Related Apoptosis-Inducing Ligand; Triterpenes; Tumor Necrosis Factor-alpha | 2004 |
Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Inhibitor of Apoptosis Proteins; Keratinocytes; Melanoma; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Pentacyclic Triterpenes; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Survivin; Time Factors; Triterpenes | 2005 |
Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status.
Topics: Apoptosis; Betulinic Acid; Butadienes; Cell Adhesion; Cell Line, Tumor; Chromatin; Cyclin A; Cyclin-Dependent Kinase 4; DNA Damage; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mitogen-Activated Protein Kinase Kinases; Nitriles; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes; Tumor Suppressor Protein p53 | 2006 |
Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Filaggrin Proteins; Humans; Keratinocytes; Melanoma; Necrosis; Pentacyclic Triterpenes; Skin Neoplasms; Triterpenes | 2005 |
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; DNA Damage; Growth Inhibitors; Guanidines; Humans; Liver Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Pentacyclic Triterpenes; Putrescine; Skin Neoplasms; Triterpenes; Tumor Cells, Cultured | 1995 |
Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma.
Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Death; Cyclin D1; Cyclin D3; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Drug Resistance, Neoplasm; Gelatinases; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Neoplasm Metastasis; Pentacyclic Triterpenes; Triterpenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Correspondence re: S. Fulda et al., Betulinic acid triggers CD95 (Apo1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res., 57: 4956-4964, 1997.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; fas Receptor; Humans; Melanoma; Neuroblastoma; Pentacyclic Triterpenes; Triterpenes; Tumor Suppressor Protein p53 | 1998 |
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Line; Cell Survival; Combined Modality Therapy; Humans; Melanocytes; Melanoma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Triterpenes | 2000 |
Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368.
Topics: Antineoplastic Agents, Phytogenic; Bacillus megaterium; Betulinic Acid; Biotransformation; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Melanoma; Pentacyclic Triterpenes; Triterpenes; Tumor Cells, Cultured | 2000 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Topics: Antibiotics, Antineoplastic; Apoptosis; Betulinic Acid; Colonic Neoplasms; Dactinomycin; Dexamethasone; DNA-Binding Proteins; Female; Glioblastoma; Glucocorticoids; Humans; Interferon-gamma; Melanoma; Mutation; Naphthoquinones; Ovarian Neoplasms; Pentacyclic Triterpenes; Prednisolone; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Triterpenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2001 |
The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Betulinic Acid; Blotting, Western; Caspase 9; Caspases; Ceramides; Cytochrome c Group; Densitometry; DNA Mutational Analysis; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mitochondria; Pentacyclic Triterpenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Triterpenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |