Compounds > betulinic acid

betulinic acid and Cancer of Prostate

betulinic acid has been researched along with Cancer of Prostate in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, DS; Kim, JY; Koo, HM1
Arai, MA; Hosoya, T; Ishibashi, M; Kowithayakorn, T; Koyano, T; Tateno, C1
de Las Pozas, A; Palenzuela, D; Parrondo, R; Perez-Stable, C; Reiner, T1
Inn, KS; Jang, DS; Jo, SJ; Kim, HI; Kim, HJ; Kim, JE; Lee, CM; Lee, NR; Quan, FS1
Franco, D; Gupta, S; Shankar, E; Zhang, A1
de las Pozas, A; Parrondo, R; Perez-Stable, C; Rai, P; Reiner, T1
Ahn, KS; Choi, SH; Jeong, SJ; Jung, DB; Jung, JH; Kim, SH; Ko, SG; Lee, EO; Lee, HJ; Lee, SG; Shim, BS; Shin, J1
de Roo, GM; Kessler, JH; Medema, JP; Mullauer, FB1
Chintharlapalli, S; Papineni, S; Ramaiah, SK; Safe, S1
Das, B; Dasgupta, SB; Ganguly, A; Majumder, HK; Mukhopadhayay, S; Roy, A; Sen, N1
Gupta, S; Rabi, T; Shukla, S1

Other Studies

11 other study(ies) available for betulinic acid and Cancer of Prostate

ArticleYear
Development of C-20 modified betulinic acid derivatives as antitumor agents.
    Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17

    Topics: Adenocarcinoma; Antineoplastic Agents; Betulinic Acid; Drug Screening Assays, Antitumor; Humans; Male; Melanoma; Oleanolic Acid; Pentacyclic Triterpenes; Prostatic Neoplasms; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured

2001
Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.
    Bioorganic & medicinal chemistry, 2008, Nov-01, Volume: 16, Issue:21

    Topics: Animals; Betulinic Acid; Blotting, Western; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Male; Maytansine; Mice; Oncogene Proteins; Pancreatic Neoplasms; Patched Receptors; Patched-1 Receptor; Pentacyclic Triterpenes; Phenols; Phenylethyl Alcohol; Plant Extracts; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trans-Activators; Transcription, Genetic; Triterpenes; Zinc Finger Protein GLI1; Zinc Fingers; Ziziphus

2008
Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Male; Mice; Neovascularization, Pathologic; Pentacyclic Triterpenes; Peptide Hydrolases; Polyubiquitin; Prostatic Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Triterpenes; Ubiquitination

2013
Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina.
    Biochemical and biophysical research communications, 2014, Aug-22, Volume: 451, Issue:2

    Topics: Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Female; Humans; Male; MCF-7 Cells; Neoplasm Proteins; Pentacyclic Triterpenes; Phytotherapy; Plants, Medicinal; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Prunella; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Triterpenes; Ursolic Acid

2014
Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways.
    Molecules (Basel, Switzerland), 2017, Feb-10, Volume: 22, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Betulinic Acid; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Humans; Male; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Triterpenes; Tumor Suppressor Protein p53

2017
NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.
    Molecular cancer, 2010, Jul-09, Volume: 9

    Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Base Sequence; Betulinic Acid; Blotting, Western; Cell Line, Tumor; DNA Primers; Docetaxel; Estradiol; Flow Cytometry; Humans; Immunohistochemistry; Male; Mitosis; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Sesquiterpenes; Taxoids; Triterpenes

2010
Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Angiogenesis Inhibitors; Betulinic Acid; Cell Death; Cell Hypoxia; Cell Line, Tumor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Neovascularization, Pathologic; Pentacyclic Triterpenes; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; STAT3 Transcription Factor; Triterpenes; Vascular Endothelial Growth Factor A

2011
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.
    Cancer letters, 2007, Jun-18, Volume: 251, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cells, Cultured; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Jurkat Cells; Lung Neoplasms; Male; Neoplasms; Pentacyclic Triterpenes; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Triterpenes; Uterine Cervical Neoplasms

2007
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
    Cancer research, 2007, Mar-15, Volume: 67, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Growth Processes; Cell Line, Tumor; Humans; Inhibitor of Apoptosis Proteins; Liver; Male; Mice; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Proteins; Neovascularization, Pathologic; Pentacyclic Triterpenes; Promoter Regions, Genetic; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Sp Transcription Factors; Sp1 Transcription Factor; Sp3 Transcription Factor; Sp4 Transcription Factor; Survivin; Triterpenes; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2007
Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death.
    Cancer research, 2007, Dec-15, Volume: 67, Issue:24

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Death; Cell Line, Tumor; DNA, Neoplasm; Enzyme Inhibitors; Humans; Male; Pentacyclic Triterpenes; Prostatic Neoplasms; Reactive Oxygen Species; Topoisomerase I Inhibitors; Triterpenes

2007
Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells.
    Molecular carcinogenesis, 2008, Volume: 47, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Formazans; Genes, Reporter; Humans; Luciferases; Male; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Tetrazolium Salts; Time Factors; Transfection; Triterpenes; Tumor Necrosis Factor-alpha

2008