Compounds > betulinic acid

betulinic acid and Breast Cancer

betulinic acid has been researched along with Breast Cancer in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (7.41)29.6817
2010's19 (70.37)24.3611
2020's6 (22.22)2.80

Authors

AuthorsStudies
Fan, J; Gao, C; Guo, C; Qi, X; Wu, X; Yin, C1
Ling, Y; Liu, X; Luo, W; Meng, C; Qian, J; Shan, W; Xu, Z; Zhang, W; Zhu, P1
Bache, M; Darnstaedt, E; Grosse, I; Güttler, A; Kappler, M; Keßler, J; Petrenko, M; Reidt, J; Ruff, E; Vordermark, D; Weinholdt, C; Wildemann, A1
Mu, H; Sun, Y; Wang, Y; Yuan, B1
Chen, J; Li, M; Lin, Y; Liu, P; Situ, H; Wang, N; Wang, S; Wang, Z; Xie, M; Yang, B; Zheng, Y1
Gupta, S; Kumar, S; Kushwaha, PP; Prajapati, KS; Shuaib, M; Singh, AK; Vardhan, PS1
Alla, PK; Avram, S; Coricovac, D; Cretu, OM; Dehelean, C; Farcas, CG; Ghiulai, R; Loghin, F; Mioc, M; Moaca, EA; Pavel, I; Pinzaru, IA; Socoliuc, V; Soica, C1
Adamczyk-Grochala, J; Bednarz, D; Lewinska, A; Wnuk, M1
Cai, Y; Fu, W; Gu, J; Wang, D; Wang, N; Wang, S; Wang, Z; Yang, B; Zhang, F; Zheng, Y1
Chen, J; Chen, Z; Cui, X; Li, G; Li, J; Qiao, H; Wang, R; Wang, X; Yang, M; Zhang, Z1
Jiao, L; Mei, W; Wang, D; Wang, N; Wang, S; Wang, Z; Yang, B; Yang, D; Zhao, Z; Zheng, Y1
Liang, ZS; Song, CK; Sun, YF; Unger, F; Viernstein, H1
Damle, AA; Narkar, AA; Pawar, YP1
Chung, WY; Kim, HJ; Kim, KR; Lee, CK; Lee, SK; Park, KK; Park, SY1
Balakrishnan, S; Mishra, KP; Puthli, A; Sapra, BK; Tiwari, R1
Inn, KS; Jang, DS; Jo, SJ; Kim, HI; Kim, HJ; Kim, JE; Lee, CM; Lee, NR; Quan, FS1
Chadalapaka, G; Cho, SG; Choi, K; Ho, SM; Jin, UH; Jutooru, I; Kim, K; Lee, SO; Leung, YK; Safe, S; Yang, WS1
Chang, FW; Chen, SP; Chen, YH; Fu, CL; Ho, JY; Hsu, RJ; Hsu, YC; Liu, JM; Yu, CP; Yu, JC1
Andrews, P; Carter, B; Gai, L; Kao, KR; Popadiuk, C; Tzenov, YR; Voisey, K; Whelan, K1
Chu, P; Fang, D; Luo, R; Tang, Z; Wu, H; Zhang, Z1
Adamczyk-Grochala, J; Deregowska, A; Kwasniewicz, E; Lewinska, A; Wnuk, M1
Beneytout, JL; Chaouki, W; Eljastimi, J; Hmamouchi, M; Leger, DY1
Alexa, E; Aluas, M; Dehelean, CA; Kása, P; Peev, C; Soica, CM; Zupkó, I1
Angel-Morales, G; Bertoldi, MC; Li, X; Mertens-Talcott, SU; Noratto, GD; Safe, S1
Brents, LK; Jutooru, I; Kim, K; Lee, SO; Lei, P; Liu, X; Prather, PL; Safe, S1
Amico, V; Barresi, V; Condorelli, D; Spatafora, C; Tringali, C1
de Roo, GM; Kessler, JH; Medema, JP; Mullauer, FB1

Reviews

2 review(s) available for betulinic acid and Breast Cancer

ArticleYear
Betulinic acid in the treatment of breast cancer: Application and mechanism progress.
    Fitoterapia, 2023, Volume: 169

    Topics: Apoptosis; Betulinic Acid; Breast Neoplasms; Female; Humans; Molecular Structure; Pentacyclic Triterpenes; Triterpenes

2023
Multiple molecular targets in breast cancer therapy by betulinic acid.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Animals; Apoptosis; Betulinic Acid; Breast Neoplasms; Drug Synergism; Female; Humans; Molecular Targeted Therapy; Pentacyclic Triterpenes; Signal Transduction; Triterpenes

2016

Other Studies

25 other study(ies) available for betulinic acid and Breast Cancer

ArticleYear
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system.
    Drug delivery, 2021, Volume: 28, Issue:1

    Topics: Animals; Animals, Outbred Strains; Antineoplastic Agents; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Chemistry, Pharmaceutical; Chickens; Drug Carriers; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Membrane Potential, Mitochondrial; Mice; Micelles; Neovascularization, Pathologic; Pentacyclic Triterpenes; Polyethylene Glycols; Polyvinyls; Reactive Oxygen Species; Signal Transduction; Surface Properties; Vascular Endothelial Growth Factor A

2021
GSH/ROS Dual-Responsive Supramolecular Nanoparticles Based on Pillar[6]arene and Betulinic Acid Prodrug for Chemo-Chemodynamic Combination Therapy.
    Molecules (Basel, Switzerland), 2021, Sep-29, Volume: 26, Issue:19

    Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Breast Neoplasms; Drug Therapy, Combination; Female; Glutathione; Humans; Lung Neoplasms; Nanoparticles; Pentacyclic Triterpenes; Prodrugs; Quaternary Ammonium Compounds; Reactive Oxygen Species; Tumor Cells, Cultured

2021
SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells.
    Cells, 2022, 12-31, Volume: 12, Issue:1

    Topics: Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hypoxia; Pentacyclic Triterpenes; Radiation Tolerance; Sestrins; Tumor Suppressor Protein p53

2022
Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Glycolysis; Heat-Shock Proteins; Humans; Neoplasm Metastasis; Neoplasm Proteins; Pentacyclic Triterpenes; Triterpenes

2019
3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere.
    Chemico-biological interactions, 2020, Sep-01, Volume: 328

    Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Female; HEK293 Cells; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Pentacyclic Triterpenes; Reactive Oxygen Species; Receptors, Notch; Signal Transduction; Triterpenes

2020
Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Drug Liberation; Female; Humans; Hyperthermia, Induced; Iron; Liposomes; Magnetic Phenomena; Metal Nanoparticles; Microtubules; Pentacyclic Triterpenes; Spectrum Analysis, Raman

2020
Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.
    Redox biology, 2017, Volume: 12

    Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; MCF-7 Cells; Pentacyclic Triterpenes; Protein Carbonylation; Sulfoxides; Superoxides; Triterpenes; Ursolic Acid

2017
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
    Cell death & disease, 2018, 05-25, Volume: 9, Issue:6

    Topics: Animals; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Heat-Shock Proteins; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Paclitaxel; Pentacyclic Triterpenes; Triterpenes; Xenograft Model Antitumor Assays

2018
Paclitaxel-betulinic acid hybrid nanosuspensions for enhanced anti-breast cancer activity.
    Colloids and surfaces. B, Biointerfaces, 2019, Feb-01, Volume: 174

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Paclitaxel; Pentacyclic Triterpenes; Structure-Activity Relationship; Tissue Distribution; Triterpenes

2019
Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway.
    Biochemical pharmacology, 2019, Volume: 161

    Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Female; Glycolysis; Humans; MCF-7 Cells; Mice; Mice, Knockout; NF-kappa B; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-myc; Random Allocation; Signal Transduction; Triterpenes; Zebrafish

2019
Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway.
    Food chemistry, 2013, Jun-01, Volume: 138, Issue:2-3

    Topics: Apoptosis; Betulinic Acid; Breast Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Drug Compounding; Female; Fruit; Humans; Mitochondria; Pentacyclic Triterpenes; Plant Extracts; Signal Transduction; Triterpenes; Ziziphus

2013
Anticancer activity of betulinic acid on MCF-7 tumors in nude mice.
    Indian journal of experimental biology, 2013, Volume: 51, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Proliferation; Female; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pentacyclic Triterpenes; Triterpenes; Tumor Cells, Cultured

2013
Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment.
    Toxicology and applied pharmacology, 2014, Mar-01, Volume: 275, Issue:2

    Topics: Administration, Oral; Animals; Betulinic Acid; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cathepsin K; Cell Differentiation; Cell Line, Tumor; Cell Survival; Down-Regulation; Estrogens; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred ICR; Osteoclasts; Osteoprotegerin; Parathyroid Hormone-Related Protein; Pentacyclic Triterpenes; RANK Ligand; Triterpenes

2014
Betulinic acid-induced cytotoxicity in human breast tumor cell lines MCF-7 and T47D and its modification by tocopherol.
    Cancer investigation, 2014, Volume: 32, Issue:8

    Topics: Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Female; Humans; MCF-7 Cells; Pentacyclic Triterpenes; Tocopherols; Triterpenes; Tumor Suppressor Protein p53

2014
Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina.
    Biochemical and biophysical research communications, 2014, Aug-22, Volume: 451, Issue:2

    Topics: Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Female; Humans; Male; MCF-7 Cells; Neoplasm Proteins; Pentacyclic Triterpenes; Phytotherapy; Plants, Medicinal; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Prunella; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Triterpenes; Ursolic Acid

2014
The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis.
    Neoplasia (New York, N.Y.), 2014, Volume: 16, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Blotting, Western; Breast Neoplasms; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasm Transplantation; Pentacyclic Triterpenes; Polycomb Repressive Complex 2; Real-Time Polymerase Chain Reaction; Repressor Proteins; Sp Transcription Factors; Transplantation, Heterologous; Triterpenes; Tumor Cells, Cultured

2014
The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells.
    BMC complementary and alternative medicine, 2015, Mar-14, Volume: 15

    Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Hibiscus; Humans; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Triterpenes

2015
Selective estrogen receptor modulators and betulinic acid act synergistically to target ERα and SP1 transcription factor dependent Pygopus expression in breast cancer.
    Journal of clinical pathology, 2016, Volume: 69, Issue:6

    Topics: Antineoplastic Agents; Betulinic Acid; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Hydroxytestosterones; Intracellular Signaling Peptides and Proteins; Microarray Analysis; Pentacyclic Triterpenes; Promoter Regions, Genetic; Selective Estrogen Receptor Modulators; Signal Transduction; Sp1 Transcription Factor; Tamoxifen; Triterpenes

2016
Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells.
    Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:6

    Topics: Apoptosis; Autophagy; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Female; G1 Phase Cell Cycle Checkpoints; Glycolysis; Humans; Models, Biological; Nitrosation; Oxidative Stress; Pentacyclic Triterpenes; Phenotype; Signal Transduction; Triterpenes; Ursolic Acid

2017
Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7.
    Pharmaceutical biology, 2010, Volume: 48, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Aristolochia; Aristolochic Acids; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Inhibitory Concentration 50; Medicine, African Traditional; Morocco; Origanum; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Solvents; Triterpenes

2010
Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines.
    Natural product research, 2012, Volume: 26, Issue:10

    Topics: Adenocarcinoma; Betula; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; HeLa Cells; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Pentacyclic Triterpenes; Plant Extracts; Skin Neoplasms; Triterpenes; Uterine Cervical Neoplasms

2012
Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.
    Molecular carcinogenesis, 2013, Volume: 52, Issue:8

    Topics: Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; MicroRNAs; Pentacyclic Triterpenes; Receptors, Estrogen; Repressor Proteins; Sp Transcription Factors; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays

2013
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cricetinae; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; MicroRNAs; Pentacyclic Triterpenes; Receptor, ErbB-2; Receptors, Cannabinoid; Repressor Proteins; Sp Transcription Factors; Triterpenes; YY1 Transcription Factor

2012
Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.
    Journal of agricultural and food chemistry, 2006, Feb-08, Volume: 54, Issue:3

    Topics: Antineoplastic Agents; Betulinic Acid; Breast Neoplasms; Cell Division; Humans; Magnetic Resonance Spectroscopy; Pentacyclic Triterpenes; Prunus; Seeds; Structure-Activity Relationship; Terpenes; Triterpenes

2006
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.
    Cancer letters, 2007, Jun-18, Volume: 251, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cells, Cultured; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Jurkat Cells; Lung Neoplasms; Male; Neoplasms; Pentacyclic Triterpenes; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Triterpenes; Uterine Cervical Neoplasms

2007