bethanechol has been researched along with Disease Models, Animal in 18 studies
Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw." | 7.72 | Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004) |
| "Bethanechol induced smooth muscle contractions via muscarinic receptor subtype M3." | 3.74 | Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero. ( Ahanya, SA; Lakshmanan, J; Liu, G; Mazdak, M; Oyachi, N; Ross, MG, 2007) |
| " In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw." | 3.72 | Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004) |
| "We used a model of bladder outlet obstruction in male guinea pigs as a way to produce detrusor overactivity." | 1.42 | Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders. ( Brookes, S; Costa, M; Gibbins, I; Keightley, L; Nicholas, S; Zagorodnyuk, V, 2015) |
| "Experimental bladder outlet obstruction in cats was produced by surgical placement of a silastic cuff around the urethra." | 1.28 | Short term functional effects of bladder outlet obstruction in the cat. ( Elbadawi, A; Kato, K; Levin, RM; Longhurst, PA; McGuire, EJ; Miller, LF; Radzinski, C; Wein, AJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lamarre, NS | 1 |
| Braverman, AS | 1 |
| Malykhina, AP | 1 |
| Barbe, MF | 1 |
| Ruggieri, MR | 1 |
| Nicholas, S | 1 |
| Keightley, L | 1 |
| Brookes, S | 1 |
| Costa, M | 1 |
| Gibbins, I | 1 |
| Zagorodnyuk, V | 1 |
| Kitamura, N | 1 |
| Araya, R | 1 |
| Kudoh, M | 1 |
| Kishida, H | 1 |
| Kimura, T | 1 |
| Murayama, M | 1 |
| Takashima, A | 1 |
| Sakamaki, Y | 1 |
| Hashikawa, T | 1 |
| Ito, S | 1 |
| Ohtsuki, S | 1 |
| Terasaki, T | 1 |
| Wess, J | 1 |
| Yamada, M | 1 |
| Adami, M | 1 |
| Pozzoli, C | 1 |
| Menozzi, A | 1 |
| Bertini, S | 1 |
| Passeri, B | 1 |
| Cantoni, AM | 1 |
| Smits, R | 1 |
| de Esch, I | 1 |
| Leurs, R | 1 |
| Coruzzi, G | 1 |
| Batista, LM | 1 |
| de Almeida, AB | 1 |
| de Pietro Magri, L | 1 |
| Toma, W | 1 |
| Calvo, TR | 1 |
| Vilegas, W | 1 |
| Souza Brito, AR | 1 |
| Prado, WA | 1 |
| Segalla, DK | 1 |
| Murata, P | 1 |
| Kase, Y | 1 |
| Tokita, Y | 1 |
| Takeda, S | 1 |
| Sasaki, H | 1 |
| Hirota, CL | 1 |
| McKay, DM | 1 |
| Lakshmanan, J | 1 |
| Oyachi, N | 1 |
| Ahanya, SA | 1 |
| Liu, G | 1 |
| Mazdak, M | 1 |
| Ross, MG | 1 |
| Saito, M | 1 |
| Wein, AJ | 2 |
| Levin, RM | 3 |
| Lee, HC | 1 |
| Curry, DL | 1 |
| Stern, JS | 1 |
| Haugaard, N | 1 |
| O'Connor, L | 1 |
| Buttyan, R | 1 |
| Das, A | 1 |
| Dixon, JS | 1 |
| Gosling, JA | 1 |
| Kobayashi, S | 1 |
| Ikeda, K | 1 |
| Suzuki, M | 1 |
| Yamada, T | 1 |
| Miyata, K | 1 |
| Young, A | 2 |
| Levin, RJ | 2 |
| Kato, K | 1 |
| Radzinski, C | 1 |
| Longhurst, PA | 1 |
| McGuire, EJ | 1 |
| Miller, LF | 1 |
| Elbadawi, A | 1 |
18 other studies available for bethanechol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis.
Topics: Adenosine Triphosphate; Animals; Atropine; Bethanechol; Coronavirus; Disease Models, Animal; Mice; M | 2014 |
Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders.
Topics: Animals; Bethanechol; Cholinesterase Inhibitors; Consciousness; Disease Models, Animal; Dose-Respons | 2015 |
Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency.
Topics: Animals; Basilar Artery; Bethanechol; Brain; Cell Line; Cerebrovascular Circulation; Cerebrovascular | 2009 |
Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
Topics: Animals; Anti-Inflammatory Agents; Bethanechol; Disease Models, Animal; Guanidines; Histamine Agonis | 2012 |
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas | 2004 |
Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats.
Topics: Acetylcholine; Analgesics; Analysis of Variance; Animals; Atropine; Bethanechol; Cholinergic Agonist | 2004 |
Intestinal ischemia/reperfusion injury aggravates talc-induced adhesions in rats.
Topics: Animals; Bethanechol; Disease Models, Animal; Jejunum; Male; Mesenteric Artery, Superior; Muscle Con | 2006 |
M3 muscarinic receptor-deficient mice retain bethanechol-mediated intestinal ion transport and are more sensitive to colitis.
Topics: Animals; Bethanechol; Cholinergic Fibers; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; I | 2006 |
Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero.
Topics: Animals; Bethanechol; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fetus | 2007 |
Effect of partial outlet obstruction on contractility: comparison between severe and mild obstruction.
Topics: Adenosine Triphosphate; Animals; Bethanechol; Bethanechol Compounds; Disease Models, Animal; Electri | 1993 |
Selective muscarinic sensitivity in perfused pancreata of obese Zucker rats.
Topics: Analysis of Variance; Animals; Atropine; Bethanechol; Bethanechol Compounds; Blood Glucose; Disease | 1993 |
Obstructive response of human bladder to BPH vs. rabbit bladder response to partial outlet obstruction: a direct comparison.
Topics: Adaptation, Physiological; Animals; Bethanechol; Calcium Signaling; Calcium-Transporting ATPases; Ca | 2000 |
Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo.
Topics: Animals; Bethanechol; Cholera Toxin; Colonic Diseases, Functional; Defecation; Diarrhea; Dinoproston | 2001 |
Intestinal hypersecretion of the refed starved rat: a model for alimentary diarrhoea.
Topics: Animals; Bethanechol; Bethanechol Compounds; Diarrhea; Dinoprostone; Disease Models, Animal; Enterot | 1992 |
Diarrhoea of famine and malnutrition: investigations using a rat model. 1. Jejunal hypersecretion induced by starvation.
Topics: Animals; Bethanechol; Bethanechol Compounds; Carbachol; Chlorides; Diarrhea; Disease Models, Animal; | 1990 |
Short term functional effects of bladder outlet obstruction in the cat.
Topics: Adenosine Triphosphate; Animals; Bethanechol; Bethanechol Compounds; Cats; Disease Models, Animal; F | 1990 |