Page last updated: 2024-10-23

bethanechol and Diabetes Mellitus, Type 2

bethanechol has been researched along with Diabetes Mellitus, Type 2 in 3 studies

Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
" Bethanechol, an acetylcholine analogue that does not cross the blood-brain barrier, was used to examine the role of peripheral muscarinic signaling on glucose homeostasis in humans with normal glucose tolerance (NGT; n = 10), impaired glucose tolerance (IGT; n = 11), and type 2 diabetes mellitus (T2DM; n = 9)."5.22Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus. ( Chowdhury, S; Dunai, J; Kilpatrick, R; Oestricker, LZ; Patterson, BW; Reeds, DN; Wallendorf, MJ; Wang, S; Wice, BM, 2016)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chowdhury, S1
Wang, S1
Dunai, J1
Kilpatrick, R1
Oestricker, LZ1
Wallendorf, MJ1
Patterson, BW1
Reeds, DN1
Wice, BM1
Itoh, H1
Morikawa, A1
Makino, I1
el Newihi, H1
Dooley, CP1
Saad, C1
Staples, J1
Zeidler, A1
Valenzuela, JE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Bethanechol, a Muscarinic Agonist, on Plasma Insulin, Glucagon, and Glucose Levels in Humans With and Without Type 2 Diabetes Mellitus[NCT01434901]Phase 150 participants (Actual)Interventional2011-08-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for bethanechol and Diabetes Mellitus, Type 2

ArticleYear
Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Administration, Oral; Adult; Bethanechol; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mel

2016

Other Studies

2 other studies available for bethanechol and Diabetes Mellitus, Type 2

ArticleYear
Urinary bladder dysfunction in spontaneously diabetic Chinese hamsters.
    Diabetes research and clinical practice, 1994, Volume: 22, Issue:2-3

    Topics: Acetylcholinesterase; Aging; Animals; Bethanechol; Bethanechol Compounds; Blood Glucose; Cricetinae;

1994
Impaired exocrine pancreatic function in diabetics with diarrhea and peripheral neuropathy.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:6

    Topics: Adult; Amino Acids; Bethanechol; Bethanechol Compounds; Cholecystokinin; Chronic Disease; Diabetes M

1988
chemdatabank.com