bethanechol has been researched along with Alzheimer Disease in 17 studies
Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients meeting the clinical criteria for Alzheimer disease, enrolled in a pilot study for the evaluation of response to intracerebroventricular administration of bethanechol chloride." | 5.09 | Progression of clinical deterioration and pathological changes in patients with Alzheimer disease evaluated at biopsy and autopsy. ( Cummings, JL; Di Patre, PL; Read, SL; Secor, DL; Tomiyasu, U; Vartavarian, LM; Vinters, HV, 1999) |
| "Neurotransmitter replacement therapy in Alzheimer's Disease is currently being attempted using bethanechol chloride (Urecholine) infused intracerebroventricularly with an Infusaid continuous infusion pump." | 2.66 | Transmitter-replacement therapy in Alzheimer's disease using intracerebroventricular infusions of receptor agonists. ( Beaulieu, M; Bouchard, R; Carlsson, G; Dastoor, D; Ervin, F; Gauthier, L; Gauthier, S; Leblanc, R; Quirion, R; Robitaille, Y, 1986) |
| "Ten patients with biopsy-proven Alzheimer's disease (AD) received low-dose (0." | 2.66 | Intraventricular bethanechol infusion for Alzheimer's disease: results of double-blind and escalating-dose trials. ( Fox, JH; Martin, EM; Penn, RD; Savoy, SM; Wilson, RS, 1988) |
| "They have been of value in treating pain of cancer and spasticity through spinal subarachnoid catheters." | 2.37 | Drug pumps for treatment of neurologic diseases and pain. ( Penn, RD, 1985) |
| " All three patients were reexamined in a dose-response paradigm." | 1.28 | Stable bimodal response to cholinomimetic drugs in Alzheimer's disease. Brain mapping correlates. ( Leuchter, AF; Read, SL; Shapira, J; Smith, C; Walter, DO, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (70.59) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harbaugh, RE | 7 |
| Roberts, DW | 1 |
| Coombs, DW | 1 |
| Saunders, RL | 1 |
| Reeder, TM | 4 |
| Di Patre, PL | 1 |
| Read, SL | 3 |
| Cummings, JL | 2 |
| Tomiyasu, U | 2 |
| Vartavarian, LM | 1 |
| Secor, DL | 1 |
| Vinters, HV | 1 |
| Tamada, J | 1 |
| Langer, R | 1 |
| DeKosky, ST | 1 |
| Schmitt, FA | 1 |
| Bakay, RA | 2 |
| Chui, HC | 2 |
| Knopman, DS | 2 |
| Shetter, AG | 2 |
| Senter, HJ | 2 |
| Markesbery, WR | 1 |
| Leuchter, AF | 1 |
| Shapira, J | 2 |
| Walter, DO | 1 |
| Smith, C | 2 |
| Frazee, J | 1 |
| Fox, JH | 2 |
| Bennett, DA | 1 |
| Goetz, CG | 1 |
| Penn, RD | 3 |
| Savoy, S | 1 |
| Clasen, R | 1 |
| Wilson, RS | 3 |
| Baskin, DS | 1 |
| Pirozzolo, F | 1 |
| Leblanc, R | 2 |
| Gauthier, S | 1 |
| Robitaille, Y | 1 |
| Quirion, R | 1 |
| Carlsson, G | 1 |
| Beaulieu, M | 1 |
| Bouchard, R | 1 |
| Dastoor, D | 1 |
| Ervin, F | 1 |
| Gauthier, L | 1 |
| Martin, EM | 2 |
| Savoy, SM | 1 |
| Whitehouse, PJ | 1 |
2 reviews available for bethanechol and Alzheimer Disease
| Article | Year |
|---|---|
The development of polyanhydrides for drug delivery applications.
Topics: Alzheimer Disease; Anhydrides; Animals; Bethanechol; Bethanechol Compounds; Biocompatible Materials; | 1992 |
Drug pumps for treatment of neurologic diseases and pain.
Topics: Alzheimer Disease; Baclofen; Bethanechol; Bethanechol Compounds; Catheters, Indwelling; Chronic Dise | 1985 |
10 trials available for bethanechol and Alzheimer Disease
| Article | Year |
|---|---|
Preliminary report: intracranial cholinergic drug infusion in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Bethanechol; Bethanechol Compounds; Catheters, Indwelling; Clinica | 1984 |
Progression of clinical deterioration and pathological changes in patients with Alzheimer disease evaluated at biopsy and autopsy.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Antigens, CD; Antigens, Differentiation, Myelomonocy | 1999 |
The development of polyanhydrides for drug delivery applications.
Topics: Alzheimer Disease; Anhydrides; Animals; Bethanechol; Bethanechol Compounds; Biocompatible Materials; | 1992 |
Induction of parkinsonism by intraventricular bethanechol in a patient with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Clinical Trials as Topic; Female; Human | 1989 |
Intracerebroventricular bethanechol chloride infusion in Alzheimer's disease. Results of a collaborative double-blind study.
Topics: Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cerebral Ventricles; Double-Blind Method; Hum | 1989 |
Direct cerebrospinal fluid infusion of bethanechol chloride in Alzheimer's disease: use of an implantable continuous infusion device.
Topics: Activities of Daily Living; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cerebrospinal Flu | 1985 |
Transmitter-replacement therapy in Alzheimer's disease using intracerebroventricular infusions of receptor agonists.
Topics: Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cerebral Cortex; Cerebral Ventricles; Clinica | 1986 |
Intracerebroventricular cholinergic drug administration in Alzheimer's disease: preliminary results of a double-blind study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cognition; Double-Bl | 1987 |
Intraventricular bethanechol infusion for Alzheimer's disease: results of double-blind and escalating-dose trials.
Topics: Aged; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cerebral Ventricles; Clinical Trials as | 1988 |
Intracerebroventricular bethanechol chloride administration in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Equipment Failure; F | 1988 |
6 other studies available for bethanechol and Alzheimer Disease
| Article | Year |
|---|---|
Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cerebral Cortex; | 1992 |
Stable bimodal response to cholinomimetic drugs in Alzheimer's disease. Brain mapping correlates.
Topics: Alzheimer Disease; Bethanechol; Bethanechol Compounds; Brain Mapping; Cerebrospinal Fluid Shunts; Co | 1991 |
Intracerebroventricular bethanechol for Alzheimer's disease. Variable dose-related responses.
Topics: Alzheimer Disease; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Humans; Inj | 1990 |
Drug delivery to the brain by central infusion: clinical application in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Female; Humans; Infusion Pumps; Injecti | 1986 |
Intraventricular bethanechol in Alzheimer's disease: a continuing controversy.
Topics: Aged; Alzheimer Disease; Bethanechol; Bethanechol Compounds; Cerebral Ventricles; Humans | 1988 |
New intrathecal drugs in Alzheimer's disease and psychometric testing.
Topics: Activities of Daily Living; Alzheimer Disease; Behavior; Bethanechol; Bethanechol Compounds; Dose-Re | 1988 |