bethanechol and Ache
bethanechol has been researched along with Ache in 8 studies
Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw." | 7.72 | Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004) |
| " To determine if bethanechol stimulation would increase the diagnostic yield, we examined 87 patients with chest pain but no gastroesophageal reflux, 47 patients with gastroesophageal reflux but no chest pain, and 20 normal subjects." | 7.67 | Bethanechol increases the diagnostic yield in patients with esophageal chest pain. ( Huber, T; Nostrant, TT; Sams, J, 1986) |
| "Daily pain was assessed by linear analog charts." | 6.69 | Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. ( Carapeti, EA; Kamm, MA; Phillips, RK, 2000) |
| " In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw." | 3.72 | Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004) |
| " To determine if bethanechol stimulation would increase the diagnostic yield, we examined 87 patients with chest pain but no gastroesophageal reflux, 47 patients with gastroesophageal reflux but no chest pain, and 20 normal subjects." | 3.67 | Bethanechol increases the diagnostic yield in patients with esophageal chest pain. ( Huber, T; Nostrant, TT; Sams, J, 1986) |
| "Daily pain was assessed by linear analog charts." | 2.69 | Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. ( Carapeti, EA; Kamm, MA; Phillips, RK, 2000) |
| "They have been of value in treating pain of cancer and spasticity through spinal subarachnoid catheters." | 2.37 | Drug pumps for treatment of neurologic diseases and pain. ( Penn, RD, 1985) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Prado, WA | 2 |
| Segalla, DK | 1 |
| Smythe, A | 1 |
| Ahmed, R | 1 |
| Fitzhenry, M | 1 |
| Johnson, AG | 1 |
| Majeed, AW | 1 |
| Turton, DB | 1 |
| Shakir, KM | 1 |
| Guimarães, AP | 1 |
| Guimarães, FS | 1 |
| Carapeti, EA | 1 |
| Kamm, MA | 1 |
| Phillips, RK | 1 |
| Penn, RD | 1 |
| Cole, MJ | 1 |
| Paterson, WG | 1 |
| Beck, IT | 1 |
| DaCosta, LR | 1 |
| Nostrant, TT | 1 |
| Sams, J | 1 |
| Huber, T | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children[NCT02419534] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for bethanechol and Ache
| Article | Year |
|---|---|
Drug pumps for treatment of neurologic diseases and pain.
Topics: Alzheimer Disease; Baclofen; Bethanechol; Bethanechol Compounds; Catheters, Indwelling; Chronic Dise | 1985 |
Trials
2 trials available for bethanechol and Ache
| Article | Year |
|---|---|
Bethanechol provocation testing does not predict symptom relief after cholecystectomy for acalculous biliary pain.
Topics: Adult; Aged; Bethanechol; Cholecystectomy; Female; Follow-Up Studies; Gallbladder Diseases; Humans; | 2004 |
Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Bethanechol; Calcium Channel Blockers; Diltiazem; | 2000 |
Other Studies
5 other studies available for bethanechol and Ache
| Article | Year |
|---|---|
Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats.
Topics: Acetylcholine; Analgesics; Analysis of Variance; Animals; Atropine; Bethanechol; Cholinergic Agonist | 2004 |
Galactorrhea caused by esophagitis.
Topics: Adult; Anti-Ulcer Agents; Bethanechol; Esophagitis; Famotidine; Female; Galactorrhea; Gastroesophage | 1995 |
Modulation of carbachol-induced antinociception from the rat periaqueductal gray.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Anxiety; Bethanechol; Carbachol; Cholinergic Agon | 2000 |
The effect of acid and bethanechol stimulation in patients with symptomatic hypertensive peristaltic (nutcracker) esophagus. Evidence that this disorder may be a precursor of diffuse esophageal spasm.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Esophageal Diseases; Humans; Hydrochloric Acid; Man | 1986 |
Bethanechol increases the diagnostic yield in patients with esophageal chest pain.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Esophageal Diseases; Esophagus; Female; Gastroesoph | 1986 |