Page last updated: 2024-10-23

bethanechol and Ache

bethanechol has been researched along with Ache in 8 studies

Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.

Research Excerpts

ExcerptRelevanceReference
" In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw."7.72Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004)
" To determine if bethanechol stimulation would increase the diagnostic yield, we examined 87 patients with chest pain but no gastroesophageal reflux, 47 patients with gastroesophageal reflux but no chest pain, and 20 normal subjects."7.67Bethanechol increases the diagnostic yield in patients with esophageal chest pain. ( Huber, T; Nostrant, TT; Sams, J, 1986)
"Daily pain was assessed by linear analog charts."6.69Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. ( Carapeti, EA; Kamm, MA; Phillips, RK, 2000)
" In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw."3.72Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004)
" To determine if bethanechol stimulation would increase the diagnostic yield, we examined 87 patients with chest pain but no gastroesophageal reflux, 47 patients with gastroesophageal reflux but no chest pain, and 20 normal subjects."3.67Bethanechol increases the diagnostic yield in patients with esophageal chest pain. ( Huber, T; Nostrant, TT; Sams, J, 1986)
"Daily pain was assessed by linear analog charts."2.69Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. ( Carapeti, EA; Kamm, MA; Phillips, RK, 2000)
"They have been of value in treating pain of cancer and spasticity through spinal subarachnoid catheters."2.37Drug pumps for treatment of neurologic diseases and pain. ( Penn, RD, 1985)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Prado, WA2
Segalla, DK1
Smythe, A1
Ahmed, R1
Fitzhenry, M1
Johnson, AG1
Majeed, AW1
Turton, DB1
Shakir, KM1
Guimarães, AP1
Guimarães, FS1
Carapeti, EA1
Kamm, MA1
Phillips, RK1
Penn, RD1
Cole, MJ1
Paterson, WG1
Beck, IT1
DaCosta, LR1
Nostrant, TT1
Sams, J1
Huber, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children[NCT02419534]Phase 446 participants (Anticipated)Interventional2014-11-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for bethanechol and Ache

ArticleYear
Drug pumps for treatment of neurologic diseases and pain.
    Neurologic clinics, 1985, Volume: 3, Issue:2

    Topics: Alzheimer Disease; Baclofen; Bethanechol; Bethanechol Compounds; Catheters, Indwelling; Chronic Dise

1985

Trials

2 trials available for bethanechol and Ache

ArticleYear
Bethanechol provocation testing does not predict symptom relief after cholecystectomy for acalculous biliary pain.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2004, Volume: 36, Issue:10

    Topics: Adult; Aged; Bethanechol; Cholecystectomy; Female; Follow-Up Studies; Gallbladder Diseases; Humans;

2004
Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects.
    Diseases of the colon and rectum, 2000, Volume: 43, Issue:10

    Topics: Administration, Topical; Adult; Aged; Anal Canal; Bethanechol; Calcium Channel Blockers; Diltiazem;

2000

Other Studies

5 other studies available for bethanechol and Ache

ArticleYear
Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats.
    Brain research, 2004, Aug-27, Volume: 1018, Issue:2

    Topics: Acetylcholine; Analgesics; Analysis of Variance; Animals; Atropine; Bethanechol; Cholinergic Agonist

2004
Galactorrhea caused by esophagitis.
    American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:5

    Topics: Adult; Anti-Ulcer Agents; Bethanechol; Esophagitis; Famotidine; Female; Galactorrhea; Gastroesophage

1995
Modulation of carbachol-induced antinociception from the rat periaqueductal gray.
    Brain research bulletin, 2000, Volume: 51, Issue:6

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Anxiety; Bethanechol; Carbachol; Cholinergic Agon

2000
The effect of acid and bethanechol stimulation in patients with symptomatic hypertensive peristaltic (nutcracker) esophagus. Evidence that this disorder may be a precursor of diffuse esophageal spasm.
    Journal of clinical gastroenterology, 1986, Volume: 8, Issue:3 Pt 1

    Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Esophageal Diseases; Humans; Hydrochloric Acid; Man

1986
Bethanechol increases the diagnostic yield in patients with esophageal chest pain.
    Gastroenterology, 1986, Volume: 91, Issue:5

    Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Esophageal Diseases; Esophagus; Female; Gastroesoph

1986