betalains and Heart-Failure

Betalain is a natural plant pigment known to elicit various biological activities. However, studies on the protective effect of betalain against heart failure have not reported yet. The experimental model of heart failure was created in Wistar rats using isoproterenol (ISO). The animals were randomly assigned into four groups such as sham-control, ISO-induced heart failure, betalain pretreated before ISO induction (50 mg/kg/day), and betalain drug control group were maintained for 6 weeks. At the end of the experimental period, anti-oxidant enzymes, inflammatory markers, matrix proteins, cardiac-specific markers, and micro RNAs were elucidated using RT-PCR, and ELISA analysis. The results demonstrated that the rats induced with ISO displayed an abnormality in cardiac functions, increased oxidative stress markers (

Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Antioxidants; Betalains; Biomarkers; Cardiotonic Agents; Cytokines; Disease Models, Animal; Heart Failure; Inflammation Mediators; Isoproterenol; Male; Rats; Rats, Wistar