betaine has been researched along with Pressure Ulcer in 3 studies
glycine betaine : The amino acid betaine derived from glycine.
Pressure Ulcer: An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our aim was to assess the clinical efficacy of a propylbetaine-polihexanide (PP) solution versus normal saline (NS) solution in WBP, assessing inflammatory signs and wound size reduction in patients with pressure ulcers (PUs) or vascular leg ulcers." | 5.22 | Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT. ( Bellingeri, A; Chiari, P; Falciani, F; Moscatelli, A; Peghetti, A; Russo, A; Tino, G; Traspedini, P, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Atkin, L | 1 |
| Stephenson, J | 1 |
| Cooper, DM | 1 |
| Bellingeri, A | 1 |
| Falciani, F | 1 |
| Traspedini, P | 1 |
| Moscatelli, A | 1 |
| Russo, A | 1 |
| Tino, G | 1 |
| Chiari, P | 1 |
| Peghetti, A | 1 |
| Romanelli, M | 1 |
| Dini, V | 1 |
| Barbanera, S | 1 |
| Bertone, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Study of Quality of Life in Patients With Chronic Leg Wound(s) Treated With Prontosan® Wound Irrigation Solution and Prontosan® Wound Gel[NCT03369756] | 43 participants (Actual) | Interventional | 2018-02-20 | Terminated (stopped due to Terminated due to prolonged subject recruitment) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Wound-QoL is a tool to measure disease-specific, health-related quality of life of patients with chronic wounds. It consists of 17 items on impairments which is assessed for the previous 7 days and is competed by the patient. It has 3 subscales that can assess Body, Psyche and Everyday Life. It can be used in clinical and observational studies and in daily practice.~Subscale Body consists of Items #1 to #5. Each individual item is rated on a scale ranging from 0 (not at all) to 4 (very much). The average of the subscale can be computed if no more than 1 item of the subscale is missing. The higher values represents more of an impact to the patient for that item." (NCT03369756)
Timeframe: 5 weeks overall (4 weeks of treatment and/or observations followed by a one-day visit at end of study in week 5)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Body Subscore change, Baseline / Week 1 to Week 2 | Body Subscore change, Baseline / Week 1 to Week 3 | Body Subscore change, Baseline / Week 1 to Week 4 | Body Subscore change, Baseline / Week 1 to End / Week 5 | |
| Prontosan Solution and Gel | -0.76 | -0.93 | -1.19 | -1.17 |
"The Wound-QoL is a tool to measure disease-specific, health-related quality of life of patients with chronic wounds. It consists of 17 items on impairments which is assessed for the previous 7 days and is competed by the patient. It has 3 subscales that can assess Body, Psyche and Everyday Life. It can be used in clinical and observational studies and in daily practice.~Subscale Everyday Life consists of Items #Items #11 to #16. Each individual item is rated on a scale ranging from 0 (not at all) to 4 (very much). The average of the subscale can be computed if no more than 1 item of the subscale is missing. Generally, the higher values represents more of an impact to the patient for that item." (NCT03369756)
Timeframe: 5 weeks overall (4 weeks of treatment and/or observations followed by a one-day visit at end of study in week 5)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Everyday Life Subscore change, Baseline / Week 1 to Week 2 | Everyday Life Subscore change, Baseline / Week 1 to Week 3 | Everyday Life Subscore change, Baseline / Week 1 to Week 4 | Everyday Life Subscore change, Baseline / Week 1 to End / Week 5 | |
| Prontosan Solution and Gel | -0.58 | -0.82 | -1.11 | -1.00 |
"The Wound-QoL is a tool to measure disease-specific, health-related quality of life of patients with chronic wounds. It consists of 17 items on impairments which is assessed for the previous 7 days and is competed by the patient. It has 3 subscales that can assess Body, Psyche and Everyday Life. It can be used in clinical and observational studies and in daily practice.~Subscale Psyche consists of Items #Items #6 to #10. Each individual item is rated on a scale ranging from 0 (not at all) to 4 (very much). The average of the subscale can be computed if no more than 1 item of the subscale is missing. The higher values represents more of an impact to the patient for that item." (NCT03369756)
Timeframe: 5 weeks overall (4 weeks of treatment and/or observations followed by a one-day visit at end of study in week 5)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Psyche Subscore change, Baseline / Week 1 to Week 2 | Psyche Subscore change, Baseline / Week 1 to Week 3 | Psyche Subscore change, Baseline / Week 1 to Week 4 | Psyche Subscore change, Baseline / Week 1 to End / Week 5 | |
| Prontosan Solution and Gel | -0.77 | -1.04 | -1.24 | -1.26 |
Change in wound size from Baseline/Week 1 to Final/Week 5. The change in the size of a wound will be evaluated using a disposable ruler to directly measure the overall wound dimensions at each scheduled visit to the study site (Weeks 1 and 5). These measurements will be done before any cleaning of the wound and after cleaning the wound (debridement). (NCT03369756)
Timeframe: 5 weeks overall (4 weeks of treatment and/or observations followed by a one-day visit at end of study in week 5)
| Intervention | wound surface area (cm^2) (Mean) | |
|---|---|---|
| Pre-Debridement Wound Size Change (Baseline/Week 1 to Week 5 / End) | Post-Debridement Wound Size Change(Baseline/Week 1 to Final/Week 5) | |
| Prontosan Solution and Gel | -6.6 | -8.2 |
"The Wound-QoL is a tool to measure disease-specific, health-related quality of life of patients with chronic wounds. It consists of 17 items on impairments which is assessed for the previous 7 days and is competed by the patient. It has 3 subscales that can assess Body, Psyche and Everyday Life. These subscales cover items 1 to 16. Item 17 is not part of any of the subscales. The Wound-QoL can be used in clinical and observational studies and in daily practice.~Each individual item is rated on a scale ranging from 0 (not at all) to 4 (very much). A Total or Global score is the average of at least 13 completed questions, regardless of which questions were not completed. The average of each of the 3 subscales can be computed if no more than 1 item of the subscale is missing. The higher values represents more of an impact to the patient for that item." (NCT03369756)
Timeframe: 5 weeks overall (4 weeks of treatment and/or observations followed by a one-day visit at end of study in week 5)
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Week 1 / Baseline | Week 2 | Week 3 | Week 4 | Week 5 / End | |
| Prontosan Solution and Gel | 2.41 | 1.74 | 1.51 | 1.25 | 1.30 |
1 review available for betaine and Pressure Ulcer
| Article | Year |
|---|---|
Wound bed preparation: a case series using polyhexanide and betaine solution and gel-a UK perspective.
Topics: Administration, Cutaneous; Betaine; Biguanides; Gels; Humans; Pressure Ulcer; State Medicine; Therap | 2020 |
2 trials available for betaine and Pressure Ulcer
| Article | Year |
|---|---|
Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT.
Topics: Aged; Aged, 80 and over; Bandages; Betaine; Biguanides; Chronic Disease; Female; Humans; Inflammatio | 2016 |
Evaluation of the efficacy and tolerability of a solution containing propyl betaine and polihexanide for wound irrigation.
Topics: Aged; Anti-Infective Agents, Local; Betaine; Biguanides; Biofilms; Female; Humans; Hydrogen-Ion Conc | 2010 |