Compounds > betaine
Page last updated: 2024-10-16

betaine and Pregnancy

betaine has been researched along with Pregnancy in 130 studies

glycine betaine : The amino acid betaine derived from glycine.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"This study used stable isotope methodology to examine the effects of pregnancy on choline partitioning and the metabolic activity of choline-related pathways."9.17Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. ( Allen, RH; Brenna, JT; Caudill, MA; Gregory, JF; Jiang, X; Malysheva, OV; Perry, CA; Stabler, SP; West, AA; Yan, J, 2013)
"Third-trimester pregnancy plasma choline and betaine were positively associated with childhood anthropometric measures."8.02Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study. ( Eussen, SJ; Moltó-Puigmartí, C; Mommers, M; Obeid, R; Thijs, C, 2021)
"Thirty-two dams were divided into four equal groups: control (C), betaine supplementation (BS), diabetic pregnancy (DP) and diabetic pregnancy plus betaine supplementation (DP + BS)."7.96In vivo: maternal betaine supplementation normalized fetal growth in diabetic pregnancy. ( Alirezaei, M; Gharabaghi, M; Rocky, A; Salahi, P, 2020)
"We aimed to compare serum betaine concentrations between South Asian and European pregnant women, and to determine the relation between betaine and tHcy concentrations in early pregnancy."7.91Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity. ( Lamers, Y; Mujica-Coopman, MF; Schroder, TH; Sinclair, G; Tan, A; Vallance, HD, 2019)
"Choline and betaine status have previously been associated with symptoms of depression."7.85Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort. ( Chen, H; Chong, MF; Chong, YS; Godfrey, KM; Meaney, MJ; Quah, PL; Saw, SM; van Lee, L; Yap, FKP, 2017)
"Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs)."7.80Dietary intake of choline and neural tube defects in Mexican Americans. ( Brender, JD; Canfield, MA; Felkner, M; Lavery, AM; Suarez, L; Sweeney, A; Zhao, H, 2014)
"Low folate status enhances the reduction in betaine and the increase in dimethylglycine during pregnancy and strengthens the association between betaine and tHcy."7.79Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. ( Ballesteros, M; Berrocal-Zaragoza, MI; Cavallé-Busquets, P; Fernandez-Ballart, JD; Fernàndez-Roig, S; Murphy, MM; Salat-Batlle, J; Ueland, PM, 2013)
" Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years."7.79Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013)
"Choline needs are increased in pregnancy."7.79Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013)
"Plasma choline (geometric x; 95% reference interval) increased continuously during pregnancy, from 6."7.73Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy. ( Fokkema, MR; Holm, PI; Muskiet, FA; Ueland, PM; van der Dijs, FP; Velzing-Aarts, FV, 2005)
"UC choline and betaine were inversely associated with birth weight (β = -60 (-89, -31) and β = -65 (-94, -36), respectively), whereas UC DMG was positively associated with birth weight (β = 35 (6."5.39Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. ( Blom, HJ; den Heijer, M; Hogeveen, M; Semmekrot, BA; Sporken, JM; Ueland, PM, 2013)
"Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland."5.29Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995)
" The World Health Organisation recommends folic acid (FA) supplementation pre-conception and in early pregnancy to reduce the risk of fetal neural tube defects (NTDs)."5.22High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus. ( Arthurs, AL; Jankovic-Karasoulos, T; Roberts, CT; Smith, MD; Williamson, JM, 2022)
"This study used stable isotope methodology to examine the effects of pregnancy on choline partitioning and the metabolic activity of choline-related pathways."5.17Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. ( Allen, RH; Brenna, JT; Caudill, MA; Gregory, JF; Jiang, X; Malysheva, OV; Perry, CA; Stabler, SP; West, AA; Yan, J, 2013)
"These data suggest that an increment of 25 mg choline/d to meet the demands of pregnancy is insufficient and show that a higher maternal choline intake increases the use of choline as a methyl donor in both maternal and fetal compartments."5.16Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. ( Allen, RH; Caudill, MA; Devapatla, S; Jiang, X; Malysheva, OV; Perry, CA; Pressman, E; Stabler, SP; Vermeylen, F; West, AA; Yan, J, 2012)
"This study confirms that plasma carnitine concentrations decline in the course of pregnancy, an effect that can be prevented by the supplementation of carnitine."5.14Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration. ( Eder, K; Keller, U; Röpke, F; Scheler, C; Seliger, G; van der Wal, C, 2009)
"Choline deficiency may contribute to the impaired lean body mass growth and pulmonary and neurocognitive development of preterm infants despite adequate macronutrient supply and weight gain."5.01Choline and choline-related nutrients in regular and preterm infant growth. ( Bernhard, W; Franz, AR; Poets, CF, 2019)
"Maternal betaine supplementation has been proven to alleviate non-alcoholic fatty liver disease (NAFLD) in offspring caused by maternal high-fat diet (MHFD)."4.31Maternal Betaine Supplementation Mitigates Maternal High Fat Diet-Induced NAFLD in Offspring Mice through Gut Microbiota. ( Chen, H; Huang, Q; Liang, X; Ou, Q; Sun, L; Tan, X; Wang, L; Wei, J; Wu, F; Wu, Q; Yi, Z; Yu, X; Zhao, H; Zhu, H, 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; 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Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
"Thirty-two dams were divided into four equal groups: control (C), betaine supplementation (BS), diabetic pregnancy (DP) and diabetic pregnancy plus betaine supplementation (DP + BS)."3.96In vivo: maternal betaine supplementation normalized fetal growth in diabetic pregnancy. ( Alirezaei, M; Gharabaghi, M; Rocky, A; Salahi, P, 2020)
"21]) were associated with higher odds of antepartum depression and 4 metabolites (betaine [OR = =0."3.96Metabolomic markers of antepartum depression and suicidal ideation. ( Clish, C; Gelaye, B; Larrabure-Torrealva, GT; Mitro, SD; Molsberry, SA; Sanchez, SE; Williams, MA, 2020)
"We aimed to compare serum betaine concentrations between South Asian and European pregnant women, and to determine the relation between betaine and tHcy concentrations in early pregnancy."3.91Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity. ( Lamers, Y; Mujica-Coopman, MF; Schroder, TH; Sinclair, G; Tan, A; Vallance, HD, 2019)
"Abnormally high levels of homocysteine (Hcy) are associated with autism spectrum disorder."3.91Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. ( Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J, 2019)
"Both insufficiency and excess of one-carbon nutrients (folate, choline, vitamins B6 and B12) during pregnancy have been associated with gestational diabetes mellitus (GDM)."3.88Fetal one-carbon nutrient concentrations may be affected by gestational diabetes. ( Barzilay, E; Berger, H; Caudill, MA; Croxford, R; Kim, YI; Ly, A; Malysheva, O; Masih, SP; Moon, A; O'Connor, DL; Plumptre, L; Sohn, KJ; Visentin, CE, 2018)
"We have shown previously that in ovo betaine injection can prevent nonalcoholic fatty liver induced by glucocorticoid exposure in chickens; yet it remains unknown whether feeding betaine to laying hens may exert similar effects in their progeny."3.88Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation. ( Abobaker, H; Hou, Z; Hu, Y; Omer, NA; Sun, Q; Zhao, R; Zong, Y, 2018)
"Choline and betaine status have previously been associated with symptoms of depression."3.85Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort. ( Chen, H; Chong, MF; Chong, YS; Godfrey, KM; Meaney, MJ; Quah, PL; Saw, SM; van Lee, L; Yap, FKP, 2017)
" We evaluated maternal methyl-group donor intake through diet (methionine, betaine, choline, folate) and supplementation (folic acid) before and during pregnancy in relation to global DNA methylation and hydroxymethylation and gene specific (IGF2 DMR, DNMT1, LEP, RXRA) cord blood methylation."3.85Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation. ( A S Langie, S; Bekaert, B; Devlieger, R; Duca, RC; Freson, K; Ghosh, M; Godderis, L; Huybrechts, I; Koppen, G; Pauwels, S, 2017)
"In this study, 3-month-old female Sprague-Dawley rats were fed diet supplemented with 1% betaine throughout the pregnancy and lactation."3.85Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation. ( Dong, H; Hu, Y; Yang, S; Zhao, N; Zhao, R, 2017)
" Here we fed gestational sows with control or betaine-supplemented diets (3g/kg) throughout the pregnancy to explore the effects of maternal methyl-donor nutrient on neonatal expression of hepatic lipogenic genes."3.83Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms. ( Cai, D; Dong, H; Jia, Y; Liu, H; Wang, J; Yuan, M; Zhao, R, 2016)
"Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects."3.81Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. ( Berger, H; Caudill, MA; Croxford, R; El-Sohemy, A; Kim, YI; Lausman, AY; Ly, A; Malysheva, O; Masih, S; Nielsen, DE; O'Connor, DL; Plumptre, L; Sohn, KJ; Visentin, CE, 2015)
"Gestational sows were fed control or betaine-supplemented (3 g/kg) diets throughout the pregnancy."3.81Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions. ( Cai, D; Jia, Y; Li, X; Song, H; Sui, S; Sun, Q; Zhao, R, 2015)
"To elucidate the effects of maternal dietary betaine supplementation on hepatic expression of cholesterol metabolic genes in newborn piglets and the involved epigenetic mechanisms, we fed gestational sows with control or betaine-supplemented diets (3 g/kg) throughout pregnancy."3.80Maternal dietary betaine supplementation modifies hepatic expression of cholesterol metabolic genes via epigenetic mechanisms in newborn piglets. ( Cai, D; Jia, Y; Lu, J; Song, H; Sui, S; Yuan, M; Zhao, R, 2014)
" Female Wistar rats fed control diet during pregnancy were assigned to four postpartum dietary groups: control, control supplemented with methyl donors (choline, betaine, folic acid, vitamin B12), HFS and HFS supplemented with methyl donors."3.80Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet. ( Campion, J; Cordero, P; Martinez, JA; Milagro, FI, 2014)
"Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs)."3.80Dietary intake of choline and neural tube defects in Mexican Americans. ( Brender, JD; Canfield, MA; Felkner, M; Lavery, AM; Suarez, L; Sweeney, A; Zhao, H, 2014)
"In this study, gestational sows were fed control or betaine-supplemented diets (3 g/kg) throughout the pregnancy, and the newborn piglets were used to elucidate whether maternal dietary betaine affected offspring hepatic gluconeogenic genes through epigenetic mechanisms."3.80Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. ( Cai, D; Jia, Y; Jiang, Z; Lu, J; Song, H; Sui, S; Zhao, R, 2014)
"Low folate status enhances the reduction in betaine and the increase in dimethylglycine during pregnancy and strengthens the association between betaine and tHcy."3.79Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. ( Ballesteros, M; Berrocal-Zaragoza, MI; Cavallé-Busquets, P; Fernandez-Ballart, JD; Fernàndez-Roig, S; Murphy, MM; Salat-Batlle, J; Ueland, PM, 2013)
"Choline needs are increased in pregnancy."3.79Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013)
" Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years."3.79Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013)
" We examined the associations of maternal intake of folate, vitamin B12, choline, betaine and methionine during the first and second trimesters of pregnancy, with tests of cognitive performance in the offspring at 3 years of age using data from 1210 participants in Project Viva, a prospective pre-birth cohort study in Massachusetts."3.78Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. ( Gillman, MW; Oken, E; Rifas-Shiman, SL; Villamor, E, 2012)
"We show that choline status in the first half of pregnancy is associated with cognitive development among healthy term gestation infants."3.78Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. ( Dyer, RA; Innis, SM; King, DJ; Richardson, KJ; Wu, BT, 2012)
" It was moreover intended to find out whether low carnitine concentrations during pregnancy could be due to a reduced availability of precursors of carnitine synthesis, namely trimethyllysine (TML) and gamma-butyrobetaine (BB)."3.76Low availability of carnitine precursors as a possible reason for the diminished plasma carnitine concentrations in pregnant women. ( Eder, K; Hanisch, N; Ringseis, R; Seliger, G, 2010)
" We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation."3.74A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats. ( Os'kina, IN; Plyusnina, IZ; Prasolova, LA; Shchepina, OA; Trut, LN, 2007)
"Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy."3.74Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study. ( Bonham, MP; Clarkson, TW; Davidson, PW; Duffy, EM; McNulty, H; Molloy, AM; Myers, GJ; Robson, PJ; Scott, JM; Shamlaye, CF; Strain, J; Ueland, PM; Wallace, JM; Ward, M, 2008)
"Plasma choline (geometric x; 95% reference interval) increased continuously during pregnancy, from 6."3.73Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy. ( Fokkema, MR; Holm, PI; Muskiet, FA; Ueland, PM; van der Dijs, FP; Velzing-Aarts, FV, 2005)
"The positive association between maternal choline and tHcy during pregnancy suggests that the high fetal demand for choline stimulates de novo synthesis of choline in maternal liver, with a resultant increase in tHcy concentrations."3.73Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. ( Brody, LC; Conley, M; Cox, C; Daly, SF; Kirke, PN; Mills, JL; Molloy, AM; Scott, JM; Ueland, PM, 2005)
"Choline supplementation of pregnant rats between d 12 and 17 of pregnancy permanently enhances the spatial memory of offspring; however, the mechanism is unknown."3.69Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. ( Garner, SC; Mar, MH; Zeisel, SH, 1995)
"This study investigated the effects of dietary inclusion of rumen-protected methionine alone or in combination with rumen-protected choline and betaine on: (i) milk yield, chemical composition and fatty acids (FA) profile and (ii) blood plasma glutathione transferase (GST) activity of periparturient ewes."2.84The effect of dietary supplementation with rumen-protected methionine alone or in combination with rumen-protected choline and betaine on sheep milk and antioxidant capacity. ( Chatzikonstantinou, M; Kalogeropoulos, T; Koutsouli, P; Labrou, N; Mavrommatis, A; Sotirakoglou, K; Tsiplakou, E; Zervas, G, 2017)
" Measured outcomes included pregnancy rates, continuation rates, adverse events, and acceptability."2.75Contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels: a randomized controlled trial. ( Archer, D; Barnhart, K; Blithe, D; Burke, AE; Carr, BR; Creinin, MD; Jensen, JT; Liu, J; Schlaff, W; Thomas, M; Walsh, TL; Wan, LS; Westhoff, C; Wu, H, 2010)
"The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide."2.66One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020)
"Betaine is an essential osmolyte and source of methyl groups and comes from either the diet or by the oxidation of choline."2.46The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. ( Lever, M; Slow, S, 2010)
"Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear."1.72Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes. ( Cao, Y; Chang, X; Dai, Y; Guo, J; Liang, W; Lu, D; Lv, S; Qi, X; Wang, Z; Wu, C; Zhang, J; Zhang, L; Zhou, Z, 2022)
"Betaine treatment following glyphosate exposure provided modest relief."1.72Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function. ( Bai, G; Jiang, X; Qin, J; Shi, B; Sun, H; Teng, T; Zhang, W; Zou, Y, 2022)
"Betaine serves as a methyl donor for DNA methylation."1.56Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus. ( Jiang, W; Qi, F; Yang, S; Yang, Y; Zhao, R, 2020)
"Birth weight was higher in the G allele homozygotes of the CHDH rs2289205 than in the minor allele carriers: GG: 3398 ± 64 g; GA+AA: 3193 ± 76 g."1.48PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women. ( Barlik, M; Chmurzynska, A; Drews, K; Jagodziński, PP; Kurzawińska, G; Malinowska, AM; Radziejewska, A; Różycka, A; Seremak-Mrozikiewicz, A; Szwengiel, A, 2018)
"Choline is an essential nutrient that is required for normal development of the brain."1.43Choline and the Brain: An Epigenetic Perspective. ( Bekdash, RA, 2016)
"Betaine has been widely used in animal and human nutrition to promote muscle growth and performance, yet it remains unknown whether maternal betaine supplementation during gestation affects the metabolic characteristics of neonatal skeletal muscles."1.42Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets. ( Cai, D; Gao, G; Jia, Y; Song, H; Yang, X; Zhao, R, 2015)
"Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system."1.39Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. ( Bonham, MP; Davidson, PW; Henderson, J; Kobrosly, RW; McAfee, AJ; McSorley, EM; Mulhern, MS; Myers, GJ; Shamlaye, CF; Strain, JJ; Thurston, SW; Ueland, PM; van Wijngaarden, E; Wallace, JM; Watson, GE, 2013)
"UC choline and betaine were inversely associated with birth weight (β = -60 (-89, -31) and β = -65 (-94, -36), respectively), whereas UC DMG was positively associated with birth weight (β = 35 (6."1.39Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. ( Blom, HJ; den Heijer, M; Hogeveen, M; Semmekrot, BA; Sporken, JM; Ueland, PM, 2013)
"The betaine diet was fed from d 3 ± 1 post-mating until farrowing, with betaine content of the diet altered during gestation to ensure a daily intake of 7."1.38Supplementing sow gestation diets with betaine during summer increases litter size of sows with greater numbers of parities. ( Herde, P; Hughes, PE; van Wettere, WH, 2012)
"Colitis was induced by dextran sulfate sodium."1.37Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. ( Dowd, SE; Harris, RA; Kellermayer, R; Schaible, TD; Smith, CW, 2011)
"Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland."1.29Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995)
"Carnitine was found to associate with the membrane vesicles in a Na(+)-dependent manner."1.29Sodium-dependent high-affinity binding of carnitine to human placental brush border membranes. ( Bhatia, JS; Ganapathy, V; Leibach, FH; Prasad, PD; Roque, AS, 1996)

Research

Studies (130)

TimeframeStudies, this research(%)All Research%
pre-19905 (3.85)18.7374
1990's6 (4.62)18.2507
2000's18 (13.85)29.6817
2010's78 (60.00)24.3611
2020's23 (17.69)2.80

Authors

AuthorsStudies
McCabe, CF1
LaBarre, JL1
Domino, SE1
Treadwell, MC1
Baylin, A1
Burant, CF1
Dolinoy, DC2
Padmanabhan, V1
Goodrich, JM1
Fernandez-Osornio, LF1
Gomez-Diaz, RA1
Mondragon-Gonzalez, R1
Gonzalez-Carranza, E1
Diaz-Flores, M1
Sharma, T1
Hernández-Pineda, J1
Maldonado-Rodriguez, R1
Wacher, NH1
Cruz, M1
Valladares-Salgado, A1
Zhang, J2
Wang, Z3
Dai, Y1
Zhang, L2
Guo, J1
Lv, S1
Qi, X1
Lu, D1
Liang, W1
Cao, Y2
Wu, C2
Chang, X1
Zhou, Z3
Williamson, JM1
Arthurs, AL1
Smith, MD2
Roberts, CT1
Jankovic-Karasoulos, T1
Bai, G2
Jiang, X9
Qin, J2
Zou, Y3
Zhang, W2
Teng, T2
Shi, B2
Sun, H2
Sun, L1
Tan, X1
Liang, X1
Chen, H2
Ou, Q1
Wu, Q3
Yu, X2
Zhao, H3
Huang, Q3
Yi, Z1
Wei, J2
Wu, F3
Zhu, H3
Wang, L4
Breton-Larrivée, M1
Elder, E1
Legault, LM1
Langford-Avelar, A1
MacFarlane, AJ1
McGraw, S1
Potts, SB1
Brady, KM1
Scholte, CM1
Moyes, KM1
Sunny, NE1
Erdman, RA1
Kubo, Y1
Shoji, K1
Tajima, A1
Horiguchi, S1
Fukuoka, H1
Nishikawa, M1
Kagawa, Y1
Kawabata, T1
Aboragah, AA1
Alharthi, AS2
Wichasit, N1
Loor, JJ3
Gong, XL1
Du, YF2
Zhao, YY1
Wu, TC2
Shi, HF2
Wang, XL2
Wei, Y2
Minarski, M1
Maas, C2
Heinrich, C1
Böckmann, KA1
Bernhard, W3
Shunova, A1
Poets, CF3
Franz, AR3
Coleman, DN2
Liang, Y1
Batistel, F1
Elolimy, AA1
Yambao, RC1
Abdel-Hamied, E1
Pan, YX2
Parys, C1
Alhidary, IA1
Abdelrahman, MM1
Mujica-Coopman, MF1
Tan, A1
Schroder, TH1
Sinclair, G1
Vallance, HD1
Lamers, Y1
Huang, KT1
Shen, YL1
Lee, CN1
Chu, KY1
Ku, WC1
Liu, CY1
Huang, RS1
Mitro, SD1
Larrabure-Torrealva, GT1
Sanchez, SE1
Molsberry, SA1
Williams, MA1
Clish, C1
Gelaye, B1
Yang, S8
Zhao, N5
Sun, B4
Yang, Y5
Hu, Y7
Zhao, R17
Radziejewska, A3
Muzsik, A1
Milagro, FI2
Martínez, JA2
Chmurzynska, A3
Jiang, W2
Qi, F1
Salahi, P1
Gharabaghi, M1
Rocky, A1
Alirezaei, M1
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J4
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Zhu, L1
Wang, J8
Xue, L1
Liu, L2
Yan, X2
Huang, S1
Li, Y7
Xu, T1
Li, C2
Ji, F1
Ming, F1
Zhao, Y3
Cheng, J1
Wang, Y4
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X3
Chen, Y6
Zhu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C3
Lin, Y3
Dong, Y1
Wu, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R1
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Lu, SH1
Lu, HZ1
Zhang, R2
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Shen, P1
Zeng, N1
Yan, D1
Cui, L1
Yang, K3
Zhai, C1
Yang, M1
Lao, X1
Sun, J3
Ma, N1
Wang, S1
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
Gupta, J1
Nakanishi, I1
Ohkubo, K1
Shoji, Y1
Fujitaka, Y1
Shimoda, K1
Matsumoto, KI1
Fukuhara, K1
Hamada, H1
van der Boom, T1
Gruppen, EG1
Lefrandt, JD1
Connelly, MA1
Links, TP1
Dullaart, RPF1
Berry, JD1
Bedlack, R1
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Fedotova, IB2
Pavlova, GV2
Poletaeva, II2
Cordero, P1
Campion, J1
Raith, M1
Kunze, R1
Koch, V1
Heni, M1
Abele, H1
Cai, D7
Song, H4
Sui, S3
Lu, J2
Yuan, M4
Mills, JL2
Fan, R1
Brody, LC2
Liu, A1
Kirke, PN2
Shane, B1
Molloy, AM3
Masih, S1
Nielsen, DE1
Lausman, AY1
El-Sohemy, A1
Dong, H2
Zabrodina, VV2
Shreder, ED2
Shreder, OV2
Durnev, AD2
Seredenin, SB1
Gao, G1
Solé-Navais, P1
Kusat Ol, K1
Kanbak, G2
Oğlakcı Ilhan, A1
Burukoglu, D1
Yücel, F2
Pan, S2
Li, R1
Tsiplakou, E1
Mavrommatis, A1
Kalogeropoulos, T1
Chatzikonstantinou, M1
Koutsouli, P1
Sotirakoglou, K1
Labrou, N1
Zervas, G1
Pauwels, S3
Duca, RC3
Devlieger, R3
Freson, K3
Straetmans, D1
Van Herck, E1
Huybrechts, I3
Koppen, G3
Godderis, L3
Bekdash, RA1
Ma, W1
Hong, J1
Ghosh, M2
Bekaert, B2
A S Langie, S1
Idriss, AA1
Sogut, I1
Uysal, O1
Oglakci, A1
Kartkaya, K1
Langie, SAS1
Anas, MK1
Lee, MB1
Zhou, C1
Hammer, MA1
Karmouch, J1
Liu, XJ1
Bröer, S1
Keller, U1
van der Wal, C1
Seliger, G2
Scheler, C1
Röpke, F1
Eder, K2
Prasolova, LA3
Os'kina, IN3
Pliusnina, IZ2
Trut, LN3
Cohn, BR1
Joe, BN1
Kornak, J1
Zhang, VY1
Iman, R1
Kurhanewicz, J1
Vahidi, K1
Yu, J1
Caughey, AB1
Swanson, MG1
Ringseis, R1
Hanisch, N1
Fischer, LM1
da Costa, KA2
Galanko, J1
Sha, W1
Stephenson, B1
Vick, J1
Zeisel, SH3
Downing, C1
Johnson, TE1
Larson, C1
Leakey, TI1
Siegfried, RN1
Rafferty, TM1
Cooney, CA2
Burke, AE1
Barnhart, K1
Jensen, JT1
Creinin, MD1
Walsh, TL1
Wan, LS1
Westhoff, C1
Thomas, M1
Archer, D1
Wu, H1
Schlaff, W1
Carr, BR1
Blithe, D1
Schaible, TD1
Harris, RA1
Dowd, SE1
Smith, CW1
Kellermayer, R1
Katayama, K1
Sato, T1
Arai, T1
Amao, H1
Ohta, Y1
Ozawa, T1
Kenyon, PR1
Hickson, RE1
Tazaki, H1
Devapatla, S1
Pressman, E1
Vermeylen, F1
Baccarelli, A1
Kleinman, KP1
Burris, HH1
Litonjua, AA1
Tarantini, L1
Gillman, M1
van Wettere, WH1
Herde, P1
Hughes, PE1
Richardson, KJ1
Mikael, LG1
Pancer, J1
Caudill, M1
Rozen, R3
Strain, JJ1
McSorley, EM1
van Wijngaarden, E1
Kobrosly, RW1
Bonham, MP2
Mulhern, MS1
McAfee, AJ1
Davidson, PW2
Shamlaye, CF2
Henderson, J1
Watson, GE1
Thurston, SW1
Wallace, JM2
Myers, GJ2
Billington, CJ1
Schmidt, B1
Hodges, JS1
Georgieff, MK1
Schotta, G1
Gopalakrishnan, R1
Petryk, A1
Hedemann, MS1
Flummer, C1
Kristensen, NB1
Theil, PK1
Schwahn, BC2
Laryea, MD1
Melnyk, S1
Pogribny, I1
Garrow, T1
James, SJ1
Shaw, GM1
Carmichael, SL1
Selvin, S1
Schaffer, DM1
Vilaseca, MA1
Cuartero, ML1
Martinez de Salinas, M1
Lambruschini, N1
Pintó, X1
Urreizti, R1
Balcells, S1
Grinberg, D1
Velzing-Aarts, FV1
Holm, PI1
Fokkema, MR1
van der Dijs, FP1
Muskiet, FA1
He, X1
Cox, C1
Daly, SF1
Conley, M1
Scott, JM2
Huemer, M1
Simma, B1
Fowler, B1
Suormala, T1
Bodamer, OA1
Sass, JO1
Gulevich, RG1
Vsevolodov, EB1
Latypov, IF1
Waterland, RA1
Lin, JR1
Smith, CA1
Shi, X1
Tahiliani, KG1
Pierre, G1
Gissen, P1
Chakrapani, A1
McDonald, A1
Preece, M1
Wright, J1
Plyusnina, IZ1
Shchepina, OA1
Friesen, RW1
Novak, EM1
Hasman, D1
Strain, J1
Duffy, EM1
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Ganapathy, V1
Walter, JH1
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White, FJ1
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Padykula, HA1
Wilson, TH1

Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168]60 participants (Anticipated)Interventional2020-04-01Recruiting
Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235]653 participants (Anticipated)Interventional2021-02-12Recruiting
Phase 1 Study of the Effect of Maternal Nutritional Status on Placental Vascular Function, Fetal Growth and Intrauterine Growth Retardation.[NCT01778205]831 participants (Actual)Observational2005-01-31Completed
Impact of Fish Oil or Probiotic Intake on Maternal Obesity and Molecular Biomarkers in the Placenta[NCT03215784]80 participants (Anticipated)Interventional2015-03-31Recruiting
Effect of Maternal Choline Intake on Maternal/Fetal Biomarkers of Choline Status[NCT01127022]82 participants (Actual)Interventional2009-01-31Completed
Supply of Term and Preterm Neonates With Choline, Lipids and Vitamines[NCT02027584]414 participants (Actual)Observational2008-11-30Completed
Nahrungsergänzung Mit Cholin- Und Docosahexaensäure Bei Sehr Unreifen Frühgeborenen[NCT02509728]24 participants (Actual)Interventional2015-07-31Completed
[NCT02244684]368 participants (Actual)Observational2010-09-30Completed
Supplemental Choline and Neurodevelopment in Humans[NCT00678925]150 participants (Actual)Interventional2004-12-31Completed
A Phase II/III Multicenter, Randomized, Double-masked, Study of the Safety and Contraceptive Efficacy of C31G Compared to Conceptrol®[NCT00274261]Phase 31,565 participants (Actual)Interventional2004-06-30Completed
Vitamin D Status and Metabolism in Pregnant and Nonpregnant Control Women Consuming Controlled and Equivalent Intakes of Vitamin D[NCT03051867]47 participants (Actual)Observational2009-01-15Completed
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)[NCT03269110]2,578 participants (Anticipated)Observational2017-07-01Enrolling by invitation
Defining Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency[NCT02691611]39 participants (Actual)Observational2015-12-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Adverse Events.

Evaluated by comparing the incidence of Adverse Events (AEs) among subjects using their assigned treatment for at least one day. (NCT00274261)
Timeframe: duration of the study - through 6 month or 12 months of use

InterventionParticipants (Count of Participants)
C31G Vaginal Gel617
Conceptrol® Vaginal Gel434

The Cumulative Probability of Typical-use 6 Month (183 Days) Pregnancy.

Number of pregnancies in women using C31G gel for 6 months (183 days) compared to women using Conceptrol gel for the same time frame. (NCT00274261)
Timeframe: 6 months

Intervention6 month probability of pregnancy (Number)
C31G0.12
Conceptrol0.12

Reviews

7 reviews available for betaine and Pregnancy

ArticleYear
High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.
    Nutrients, 2022, Sep-22, Volume: 14, Issue:19

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Carbon; Choline; Diabet

2022
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
    Lifestyle genomics, 2020, Volume: 13, Issue:2

    Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
[Research advances in the association between maternal intake of methyl donor nutrients during pregnancy and DNA methylation in offspring].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2017, Volume: 19, Issue:5

    Topics: Betaine; Choline; DNA Methylation; Female; Folic Acid; Humans; Maternal Nutritional Physiological Ph

2017
Choline and choline-related nutrients in regular and preterm infant growth.
    European journal of nutrition, 2019, Volume: 58, Issue:3

    Topics: Betaine; Child Development; Choline; Choline Deficiency; Female; Humans; Infant; Infant, Low Birth W

2019
Early pregnancy B vitamin status, one carbon metabolism, pregnancy outcome and child development.
    Biochimie, 2016, Volume: 126

    Topics: Betaine; Carbon; Child; Child Development; Child, Preschool; Female; Fetal Growth Retardation; Folic

2016
The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism.
    Clinical biochemistry, 2010, Volume: 43, Issue:9

    Topics: Betaine; Dietary Supplements; Female; Gastrointestinal Agents; Humans; Male; Metabolism; Methylation

2010

Trials

10 trials available for betaine and Pregnancy

ArticleYear
Rumen-protected choline and methionine during the periparturient period affect choline metabolites, amino acids, and hepatic expression of genes associated with one-carbon and lipid metabolism.
    Journal of dairy science, 2023, Volume: 106, Issue:7

    Topics: Amino Acids; Animals; Betaine; Cattle; Choline; Diet; Dietary Supplements; Female; Lactation; Lecith

2023
Choline and Betaine Levels in Plasma Mirror Choline Intake in Very Preterm Infants.
    Nutrients, 2023, Nov-12, Volume: 15, Issue:22

    Topics: Betaine; Choline; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Dis

2023
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Maternal methyl donor supplementation during gestation counteracts bisphenol A-induced oxidative stress in sows and offspring.
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 45

    Topics: Actins; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Benzhydryl Compounds; Beta

2018
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:6

    Topics: Adult; Betaine; Choline; Deuterium; Diet; Dietary Supplements; Female; Fetal Blood; Humans; Hydrolys

2013
The effect of dietary supplementation with rumen-protected methionine alone or in combination with rumen-protected choline and betaine on sheep milk and antioxidant capacity.
    Journal of animal physiology and animal nutrition, 2017, Volume: 101, Issue:5

    Topics: Animal Feed; Animals; Antioxidants; Betaine; Choline; Diet; Dietary Supplements; Fatty Acids; Female

2017
Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration.
    European journal of clinical nutrition, 2009, Volume: 63, Issue:9

    Topics: Adult; Betaine; Carnitine; Dietary Supplements; Erythrocyte Indices; Female; Ferritins; Humans; Infa

2009
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.
    The American journal of clinical nutrition, 2010, Volume: 92, Issue:2

    Topics: Adult; Betaine; Choline; Diet; Diet Records; Dietary Supplements; Female; Genotype; Humans; Lactatio

2010
Contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels: a randomized controlled trial.
    Obstetrics and gynecology, 2010, Volume: 116, Issue:6

    Topics: Adolescent; Adult; Betaine; Double-Blind Method; Fatty Acids, Unsaturated; Female; Gels; Humans; Non

2010
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:5

    Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc

2012

Other Studies

114 other studies available for betaine and Pregnancy

ArticleYear
Maternal and neonatal one-carbon metabolites and the epigenome-wide infant response.
    The Journal of nutritional biochemistry, 2022, Volume: 101

    Topics: Adult; Betaine; Carbon; Choline; Cohort Studies; DNA Methylation; Epigenome; Female; Fetal Blood; Hi

2022
Micronutrients of the one-carbon metabolism cycle are altered in mothers and neonates by gestational diabetes and are associated with weight, height and head circumference at birth.
    The Journal of nutritional biochemistry, 2022, Volume: 105

    Topics: Betaine; Birth Weight; Carbon; Choline; Diabetes, Gestational; Female; Folic Acid; Glycine; Humans;

2022
Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes.
    Environmental research, 2022, Volume: 215, Issue:Pt 1

    Topics: Acetylcarnitine; Bayes Theorem; Betaine; Choline; Cohort Studies; Estradiol; Female; Humans; Leptin;

2022
Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function.
    Environment international, 2022, Volume: 170

    Topics: Animals; Betaine; Female; Government; Herbicides; Mitochondria; Placenta; Pregnancy; Swine

2022
Perinatal exposure to high concentration glyphosate-based herbicides induces intestinal apoptosis by activating endoplasmic reticulum stress in offspring.
    The Science of the total environment, 2023, Mar-20, Volume: 865

    Topics: Animals; Apoptosis; Betaine; Endoplasmic Reticulum Stress; Female; Glyphosate; Herbicides; Humans; H

2023
Maternal Betaine Supplementation Mitigates Maternal High Fat Diet-Induced NAFLD in Offspring Mice through Gut Microbiota.
    Nutrients, 2023, Jan-06, Volume: 15, Issue:2

    Topics: Animals; Betaine; Diet, High-Fat; Dietary Supplements; Female; Gastrointestinal Microbiome; Liver; M

2023
Mitigating the detrimental developmental impact of early fetal alcohol exposure using a maternal methyl donor-enriched diet.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:4

    Topics: Animals; Betaine; Diet; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Mice; Pregnancy;

2023
Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women.
    International journal of molecular sciences, 2023, Jul-01, Volume: 24, Issue:13

    Topics: Adolescent; Adult; Betaine; Carbon; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Human

2023
Body condition prepartum and its association with term placentome nutrient transporters, one‑carbon metabolism pathway activity, and intermediate metabolites in Holstein cows.
    Research in veterinary science, 2023, Volume: 162

    Topics: Animals; Betaine; Carbon; Cattle; Cystathionine; Diet; Female; Lactation; Membrane Transport Protein

2023
[Association between maternal plasma one-carbon biomarkers during pregnancy and fetal growth in twin pregnancies].
    Zhonghua fu chan ke za zhi, 2023, Oct-25, Volume: 58, Issue:10

    Topics: Adult; Betaine; Biomarkers; Birth Weight; Choline; Cohort Studies; Female; Fetal Development; Fetal

2023
Hepatic 1-carbon metabolism enzyme activity, intermediate metabolites, and growth in neonatal Holstein dairy calves are altered by maternal supply of methionine during late pregnancy.
    Journal of dairy science, 2019, Volume: 102, Issue:11

    Topics: Animals; Animals, Newborn; Betaine; Betaine-Homocysteine S-Methyltransferase; Biomarkers; Carbon; Ca

2019
Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity.
    The Journal of nutrition, 2019, 12-01, Volume: 149, Issue:12

    Topics: Adult; Betaine; Canada; Ethnicity; Europe; Female; Homocysteine; Humans; India; Pregnancy; Retrospec

2019
Using Differential Threshold Effects of Individual and Combined Periconceptional Methyl Donor Status on Maternal Genomic LINE-1 and Imprinted H19 DNA Methylation to Predict Birth Weight Variance in the Taiwan Pregnancy-Newborn Epigenetics (TPNE) Cohort St
    The Journal of nutrition, 2020, 01-01, Volume: 150, Issue:1

    Topics: Adult; Betaine; Birth Weight; Choline; Cohort Studies; Differential Threshold; DNA; DNA Methylation;

2020
Metabolomic markers of antepartum depression and suicidal ideation.
    Journal of affective disorders, 2020, 02-01, Volume: 262

    Topics: 5-Hydroxytryptophan; Adult; Betaine; Biomarkers; Carnitine; Citrulline; Cross-Sectional Studies; Dep

2020
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
    Journal of the science of food and agriculture, 2020, Mar-15, Volume: 100, Issue:4

    Topics: Animals; Betaine; Dietary Supplements; DNA Methylation; Female; Insulin-Like Growth Factor II; Liver

2020
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
    Molecular nutrition & food research, 2020, Volume: 64, Issue:8

    Topics: Animals; Aromatase; Betaine; Body Weight; Dietary Supplements; DNA Methylation; Epigenesis, Genetic;

2020
In vivo: maternal betaine supplementation normalized fetal growth in diabetic pregnancy.
    Archives of gynecology and obstetrics, 2020, Volume: 302, Issue:4

    Topics: Animals; Betaine; Body Weight; Dietary Supplements; Female; Fetal Development; Fetal Growth Retardat

2020
Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study.
    The American journal of clinical nutrition, 2021, 10-04, Volume: 114, Issue:4

    Topics: Adult; Betaine; Biomarkers; Child; Choline; Cohort Studies; Female; Humans; Male; Pregnancy; Prenata

2021
Betaine hydrochloride addition in Bama mini-pig's diets during gestation and lactation enhances immunity and alters intestine microbiota of suckling piglets.
    Journal of the science of food and agriculture, 2022, Jan-30, Volume: 102, Issue:2

    Topics: Animal Feed; Animals; Animals, Newborn; Bacteria; Betaine; Dietary Supplements; Female; Gastrointest

2022
Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort.
    Depression and anxiety, 2017, Volume: 34, Issue:10

    Topics: Adult; Anxiety; Betaine; Choline; Cohort Studies; Depression; Female; Humans; Personal Satisfaction;

2017
Betaine Aldehyde Dehydrogenase expression during physiological cardiac hypertrophy induced by pregnancy.
    Biochemical and biophysical research communications, 2017, 08-26, Volume: 490, Issue:3

    Topics: Animals; Betaine; Betaine-Aldehyde Dehydrogenase; Cardiomegaly; Female; Gene Expression; Oxidation-R

2017
Supplementation with the Methyl Donor Betaine Prevents Congenital Defects Induced by Prenatal Alcohol Exposure.
    Alcoholism, clinical and experimental research, 2017, Volume: 41, Issue:11

    Topics: Animals; Betaine; Coturnix; Dietary Supplements; Embryonic Development; Ethanol; Female; Heart Defec

2017
From the Cover: Metabolomics Reveals a Role of Betaine in Prenatal DBP Exposure-Induced Epigenetic Transgenerational Failure of Spermatogenesis in Rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 08-01, Volume: 158, Issue:2

    Topics: Animals; Betaine; Epigenesis, Genetic; Female; Male; Maternal Exposure; Metabolomics; Pregnancy; Rat

2017
Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
    The Journal of nutritional biochemistry, 2018, Volume: 54

    Topics: Animals; Betaine; Body Weight; Dexamethasone; Dietary Supplements; DNA Methylation; Epigenesis, Gene

2018
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
    The Journal of nutrition, 2018, 03-01, Volume: 148, Issue:3

    Topics: Animals; Betaine; Chickens; Corticosterone; Dietary Supplements; Disease Models, Animal; DNA Methyla

2018
Fetal one-carbon nutrient concentrations may be affected by gestational diabetes.
    Nutrition research (New York, N.Y.), 2018, Volume: 55

    Topics: Adult; Betaine; Carbon; Choline; Diabetes, Gestational; Female; Fetal Blood; Fetal Development; Fetu

2018
Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model.
    Biochimie, 2018, Volume: 152

    Topics: Animals; Betaine; Caloric Restriction; Carbon; Choline; DNA Methylation; Female; Gene Expression; Ho

2018
Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner.
    Nutrition & diabetes, 2018, 05-24, Volume: 8, Issue:1

    Topics: Animals; Betaine; Diet, High-Fat; Down-Regulation; Fatty Acid Transport Proteins; Female; Fetal Deve

2018
PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women.
    Nutrition research (New York, N.Y.), 2018, Volume: 56

    Topics: Adolescent; Adult; Alleles; Betaine; Birth Weight; Carnitine; Choline; Choline-Phosphate Cytidylyltr

2018
Effect of maternal or post-weaning methyl donor supplementation on growth performance, carcass traits, and meat quality of pig offspring.
    Journal of the science of food and agriculture, 2019, Mar-30, Volume: 99, Issue:5

    Topics: Animal Feed; Animals; Betaine; Body Weight; Dietary Supplements; Female; Folic Acid; Humans; Male; M

2019
Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts.
    Nutrients, 2018, Oct-15, Volume: 10, Issue:10

    Topics: Animal Feed; Animals; Betaine; Biomarkers; Blood Glucose; Cell Line, Tumor; Choline; Diabetes, Gesta

2018
Methyl donor supplementation suppresses the progression of liver lipid accumulation while modifying the plasma triacylglycerol lipidome in periparturient Holstein dairy cows.
    Journal of dairy science, 2019, Volume: 102, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Betaine; Body Weight; Cattle; Choline; Diet; Dietary Supplements; Fe

2019
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
    Psychiatry and clinical neurosciences, 2019, Volume: 73, Issue:6

    Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Anim

2019
Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight.
    The British journal of nutrition, 2019, Volume: 121, Issue:11

    Topics: Adult; Betaine; Birth Weight; Choline; Female; Homocysteine; Humans; Infant, Newborn; Infant, Small

2019
Enhanced hepatic cholesterol accumulation induced by maternal betaine exposure is associated with hypermethylation of CYP7A1 gene promoter.
    Endocrine, 2019, Volume: 64, Issue:3

    Topics: Animals; Betaine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; DNA Methylation; Female; Liver; Mate

2019
One-Carbon Cofactor Intake and Risk of Neural Tube Defects Among Women Who Meet Folic Acid Recommendations: A Multicenter Case-Control Study.
    American journal of epidemiology, 2019, 06-01, Volume: 188, Issue:6

    Topics: Adult; Betaine; Carbon; Case-Control Studies; Choline; Dietary Supplements; Dose-Response Relationsh

2019
Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows.
    Journal of dairy science, 2019, Volume: 102, Issue:9

    Topics: Abomasum; Animals; Betaine; Cattle; Choline; Cystathionine beta-Synthase; Diet; Energy Metabolism; F

2019
Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation.
    European journal of nutrition, 2020, Volume: 59, Issue:4

    Topics: Adipose Tissue; Animals; Betaine; Dietary Supplements; DNA Methylation; Female; Glucocorticoids; Lip

2020
Trimethylamine N-Oxide Metabolites in Early Pregnancy and Risk of Gestational Diabetes: A Nested Case-Control Study.
    The Journal of clinical endocrinology and metabolism, 2019, 11-01, Volume: 104, Issue:11

    Topics: Adult; Betaine; Blood Glucose; Carnitine; Case-Control Studies; China; Choline; Diabetes, Gestationa

2019
Choline intake during pregnancy and child cognition at age 7 years.
    American journal of epidemiology, 2013, Jun-15, Volume: 177, Issue:12

    Topics: Adult; Betaine; Child; Child Development; Choline; Cognition; Dietary Supplements; Female; Folic Aci

2013
Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight.
    Pediatric research, 2013, Volume: 73, Issue:6

    Topics: Betaine; Birth Weight; Choline; Female; Humans; Infant, Newborn; Male; Pregnancy; Sarcosine; Umbilic

2013
Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.
    The American journal of clinical nutrition, 2013, Volume: 97, Issue:6

    Topics: Adult; Betaine; Choline; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Lon

2013
Methylation metabolites in amniotic fluid depend on gestational age.
    Prenatal diagnosis, 2013, Volume: 33, Issue:9

    Topics: Adult; Amniotic Fluid; Betaine; Choline; Female; Gestational Age; Humans; Methionine; Methylation; M

2013
Urinary metabolomics in newborns infected by human cytomegalovirus: a preliminary investigation.
    Early human development, 2013, Volume: 89 Suppl 1

    Topics: 3-Hydroxybutyric Acid; Adult; Aminoisobutyric Acids; Betaine; Creatine; Cytomegalovirus; Cytomegalov

2013
Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants.
    The American journal of clinical nutrition, 2013, Volume: 98, Issue:5

    Topics: Adult; Betaine; British Columbia; Child Development; Choline; Dietary Supplements; Female; Folic Aci

2013
System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.
    Biochimica et biophysica acta, 2014, Volume: 1838, Issue:5

    Topics: Amino Acid Transport System A; Amino Acid Transport Systems; Animals; Betaine; Biological Transport;

2014
Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats.
    The British journal of nutrition, 2014, Volume: 111, Issue:9

    Topics: Animals; Betaine; Brain; Dietary Supplements; DNA; DNA Methylation; Down-Regulation; Epigenesis, Gen

2014
Uptake of betaine into mouse cumulus-oocyte complexes via the SLC7A6 isoform of y+L transporter.
    Biology of reproduction, 2014, Volume: 90, Issue:4

    Topics: Amino Acid Transport Systems, Basic; Amino Acids; Animals; Betaine; Biological Transport; Blastocyst

2014
Dietary intake of choline and neural tube defects in Mexican Americans.
    Birth defects research. Part A, Clinical and molecular teratology, 2014, Volume: 100, Issue:6

    Topics: Adult; Betaine; Case-Control Studies; Choline; Dietary Supplements; Female; Humans; Mexican American

2014
Audiogenic seizure proneness after methyl-enriched diet in ontogeny.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2014, Volume: 454

    Topics: Animals; Betaine; Choline; Diet; DNA Methylation; Epilepsy, Reflex; Female; Methionine; Pregnancy; P

2014
Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet.
    Journal of developmental origins of health and disease, 2014, Volume: 5, Issue:5

    Topics: Adipose Tissue; Animals; Betaine; Body Composition; Choline; Diet; Diet, High-Fat; Dietary Sucrose;

2014
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
    European journal of nutrition, 2015, Volume: 54, Issue:5

    Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;

2015
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
    European journal of nutrition, 2015, Volume: 54, Issue:5

    Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;

2015
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
    European journal of nutrition, 2015, Volume: 54, Issue:5

    Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;

2015
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
    European journal of nutrition, 2015, Volume: 54, Issue:5

    Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;

2015
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Femal

2014
Maternal dietary betaine supplementation modifies hepatic expression of cholesterol metabolic genes via epigenetic mechanisms in newborn piglets.
    The British journal of nutrition, 2014, Nov-14, Volume: 112, Issue:9

    Topics: Animals; Animals, Newborn; Betaine; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxyla

2014
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.
    The American journal of clinical nutrition, 2014, Volume: 100, Issue:4

    Topics: Adult; Betaine; Case-Control Studies; Choline; Dietary Supplements; Female; Folic Acid; Genome, Huma

2014
Maternal methyl-enriched diet in rat reduced the audiogenic seizure proneness in progeny.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 127

    Topics: Animals; Animals, Newborn; Betaine; Choline; Diet; Epilepsy, Reflex; Female; Folic Acid; Male; Mater

2014
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
    European journal of nutrition, 2015, Volume: 54, Issue:7

    Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; DNA Methylation; Female; Gene Expression; G

2015
Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations.
    The Journal of nutrition, 2015, Volume: 145, Issue:7

    Topics: Adolescent; Adult; Betaine; Canada; Choline; Female; Fetal Blood; Fetus; Genotype; Healthy Volunteer

2015
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.
    The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:12

    Topics: Animal Feed; Animals; Animals, Newborn; Betaine; Body Weight; Cell Proliferation; Cyclin D2; Dietary

2015
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
    Biochimica et biophysica acta, 2016, Volume: 1861, Issue:1

    Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Femal

2016
Effect of Afobazole and Betaine on DNA Damage in Placental and Embryonic Tissues of Rats with Experimental Streptozocin Diabetes.
    Bulletin of experimental biology and medicine, 2015, Volume: 159, Issue:6

    Topics: Animals; Antimutagenic Agents; Benzimidazoles; Betaine; Diabetes Mellitus, Experimental; Diabetes, G

2015
Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
    Journal of agricultural and food chemistry, 2015, Nov-25, Volume: 63, Issue:46

    Topics: Animals; Animals, Newborn; Betaine; DNA Methylation; DNA, Mitochondrial; Female; Gene Expression; Ma

2015
The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:3

    Topics: Animals; Betaine; Brain; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Fatty

2016
Maternal betaine supplementation during gestation modifies hippocampal expression of GR and its regulatory miRNAs in neonatal piglets.
    The Journal of veterinary medical science, 2016, Jul-01, Volume: 78, Issue:6

    Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; Female; Gene Expression Regulation, Develop

2016
Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage.
    Bulletin of experimental biology and medicine, 2016, Volume: 161, Issue:3

    Topics: Animals; Benzimidazoles; Betaine; Cognition; Cognition Disorders; Comet Assay; Diabetes Mellitus, Ex

2016
Maternal Methyl-Group Donor Intake and Global DNA (Hydroxy)Methylation before and during Pregnancy.
    Nutrients, 2016, Aug-06, Volume: 8, Issue:8

    Topics: 5-Methylcytosine; Adult; Belgium; Betaine; Biomarkers; Choline; Cohort Studies; Cytosine; Diet; Diet

2016
Choline and the Brain: An Epigenetic Perspective.
    Advances in neurobiology, 2016, Volume: 12

    Topics: Animals; Betaine; Brain; Choline; Dietary Supplements; DNA Methylation; Environment; Epigenesis, Gen

2016
Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.
    Nutrients, 2016, Oct-18, Volume: 8, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Betaine; Breast Feeding; Cholesterol; Chol

2016
Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation.
    Epigenetics, 2017, 01-02, Volume: 12, Issue:1

    Topics: Adult; Betaine; Choline; Cohort Studies; Diet; Dietary Supplements; DNA Methylation; Epigenomics; Fe

2017
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
    General and comparative endocrinology, 2017, 05-15, Volume: 246

    Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents; Betaine; Blotting, Western; Chickens; Ch

2017
Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017, Volume: 33, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Blood Alcohol Content; Calpain; Caspase 3; Cathepsin

2017
Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat.
    Amino acids, 2017, Volume: 49, Issue:4

    Topics: Amino Acid Transport System A; Animals; Arginine; beta-Alanine; Betaine; Female; HEK293 Cells; Human

2017
Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants.
    Clinical epigenetics, 2017, Volume: 9

    Topics: Betaine; Choline; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Meth

2017
Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:8

    Topics: Animals; Animals, Newborn; Betaine; Body Weight; Dietary Supplements; DNA Methylation; Female; Insul

2017
SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage.
    Development (Cambridge, England), 2008, Volume: 135, Issue:24

    Topics: Amino Acid Transport Systems, Neutral; Animals; Base Sequence; Betaine; Carrier Proteins; Cleavage S

2008
[Methyl-containing diet of mothers affects the AGOUTI gene expression in the offspring of rats with various behavioral types].
    Genetika, 2009, Volume: 45, Issue:5

    Topics: Aggression; Agouti Signaling Protein; Animals; Behavior, Animal; Betaine; Choline; Dietary Supplemen

2009
Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy.
    Magma (New York, N.Y.), 2009, Volume: 22, Issue:6

    Topics: Adult; Alanine; Amniotic Fluid; Betaine; Biomarkers; Citric Acid; Creatinine; Female; Glucose; Human

2009
Low availability of carnitine precursors as a possible reason for the diminished plasma carnitine concentrations in pregnant women.
    BMC pregnancy and childbirth, 2010, Apr-25, Volume: 10

    Topics: Adult; Anemia, Iron-Deficiency; Betaine; Carnitine; Erythrocyte Indices; Female; Ferritins; Germany;

2010
Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet.
    Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Betaine; Choline; Diet; DNA Methylation; Drug Resistance; Etha

2011
Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes.
    Human molecular genetics, 2011, May-01, Volume: 20, Issue:9

    Topics: Animals; Bacteria; Betaine; Choline; Colitis; Dietary Supplements; Disease Susceptibility; DNA Methy

2011
Non-targeted analyses of animal plasma: betaine and choline represent the nutritional and metabolic status.
    Journal of animal physiology and animal nutrition, 2013, Volume: 97, Issue:1

    Topics: Animals; Betaine; Cattle; Chickens; Choline; Diabetes Mellitus, Experimental; Female; Male; Mice; Mi

2013
Gestational intake of methyl donors and global LINE-1 DNA methylation in maternal and cord blood: prospective results from a folate-replete population.
    Epigenetics, 2012, Volume: 7, Issue:3

    Topics: Adult; Betaine; Choline; Diet; Dietary Supplements; DNA Methylation; Female; Fetal Blood; Folic Acid

2012
Supplementing sow gestation diets with betaine during summer increases litter size of sows with greater numbers of parities.
    Animal reproduction science, 2012, Volume: 132, Issue:1-2

    Topics: Animals; Animals, Newborn; Betaine; Body Weight; Chi-Square Distribution; Dietary Supplements; Femal

2012
Maternal intake of methyl-donor nutrients and child cognition at 3 years of age.
    Paediatric and perinatal epidemiology, 2012, Volume: 26, Issue:4

    Topics: Adult; Betaine; Child Development; Child, Preschool; Choline; Cognition; Cohort Studies; Diet; DNA M

2012
Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Betaine; Child Development; Choline; Cognition; Female; Humans; Infant; Male; Pregnancy; Pregnancy T

2012
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:4

    Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo

2013
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
    The British journal of nutrition, 2013, Jul-28, Volume: 110, Issue:2

    Topics: Betaine; Child Development; Child, Preschool; Choline; Cognition; Female; Homocysteine; Humans; Lang

2013
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice.
    The Journal of nutrition, 2013, Volume: 143, Issue:3

    Topics: Animals; Betaine; Choline; Craniofacial Abnormalities; Dietary Supplements; Disease Models, Animal;

2013
Metabolic profiling of plasma from sows before parturition and during lactation using a liquid chromatography-mass spectrometry-based approach.
    Journal of animal science, 2012, Volume: 90 Suppl 4

    Topics: Animals; Betaine; Choline; Chromatography, Liquid; Female; Lactation; Lipids; Mass Spectrometry; Par

2012
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
    The Biochemical journal, 2004, Sep-15, Volume: 382, Issue:Pt 3

    Topics: Animals; Animals, Suckling; Betaine; Body Weight; Brain; Disease Models, Animal; Female; Genotype; H

2004
Periconceptional dietary intake of choline and betaine and neural tube defects in offspring.
    American journal of epidemiology, 2004, Jul-15, Volume: 160, Issue:2

    Topics: Betaine; California; Case-Control Studies; Choline; Female; Humans; Infant, Newborn; Maternal Nutrit

2004
Two successful pregnancies in pyridoxine-nonresponsive homocystinuria.
    Journal of inherited metabolic disease, 2004, Volume: 27, Issue:6

    Topics: Abortion, Spontaneous; Adult; Anticoagulants; Betaine; Diet, Protein-Restricted; Female; Gastrointes

2004
Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy.
    The American journal of clinical nutrition, 2005, Volume: 81, Issue:6

    Topics: Adult; Africa, Western; Betaine; Black People; Choline; Dietary Supplements; Female; Folic Acid; Ges

2005
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2005, Volume: 23, Issue:5

    Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Body Patterning; Body Weight; Brain; Cell Division; C

2005
Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery.
    The American journal of clinical nutrition, 2005, Volume: 82, Issue:4

    Topics: Betaine; Choline; Chromatography, Liquid; Creatinine; Cross-Sectional Studies; Female; Fetal Blood;

2005
Prenatal and postnatal treatment in cobalamin C defect.
    The Journal of pediatrics, 2005, Volume: 147, Issue:4

    Topics: Betaine; Carnitine; Female; Folic Acid; Hematinics; Humans; Hydroxocobalamin; Infant, Newborn; Lipot

2005
[The effect of methyl-containing supplements during pregnancy on the phenotypic modification of offspring hair color in rats].
    Genetika, 2006, Volume: 42, Issue:1

    Topics: Agouti Signaling Protein; Animals; Betaine; Choline; Color; Dietary Supplements; Electron Spin Reson

2006
Maternal methyl supplements increase offspring DNA methylation at Axin Fused.
    Genesis (New York, N.Y. : 2000), 2006, Volume: 44, Issue:9

    Topics: Alleles; Animals; Axin Protein; Betaine; Body Weight; Choline; CpG Islands; Diet; Dietary Supplement

2006
Successful treatment of pyridoxine-unresponsive homocystinuria with betaine in pregnancy.
    Journal of inherited metabolic disease, 2006, Volume: 29, Issue:5

    Topics: Adult; Betaine; Female; Gastrointestinal Agents; Homocystinuria; Humans; Pregnancy; Pregnancy Compli

2006
A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats.
    Neuroscience and behavioral physiology, 2007, Volume: 37, Issue:5

    Topics: Age Factors; Animal Feed; Animals; Anxiety; Betaine; Brain; Choline; Critical Period, Psychological;

2007
Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants.
    The Journal of nutrition, 2007, Volume: 137, Issue:12

    Topics: Adolescent; Adult; Betaine; Choline; Choline Dehydrogenase; Female; Gene Expression Regulation, Enzy

2007
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study.
    The American journal of clinical nutrition, 2008, Volume: 87, Issue:2

    Topics: Adult; Betaine; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methionine;

2008
Supplementing limited methionine diets with rumen-protected methionine, betaine, and choline in early lactation Holstein cows.
    Journal of dairy science, 2008, Volume: 91, Issue:4

    Topics: Animal Feed; Animals; Betaine; Body Constitution; Body Weight; Cattle; Choline; Dairying; Diet; Diet

2008
Distribution of 14C-labelled acrylamide and betaine in foetuses of rats, rabbits, beagle dogs and miniature pigs.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1983, Volume: 21, Issue:1

    Topics: Acrylamides; Animals; Betaine; Carbon Radioisotopes; Dogs; Female; Fetus; Male; Pregnancy; Rabbits;

1983
Inhibition of placental amino acid uptake in rats following acute and chronic ethanol exposure.
    Alcoholism, clinical and experimental research, 1982,Fall, Volume: 6, Issue:4

    Topics: Acetaldehyde; Alanine; Alcoholism; Amino Acids; Aminoisobutyric Acids; Animals; Betaine; Cycloleucin

1982
The development of carnitine synthesis from gamma-butyrobetaine in the rat.
    Life sciences, 1981, Mar-02, Volume: 28, Issue:9

    Topics: Animals; Betaine; Carnitine; Female; Liver; Male; Pregnancy; Rats

1981
Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet.
    The Journal of nutrition, 1995, Volume: 125, Issue:11

    Topics: Administration, Oral; Animals; Betaine; Brain; Carbon Radioisotopes; Choline; Chromatography, High P

1995
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
    The Journal of nutrition, 1995, Volume: 125, Issue:12

    Topics: Animals; Betaine; Choline; Choline Deficiency; Female; Lactation; Liver; Male; Maternal-Fetal Exchan

1995
Effect of sodium and betaine in culture media on development and relative rates of protein synthesis in preimplantation mouse embryos in vitro.
    Molecular reproduction and development, 1993, Volume: 35, Issue:1

    Topics: Animals; Betaine; Blastocyst; Culture Media; Embryonic and Fetal Development; Female; In Vitro Techn

1993
Sodium-dependent high-affinity binding of carnitine to human placental brush border membranes.
    Biochimica et biophysica acta, 1996, Jul-25, Volume: 1282, Issue:2

    Topics: Anions; Betaine; Binding, Competitive; Biological Transport; Carnitine; Cations; Female; Humans; Int

1996
Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years.
    European journal of pediatrics, 1998, Volume: 157 Suppl 2

    Topics: Adolescent; Adult; Betaine; Child; Child, Preschool; Cystathionine beta-Synthase; Dose-Response Rela

1998
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements

1998
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements

1998
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements

1998
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:11

    Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements

1998
Maternal-foetal distribution studies in late pregnancy. I. Distribution of [N-methyl-14C]betaine in tissues of beagle dogs and miniature pigs.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1985, Volume: 23, Issue:6

    Topics: Animals; Betaine; Brain; Carbon Radioisotopes; Dogs; Female; Fetus; Kidney; Liver; Lung; Maternal-Fe

1985
Development of structure and function in the mammalian yolk sac. 3. The development of amino acid transport by rabbit yolk sac.
    Developmental biology, 1966, Volume: 13, Issue:3

    Topics: Alanine; Amino Acids; Animals; Betaine; Biological Transport; Carbon Isotopes; Female; Fetus; Glycin

1966