betaine has been researched along with Obesity in 38 studies
glycine betaine : The amino acid betaine derived from glycine.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Plasma betaine correlates with insulin sensitivity in humans." | 9.27 | Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes. ( Basu, R; Beckman, JA; Cloutier, E; Dreyfuss, JM; Fowler, KM; Gerszten, RE; Goldfine, AB; Grizales, AM; Kozuka, C; Lee, A; Lin, AP; Pan, H; Patti, ME; Pober, DM; Sahni, VA, 2018) |
| "We evaluate the effect of supplementation, at 300 mg kg(-1) body weight (BW), with the antioxidants α-lipoic acid (AL), betaine (BT), l-carnitine (LC), and the combination of these and exercise on obesity induced by a 9 week high-fat diet (HFD) in mice." | 7.80 | The effect of dietary α-lipoic acid, betaine, l-carnitine, and swimming on the obesity of mice induced by a high-fat diet. ( Jang, A; Jo, C; Jung, S; Kim, D; Kim, HJ; Sung, KS, 2014) |
| "Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine." | 5.91 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults. ( Abbasi, MSP; Ardekani, AM; Gharebakhshi, F; Jafarzadeh, F; Manzouri, A; Nikrad, N; Tousi, AZ; Vahdat, S; Yazdani, Y, 2023) |
| "Betaine is a nontoxic, chemically stable and naturally occurring molecule." | 5.48 | Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet. ( Bai, L; Du, J; Gan, M; Jiang, A; Jiang, Y; Jin, L; Li, M; Li, X; Ma, J; Shen, L; Tan, Z; Tang, G; Wang, J; Xu, Y; Yang, Q; Zhang, P; Zhang, S; Zhao, X; Zhu, L, 2018) |
| "Plasma betaine correlates with insulin sensitivity in humans." | 5.27 | Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes. ( Basu, R; Beckman, JA; Cloutier, E; Dreyfuss, JM; Fowler, KM; Gerszten, RE; Goldfine, AB; Grizales, AM; Kozuka, C; Lee, A; Lin, AP; Pan, H; Patti, ME; Pober, DM; Sahni, VA, 2018) |
| " Furthermore, glycine could be linked to metabolic health and insulin sensitivity through the betaine osmolyte." | 5.22 | Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance. ( Astrup, A; Carayol, J; Charon, C; Fazelzadeh, P; Hager, J; Lefebvre, G; Matone, A; Morine, M; Saris, WH; Scott-Boyer, MP; Valsesia, A; Vervoort, J, 2016) |
| " Among them, amino acid (AA) derivatives, such as taurine, glutathione (GSH), betaine, α-ketoglutarate (AKG), β-aminoisobutyric acid (BAIBA), and β-hydroxy-β-methylbutyrate (HMB), have recently gained popularity due to their beneficial effects on the promotion of weight loss and improvement in the lipid profile." | 5.12 | Roles of amino acid derivatives in the regulation of obesity. ( Duan, Y; Guo, Q; Li, F; Li, T; Song, B; Xiao, H; Zheng, C; Zheng, J, 2021) |
| "5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet." | 4.31 | 5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes. ( Haberbosch, L; Kierszniowska, S; Mai, K; Maurer, L; Spranger, J; Willmitzer, L, 2023) |
| "Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)." | 4.02 | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021) |
| "Significantly inverse correlations were found between serum betaine levels and all obesity measurements in males (r ranged from -0." | 3.88 | Higher serum choline and betaine levels are associated with better body composition in male but not female population. ( Gao, X; Randell, E; Sun, G; Zhou, H, 2018) |
| " Maternal nutrition is critically involved in the growth and development of the fetus, but what about the father? The aim is to investigate the effects of paternal methyl-group donor intake (methionine, folate, betaine, choline) on paternal and offspring global DNA (hydroxy)methylation, offspring IGF2 DMR DNA methylation, and birth weight." | 3.85 | The effect of paternal methyl-group donor intake on offspring DNA methylation and birth weight. ( Bekaert, B; Devlieger, R; Duca, RC; Freson, K; Ghosh, M; Godderis, L; Huybrechts, I; Koppen, G; Langie, SAS; Pauwels, S; Truijen, I, 2017) |
| " We hypothesized that increasing free carnitine levels by administration of the carnitine precursor γ-butyrobetaine (γBB) could facilitate FAO, thereby improving insulin sensitivity." | 3.83 | The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice. ( Hollak, CE; Houten, SM; Houtkooper, RH; Schooneman, MG; Soeters, MR; Vaz, FM; Wanders, RJ, 2016) |
| "We evaluate the effect of supplementation, at 300 mg kg(-1) body weight (BW), with the antioxidants α-lipoic acid (AL), betaine (BT), l-carnitine (LC), and the combination of these and exercise on obesity induced by a 9 week high-fat diet (HFD) in mice." | 3.80 | The effect of dietary α-lipoic acid, betaine, l-carnitine, and swimming on the obesity of mice induced by a high-fat diet. ( Jang, A; Jo, C; Jung, S; Kim, D; Kim, HJ; Sung, KS, 2014) |
| " Female Wistar rats fed control diet during pregnancy were assigned to four postpartum dietary groups: control, control supplemented with methyl donors (choline, betaine, folic acid, vitamin B12), HFS and HFS supplemented with methyl donors." | 3.80 | Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet. ( Campion, J; Cordero, P; Martinez, JA; Milagro, FI, 2014) |
| "Betaine (BET) reduces diet-induced liver lipid accumulation, and may relieve obesity-related metabolic disturbances." | 3.79 | Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. ( Auriola, S; Hanhineva, K; Huotari, A; Keski-Rahkonen, P; Kolehmainen, M; Lehtonen, M; Mykkänen, H; Olli, K; Pekkinen, J; Poutanen, K; Tiihonen, K, 2013) |
| "Identifying novel biomarkers of type 2 diabetes risk may improve prediction and prevention among individuals at high risk of the disease and elucidate new biological pathways relevant to diabetes development." | 2.82 | Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program. ( Clish, C; Florez, JC; Gerszten, RE; Ma, Y; Walford, GA; Wang, TJ, 2016) |
| "Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine." | 1.91 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults. ( Abbasi, MSP; Ardekani, AM; Gharebakhshi, F; Jafarzadeh, F; Manzouri, A; Nikrad, N; Tousi, AZ; Vahdat, S; Yazdani, Y, 2023) |
| "Obesity is a serious health issue as it is a social burden and the main risk factor for other metabolic diseases." | 1.62 | Free fatty acids induce the demethylation of the fructose 1,6-biphosphatase 2 gene promoter and potentiate its expression in hepatocytes. ( Li, X; Liu, J; Liu, M; Wang, L; Wu, Y; Yin, F; Yin, L, 2021) |
| "The incidence of type 2 diabetes is increasing more rapidly in adolescents than in any other age group." | 1.56 | Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes. ( Barshop, BA; Chen, K; Concepcion, J; Gangoiti, J; Kim, JJ; Mendez, E; Natarajan, L; Nikita, ME; Saito, R; Sharma, K, 2020) |
| "Betaine is a nontoxic, chemically stable and naturally occurring molecule." | 1.48 | Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet. ( Bai, L; Du, J; Gan, M; Jiang, A; Jiang, Y; Jin, L; Li, M; Li, X; Ma, J; Shen, L; Tan, Z; Tang, G; Wang, J; Xu, Y; Yang, Q; Zhang, P; Zhang, S; Zhao, X; Zhu, L, 2018) |
| "Bioprocessing of whole grain cereals may affect the bioavailability of phytochemicals associated with grain fiber and ultimately lead to different health outcomes." | 1.42 | Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet--A nontargeted metabolomics study. ( Hanhineva, K; Keski-Rahkonen, P; Lehtonen, M; Micard, V; Mykkänen, H; Pekkinen, J; Poutanen, K; Rosa-Sibakov, N, 2015) |
| "Betaine has been used for NASH, with mixed results, and may show promise in conjunction with other agents in clinical trials." | 1.37 | Betaine and nonalcoholic steatohepatitis: back to the future? ( Mukherjee, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 21 (55.26) | 24.3611 |
| 2020's | 11 (28.95) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, TY | 1 |
| Wu, CH | 1 |
| Chang, CY | 1 |
| Lee, FJ | 1 |
| Wang, BW | 1 |
| Doong, JY | 1 |
| Lin, YS | 1 |
| Kuo, CS | 1 |
| Huang, RS | 1 |
| Yu, J | 1 |
| Laybutt, DR | 1 |
| Youngson, NA | 1 |
| Morris, MJ | 1 |
| Abbasi, MSP | 1 |
| Tousi, AZ | 1 |
| Yazdani, Y | 1 |
| Vahdat, S | 1 |
| Gharebakhshi, F | 1 |
| Nikrad, N | 1 |
| Manzouri, A | 1 |
| Ardekani, AM | 1 |
| Jafarzadeh, F | 1 |
| Haberbosch, L | 1 |
| Kierszniowska, S | 1 |
| Willmitzer, L | 1 |
| Mai, K | 1 |
| Spranger, J | 1 |
| Maurer, L | 1 |
| Eyupoglu, ND | 1 |
| Caliskan Guzelce, E | 1 |
| Acikgoz, A | 1 |
| Uyanik, E | 1 |
| Bjørndal, B | 1 |
| Berge, RK | 2 |
| Svardal, A | 2 |
| Yildiz, BO | 1 |
| Zhu, C | 1 |
| Sawrey-Kubicek, L | 1 |
| Bardagjy, AS | 1 |
| Houts, H | 1 |
| Tang, X | 1 |
| Sacchi, R | 1 |
| Randolph, JM | 1 |
| Steinberg, FM | 1 |
| Zivkovic, AM | 1 |
| Concepcion, J | 1 |
| Chen, K | 1 |
| Saito, R | 1 |
| Gangoiti, J | 1 |
| Mendez, E | 1 |
| Nikita, ME | 1 |
| Barshop, BA | 1 |
| Natarajan, L | 1 |
| Sharma, K | 1 |
| Kim, JJ | 1 |
| León-Mimila, P | 1 |
| Villamil-Ramírez, H | 1 |
| Li, XS | 1 |
| Shih, DM | 1 |
| Hui, ST | 1 |
| Ocampo-Medina, E | 1 |
| López-Contreras, B | 1 |
| Morán-Ramos, S | 1 |
| Olivares-Arevalo, M | 1 |
| Grandini-Rosales, P | 1 |
| Macías-Kauffer, L | 1 |
| González-González, I | 1 |
| Hernández-Pando, R | 1 |
| Gómez-Pérez, F | 1 |
| Campos-Pérez, F | 1 |
| Aguilar-Salinas, C | 1 |
| Larrieta-Carrasco, E | 1 |
| Villarreal-Molina, T | 1 |
| Wang, Z | 1 |
| Lusis, AJ | 1 |
| Hazen, SL | 1 |
| Huertas-Vazquez, A | 1 |
| Canizales-Quinteros, S | 1 |
| Mukherjee, S | 2 |
| Kwee, LC | 1 |
| Ilkayeva, O | 1 |
| Muehlbauer, MJ | 1 |
| Bihlmeyer, N | 1 |
| Wolfe, B | 1 |
| Purnell, JQ | 1 |
| Xavier Pi-Sunyer, F | 1 |
| Chen, H | 1 |
| Bahnson, J | 1 |
| Newgard, CB | 1 |
| Shah, SH | 1 |
| Laferrère, B | 1 |
| Wang, L | 1 |
| Liu, M | 1 |
| Wu, Y | 1 |
| Li, X | 2 |
| Yin, F | 1 |
| Yin, L | 1 |
| Liu, J | 1 |
| Zheng, J | 1 |
| Xiao, H | 1 |
| Duan, Y | 1 |
| Song, B | 1 |
| Zheng, C | 1 |
| Guo, Q | 1 |
| Li, F | 1 |
| Li, T | 1 |
| Du, J | 1 |
| Shen, L | 1 |
| Tan, Z | 1 |
| Zhang, P | 1 |
| Zhao, X | 1 |
| Xu, Y | 1 |
| Gan, M | 1 |
| Yang, Q | 1 |
| Ma, J | 1 |
| Jiang, A | 1 |
| Tang, G | 1 |
| Jiang, Y | 1 |
| Jin, L | 1 |
| Li, M | 1 |
| Bai, L | 1 |
| Wang, J | 1 |
| Zhang, S | 1 |
| Zhu, L | 1 |
| Gao, X | 1 |
| Randell, E | 1 |
| Zhou, H | 1 |
| Sun, G | 1 |
| Grizales, AM | 1 |
| Patti, ME | 1 |
| Lin, AP | 1 |
| Beckman, JA | 1 |
| Sahni, VA | 1 |
| Cloutier, E | 1 |
| Fowler, KM | 1 |
| Dreyfuss, JM | 1 |
| Pan, H | 1 |
| Kozuka, C | 1 |
| Lee, A | 1 |
| Basu, R | 1 |
| Pober, DM | 1 |
| Gerszten, RE | 2 |
| Goldfine, AB | 1 |
| Airaksinen, K | 1 |
| Jokkala, J | 1 |
| Ahonen, I | 1 |
| Auriola, S | 2 |
| Kolehmainen, M | 2 |
| Hanhineva, K | 3 |
| Tiihonen, K | 2 |
| de Castro, NM | 1 |
| Yaqoob, P | 1 |
| de la Fuente, M | 1 |
| Baeza, I | 1 |
| Claus, SP | 1 |
| Pekkinen, J | 2 |
| Olli, K | 1 |
| Huotari, A | 1 |
| Keski-Rahkonen, P | 2 |
| Lehtonen, M | 2 |
| Mykkänen, H | 2 |
| Poutanen, K | 2 |
| Jang, A | 1 |
| Kim, D | 1 |
| Sung, KS | 1 |
| Jung, S | 1 |
| Kim, HJ | 1 |
| Jo, C | 1 |
| Cordero, P | 1 |
| Milagro, FI | 1 |
| Campion, J | 1 |
| Martinez, JA | 1 |
| Rosa-Sibakov, N | 1 |
| Micard, V | 1 |
| Walford, GA | 1 |
| Ma, Y | 1 |
| Clish, C | 1 |
| Florez, JC | 1 |
| Wang, TJ | 1 |
| Matone, A | 1 |
| Scott-Boyer, MP | 1 |
| Carayol, J | 1 |
| Fazelzadeh, P | 1 |
| Lefebvre, G | 1 |
| Valsesia, A | 1 |
| Charon, C | 1 |
| Vervoort, J | 1 |
| Astrup, A | 1 |
| Saris, WH | 1 |
| Morine, M | 1 |
| Hager, J | 1 |
| Trøseid, M | 1 |
| Hov, JR | 1 |
| Nestvold, TK | 1 |
| Thoresen, H | 1 |
| Lappegård, KT | 1 |
| Schooneman, MG | 1 |
| Houtkooper, RH | 1 |
| Hollak, CE | 1 |
| Wanders, RJ | 1 |
| Vaz, FM | 1 |
| Soeters, MR | 1 |
| Houten, SM | 1 |
| Albuquerque, A | 1 |
| Neves, JA | 1 |
| Redondeiro, M | 1 |
| Laranjo, M | 1 |
| Félix, MR | 1 |
| Freitas, A | 1 |
| Tirapicos, JL | 1 |
| Martins, JM | 1 |
| Pauwels, S | 1 |
| Truijen, I | 1 |
| Ghosh, M | 1 |
| Duca, RC | 1 |
| Langie, SAS | 1 |
| Bekaert, B | 1 |
| Freson, K | 1 |
| Huybrechts, I | 1 |
| Koppen, G | 1 |
| Devlieger, R | 1 |
| Godderis, L | 1 |
| Kim, SH | 1 |
| Yang, SO | 1 |
| Kim, HS | 1 |
| Kim, Y | 1 |
| Park, T | 1 |
| Choi, HK | 1 |
| Jacobs, RL | 1 |
| Zhao, Y | 1 |
| Koonen, DP | 1 |
| Sletten, T | 1 |
| Su, B | 1 |
| Lingrell, S | 1 |
| Cao, G | 1 |
| Peake, DA | 1 |
| Kuo, MS | 1 |
| Proctor, SD | 1 |
| Kennedy, BP | 1 |
| Dyck, JR | 1 |
| Vance, DE | 1 |
| Sledzinski, T | 1 |
| Goyke, E | 1 |
| Smolenski, RT | 1 |
| Sledzinski, Z | 1 |
| Swierczynski, J | 1 |
| Fernández-Fígares, I | 1 |
| Lachica, M | 1 |
| Martín, A | 1 |
| Nieto, R | 1 |
| González-Valero, L | 1 |
| Rodríguez-López, JM | 1 |
| Aguilera, JF | 1 |
| Zeisel, SH | 1 |
| Patrick, L | 1 |
| Williams, RE | 1 |
| Lenz, EM | 1 |
| Evans, JA | 1 |
| Wilson, ID | 1 |
| Granger, JH | 1 |
| Plumb, RS | 1 |
| Stumpf, CL | 1 |
| Serkova, NJ | 1 |
| Jackman, M | 1 |
| Brown, JL | 1 |
| Liu, T | 1 |
| Hirose, R | 1 |
| Roberts, JP | 1 |
| Maher, JJ | 1 |
| Niemann, CU | 1 |
| Hilt, G | 1 |
| Tuzin, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bedside to Bench and Back: Cardiometabolic Effects of Betaine Supplementation[NCT01950039] | Phase 2 | 28 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| [NCT00004992] | Phase 3 | 3,234 participants (Actual) | Interventional | 1996-07-31 | Completed | ||
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Glucose tolerance was assessed by oral glucose tolerance, assessed using the change from baseline for fasting and 2 hour glucose, and change in Glucose AUC at 12 weeks from baseline was measured. (NCT01950039)
Timeframe: baseline and 12 weeks
| Intervention | mg*min/dL (Mean) |
|---|---|
| Betaine | 340 |
| Placebo | -413 |
Intrahepatic triglyceride levels were assessed by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (Siemens 3T TIM Skyra, software version VD13; Siemens, Erlangen, Germany). (NCT01950039)
Timeframe: baseline and 12 weeks
| Intervention | percent change in hepatic triglyceride (Mean) |
|---|---|
| Betaine | -0.01 |
| Placebo | -0.03 |
Brachial artery reactivity to flow and nitroglycerin stimuli, assessed as percent change from baseline (NCT01950039)
Timeframe: baseline and 12 weeks
| Intervention | percent change from baseline (Mean) | |
|---|---|---|
| Percent change in flow-mediated dilation | Percent change in nitroglycerine-mediated dilation | |
| Betaine | -0.5 | -0.9 |
| Placebo | -1.9 | -0.9 |
Glucose levels were analyzed in the fasting state and two hours after glucose load, comparing baseline to 12 weeks. (NCT01950039)
Timeframe: baseline and 12 weeks
| Intervention | mg/dl (Mean) | |
|---|---|---|
| fasting glucose | 2-hour glucose | |
| Betaine | -5 | 7 |
| Placebo | 3 | -4 |
"Euglycemic hyperinsulinemic clamp at baseline and at end of study (12 weeks) for assessment of:~glucose disposal (M) at low (25 mU/m2/min) and high (180 mU/m2/min) insulin infusion rates, reported as raw data~measurement of endogenous glucose production at basal and low insulin infusion (25 mU/m2/min), reported as change from measures at baseline of individual study days" (NCT01950039)
Timeframe: Baseline and 12 weeks
| Intervention | umol/kg/min (Mean) | |||||
|---|---|---|---|---|---|---|
| Glucose Utilization (M), 25 mU/m2/min, baseline | Glucose Utilization (M), 25 mU/m2/min, 12 weeks | Glucose Utilization (M), 180 mU/m2/min, baseline | Glucose Utilization (M), 180 mU/m2/min, 12 weeks | Endogenous Glucose Production, basal insulin | Endogenous Glucose Production, 25 mU/m2/min | |
| Betaine | 90.4 | 110.9 | 406.8 | 458.1 | .03 | -0.01 |
| Placebo | 62.8 | 73.5 | 332.6 | 393.7 | -0.01 | -0.12 |
4 reviews available for betaine and Obesity
| Article | Year |
|---|---|
Role of betaine in liver disease-worth revisiting or has the die been cast?
Topics: Betaine; Humans; Insulin Resistance; Liver; Liver Cirrhosis; Liver Transplantation; Non-alcoholic Fa | 2020 |
Roles of amino acid derivatives in the regulation of obesity.
Topics: Adipogenesis; Adipose Tissue, Beige; Adipose Tissue, Brown; Amino Acids; Aminoisobutyric Acids; Anim | 2021 |
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.
Topics: Animals; Betaine; Carbon; Choline; Energy Metabolism; Humans; Insulin Resistance; Metabolic Networks | 2013 |
Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine.
Topics: Antioxidants; Betaine; Fatty Liver; Female; Humans; Insulin Resistance; Lipotropic Agents; Liver; Ma | 2002 |
7 trials available for betaine and Obesity
| Article | Year |
|---|---|
Whole egg consumption increases plasma choline and betaine without affecting TMAO levels or gut microbiome in overweight postmenopausal women.
Topics: Aged; Bacteria; Betaine; Choline; Cross-Over Studies; Diet; Eggs; Feces; Female; Gastrointestinal Mi | 2020 |
Metabolites and diabetes remission after weight loss.
Topics: Amino Acids, Branched-Chain; Bariatric Surgery; Betaine; Biomarkers; Choline; Diabetes Mellitus, Typ | 2021 |
Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes.
Topics: Aged; Betaine; Blood Glucose; Dietary Supplements; Double-Blind Method; Energy Metabolism; Female; H | 2018 |
Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program.
Topics: Adult; Betaine; Biomarkers; Case-Control Studies; Cohort Studies; Combined Modality Therapy; Diabete | 2016 |
Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.
Topics: Adult; Ammonia; Betaine; Caloric Restriction; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosp | 2016 |
Long term betaine supplementation regulates genes involved in lipid and cholesterol metabolism of two muscles from an obese pig breed.
Topics: Adipose Tissue; Animal Feed; Animals; Betaine; Breeding; Cholesterol; Diet; Dietary Supplements; Dow | 2017 |
Impact of dietary betaine and conjugated linoleic acid on insulin sensitivity, protein and fat metabolism of obese pigs.
Topics: Analysis of Variance; Animal Nutritional Physiological Phenomena; Animals; Betaine; Dietary Proteins | 2012 |
27 other studies available for betaine and Obesity
| Article | Year |
|---|---|
Optimal Dietary Intake Composition of Choline and Betaine Is Associated with Minimized Visceral Obesity-Related Hepatic Steatosis in a Case-Control Study.
Topics: Adiposity; Aged; Betaine; Biomarkers; Body Composition; Case-Control Studies; Choline; Diet Records; | 2022 |
Concurrent betaine administration enhances exercise-induced improvements to glucose handling in obese mice.
Topics: Animals; Betaine; Diet, High-Fat; Fatty Acids; Glucose; Insulin Resistance; Insulins; Liver; Male; M | 2022 |
Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults.
Topics: Adult; Betaine; Biomarkers; Cardiometabolic Risk Factors; Cholesterol; Choline; Diet; Eating; Humans | 2023 |
5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes.
Topics: Animals; Betaine; Diabetes Mellitus; Glucose; Humans; Mice; Non-alcoholic Fatty Liver Disease; Obesi | 2023 |
Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome.
Topics: Adolescent; Adult; Betaine; Blood Glucose; Cardiovascular Diseases; Carnitine; Choline; Female; Gast | 2019 |
Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes.
Topics: Adolescent; Amino Acids, Branched-Chain; Betaine; Biomarkers; Biosynthetic Pathways; Chromatography, | 2020 |
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female | 2021 |
Free fatty acids induce the demethylation of the fructose 1,6-biphosphatase 2 gene promoter and potentiate its expression in hepatocytes.
Topics: Animals; Betaine; Cell Line; Diet, High-Fat; DNA Demethylation; Fatty Acids, Nonesterified; Fructose | 2021 |
Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet.
Topics: 3T3-L1 Cells; Adipocytes, White; Adipogenesis; Adiposity; Animals; Animals, Outbred Strains; Anti-Ob | 2018 |
Higher serum choline and betaine levels are associated with better body composition in male but not female population.
Topics: Absorptiometry, Photon; Adult; Betaine; Body Composition; Body Mass Index; Body Weight; Choline; Cro | 2018 |
High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice.
Topics: Adipose Tissue; Animals; Betaine; Diet, Fat-Restricted; Diet, High-Fat; Dietary Supplements; Gene Ex | 2018 |
Premature impairment of methylation pathway and cardiac metabolic dysfunction in fa/fa obese Zucker rats.
Topics: Adipose Tissue, White; Age Factors; Animals; Betaine; Disease Models, Animal; Inositol; Liver; Magne | 2013 |
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach.
Topics: Acetylcarnitine; Adipose Tissue; Adiposity; Animals; Betaine; Blood Glucose; Carnitine; Chromatograp | 2013 |
The effect of dietary α-lipoic acid, betaine, l-carnitine, and swimming on the obesity of mice induced by a high-fat diet.
Topics: Adipocytes; Animals; Antioxidants; Betaine; Blood Glucose; Body Weight; Carnitine; Cholesterol; Diet | 2014 |
Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet.
Topics: Adipose Tissue; Animals; Betaine; Body Composition; Choline; Diet; Diet, High-Fat; Dietary Sucrose; | 2014 |
Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet--A nontargeted metabolomics study.
Topics: Alkaloids; Amino Acids; Animals; Betaine; Biomarkers; Diet, High-Fat; Dietary Fiber; Feces; Fermenta | 2015 |
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery.
Topics: Adult; Atherosclerosis; Bariatric Surgery; Betaine; Body Mass Index; Cardiovascular Diseases; Carnit | 2016 |
The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice.
Topics: Animals; Betaine; Carnitine; Dietary Fats; Energy Metabolism; Glucose Intolerance; Insulin Resistanc | 2016 |
The effect of paternal methyl-group donor intake on offspring DNA methylation and birth weight.
Topics: Adult; Belgium; Betaine; Birth Weight; Choline; DNA Methylation; Female; Fetal Blood; Folic Acid; Hu | 2017 |
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine | 2009 |
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
Topics: Animals; Betaine; Choline; Diet; Dietary Fats; Dietary Supplements; Energy Metabolism; Fatty Liver; | 2010 |
Decreased serum betaine concentrations in patients after bariatric surgery.
Topics: Adult; Bariatric Surgery; Betaine; Female; Homocysteine; Humans; Male; Middle Aged; Obesity | 2011 |
Betaine and nonalcoholic steatohepatitis: back to the future?
Topics: Animals; Betaine; Clinical Trials as Topic; Fatty Liver; Humans; Insulin Resistance; Liver Transplan | 2011 |
Betaine. Monograph.
Topics: Betaine; Cardiovascular Diseases; Fatty Liver; Homocysteine; Homocystinuria; Humans; Hyperhomocystei | 2003 |
A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.
Topics: Acetates; Animals; Betaine; Biomarkers; Chromatography, High Pressure Liquid; Circadian Rhythm; Fema | 2005 |
Metabolic profiling of livers and blood from obese Zucker rats.
Topics: Animals; Betaine; Energy Metabolism; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Fatty L | 2006 |
[Clinical results using betaine citrate (Flacar) in fatty livers].
Topics: Animals; Betaine; Citrates; Diet, Reducing; Fatty Liver; Female; Humans; Male; Obesity; Rats | 1973 |