betaine has been researched along with Non-alcoholic Fatty Liver Disease in 26 studies
glycine betaine : The amino acid betaine derived from glycine.
Non-alcoholic Fatty Liver Disease: Fatty liver finding without excessive ALCOHOL CONSUMPTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the effects of betaine, an endogenous and dietary methyl donor essential for the methionine-homocysteine cycle, on oxidative stress, inflammation, apoptosis, and autophagy in methionine-choline deficient diet (MCD)-induced non-alcoholic fatty liver disease (NAFLD)." | 7.91 | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. ( Borozan, S; Dragutinovic, V; Gopcevic, K; Isakovic, A; Jorgacevic, B; Labudovic-Borovic, M; Milenkovic, M; Mladenovic, D; Radosavljevic, T; Tosic, J; Trajkovic, V; Veskovic, M; Vucevic, D, 2019) |
| "Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk of cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD)." | 7.83 | Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. ( Chen, XL; Chen, YM; Ling, WH; Liu, Y; Tan, XY; Wang, C; Wang, LJ; Zhang, HW; Zheng, RD; Zhou, RF; Zhu, HL, 2016) |
| "Betaine attenuated MCD diet-induced NAFLD by reducing fat accumulation and inhibiting hepatocyte proliferation." | 5.48 | The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease. ( Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Rakočević, J; Vesković, M; Vučević, D; Zaletel, I, 2018) |
| " The focus should be on the long-term use of betaine in large patient populations with liver diseases characterized by development of fatty liver, especially non-alcoholic fatty liver disease and alcoholic liver disease." | 4.93 | Betaine chemistry, roles, and potential use in liver disease. ( Day, CR; Kempson, SA, 2016) |
| "Maternal betaine supplementation has been proven to alleviate non-alcoholic fatty liver disease (NAFLD) in offspring caused by maternal high-fat diet (MHFD)." | 4.31 | Maternal Betaine Supplementation Mitigates Maternal High Fat Diet-Induced NAFLD in Offspring Mice through Gut Microbiota. ( Chen, H; Huang, Q; Liang, X; Ou, Q; Sun, L; Tan, X; Wang, L; Wei, J; Wu, F; Wu, Q; Yi, Z; Yu, X; Zhao, H; Zhu, H, 2023) |
| "5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet." | 4.31 | 5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes. ( Haberbosch, L; Kierszniowska, S; Mai, K; Maurer, L; Spranger, J; Willmitzer, L, 2023) |
| "Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)." | 4.02 | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021) |
| "We examined the effects of betaine, an endogenous and dietary methyl donor essential for the methionine-homocysteine cycle, on oxidative stress, inflammation, apoptosis, and autophagy in methionine-choline deficient diet (MCD)-induced non-alcoholic fatty liver disease (NAFLD)." | 3.91 | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. ( Borozan, S; Dragutinovic, V; Gopcevic, K; Isakovic, A; Jorgacevic, B; Labudovic-Borovic, M; Milenkovic, M; Mladenovic, D; Radosavljevic, T; Tosic, J; Trajkovic, V; Veskovic, M; Vucevic, D, 2019) |
| "Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk of cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD)." | 3.83 | Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. ( Chen, XL; Chen, YM; Ling, WH; Liu, Y; Tan, XY; Wang, C; Wang, LJ; Zhang, HW; Zheng, RD; Zhou, RF; Zhu, HL, 2016) |
| "SAM reduces colorectal cancer progression and inhibits the proliferation of preneoplastic rat liver cells in vivo." | 2.82 | S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent. ( Calvisi, DF; Feo, CF; Feo, F; Pascale, RM; Simile, MM, 2022) |
| "Betaine is a kind of water-soluble quaternary amine-type alkaloid widely existing in food, such as wheat germ, beet, spinach, shrimp and wolfberry." | 2.72 | Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms. ( Dai, S; Gong, L; Li, Y; Ma, C; Wang, C, 2021) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide." | 2.66 | One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020) |
| "Betaine treatment significantly upregulated AMP-activated protein kinase (AMPK), fibroblast growth factor 10 (FGF10), and adipose triglyceride lipase (ATGL) protein levels both in vivo and in vitro and suppressed lipid metabolism-related genes." | 1.62 | Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE ( Chen, W; Chen, Z; Jiang, L; Liu, W; Wang, L; Wang, Y; Xu, M; Zhang, X; Zhou, M; Zou, Q, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is a common disease with a multitude of complications." | 1.62 | Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis. ( Huang, T; Jia, M; Li, Y; Liu, S; Luo, Z; Miao, W; Song, Z; Wang, P; Wu, T; Yu, J; Yu, L; Zhang, H; Zhou, L, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) represents a hepatic manifestation of metabolic syndrome." | 1.56 | Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD. ( Jadžić, J; Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Vesković, M; Vučević, D; Vukićević, D, 2020) |
| "Rats were fed with high fat diet and NAFLD rats were orally treated with different doses of betaine or choline or folic acid for 28 days." | 1.51 | Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease. ( Ali, MA; Bakir, MB; Kamel, MA; Khalifa, EA; Refaat, R; Salama, MA, 2019) |
| "Betaine attenuated MCD diet-induced NAFLD by reducing fat accumulation and inhibiting hepatocyte proliferation." | 1.48 | The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease. ( Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Rakočević, J; Vesković, M; Vučević, D; Zaletel, I, 2018) |
| "Betaine plays a pivotal role in the regulation of methylogenesis." | 1.46 | Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency. ( Castaño, GO; Mirshahi, F; Pirola, CJ; Puri, P; Sanyal, AJ; Scian, R; Sookoian, S, 2017) |
| "Betaine has been proven effective in treating nonalcoholic fatty liver disease (NAFLD) in animal models, however, its molecular mechanisms remain elusive." | 1.43 | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. ( Fan, CY; Ge, CX; Kong, LD; Li, JM; Li, PQ; Xu, MX; Yu, R, 2016) |
| "Nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease among children and adolescents in the developed world." | 1.42 | FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice. ( Chen, J; Wang, X; Wang, Y; Wu, W; Zhou, X, 2015) |
| "Betaine has been used for NASH, with mixed results, and may show promise in conjunction with other agents in clinical trials." | 1.37 | Betaine and nonalcoholic steatohepatitis: back to the future? ( Mukherjee, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (57.69) | 24.3611 |
| 2020's | 11 (42.31) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, C | 2 |
| Ma, C | 1 |
| Gong, L | 1 |
| Dai, S | 1 |
| Li, Y | 2 |
| Pascale, RM | 1 |
| Simile, MM | 1 |
| Calvisi, DF | 1 |
| Feo, CF | 1 |
| Feo, F | 1 |
| Sun, L | 1 |
| Tan, X | 1 |
| Liang, X | 1 |
| Chen, H | 1 |
| Ou, Q | 1 |
| Wu, Q | 1 |
| Yu, X | 1 |
| Zhao, H | 1 |
| Huang, Q | 1 |
| Yi, Z | 1 |
| Wei, J | 1 |
| Wu, F | 1 |
| Zhu, H | 1 |
| Wang, L | 3 |
| Haberbosch, L | 1 |
| Kierszniowska, S | 1 |
| Willmitzer, L | 1 |
| Mai, K | 1 |
| Spranger, J | 1 |
| Maurer, L | 1 |
| Radziejewska, A | 1 |
| Muzsik, A | 1 |
| Milagro, FI | 2 |
| Martínez, JA | 2 |
| Chmurzynska, A | 1 |
| Vesković, M | 3 |
| Labudović-Borović, M | 3 |
| Mladenović, D | 3 |
| Jadžić, J | 1 |
| Jorgačević, B | 3 |
| Vukićević, D | 1 |
| Vučević, D | 3 |
| Radosavljević, T | 3 |
| León-Mimila, P | 1 |
| Villamil-Ramírez, H | 1 |
| Li, XS | 1 |
| Shih, DM | 1 |
| Hui, ST | 1 |
| Ocampo-Medina, E | 1 |
| López-Contreras, B | 1 |
| Morán-Ramos, S | 1 |
| Olivares-Arevalo, M | 1 |
| Grandini-Rosales, P | 1 |
| Macías-Kauffer, L | 1 |
| González-González, I | 1 |
| Hernández-Pando, R | 1 |
| Gómez-Pérez, F | 1 |
| Campos-Pérez, F | 1 |
| Aguilar-Salinas, C | 1 |
| Larrieta-Carrasco, E | 1 |
| Villarreal-Molina, T | 1 |
| Wang, Z | 1 |
| Lusis, AJ | 1 |
| Hazen, SL | 1 |
| Huertas-Vazquez, A | 1 |
| Canizales-Quinteros, S | 1 |
| Chen, W | 2 |
| Zhang, X | 1 |
| Xu, M | 3 |
| Jiang, L | 1 |
| Zhou, M | 1 |
| Liu, W | 1 |
| Chen, Z | 1 |
| Wang, Y | 3 |
| Zou, Q | 2 |
| Mukherjee, S | 2 |
| Xie, S | 1 |
| Huang, T | 1 |
| Yu, J | 1 |
| Luo, Z | 1 |
| Yu, L | 1 |
| Liu, S | 1 |
| Wang, P | 1 |
| Jia, M | 1 |
| Wu, T | 1 |
| Miao, W | 1 |
| Zhou, L | 1 |
| Song, Z | 1 |
| Zhang, H | 2 |
| Zhao, N | 1 |
| Yang, S | 1 |
| Jia, Y | 1 |
| Sun, B | 1 |
| He, B | 1 |
| Zhao, R | 1 |
| Zaletel, I | 1 |
| Rakočević, J | 1 |
| Bakir, MB | 1 |
| Salama, MA | 1 |
| Refaat, R | 1 |
| Ali, MA | 1 |
| Khalifa, EA | 1 |
| Kamel, MA | 1 |
| Milenkovic, M | 1 |
| Tosic, J | 1 |
| Borozan, S | 1 |
| Gopcevic, K | 1 |
| Dragutinovic, V | 1 |
| Isakovic, A | 1 |
| Trajkovic, V | 1 |
| Zhang, W | 1 |
| Wang, LW | 1 |
| Wang, LK | 1 |
| Li, X | 1 |
| Luo, LP | 1 |
| Song, JC | 1 |
| Gong, ZJ | 1 |
| Liu, H | 1 |
| Gong, M | 1 |
| French, BA | 1 |
| Li, J | 1 |
| Tillman, B | 1 |
| French, SW | 1 |
| Chen, J | 1 |
| Zhou, X | 1 |
| Wu, W | 1 |
| Wang, X | 1 |
| Ge, CX | 1 |
| Yu, R | 1 |
| Xu, MX | 1 |
| Li, PQ | 1 |
| Fan, CY | 1 |
| Li, JM | 1 |
| Kong, LD | 1 |
| Chen, YM | 1 |
| Liu, Y | 1 |
| Zhou, RF | 1 |
| Chen, XL | 1 |
| Tan, XY | 1 |
| Wang, LJ | 1 |
| Zheng, RD | 1 |
| Zhang, HW | 1 |
| Ling, WH | 1 |
| Zhu, HL | 1 |
| Day, CR | 1 |
| Kempson, SA | 1 |
| Sookoian, S | 1 |
| Puri, P | 1 |
| Castaño, GO | 1 |
| Scian, R | 1 |
| Mirshahi, F | 1 |
| Sanyal, AJ | 1 |
| Pirola, CJ | 1 |
| Cordero, P | 1 |
| Campion, J | 1 |
| Niebergall, LJ | 1 |
| Jacobs, RL | 1 |
| Chaba, T | 1 |
| Vance, DE | 1 |
| Kawakami, S | 1 |
| Han, KH | 1 |
| Nakamura, Y | 1 |
| Shimada, K | 1 |
| Kitano, T | 1 |
| Aritsuka, T | 1 |
| Nagura, T | 1 |
| Ohba, K | 1 |
| Nakamura, K | 1 |
| Fukushima, M | 1 |
6 reviews available for betaine and Non-alcoholic Fatty Liver Disease
| Article | Year |
|---|---|
Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms.
Topics: Animals; Betaine; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Liver Diseases, Al | 2021 |
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent.
Topics: Animals; Antiviral Agents; Betaine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, | 2022 |
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi | 2020 |
Role of betaine in liver disease-worth revisiting or has the die been cast?
Topics: Betaine; Humans; Insulin Resistance; Liver; Liver Cirrhosis; Liver Transplantation; Non-alcoholic Fa | 2020 |
Effects of betaine on non-alcoholic liver disease.
Topics: Betaine; Humans; Insulin Resistance; Lipogenesis; Liver; Non-alcoholic Fatty Liver Disease | 2022 |
Betaine chemistry, roles, and potential use in liver disease.
Topics: Animals; Betaine; Humans; Kidney; Liver; Liver Diseases; Liver Diseases, Alcoholic; Non-alcoholic Fa | 2016 |
20 other studies available for betaine and Non-alcoholic Fatty Liver Disease
| Article | Year |
|---|---|
Maternal Betaine Supplementation Mitigates Maternal High Fat Diet-Induced NAFLD in Offspring Mice through Gut Microbiota.
Topics: Animals; Betaine; Diet, High-Fat; Dietary Supplements; Female; Gastrointestinal Microbiome; Liver; M | 2023 |
5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes.
Topics: Animals; Betaine; Diabetes Mellitus; Glucose; Humans; Mice; Non-alcoholic Fatty Liver Disease; Obesi | 2023 |
Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD.
Topics: Animals; Betaine; Choline; Collagen; Diet; Dietary Supplements; Disease Models, Animal; Hepatocytes; | 2020 |
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female | 2021 |
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE
Topics: AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Betaine; Diet, High-Fat; Fibroblast Growt | 2021 |
Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis.
Topics: Animals; Betaine; Diet, High-Fat; Disease Models, Animal; Gene Expression Profiling; Lipid Metabolis | 2021 |
Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
Topics: Animals; Betaine; Body Weight; Dexamethasone; Dietary Supplements; DNA Methylation; Epigenesis, Gene | 2018 |
The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease.
Topics: Animals; Betaine; Cell Nucleus; Cell Proliferation; Chromatin; Disease Models, Animal; Gastrointesti | 2018 |
Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease.
Topics: Animals; Betaine; Carbon; Choline; Diet, High-Fat; Dietary Supplements; DNA Methylation; Folic Acid; | 2019 |
Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease.
Topics: Animals; Autophagy; Betaine; Choline Deficiency; Gastrointestinal Agents; Inflammation; Male; Methio | 2019 |
Betaine protects against high-fat-diet-induced liver injury by inhibition of high-mobility group box 1 and Toll-like receptor 4 expression in rats.
Topics: Animals; Betaine; Chemical and Drug Induced Liver Injury; Cytokines; Dietary Fats; Fatty Liver; Fema | 2013 |
Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).
Topics: Animals; Betaine; Blotting, Western; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; H | 2014 |
FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Betaine; Blood Glucose; Cholester | 2015 |
Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats.
Topics: Animals; Betaine; Carrier Proteins; Cytokines; Endoplasmic Reticulum Stress; Fatty Acids; Fructose; | 2016 |
Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults.
Topics: Adolescent; Adult; Aged; Betaine; Biomarkers; Case-Control Studies; Choline; Chromatography, High Pr | 2016 |
Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency.
Topics: Adult; Argentina; Betaine; Biomarkers; Case-Control Studies; Dimethylglycine Dehydrogenase; Disease | 2017 |
Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver.
Topics: Animals; Betaine; Choline; Dietary Fats; Dietary Sucrose; Dietary Supplements; Disease Models, Anima | 2011 |
Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.
Topics: Adenoviridae; Animals; Betaine; Ceramides; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosph | 2011 |
Betaine and nonalcoholic steatohepatitis: back to the future?
Topics: Animals; Betaine; Clinical Trials as Topic; Fatty Liver; Humans; Insulin Resistance; Liver Transplan | 2011 |
Effects of dietary supplementation with betaine on a nonalcoholic steatohepatitis (NASH) mouse model.
Topics: Alanine Transaminase; Animals; Betaine; Body Weight; Diet, High-Fat; Dietary Fats; Dietary Supplemen | 2012 |