betaine has been researched along with Muscle Spasticity in 9 studies
glycine betaine : The amino acid betaine derived from glycine.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with betaine, B12 and folic acid was started in four subjects with variable outcomes." | 1.72 | Variable neurological phenotypes of homocystinuria caused by biallelic methylenetetrahydrofolate reductase variants. ( Masih, S; Moirangthem, A; Nilay, M; Phadke, SR; Saxena, D; Shambhavi, A, 2022) |
| "Treatment with betaine produced a rapid decline of homocysteine by 50% to 70% in all 4 patients and, over 9 to 15 years, improved the conditions of the 3 ambulatory patients." | 1.40 | Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia. ( Abramsky, O; Gal, A; Heyman, SN; Karp, N; Kohn, Y; Korman, SH; Leclerc, D; Lossos, A; Meiner, V; Milman, T; Newman, JP; Rosenblatt, DS; Rozen, R; Schwahn, BC; Shaag, A; Steiner-Birmanns, B; Teltsh, O; Watkins, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Moirangthem, A | 1 |
| Saxena, D | 1 |
| Masih, S | 1 |
| Shambhavi, A | 1 |
| Nilay, M | 1 |
| Phadke, SR | 1 |
| Nishimoto, E | 1 |
| Ito, Y | 1 |
| Sakakibara, T | 1 |
| Nishikubo, T | 1 |
| Vieira, D | 1 |
| Florindo, C | 1 |
| Tavares de Almeida, I | 1 |
| Macário, MC | 1 |
| Jaisson, S | 1 |
| Desmons, A | 1 |
| Braconnier, A | 1 |
| Wynckel, A | 1 |
| Rieu, P | 1 |
| Gillery, P | 1 |
| Garnotel, R | 1 |
| Diekman, EF | 1 |
| de Koning, TJ | 1 |
| Verhoeven-Duif, NM | 1 |
| Rovers, MM | 1 |
| van Hasselt, PM | 1 |
| Lossos, A | 2 |
| Teltsh, O | 1 |
| Milman, T | 1 |
| Meiner, V | 1 |
| Rozen, R | 2 |
| Leclerc, D | 1 |
| Schwahn, BC | 1 |
| Karp, N | 1 |
| Rosenblatt, DS | 2 |
| Watkins, D | 2 |
| Shaag, A | 1 |
| Korman, SH | 1 |
| Heyman, SN | 1 |
| Gal, A | 1 |
| Newman, JP | 1 |
| Steiner-Birmanns, B | 1 |
| Abramsky, O | 1 |
| Kohn, Y | 1 |
| D'Aco, KE | 1 |
| Bearden, D | 1 |
| Hyland, K | 1 |
| Ficicioglu, C | 1 |
| Huemer, M | 1 |
| Mulder-Bleile, R | 1 |
| Burda, P | 1 |
| Froese, DS | 1 |
| Suormala, T | 1 |
| Zeev, BB | 1 |
| Chinnery, PF | 1 |
| Dionisi-Vici, C | 1 |
| Dobbelaere, D | 1 |
| Gökcay, G | 1 |
| Demirkol, M | 1 |
| Häberle, J | 1 |
| Mengel, E | 1 |
| Morris, AA | 1 |
| Niezen-Koning, KE | 1 |
| Plecko, B | 1 |
| Parini, R | 1 |
| Rokicki, D | 1 |
| Schiff, M | 1 |
| Schimmel, M | 1 |
| Sewell, AC | 1 |
| Sperl, W | 1 |
| Spiekerkoetter, U | 1 |
| Steinmann, B | 1 |
| Taddeucci, G | 1 |
| Trejo-Gabriel-Galán, JM | 1 |
| Trefz, F | 1 |
| Tsuji, M | 1 |
| Vilaseca, MA | 1 |
| von Kleist-Retzow, JC | 1 |
| Walker, V | 1 |
| Zeman, J | 1 |
| Baumgartner, MR | 1 |
| Fowler, B | 1 |
| Mikael, LG | 1 |
| Pancer, J | 1 |
| Jiang, X | 1 |
| Wu, Q | 1 |
| Caudill, M | 1 |
1 review available for betaine and Muscle Spasticity
| Article | Year |
|---|---|
Survival and psychomotor development with early betaine treatment in patients with severe methylenetetrahydrofolate reductase deficiency.
Topics: Adolescent; Betaine; Child; Child, Preschool; Female; Homocystinuria; Humans; Infant; Infant, Newbor | 2014 |
8 other studies available for betaine and Muscle Spasticity
| Article | Year |
|---|---|
Variable neurological phenotypes of homocystinuria caused by biallelic methylenetetrahydrofolate reductase variants.
Topics: Betaine; Homocystinuria; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Ne | 2022 |
Early treatment using betaine and methionine for a neonate with MTHFR deficiency.
Topics: Betaine; Homocysteine; Homocystinuria; Humans; Infant; Infant, Newborn; Japan; Male; Methionine; Met | 2019 |
Adult-onset methylenetetrahydrofolate reductase deficiency.
Topics: Age of Onset; Betaine; Dysarthria; Folic Acid; Gait Ataxia; Homocystinuria; Humans; Male; Methylenet | 2020 |
An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies.
Topics: Aged; Betaine; Female; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Leucovorin; Methy | 2020 |
Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.
Topics: Adult; Age of Onset; Aged; Betaine; Female; Homocystinuria; Humans; Lipotropic Agents; Magnetic Reso | 2014 |
Severe 5,10-methylenetetrahydrofolate reductase deficiency and two MTHFR variants in an adolescent with progressive myoclonic epilepsy.
Topics: Adolescent; Betaine; Female; Folic Acid; Homocystinuria; Humans; Lipotropic Agents; Methionine; Meth | 2014 |
Clinical pattern, mutations and in vitro residual activity in 33 patients with severe 5, 10 methylenetetrahydrofolate reductase (MTHFR) deficiency.
Topics: Ataxia; Betaine; Child; Female; Folic Acid; Genetic Association Studies; Homocystinuria; Humans; Int | 2016 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo | 2013 |