betaine has been researched along with Metabolic Syndrome in 13 studies
glycine betaine : The amino acid betaine derived from glycine.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland." | 7.91 | Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population. ( Gao, X; Randell, E; Sun, G; Tian, Y; Zhou, H, 2019) |
| "Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine." | 5.91 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults. ( Abbasi, MSP; Ardekani, AM; Gharebakhshi, F; Jafarzadeh, F; Manzouri, A; Nikrad, N; Tousi, AZ; Vahdat, S; Yazdani, Y, 2023) |
| "Betaine was inversely associated with serum non-HDL cholesterol, triglycerides, BMI, percent body fat, waist circumference, systolic and diastolic blood pressure (P < 0." | 5.35 | Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. ( Bleie, Ø; Konstantinova, SV; Nygård, O; Tell, GS; Ueland, PM; Vollset, SE, 2008) |
| "We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland." | 3.91 | Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population. ( Gao, X; Randell, E; Sun, G; Tian, Y; Zhou, H, 2019) |
| "The betaines that were increased in mouse plasma after bran-enriched feeding were identified de novo via chemical synthesis and liquid chromatography-tandem mass spectrometry, and confirmed to be associated with an increased intake of whole-grain products in humans." | 2.87 | Diets rich in whole grains increase betainized compounds associated with glucose metabolism. ( Auriola, S; Giacco, R; Hanhineva, K; Jokkala, J; Kärkkäinen, O; Koistinen, V; Kolehmainen, M; Lankinen, MA; Lehtonen, M; Leppänen, J; Micard, V; Mykkänen, H; Poutanen, K; Riccardi, G; Rivellese, AAA; Rosa-Sibakov, N; Schwab, U; Uusitupa, M; Vitale, M, 2018) |
| "Nonalcoholic steatohepatitis (NASH), a more serious form of NAFLD, can proceed to cirrhosis and even hepatocellular carcinoma." | 2.44 | Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. ( Barve, S; Cave, M; Deaciuc, I; Joshi-Barve, S; McClain, C; Mendez, C; Song, Z, 2007) |
| "Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine." | 1.91 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults. ( Abbasi, MSP; Ardekani, AM; Gharebakhshi, F; Jafarzadeh, F; Manzouri, A; Nikrad, N; Tousi, AZ; Vahdat, S; Yazdani, Y, 2023) |
| "Betaine was inversely associated with serum non-HDL cholesterol, triglycerides, BMI, percent body fat, waist circumference, systolic and diastolic blood pressure (P < 0." | 1.35 | Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. ( Bleie, Ø; Konstantinova, SV; Nygård, O; Tell, GS; Ueland, PM; Vollset, SE, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Poursalehi, D | 1 |
| Lotfi, K | 1 |
| Mirzaei, S | 1 |
| Asadi, A | 1 |
| Akhlaghi, M | 1 |
| Saneei, P | 1 |
| Abbasi, MSP | 1 |
| Tousi, AZ | 1 |
| Yazdani, Y | 1 |
| Vahdat, S | 1 |
| Gharebakhshi, F | 1 |
| Nikrad, N | 1 |
| Manzouri, A | 1 |
| Ardekani, AM | 1 |
| Jafarzadeh, F | 1 |
| Tuomainen, M | 1 |
| Kärkkäinen, O | 2 |
| Leppänen, J | 2 |
| Auriola, S | 2 |
| Lehtonen, M | 2 |
| Savolainen, MJ | 1 |
| Hermansen, K | 1 |
| Risérus, U | 1 |
| Åkesson, B | 1 |
| Thorsdottir, I | 1 |
| Kolehmainen, M | 2 |
| Uusitupa, M | 3 |
| Poutanen, K | 2 |
| Schwab, U | 3 |
| Hanhineva, K | 2 |
| Lankinen, MA | 1 |
| Vitale, M | 1 |
| Jokkala, J | 1 |
| Koistinen, V | 1 |
| Giacco, R | 1 |
| Rosa-Sibakov, N | 1 |
| Micard, V | 1 |
| Rivellese, AAA | 1 |
| Mykkänen, H | 1 |
| Riccardi, G | 1 |
| Gao, X | 1 |
| Randell, E | 1 |
| Tian, Y | 1 |
| Zhou, H | 1 |
| Sun, G | 1 |
| Mueller, DM | 1 |
| Allenspach, M | 1 |
| Othman, A | 1 |
| Saely, CH | 1 |
| Muendlein, A | 1 |
| Vonbank, A | 1 |
| Drexel, H | 1 |
| von Eckardstein, A | 1 |
| Konstantinova, SV | 2 |
| Tell, GS | 2 |
| Vollset, SE | 2 |
| Ulvik, A | 1 |
| Drevon, CA | 1 |
| Ueland, PM | 2 |
| Davidson, MH | 1 |
| Alfthan, G | 1 |
| Aro, A | 1 |
| Slow, S | 2 |
| Lever, M | 2 |
| Elmslie, J | 1 |
| George, PM | 1 |
| Chambers, ST | 1 |
| Cave, M | 1 |
| Deaciuc, I | 1 |
| Mendez, C | 1 |
| Song, Z | 1 |
| Joshi-Barve, S | 1 |
| Barve, S | 1 |
| McClain, C | 1 |
| Nygård, O | 1 |
| Bleie, Ø | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Nordic Diet Rich in Whole Grain, Berries, Fruits, Vegetables and Fish on Features of Metabolic Syndrome - a Systems Biology Approach[NCT00992641] | 167 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
| Systems Biology Approach to Understand Dietary Modulation of Gene Expression and Metabolic Pathways in Subjects With Abnormal Glucose Metabolism (Sysdimet)[NCT00573781] | Phase 2 | 106 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Effect of Whole Grain Rich Diet on Insulin Sensitivity in Individuals With Metabolic Syndrome[NCT00945854] | 60 participants (Actual) | Interventional | 2008-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Peripheral insulin sensitivity was assessed by FSIGT. A glucose dose of 300 mg/kg body weight was given intravenously followed by a bolus of 0.03 U/kg of insulin injected after 20 min. Blood samples were frequently collected for 3 h for the measurement of plasma glucose and serum insulin concentrations, utilized to calculate the insulin sensitivity index Si (NCT00945854)
Timeframe: 12 weeks
| Intervention | 104xmin-1/microU/ml (Mean) |
|---|---|
| Wholegrain Cereal Diet | 3.03 |
| Refined Cereal Diet | 3.15 |
Blood samples during the standard meal test were drawn from an antecubital vein after a 12 h overnight fast and 0, 30, 60, 90, 120, 150 and 180 min postprandial for the measurement of plasma insulin response reported as average mean postprandial increment. (NCT00945854)
Timeframe: 12 weeks
| Intervention | (microU/mlx3hrs) (Mean) |
|---|---|
| Wholegrain Cereal Diet | 50.01 |
| Refined Cereal Diet | 64.4 |
Blood samples during the standard meal test were drawn from an antecubital vein after a 12 h overnight fast and 0, 30, 60, 90, 120, 150 and 180 min postprandial for the measurement of triglyceride response reported as average mean postprandial increment. (NCT00945854)
Timeframe: 12 weeks
| Intervention | mg/dlx3hrs (Mean) |
|---|---|
| Wholegrain Cereal Diet | 22.7 |
| Refined Cereal Diet | 47.6 |
1 review available for betaine and Metabolic Syndrome
| Article | Year |
|---|---|
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.
Topics: Betaine; Cytokines; Dietary Supplements; Environmental Exposure; Fatty Liver; Female; Humans; Insuli | 2007 |
3 trials available for betaine and Metabolic Syndrome
| Article | Year |
|---|---|
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET).
Topics: Adult; Aged; Betaine; Biomarkers; Diet; Dietary Fiber; Female; Humans; Male; Mass Spectrometry; Meta | 2019 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects.
Topics: Adult; Betaine; Cholesterol, HDL; Double-Blind Method; Female; Homocysteine; Humans; Linear Models; | 2011 |
9 other studies available for betaine and Metabolic Syndrome
| Article | Year |
|---|---|
Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents.
Topics: Adolescent; Betaine; Body Mass Index; Choline; Cross-Sectional Studies; Female; Health Status; Human | 2022 |
Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults.
Topics: Adult; Betaine; Biomarkers; Cardiometabolic Risk Factors; Cholesterol; Choline; Diet; Eating; Humans | 2023 |
Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population.
Topics: Adult; Betaine; Blood Glucose; Blood Pressure; Choline; Female; Humans; Insulin Resistance; Lipids; | 2019 |
Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control.
Topics: Aged; Betaine; Biomarkers; Blood Glucose; Choline; Chromatography, Liquid; Coronary Angiography; Cor | 2015 |
Dietary patterns, food groups, and nutrients as predictors of plasma choline and betaine in middle-aged and elderly men and women.
Topics: Aged; Betaine; Bread; Cardiovascular Diseases; Choline; Cohort Studies; Diet Surveys; Dietary Fats; | 2008 |
A clinical puzzle: fibrates and homocysteine elevation: editorial to: "fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine" by M. Lever et al.
Topics: Animals; Betaine; Bezafibrate; Clofibric Acid; Dyslipidemias; Folic Acid; Homocysteine; Humans; Hypo | 2009 |
Betaine supplementation and the metabolic syndrome.
Topics: Betaine; Female; Homocysteine; Humans; Lipoproteins, LDL; Male; Metabolic Syndrome | 2011 |
Betaine excretion correlates with plasma homocysteine when plasma lipids are elevated.
Topics: Aged; Betaine; Cholesterol; Dose-Response Relationship, Drug; Female; Homocysteine; Humans; Lipids; | 2012 |
Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women.
Topics: Aged; Betaine; Blood Glucose; Blood Pressure; Body Composition; Body Mass Index; Body Weights and Me | 2008 |