betaine has been researched along with Hyperhomocysteinemia in 49 studies
glycine betaine : The amino acid betaine derived from glycine.
Hyperhomocysteinemia: Condition in which the plasma levels of homocysteine and related metabolites are elevated (
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred apparently healthy adults aged 18-65 years with hyperhomocysteinemia were recruited in South China from July 2019 to June 2021." | 9.69 | Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial. ( Chen, S; Fang, AP; He, TT; Huang, BX; Huang, RZ; Huang, ZH; Li, SY; Liu, XZ; Liu, ZY; Lu, XT; Luo, Y; Maierhaba, W; Mo, QW; Wang, YF; Wang, YN; Yang, MT; Zhang, XG; Zhu, HL, 2023) |
| "Alzheimer's disease (AD) is a neurodegenerative disease, which is associated with malnutrition and hyperhomocysteine." | 9.24 | Association between malnutrition and hyperhomocysteine in Alzheimer's disease patients and diet intervention of betaine. ( Ding, S; Sun, J; Wen, S; Zhou, J, 2017) |
| "Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure." | 9.10 | Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2002) |
| "Treatment of hereditary hyperhomocysteinemia and the achievement of optimal folate status is necessary for persons of reproductive age in order to increase live birth rate." | 7.96 | POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS. ( Fishchuk, L; Gorovenko, N; Medvedieva, N; Rossokha, Z; Sheyko, L, 2020) |
| "To investigate the dose-dependent effects of beet powder supplementation on hyperhomocysteinemia induced by choline deprivation in rats." | 7.81 | [Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats]. ( Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q, 2015) |
| "The effect of betaine status on folate deficiency-induced hyperhomocysteinemia was investigated to determine whether folate deficiency impairs homocysteine removal not only by the methionine synthase (MS) pathway but also by the betaine-homocysteine S-methyltransferase (BHMT) pathway." | 7.78 | Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2012) |
| "75% L-methionine for 7 d to determine the effects of dietary choline level on experimental hyperhomocysteinemia." | 7.74 | Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| " The hyperhomocysteinemia induced by choline deprivation was effectively suppressed by betaine or methionine supplementation." | 7.74 | Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| "The results strongly suggest that alcohol may modulate both apoptotic and fat synthetic gene expression through homocysteine-induced ER stress in chronic alcoholic mouse liver and that correction of hyperhomocysteinemia by betaine or other approaches may be useful to prevent alcoholic liver disease." | 7.72 | Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. ( Ji, C; Kaplowitz, N, 2003) |
| " These findings suggest that reduced BHMT activity is important in the pathogenesis of hyperhomocysteinemia in CRF." | 7.71 | Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2001) |
| "Analytic approaches to treat hyperhomocysteinemia are discussed in which stepwise administration with nutritional doses of folic acid, 5-methyitetrahydrofolate (5-MTHF), and betaine is provided singly or by combined manner based on clinical and laboratory evaluations." | 6.58 | Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease. ( Kang, SS; Rosenson, RS, 2018) |
| "One hundred apparently healthy adults aged 18-65 years with hyperhomocysteinemia were recruited in South China from July 2019 to June 2021." | 5.69 | Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial. ( Chen, S; Fang, AP; He, TT; Huang, BX; Huang, RZ; Huang, ZH; Li, SY; Liu, XZ; Liu, ZY; Lu, XT; Luo, Y; Maierhaba, W; Mo, QW; Wang, YF; Wang, YN; Yang, MT; Zhang, XG; Zhu, HL, 2023) |
| "Betaine is an important natural component of rich food sources, especially spinach." | 5.40 | Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. ( Han, F; Huang, ZW; Inakuma, T; Jia, Z; Liu, YQ; Miyashita, T; Sugiyama, K; Sun, LC; Xiang, XS, 2014) |
| "Betaine has a lipotropic effect, which is associated with a reduction in homocysteine, an increase in ApoA-I and an amelioration of the atherogenic risk profile." | 5.34 | Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. ( Cohn, J; Jiang, H; Maclean, KN; Mikael, LG; Rozen, R; Schwahn, BC; Wang, XL; Wu, Q, 2007) |
| "Alzheimer's disease (AD) is a neurodegenerative disease, which is associated with malnutrition and hyperhomocysteine." | 5.24 | Association between malnutrition and hyperhomocysteine in Alzheimer's disease patients and diet intervention of betaine. ( Ding, S; Sun, J; Wen, S; Zhou, J, 2017) |
| "Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure." | 5.10 | Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2002) |
| " Other research has shown that betaine and choline seem to be more effective than folate at reducing hyperhomocysteinemia and impacting cardiovascular outcomes suggesting they may be limiting." | 4.89 | The nutritional burden of methylation reactions. ( Bertolo, RF; McBreairty, LE, 2013) |
| "Elevation of homocysteine is implicated in multiple medical conditions, including classical homocystinuria, a variety of remethylation disorders, and most recently in coronary artery disease." | 4.83 | The use of betaine in the treatment of elevated homocysteine. ( Lawson-Yuen, A; Levy, HL, 2006) |
| " The proximate cause appears to be hyperhomocysteinemia, a well-known cause of ER stress in other contexts." | 4.83 | Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. ( Ji, C; Kaplowitz, N, 2006) |
| "Treatment of hereditary hyperhomocysteinemia and the achievement of optimal folate status is necessary for persons of reproductive age in order to increase live birth rate." | 3.96 | POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS. ( Fishchuk, L; Gorovenko, N; Medvedieva, N; Rossokha, Z; Sheyko, L, 2020) |
| "To investigate the dose-dependent effects of beet powder supplementation on hyperhomocysteinemia induced by choline deprivation in rats." | 3.81 | [Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats]. ( Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q, 2015) |
| " The present results show beneficial antioxidant and methyl donor properties of betaine versus oxidative stress and hyperhomocysteinemia induced by levodopa and benserazide in an animal model." | 3.81 | Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats. ( Alirezaei, M; Dezfoulian, O; Khoshdel, Z; Rashidipour, M; Taghadosi, V, 2015) |
| "Hyperhomocysteinemia (Hhcy) may induce memory deficits with β-amyloid (Aβ) accumulation and tau hyperphosphorylation." | 3.79 | Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. ( Chai, GS; Cheng, XS; Jiang, X; Liu, GP; Ma, ZW; Ni, ZF; Wang, JZ; Wang, Q; Xie, AJ, 2013) |
| "The effect of betaine status on folate deficiency-induced hyperhomocysteinemia was investigated to determine whether folate deficiency impairs homocysteine removal not only by the methionine synthase (MS) pathway but also by the betaine-homocysteine S-methyltransferase (BHMT) pathway." | 3.78 | Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2012) |
| " The hyperhomocysteinemia induced by choline deprivation was effectively suppressed by betaine or methionine supplementation." | 3.74 | Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| "75% L-methionine for 7 d to determine the effects of dietary choline level on experimental hyperhomocysteinemia." | 3.74 | Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| "Hyperhomocysteinemia, a proposed risk factor for cardiovascular disease, is also observed in other common disorders." | 3.72 | Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. ( Castro, C; Chen, Z; Garrow, T; Genest, J; Laryea, MD; Lussier-Cacan, S; Mar, MH; Rozen, R; Schwahn, BC; Wendel, U; Zeisel, SH, 2003) |
| "The results strongly suggest that alcohol may modulate both apoptotic and fat synthetic gene expression through homocysteine-induced ER stress in chronic alcoholic mouse liver and that correction of hyperhomocysteinemia by betaine or other approaches may be useful to prevent alcoholic liver disease." | 3.72 | Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. ( Ji, C; Kaplowitz, N, 2003) |
| " These findings suggest that reduced BHMT activity is important in the pathogenesis of hyperhomocysteinemia in CRF." | 3.71 | Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2001) |
| "Choline is an essential nutrient and can also be obtained by de novo synthesis via an oestrogen responsive pathway." | 2.77 | Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. ( Bonham, MP; Duffy, ME; McCormack, JM; McNulty, H; Molloy, AM; Robson, PJ; Scott, JM; Strain, JJ; Ueland, PM; Wallace, JM; Walsh, PM; Ward, M, 2012) |
| "Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden." | 2.66 | Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery. ( Bergamini, C; Capelli, I; Cappuccilli, M; Cianciolo, G; Conte, D; Donati, G; Giacomelli, FA; La Manna, G; Natali, T, 2020) |
| "Analytic approaches to treat hyperhomocysteinemia are discussed in which stepwise administration with nutritional doses of folic acid, 5-methyitetrahydrofolate (5-MTHF), and betaine is provided singly or by combined manner based on clinical and laboratory evaluations." | 2.58 | Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease. ( Kang, SS; Rosenson, RS, 2018) |
| "Betaine has been shown to protect internal organs, improve vascular risk factors, and enhance performance." | 2.42 | Betaine in human nutrition. ( Craig, SA, 2004) |
| "Betaine plays important roles that include acting as a methyl donor and converting homocysteine (Hcy) to methionine." | 1.42 | Betaine prevents homocysteine-induced memory impairment via matrix metalloproteinase-9 in the frontal cortex. ( Hiramatsu, M; Kinoshita, S; Kunisawa, K; Nagao, M; Nakashima, N; Nomura, T, 2015) |
| "Betaine is an important natural component of rich food sources, especially spinach." | 1.40 | Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. ( Han, F; Huang, ZW; Inakuma, T; Jia, Z; Liu, YQ; Miyashita, T; Sugiyama, K; Sun, LC; Xiang, XS, 2014) |
| "Over 80% of chronic renal failure patients have elevated plasma Hcy and a 10-20 times higher incidence of vascular disease." | 1.34 | Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD). ( Chambers, S; Fraser, R; George, P; Lever, M; McEntyre, C; Slow, S; Vasudevamurthy, M, 2007) |
| "Betaine has a lipotropic effect, which is associated with a reduction in homocysteine, an increase in ApoA-I and an amelioration of the atherogenic risk profile." | 1.34 | Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. ( Cohn, J; Jiang, H; Maclean, KN; Mikael, LG; Rozen, R; Schwahn, BC; Wang, XL; Wu, Q, 2007) |
| "Betaine was then intravenously administered at the same time as the methionine loading." | 1.32 | Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats. ( Nakata, R; Okawa, N; Shigematsu, N; Yagisawa, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.04) | 18.2507 |
| 2000's | 21 (42.86) | 29.6817 |
| 2010's | 18 (36.73) | 24.3611 |
| 2020's | 9 (18.37) | 2.80 |
| Authors | Studies |
|---|---|
| Rosas-Rodríguez, JA | 1 |
| Valenzuela-Soto, EM | 1 |
| Lu, XT | 1 |
| Wang, YN | 1 |
| Mo, QW | 1 |
| Huang, BX | 1 |
| Wang, YF | 1 |
| Huang, ZH | 1 |
| Luo, Y | 1 |
| Maierhaba, W | 1 |
| He, TT | 1 |
| Li, SY | 1 |
| Huang, RZ | 1 |
| Yang, MT | 1 |
| Liu, XZ | 1 |
| Liu, ZY | 1 |
| Chen, S | 1 |
| Fang, AP | 1 |
| Zhang, XG | 1 |
| Zhu, HL | 1 |
| Tanaka, Y | 1 |
| Kawano, M | 1 |
| Nakashima, S | 1 |
| Yamaguchi, C | 1 |
| Asahina, M | 1 |
| Sakamoto, M | 1 |
| Shirouchi, B | 1 |
| Tashiro, K | 1 |
| Imaizumi, K | 1 |
| Sato, M | 1 |
| Zawieja, EE | 1 |
| Zawieja, B | 1 |
| Chmurzynska, A | 1 |
| Jaisson, S | 1 |
| Desmons, A | 1 |
| Braconnier, A | 1 |
| Wynckel, A | 1 |
| Rieu, P | 1 |
| Gillery, P | 1 |
| Garnotel, R | 1 |
| Cappuccilli, M | 1 |
| Bergamini, C | 1 |
| Giacomelli, FA | 1 |
| Cianciolo, G | 1 |
| Donati, G | 1 |
| Conte, D | 1 |
| Natali, T | 1 |
| La Manna, G | 1 |
| Capelli, I | 1 |
| Blachier, F | 1 |
| Andriamihaja, M | 1 |
| Blais, A | 1 |
| Zhang, T | 1 |
| Lu, R | 1 |
| Chen, Y | 1 |
| Yuan, Y | 1 |
| Song, S | 1 |
| Yan, K | 1 |
| Zha, Y | 1 |
| Zhuang, W | 1 |
| Cheng, Y | 1 |
| Liang, J | 1 |
| Rossokha, Z | 1 |
| Fishchuk, L | 1 |
| Sheyko, L | 1 |
| Medvedieva, N | 1 |
| Gorovenko, N | 1 |
| Sun, J | 1 |
| Wen, S | 1 |
| Zhou, J | 1 |
| Ding, S | 1 |
| Kang, SS | 1 |
| Rosenson, RS | 1 |
| Liu, YP | 1 |
| Yang, YL | 1 |
| Jadavji, NM | 1 |
| Bahous, RH | 1 |
| Deng, L | 1 |
| Malysheva, O | 1 |
| Grand'maison, M | 1 |
| Bedell, BJ | 1 |
| Caudill, MA | 1 |
| Rozen, R | 5 |
| Liu, YQ | 2 |
| Jia, Z | 1 |
| Han, F | 2 |
| Inakuma, T | 1 |
| Miyashita, T | 1 |
| Sugiyama, K | 6 |
| Sun, LC | 1 |
| Xiang, XS | 1 |
| Huang, ZW | 1 |
| Alirezaei, M | 1 |
| Khoshdel, Z | 1 |
| Dezfoulian, O | 1 |
| Rashidipour, M | 1 |
| Taghadosi, V | 1 |
| Ruiz-Mercado, M | 1 |
| Vargas, MT | 1 |
| de Soto, IP | 1 |
| Pecellín, CD | 1 |
| Sánchez, MC | 1 |
| Delgado, MA | 1 |
| Ruiz, RB | 1 |
| Pérez-Simón, JA | 1 |
| Díaz-Aguado, AH | 1 |
| Liu, Y | 2 |
| Sun, L | 1 |
| Lu, J | 1 |
| Wang, Q | 2 |
| Huang, Z | 1 |
| Kunisawa, K | 1 |
| Nakashima, N | 1 |
| Nagao, M | 1 |
| Nomura, T | 1 |
| Kinoshita, S | 1 |
| Hiramatsu, M | 1 |
| Robinson, JL | 1 |
| McBreairty, LE | 2 |
| Randell, EW | 1 |
| Brunton, JA | 1 |
| Bertolo, RF | 2 |
| Setoue, M | 2 |
| Ohuchi, S | 3 |
| Morita, T | 4 |
| Matsumoto, Y | 1 |
| Strakova, J | 1 |
| Williams, KT | 1 |
| Gupta, S | 1 |
| Schalinske, KL | 1 |
| Kruger, WD | 1 |
| Jiracek, J | 1 |
| Li, L | 1 |
| Garrow, TA | 2 |
| Wallace, JM | 1 |
| McCormack, JM | 1 |
| McNulty, H | 1 |
| Walsh, PM | 1 |
| Robson, PJ | 1 |
| Bonham, MP | 1 |
| Duffy, ME | 1 |
| Ward, M | 1 |
| Molloy, AM | 1 |
| Scott, JM | 1 |
| Ueland, PM | 1 |
| Strain, JJ | 1 |
| Cheng, S | 1 |
| Feng, J | 1 |
| Wang, X | 1 |
| Ukachukwu, V | 1 |
| Idris, S | 1 |
| McIlwee, A | 1 |
| Chai, GS | 1 |
| Jiang, X | 1 |
| Ni, ZF | 1 |
| Ma, ZW | 1 |
| Xie, AJ | 1 |
| Cheng, XS | 1 |
| Wang, JZ | 1 |
| Liu, GP | 1 |
| Ostojic, SM | 1 |
| Niess, B | 1 |
| Stojanovic, M | 1 |
| Obrenovic, M | 1 |
| Schwahn, BC | 3 |
| Chen, Z | 1 |
| Laryea, MD | 1 |
| Wendel, U | 2 |
| Lussier-Cacan, S | 2 |
| Genest, J | 1 |
| Mar, MH | 2 |
| Zeisel, SH | 2 |
| Castro, C | 2 |
| Garrow, T | 1 |
| Ji, C | 3 |
| Kaplowitz, N | 3 |
| Leclerc, D | 1 |
| Craig, SA | 1 |
| Yagisawa, M | 1 |
| Okawa, N | 1 |
| Shigematsu, N | 1 |
| Nakata, R | 1 |
| Boxer, AL | 1 |
| Kramer, JH | 1 |
| Johnston, K | 1 |
| Goldman, J | 1 |
| Finley, R | 1 |
| Miller, BL | 1 |
| Lawson-Yuen, A | 1 |
| Levy, HL | 1 |
| Nakajima, K | 1 |
| Chan, C | 1 |
| Slow, S | 1 |
| Vasudevamurthy, M | 1 |
| Fraser, R | 1 |
| McEntyre, C | 1 |
| Lever, M | 3 |
| Chambers, S | 1 |
| George, P | 1 |
| Colgan, SM | 1 |
| Austin, RC | 1 |
| Wang, XL | 1 |
| Mikael, LG | 1 |
| Wu, Q | 1 |
| Cohn, J | 1 |
| Jiang, H | 1 |
| Maclean, KN | 1 |
| Song, Z | 1 |
| Zhou, Z | 1 |
| Deaciuc, I | 1 |
| Chen, T | 1 |
| McClain, CJ | 1 |
| van Guldener, C | 1 |
| Janssen, MJ | 1 |
| de Meer, K | 1 |
| Donker, AJ | 1 |
| Stehouwer, CD | 1 |
| McGregor, DO | 2 |
| Dellow, WJ | 2 |
| George, PM | 2 |
| Robson, RA | 2 |
| Chambers, ST | 2 |
| Desouza, C | 1 |
| Keebler, M | 1 |
| McNamara, DB | 1 |
| Fonseca, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Medium-term Oral Guanidinoacetic Acid (GAA) Administration on Human Performance, Body Composition, and Metabolic Outcomes in Physically Active Men and Women[NCT01133899] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| [NCT01371357] | Phase 3 | 40 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome[NCT02213679] | 20 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria[NCT00283387] | Phase 2 | 15 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The patients were randomly assigned oral betaine or placebo for 2 months, followed by a 2 month washout. Each patient then received the alternate study medication for 2 months.~Urinary Oxalate Excretion was measured by oxalate oxidase. Two 24 hour urine collections were obtained at baseline, and during the eighth week of each study period." (NCT00283387)
Timeframe: baseline, 2 months, 6 months
| Intervention | umol/mg (Mean) |
|---|---|
| Betaine | 1.43 |
| Placebo | 1.04 |
12 reviews available for betaine and Hyperhomocysteinemia
| Article | Year |
|---|---|
The glycine betaine role in neurodegenerative, cardiovascular, hepatic, and renal diseases: Insights into disease and dysfunction networks.
Topics: Betaine; Cardiovascular Diseases; Cell Size; Humans; Hyperhomocysteinemia; Kidney Diseases; Liver Di | 2021 |
Betaine Supplementation Moderately Increases Total Cholesterol Levels: A Systematic Review and Meta-Analysis.
Topics: Adult; Betaine; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Humans; Hyperh | 2021 |
Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery.
Topics: Betaine; Cardiovascular Diseases; Choline; Dietary Supplements; DNA Methylation; Eating; Epigenesis, | 2020 |
Sulfur-Containing Amino Acids and Lipid Metabolism.
Topics: Amino Acids, Sulfur; Animals; Atherosclerosis; Betaine; Cholesterol; Cysteine; Dietary Proteins; Die | 2020 |
Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.
Topics: Animals; Betaine; Biomarkers; Cardiovascular Diseases; Folic Acid; Genetic Predisposition to Disease | 2018 |
[Advances in the clinical and laboratory studies on methylmalonic aciduria combined with homocysteinemia type cblC].
Topics: Adult; Age of Onset; Amino Acid Metabolism, Inborn Errors; Betaine; Carrier Proteins; Child; China; | 2013 |
[Research advances in the treatment of hyperhomocysteinemia].
Topics: Animals; Betaine; Folic Acid; Genetic Therapy; Humans; Hyperhomocysteinemia; Taurine | 2011 |
The nutritional burden of methylation reactions.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Creatine; Diet; Dietary Supplements; Folic Acid; | 2013 |
Betaine in human nutrition.
Topics: Animals; Betaine; Cardiovascular Diseases; DNA Methylation; Gastrointestinal Agents; Humans; Hyperho | 2004 |
The use of betaine in the treatment of elevated homocysteine.
Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Homocysteine; Homocystinuria; Humans; Hyperhomocystei | 2006 |
Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum.
Topics: Animals; Betaine; Endoplasmic Reticulum; Gastrointestinal Agents; Gene Expression Profiling; Glutath | 2006 |
Drugs affecting homocysteine metabolism: impact on cardiovascular risk.
Topics: Anticonvulsants; Betaine; Cardiovascular Diseases; Clinical Trials as Topic; Gonadal Steroid Hormone | 2002 |
6 trials available for betaine and Hyperhomocysteinemia
| Article | Year |
|---|---|
Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial.
Topics: Adolescent; Adult; Aged; Betaine; Dietary Supplements; Double-Blind Method; East Asian People; Folic | 2023 |
Association between malnutrition and hyperhomocysteine in Alzheimer's disease patients and diet intervention of betaine.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Betaine; Case-Control Studies; Dementia; Dietary Supplem | 2017 |
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Met | 2012 |
Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone.
Topics: Adult; Betaine; Double-Blind Method; Female; Glycine; Humans; Hyperhomocysteinemia; Male; Vitamin B | 2013 |
Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients.
Topics: Adult; Betaine; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; | 1999 |
Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.
Topics: Aged; Betaine; Cross-Over Studies; Drug Therapy, Combination; Fasting; Female; Folic Acid; Hematinic | 2002 |
31 other studies available for betaine and Hyperhomocysteinemia
| Article | Year |
|---|---|
Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Betaine; Glucose; Homocysteine; Hypercholesterolemia; | 2023 |
An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies.
Topics: Aged; Betaine; Female; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Leucovorin; Methy | 2020 |
Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9.
Topics: Animals; Betaine; Body Weight; CRISPR-Cas Systems; Cystathionine beta-Synthase; Disease Models, Anim | 2020 |
POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS.
Topics: Arginine; Betaine; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12 | 2020 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; | 2014 |
Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats.
Topics: Animals; Betaine; Choline Deficiency; Dietary Supplements; Glycine; Hyperhomocysteinemia; Male; Rats | 2014 |
Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats.
Topics: Animals; Antioxidants; Benserazide; Betaine; Brain; Dopamine; Dopamine Agents; Drug Combinations; Gl | 2015 |
Methionine synthase reductase deficiency (CblE): A report of two patients and a novel mutation.
Topics: Adult; Amino Acid Substitution; Anemia, Macrocytic; Betaine; Child; Female; Ferredoxin-NADP Reductas | 2016 |
[Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats].
Topics: Amino Acids; Animals; Beta vulgaris; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cho | 2015 |
Betaine prevents homocysteine-induced memory impairment via matrix metalloproteinase-9 in the frontal cortex.
Topics: Animals; Betaine; Drug Interactions; Frontal Lobe; Homocysteine; Hyperhomocysteinemia; Lipopolysacch | 2015 |
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficienc | 2016 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocyste | 2008 |
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
Topics: Animals; Betaine; Choline; Choline Deficiency; Cysteine; Dietary Supplements; Growth; Homocysteine; | 2008 |
High casein diet decreases plasma homocysteine concentration in rats.
Topics: Amino Acids; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Caseins; Cystathionine beta | 2009 |
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.
Topics: Amino Acids; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta | 2010 |
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S- | 2012 |
Acute myocardial infarction in a young patient with hyperhomocysteinaemia.
Topics: Acute Disease; Adult; Betaine; Coronary Vessels; Folic Acid; Heart; Homocysteine; Humans; Hyperhomoc | 2012 |
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
Topics: Alzheimer Disease; Animals; Betaine; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Lip | 2013 |
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Dose-Response Relationship, Drug; Female; Genoty | 2003 |
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice.
Topics: Animals; Betaine; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum; | 2003 |
Betaine. Monograph.
Topics: Betaine; Cardiovascular Diseases; Fatty Liver; Homocysteine; Homocystinuria; Humans; Hyperhomocystei | 2003 |
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
Topics: Animal Feed; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta | 2004 |
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
Topics: Animals; Betaine; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Injections, I | 2004 |
Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment.
Topics: Adult; Anticoagulants; Betaine; Cognition Disorders; Confusion; Disease Progression; Drug Therapy, C | 2005 |
Hyperhomocysteinemia can be ameliorated by dimethylsulfoniopropionate in place of folic acid in mice.
Topics: Animals; Betaine; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Hyperhomocysteinem | 2006 |
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model.
Topics: Alanine Transaminase; Animals; Betaine; Biosynthetic Pathways; Central Nervous System Depressants; E | 2006 |
Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD).
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Dialysis Solutions; Disease Models, Anim | 2007 |
Homocysteinylation of metallothionein impairs intracellular redox homeostasis: the enemy within!
Topics: Atherosclerosis; Betaine; Endothelium, Vascular; Folic Acid; Homeostasis; Homocysteine; Humans; Hype | 2007 |
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Topics: Animals; Animals, Genetically Modified; Aorta; Apolipoprotein A-I; Betaine; Cholesterol; Disease Mod | 2007 |
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.
Topics: Adiponectin; Adipose Tissue; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; | 2008 |
Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Betaine; Betaine-Homocysteine S-Methyltransferase; | 2001 |