betaine has been researched along with Huntington Disease in 2 studies
glycine betaine : The amino acid betaine derived from glycine.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a unified rapid betaine-based-PCR protocol for amplification of the (CAG)n region in Huntington disease (HD) and the (CGG)n region in Fragile X syndrome (FXS), followed by an electrophoretic separation on automated sequencer for precise determination of the triplet numbers." | 3.76 | A unified rapid PCR method for detection of normal and expanded trinucleotide alleles of CAG repeats in huntington chorea and CGG repeats in fragile X syndrome. ( Georgieva, B; Mitev, V; Todorov, T; Todorova, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Todorov, T | 1 |
| Todorova, A | 1 |
| Georgieva, B | 1 |
| Mitev, V | 1 |
| Shoulson, I | 1 |
| Goldblatt, D | 1 |
| Charlton, M | 1 |
| Joynt, RJ | 1 |
1 trial available for betaine and Huntington Disease
| Article | Year |
|---|---|
Huntington's disease: treatment with muscimol, a GABA-mimetic drug.
Topics: Amanita; Betaine; Clinical Trials as Topic; Double-Blind Method; Humans; Huntington Disease; Isoxazo | 1977 |
1 other study available for betaine and Huntington Disease
| Article | Year |
|---|---|
A unified rapid PCR method for detection of normal and expanded trinucleotide alleles of CAG repeats in huntington chorea and CGG repeats in fragile X syndrome.
Topics: Alleles; Betaine; Fragile X Syndrome; Humans; Huntington Disease; Male; Polymerase Chain Reaction; R | 2010 |