Page last updated: 2024-10-16

betaine and Heart Failure

betaine has been researched along with Heart Failure in 7 studies

glycine betaine : The amino acid betaine derived from glycine.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)."8.02Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021)
"The highest and lowest quintiles of urinary betaine excretion associated with risk of heart failure (p = 0."7.78Betaine and secondary events in an acute coronary syndrome cohort. ( Atkinson, W; Chambers, ST; Elmslie, JL; Frampton, CM; George, PM; Lever, M; Molyneux, SL; Richards, AM; Slow, S; Troughton, RW, 2012)
"Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)."4.02Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021)
"Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes."4.02Association of gut-related metabolites with outcome in acute heart failure. ( Bernieh, D; Cassambai, S; Heaney, LM; Israr, MZ; Jones, DJL; Ng, LL; Salzano, A; Suzuki, T; Yazaki, Y, 2021)
"The highest and lowest quintiles of urinary betaine excretion associated with risk of heart failure (p = 0."3.78Betaine and secondary events in an acute coronary syndrome cohort. ( Atkinson, W; Chambers, ST; Elmslie, JL; Frampton, CM; George, PM; Lever, M; Molyneux, SL; Richards, AM; Slow, S; Troughton, RW, 2012)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (28.57)24.3611
2020's4 (57.14)2.80

Authors

AuthorsStudies
Wargny, M1
Croyal, M1
Ragot, S1
Gand, E1
Jacobi, D1
Trochu, JN1
Prieur, X1
Le May, C1
Goronflot, T1
Cariou, B1
Saulnier, PJ1
Hadjadj, S1
Papandreou, C1
Bulló, M1
Hernández-Alonso, P1
Ruiz-Canela, M1
Li, J1
Guasch-Ferré, M1
Toledo, E1
Clish, C1
Corella, D1
Estruch, R1
Ros, E1
Fitó, M1
Alonso-Gómez, A1
Fiol, M1
Santos-Lozano, JM1
Serra-Majem, L1
Liang, L1
Martínez-González, MA1
Hu, FB1
Salas-Salvadó, J1
Israr, MZ1
Bernieh, D1
Salzano, A1
Cassambai, S1
Yazaki, Y1
Heaney, LM1
Jones, DJL1
Ng, LL1
Suzuki, T1
Lv, Y1
Ma, P2
Wang, J1
Xu, Q1
Fan, J1
Yan, L1
Zhou, R1
Trøseid, M1
Ueland, T1
Hov, JR1
Svardal, A1
Gregersen, I1
Dahl, CP1
Aakhus, S1
Gude, E1
Bjørndal, B1
Halvorsen, B1
Karlsen, TH1
Aukrust, P1
Gullestad, L1
Berge, RK1
Yndestad, A1
Lever, M1
George, PM1
Elmslie, JL1
Atkinson, W1
Slow, S1
Molyneux, SL1
Troughton, RW1
Richards, AM1
Frampton, CM1
Chambers, ST1
BORSOOK, ME1
BORSOOK, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
GutHeart: Targeting Gut Microbiota to Treat Heart Failure[NCT02637167]Phase 2150 participants (Anticipated)Interventional2016-03-11Recruiting
The Effects of Medium-term Oral Guanidinoacetic Acid (GAA) Administration on Human Performance, Body Composition, and Metabolic Outcomes in Physically Active Men and Women[NCT01133899]Phase 1/Phase 240 participants (Actual)Interventional2010-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

7 other studies available for betaine and Heart Failure

ArticleYear
Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort.
    Cardiovascular diabetology, 2022, 06-09, Volume: 21, Issue:1

    Topics: Aged; Betaine; Biomarkers; Carnitine; Choline; Cohort Studies; Cysteine; Diabetes Mellitus, Type 2;

2022
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.
    Clinical chemistry, 2021, 01-08, Volume: 67, Issue:1

    Topics: Aged; Atrial Fibrillation; Betaine; Carnitine; Case-Control Studies; Choline; Female; Heart Failure;

2021
Association of gut-related metabolites with outcome in acute heart failure.
    American heart journal, 2021, Volume: 234

    Topics: Acetylcarnitine; Acute Disease; Aged; Aged, 80 and over; Betaine; Carnitine; Choline; Female; Gastro

2021
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
    European journal of pharmacology, 2021, Nov-05, Volume: 910

    Topics: Actins; Administration, Oral; Animals; Apoptosis; Arterioles; Betaine; Cardiotonic Agents; Disease M

2021
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
    Journal of internal medicine, 2015, Volume: 277, Issue:6

    Topics: Aged; Betaine; Biomarkers; Choline; Chronic Disease; Female; Heart Failure; Humans; Intestinal Mucos

2015
Betaine and secondary events in an acute coronary syndrome cohort.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Betaine; Chromatography, High Pressure Liquid; Coh

2012
Treatment of cardiac decompensation with betaine and glycocyamine.
    Annals of western medicine and surgery, 1951, Volume: 5, Issue:10

    Topics: Betaine; Biochemical Phenomena; Cardiovascular Diseases; Creatine; Glycine; Heart Failure; Humans

1951