betaine has been researched along with Folic Acid Deficiency in 16 studies
glycine betaine : The amino acid betaine derived from glycine.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of betaine status on folate deficiency-induced hyperhomocysteinemia was investigated to determine whether folate deficiency impairs homocysteine removal not only by the methionine synthase (MS) pathway but also by the betaine-homocysteine S-methyltransferase (BHMT) pathway." | 7.78 | Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2012) |
| "The effect of betaine status on folate deficiency-induced hyperhomocysteinemia was investigated to determine whether folate deficiency impairs homocysteine removal not only by the methionine synthase (MS) pathway but also by the betaine-homocysteine S-methyltransferase (BHMT) pathway." | 3.78 | Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2012) |
| "Betaine therapy was given for 2 years to a 2-year-old boy with 5,10-methylenetetrahydrofolate reductase deficiency." | 1.36 | Titration of betaine therapy to optimize therapy in an infant with 5,10-methylenetetrahydrofolate reductase deficiency. ( Berk, O; Blom, HJ; Coker, M; Koroğlu, OA; Kültürsay, N; Ucar, SK; Yalaz, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ganz, AB | 1 |
| Shields, K | 1 |
| Fomin, VG | 1 |
| Lopez, YS | 1 |
| Mohan, S | 1 |
| Lovesky, J | 1 |
| Chuang, JC | 1 |
| Ganti, A | 1 |
| Carrier, B | 1 |
| Yan, J | 2 |
| Taeswuan, S | 1 |
| Cohen, VV | 1 |
| Swersky, CC | 1 |
| Stover, JA | 1 |
| Vitiello, GA | 1 |
| Malysheva, OV | 1 |
| Mudrak, E | 1 |
| Caudill, MA | 3 |
| Robinson, JL | 1 |
| McBreairty, LE | 1 |
| Randell, EW | 1 |
| Brunton, JA | 1 |
| Bertolo, RF | 1 |
| Ucar, SK | 1 |
| Koroğlu, OA | 1 |
| Berk, O | 1 |
| Yalaz, M | 1 |
| Kültürsay, N | 1 |
| Blom, HJ | 1 |
| Coker, M | 1 |
| Christensen, KE | 1 |
| Wu, Q | 3 |
| Wang, X | 1 |
| Deng, L | 2 |
| Rozen, R | 3 |
| Wang, W | 1 |
| Gregory, JF | 1 |
| Malysheva, O | 1 |
| Brenna, JT | 1 |
| Stabler, SP | 3 |
| Allen, RH | 3 |
| Schoendorfer, NC | 1 |
| Obeid, R | 1 |
| Moxon-Lester, L | 1 |
| Sharp, N | 1 |
| Vitetta, L | 1 |
| Boyd, RN | 1 |
| Davies, PS | 1 |
| Liu, Y | 1 |
| Liu, YQ | 1 |
| Morita, T | 1 |
| Sugiyama, K | 1 |
| Serrano, M | 1 |
| Pérez-Dueñas, B | 1 |
| Montoya, J | 1 |
| Ormazabal, A | 1 |
| Artuch, R | 1 |
| Mikael, LG | 1 |
| Pancer, J | 1 |
| Jiang, X | 1 |
| Caudill, M | 1 |
| STEKOL, JA | 1 |
| WEISS, S | 1 |
| ANDERSON, EI | 1 |
| HSU, PT | 1 |
| WATJEN, A | 1 |
| Knock, E | 1 |
| Lawrance, AK | 1 |
| Wang, XL | 1 |
| Lindenbaum, J | 2 |
| Savage, DG | 1 |
| Poirier, LA | 1 |
| Whitehead, VM | 1 |
| Keshavarz, K | 1 |
| Fuller, HL | 1 |
| Marston, HR | 1 |
| Allen, SH | 1 |
2 reviews available for betaine and Folic Acid Deficiency
| Article | Year |
|---|---|
Genetic causes of cerebral folate deficiency: clinical, biochemical and therapeutic aspects.
Topics: Betaine; Cerebral Cortex; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Huma | 2012 |
Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Animals; Betaine | 1993 |
2 trials available for betaine and Folic Acid Deficiency
| Article | Year |
|---|---|
Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.
Topics: Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Genotype; Humans; Lactation; Meth | 2016 |
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.
Topics: Adolescent; Adult; Betaine; Choline; Deuterium; Dietary Supplements; Folic Acid Deficiency; Genotype | 2011 |
12 other studies available for betaine and Folic Acid Deficiency
| Article | Year |
|---|---|
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficienc | 2016 |
Titration of betaine therapy to optimize therapy in an infant with 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Betaine; Child, Preschool; Dose-Response Relations | 2010 |
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S- | 2010 |
Methylation capacity in children with severe cerebral palsy.
Topics: Betaine; Biomarkers; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Choline; Cystath | 2012 |
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S- | 2012 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homo | 2013 |
Vitamin B12 and folic acid in relation to methionine synthesis from betaine in vivo and invitro.
Topics: Betaine; Choline; Folic Acid; Folic Acid Deficiency; Humans; Methionine; Vitamin B 12; Vitamin B 12 | 1957 |
Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.
Topics: Animals; Betaine; Diet; DNA Damage; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Gast | 2008 |
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.
Topics: Adolescent; Adult; Aged; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Chromatography; | 1993 |
Folate deficiency and formiminoglutamic acid excretion during chronic diethylnitrosamine administration to rats.
Topics: Animals; Betaine; Carcinogens; Choline; Diet; Drinking; FIGLU Test; Folic Acid; Folic Acid Deficienc | 1973 |
Relationship of arginine and methionine to creatine formation in chicks.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Arginine; Betaine; Body Weight; Ch | 1971 |
Factors affecting formiminoglutamic acid excretion in vitamin B 12 deficiency.
Topics: Aminopterin; Animals; Betaine; Female; Folic Acid; Folic Acid Deficiency; Glutarates; Histidine; Mal | 1970 |