Compounds > betaine
Page last updated: 2024-10-16

betaine and Disease Models, Animal

betaine has been researched along with Disease Models, Animal in 87 studies

glycine betaine : The amino acid betaine derived from glycine.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"Betaine inhibits colonic oxidative stress induced inflammatory pyroptosis to alleviate ASUC, which shows therapeutic potential against colitis and other acute inflammatory disorder."8.12Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis. ( Cao, W; Chen, L; Liang, Y; Liu, D; Liu, W; Mao, M; Wang, Y; Zhong, X, 2022)
"Betaine is known to act against various biological stresses and its levels were reported to be decreased in schizophrenia patients."7.91Investigation of betaine as a novel psychotherapeutic for schizophrenia. ( Balan, S; Esaki, K; Fujita, Y; Hashimoto, K; Hayashi-Takagi, A; Hino, M; Hisano, Y; Iwayama, Y; Kakita, A; Kunii, Y; Maekawa, M; Mataga, N; Matsumoto, J; Nagaoka, A; Nozaki, Y; Ohba, H; Ohnishi, T; Shimamoto-Mitsuyama, C; Tan, Y; Toyoshima, M; Watanabe, A; Yabe, H; Yoshikawa, T, 2019)
"Alcohol-induced hyperhomocysteinemia has been reported in rats and humans."7.72Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. ( Ji, C; Kaplowitz, N, 2003)
"Betaine is a natural compound that exerts beneficial anti-inflammatory effects."5.72Betaine supplementation alleviates dextran sulfate sodium-induced colitis ( Chen, C; Cui, J; He, Y; Hu, Y; Jing, T; Liu, E; Wang, S; Xu, H; Yang, Y; Zhao, N, 2022)
"Betaine treatment restored normal spermine and spermidine levels but further increased 5'-methylthioadenosine."5.62Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. ( Jiang, H; Maclean, KN; Mclagan, BM; Phinney, WN; Roede, JR; Stabler, SP, 2021)
"Betaine attenuated MCD diet-induced NAFLD by reducing fat accumulation and inhibiting hepatocyte proliferation."5.48The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease. ( Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Rakočević, J; Vesković, M; Vučević, D; Zaletel, I, 2018)
"Betaine was intravitreally injected in OIR mice at postnatal day (P) 14."5.46Antiangiogenic effect of betaine on pathologic retinal neovascularization via suppression of reactive oxygen species mediated vascular endothelial growth factor signaling. ( Jun, HO; Kang, BC; Kim, JH; Kwon, E; Park, SW; Park, YJ; Yun, JW, 2017)
"Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date."5.42Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015)
" Our findings are consistent with a relatively sharp threshold effect between severely elevated plasma homocysteine and thrombotic risk in HCU and indicate that the HO mouse model can serve as a useful tool for both testing novel treatment strategies and examining the optimal timing and dosing of betaine treatment with a view toward optimizing clinical outcome."5.38Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. ( Allen, RH; Greiner, LS; Jiang, H; Maclean, KN; Stabler, SP, 2012)
"Betaine has a lipotropic effect, which is associated with a reduction in homocysteine, an increase in ApoA-I and an amelioration of the atherogenic risk profile."5.34Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. ( Cohn, J; Jiang, H; Maclean, KN; Mikael, LG; Rozen, R; Schwahn, BC; Wang, XL; Wu, Q, 2007)
"Betaine inhibits colonic oxidative stress induced inflammatory pyroptosis to alleviate ASUC, which shows therapeutic potential against colitis and other acute inflammatory disorder."4.12Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis. ( Cao, W; Chen, L; Liang, Y; Liu, D; Liu, W; Mao, M; Wang, Y; Zhong, X, 2022)
"Abnormally high levels of homocysteine (Hcy) are associated with autism spectrum disorder."3.91Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. ( Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J, 2019)
"Betaine is known to act against various biological stresses and its levels were reported to be decreased in schizophrenia patients."3.91Investigation of betaine as a novel psychotherapeutic for schizophrenia. ( Balan, S; Esaki, K; Fujita, Y; Hashimoto, K; Hayashi-Takagi, A; Hino, M; Hisano, Y; Iwayama, Y; Kakita, A; Kunii, Y; Maekawa, M; Mataga, N; Matsumoto, J; Nagaoka, A; Nozaki, Y; Ohba, H; Ohnishi, T; Shimamoto-Mitsuyama, C; Tan, Y; Toyoshima, M; Watanabe, A; Yabe, H; Yoshikawa, T, 2019)
"We have shown previously that in ovo betaine injection can prevent nonalcoholic fatty liver induced by glucocorticoid exposure in chickens; yet it remains unknown whether feeding betaine to laying hens may exert similar effects in their progeny."3.88Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation. ( Abobaker, H; Hou, Z; Hu, Y; Omer, NA; Sun, Q; Zhao, R; Zong, Y, 2018)
"Topical application of betaine, L-carnitine, or erythritol systematically limited progression of environmentally induced dry eye."3.79Efficacy of osmoprotectants on prevention and treatment of murine dry eye. ( Chen, Q; Chen, W; Garrett, Q; Hou, C; Li, J; Wang, Y; Zhang, X, 2013)
"Hyperhomocysteinemia (Hhcy) may induce memory deficits with β-amyloid (Aβ) accumulation and tau hyperphosphorylation."3.79Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. ( Chai, GS; Cheng, XS; Jiang, X; Liu, GP; Ma, ZW; Ni, ZF; Wang, JZ; Wang, Q; Xie, AJ, 2013)
"Betaine could inhibit the development of atherosclerosis via anti-inflammation."3.74[Anti-atherosclerotic effect of betaine in apolipoprotein E-deficient mice]. ( DU, YP; Fan, RX; Hou, MJ; Lü, SW; Zhu, HL, 2008)
"Alcohol-induced hyperhomocysteinemia has been reported in rats and humans."3.72Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. ( Ji, C; Kaplowitz, N, 2003)
"Betaine is a significant determinant of plasma tHcy, particularly in case of folate deficiency, methionine load, or alcohol consumption."2.49The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. ( Obeid, R, 2013)
"In the pathophysiology of Alzheimer's disease, the deposition of amyloid β peptide (Aβ) is associated with oxidative stress, leading to cognitive impairment and neurodegeneration."1.72Preventive Effect of Betaine Against Cognitive Impairments in Amyloid β Peptide-Injected Mice Through Sirtuin1 in Hippocampus. ( Hiramatsu, M; Ibi, D; Kojima, Y; Kondo, S; Nakasai, G; Ohmi, A; Takaba, R, 2022)
"Betaine is a natural compound that exerts beneficial anti-inflammatory effects."1.72Betaine supplementation alleviates dextran sulfate sodium-induced colitis ( Chen, C; Cui, J; He, Y; Hu, Y; Jing, T; Liu, E; Wang, S; Xu, H; Yang, Y; Zhao, N, 2022)
"Betaine treatment restored normal spermine and spermidine levels but further increased 5'-methylthioadenosine."1.62Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. ( Jiang, H; Maclean, KN; Mclagan, BM; Phinney, WN; Roede, JR; Stabler, SP, 2021)
"Non-alcoholic fatty liver disease (NAFLD) is a common disease with a multitude of complications."1.62Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis. ( Huang, T; Jia, M; Li, Y; Liu, S; Luo, Z; Miao, W; Song, Z; Wang, P; Wu, T; Yu, J; Yu, L; Zhang, H; Zhou, L, 2021)
"Nonalcoholic fatty liver disease (NAFLD) represents a hepatic manifestation of metabolic syndrome."1.56Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD. ( Jadžić, J; Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Vesković, M; Vučević, D; Vukićević, D, 2020)
"Male Sprague‑Dawley rats with induced dry eye disease were randomly assigned to four groups: Vehicle (control), low‑dose goji berry extract [GBE; 250 mg/kg/body weight (bw)], median‑dose GBE (350 mg/kg/bw), and high‑dose GBE (500 mg/kg/bw)."1.48Effects of Lycium barbarum (goji berry) on dry eye disease in rats. ( Chen, FA; Chien, KJ; Horng, CT; Hsieh, YH; Huang, YS; Lu, CC; Wang, CJ; Yang, JS, 2018)
"Betaine attenuated MCD diet-induced NAFLD by reducing fat accumulation and inhibiting hepatocyte proliferation."1.48The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease. ( Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Rakočević, J; Vesković, M; Vučević, D; Zaletel, I, 2018)
"Betaine is a derivative of the amino acid glycine widely investigated for its hepatoprotective properties against alcoholism."1.48Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury. ( Ahmadi, A; Azarpira, N; Farshad, O; Ghanbarinejad, V; Heidari, R; Hosseini, A; Jamshidzadeh, A; Khodaei, F; Mohammadi, H; Najibi, A; Niknahad, H; Ommati, MM; Rashidi, E; Sadeghi, A; Siavashpour, A, 2018)
"Betaine was intravitreally injected in OIR mice at postnatal day (P) 14."1.46Antiangiogenic effect of betaine on pathologic retinal neovascularization via suppression of reactive oxygen species mediated vascular endothelial growth factor signaling. ( Jun, HO; Kang, BC; Kim, JH; Kwon, E; Park, SW; Park, YJ; Yun, JW, 2017)
"Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin."1.46Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model. ( Davis, SC; Gil, J; Harding, A; Higa, A; Parajon, F; Solis, M; Valdes, J, 2017)
"Betaine was administered orally (250 mg/kg) for a period of 21 days before burn injury, and single dose of betaine was administered after thermal injury."1.43Protective effect of betaine against burn-induced pulmonary injury in rats. ( Aykaç, A; Çetinel, Ş; Satılmış, B; Şehirli, AÖ; Şener, G; Tetik, Ş; Yeğen, B, 2016)
"Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver."1.43Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. ( Gupta, S; Kruger, WD; Wang, L, 2016)
"Betaine is a natural product that had been implicated in many biological processes and had been used for the therapy of some neurodegenerative disease, such as Alzheimer's disease."1.43Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model. ( Nie, C; Nie, H; Wu, J; Zhang, X; Zhao, Y, 2016)
"Choline is an essential nutrient, and its deficiency is related to PN-associated organ diseases."1.43Choline Alleviates Parenteral Nutrition-Associated Duodenal Motility Disorder in Infant Rats. ( Cai, W; Guo, Y; Huang, H; Lu, T; Tang, Q; Wu, Y; Zhu, J, 2016)
"Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date."1.42Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. ( Hu, C; Huang, X; Lin, X; Niu, J; Tan, Y; Wang, H; Wang, X; Yin, P; Zeng, J; Zhou, L, 2015)
"Betaine treatment attenuated this increase in VEGF and HIF-1α expression via suppression of diabetes-induced Akt activation in the retinas of the diabetic rats."1.42Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats. ( Kim, CJ; Kim, YG; Lee, SH; Lim, HH; Shin, MS; Yang, HJ, 2015)
"C31G has the potential to be used to treat herpetic keratitis as well as other herpetic topical lesions in humans."1.39The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model. ( Bhattacharjee, PS; Clement, C; Foster, TP; Hill, JM; Lukiw, WJ; Malamud, D; McFerrin, HE; Ochoa, AC; Rodriguez, P; Stern, EM; Velasco, C, 2013)
" Our findings are consistent with a relatively sharp threshold effect between severely elevated plasma homocysteine and thrombotic risk in HCU and indicate that the HO mouse model can serve as a useful tool for both testing novel treatment strategies and examining the optimal timing and dosing of betaine treatment with a view toward optimizing clinical outcome."1.38Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. ( Allen, RH; Greiner, LS; Jiang, H; Maclean, KN; Stabler, SP, 2012)
"Betaine was administered intragastrically after exposure of ethanol for 4 wk."1.36Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury. ( Gong, ZJ; Shi, QZ; Wang, LW; Zhang, W, 2010)
"Betaine serves as a methyl donor in a reaction converting homocysteine to methionine."1.35Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice. ( Du, Y; Fan, R; Hou, M; Ling, W; Lv, S; Tang, Z; Zhu, H, 2009)
"Over 80% of chronic renal failure patients have elevated plasma Hcy and a 10-20 times higher incidence of vascular disease."1.34Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD). ( Chambers, S; Fraser, R; George, P; Lever, M; McEntyre, C; Slow, S; Vasudevamurthy, M, 2007)
"Betaine has a lipotropic effect, which is associated with a reduction in homocysteine, an increase in ApoA-I and an amelioration of the atherogenic risk profile."1.34Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. ( Cohn, J; Jiang, H; Maclean, KN; Mikael, LG; Rozen, R; Schwahn, BC; Wang, XL; Wu, Q, 2007)
"Betaine was supplemented in the drinking water at a concentration of 1% (wt/vol) (anhydrous)."1.34Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. ( Chen, T; Deaciuc, I; Hill, D; McClain, CJ; Song, M; Song, Z; Zhou, Z, 2007)
" C31G was shown to be safe to both vaginal and rectal mucosal tissues and to the microflora with repeated daily use."1.33Vaginal and rectal topical microbicide development: safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque. ( Balkus, JE; Hillier, SL; Patton, DL; Sweeney, YT, 2006)
"Betaine was then intravenously administered at the same time as the methionine loading."1.32Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats. ( Nakata, R; Okawa, N; Shigematsu, N; Yagisawa, M, 2004)
"Primary demyelination of these fibres was induced by sensitization of the animals to bovine cerebral white matter or myelin basic protein in complete Freund's adjuvant and challenge thereafter by intravitreous injection of basic protein (BP) or purified tuberculin (PPD)."1.25Experimental allergic optic neuritis (EAON) in the rabbit. A new model to study primary demyelinating diseases. ( Bloom, BR; Wiśniewski, HM, 1975)

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.15)18.7374
1990's3 (3.45)18.2507
2000's17 (19.54)29.6817
2010's51 (58.62)24.3611
2020's15 (17.24)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Chen, ST1
Hsieh, CP1
Lee, MY1
Chen, LC1
Huang, CM1
Chen, HH1
Chan, MH1
Ibi, D2
Kondo, S2
Ohmi, A1
Kojima, Y2
Nakasai, G1
Takaba, R1
Hiramatsu, M2
Chen, L1
Liu, D1
Mao, M1
Liu, W1
Wang, Y3
Liang, Y1
Cao, W1
Zhong, X1
Zhao, N3
Yang, Y3
Chen, C3
Jing, T3
Hu, Y5
Xu, H3
Wang, S3
He, Y3
Liu, E3
Cui, J3
van Hummel, A1
Taleski, G1
Sontag, JM1
Feiten, AF1
Ke, YD1
Ittner, LM1
Sontag, E1
Jiang, YP1
Yang, JM2
Ye, RJ1
Liu, N1
Zhang, WJ1
Ma, L1
Zheng, P1
Niu, JG1
Liu, P1
Yu, JQ2
Vesković, M2
Labudović-Borović, M2
Mladenović, D2
Jadžić, J1
Jorgačević, B2
Vukićević, D1
Vučević, D2
Radosavljević, T2
Pourmehdi, A1
Sakhaei, Z1
Alirezaei, M1
Dezfoulian, O1
Zhang, T1
Lu, R1
Chen, Y1
Yuan, Y1
Song, S1
Yan, K1
Zha, Y1
Zhuang, W1
Cheng, Y1
Liang, J1
Chen, Q2
Jiao, F1
Shi, C1
Pei, M1
Wang, L2
Gong, Z1
Hirashima, K1
Sumiya, K1
Yamamoto, M1
Ando, T1
Maclean, KN5
Jiang, H5
Phinney, WN2
Mclagan, BM1
Roede, JR1
Stabler, SP4
Yoshihara, S1
Jiang, X4
Morikawa, M1
Ogawa, T1
Ichinose, S1
Yabe, H2
Kakita, A2
Toyoshima, M2
Kunii, Y2
Yoshikawa, T2
Tanaka, Y1
Hirokawa, N1
Lv, Y1
Ma, P2
Wang, J1
Xu, Q1
Fan, J1
Yan, L1
Zhou, R2
Huang, T1
Yu, J1
Luo, Z1
Yu, L1
Liu, S2
Wang, P1
Jia, M1
Wu, T1
Miao, W1
Zhou, L2
Song, Z4
Zhang, H1
Li, Y1
Chien, KJ1
Horng, CT1
Huang, YS1
Hsieh, YH1
Wang, CJ1
Yang, JS1
Lu, CC1
Chen, FA1
Zaletel, I1
Rakočević, J1
Sun, Q1
Hou, Z1
Zong, Y1
Omer, NA1
Abobaker, H1
Zhao, R1
Shiels, SM1
Bouchard, M1
Wang, H2
Wenke, JC1
Heidari, R1
Niknahad, H1
Sadeghi, A1
Mohammadi, H1
Ghanbarinejad, V1
Ommati, MM1
Hosseini, A1
Azarpira, N1
Khodaei, F1
Farshad, O1
Rashidi, E1
Siavashpour, A1
Najibi, A1
Ahmadi, A1
Jamshidzadeh, A1
Zhang, M1
Tan, HR1
Nanobashvili, K1
Jack-Roberts, C1
Bretter, R1
Jones, N1
Axen, K1
Saxena, A1
Blain, K1
Sánchez-López, E1
Kammeijer, GSM1
Crego, AL1
Marina, ML1
Ramautar, R1
Peters, DJM1
Mayboroda, OA1
Keating, AK1
Hurt, KJ1
Huang, F1
Chen, X1
Niu, J2
Cui, C1
Chen, Z2
Sun, J1
Gautam, A1
Muhie, S1
Chakraborty, N1
Hoke, A1
Donohue, D1
Miller, SA1
Hammamieh, R1
Jett, M1
Drobny, A1
Meloh, H1
Wächtershäuser, E1
Hellmann, B1
Mueller, AS1
van der Klis, JD1
Fitzenberger, E1
Wenzel, U1
Ohnishi, T1
Balan, S1
Maekawa, M1
Ohba, H1
Watanabe, A1
Iwayama, Y1
Fujita, Y1
Tan, Y2
Hisano, Y1
Shimamoto-Mitsuyama, C1
Nozaki, Y1
Esaki, K1
Nagaoka, A1
Matsumoto, J1
Hino, M1
Mataga, N1
Hayashi-Takagi, A1
Hashimoto, K1
de Castro, NM1
Yaqoob, P1
de la Fuente, M1
Baeza, I1
Claus, SP1
Strickland, FM1
Hewagama, A1
Wu, A1
Sawalha, AH1
Delaney, C1
Hoeltzel, MF1
Yung, R1
Johnson, K1
Mickelson, B1
Richardson, BC1
Jhong, JF1
Venault, A1
Hou, CC1
Chen, SH1
Wei, TC1
Zheng, J1
Huang, J1
Chang, Y1
Hill, JM1
Stern, EM1
Bhattacharjee, PS1
Malamud, D1
Clement, C1
Rodriguez, P1
Lukiw, WJ1
Ochoa, AC1
Foster, TP1
Velasco, C1
McFerrin, HE1
Chen, W1
Zhang, X3
Li, J2
Hou, C1
Garrett, Q1
Obeid, R1
Liu, YL1
Pan, Y1
Wang, X2
Fan, CY1
Zhu, Q1
Li, JM1
Wang, SJ1
Kong, LD1
Jadavji, NM1
Bahous, RH1
Deng, L1
Malysheva, O1
Grand'maison, M1
Bedell, BJ1
Caudill, MA1
Rozen, R3
Dou, X1
Xia, Y1
Chen, J1
Qian, Y1
Li, S1
Jinzenji, A1
Sogawa, C1
Miyawaki, T1
Wen, XF1
Yi, D1
Ohyama, K1
Kitayama, S1
Sogawa, N1
Morita, K1
Liu, H1
Gong, M1
French, BA1
Tillman, B1
French, SW1
Kim, YG1
Lim, HH1
Lee, SH1
Shin, MS1
Kim, CJ1
Yang, HJ1
Zhu, J1
Wu, Y1
Guo, Y1
Tang, Q1
Lu, T1
Cai, W1
Huang, H1
Imbard, A1
Benoist, JF1
Esse, R1
Gupta, S3
Lebon, S1
de Vriese, AS1
de Baulny, HO1
Kruger, W1
Schiff, M1
Blom, HJ1
Kruger, WD2
Zeng, J1
Huang, X1
Hu, C1
Lin, X1
Yin, P1
Nie, C1
Nie, H1
Zhao, Y1
Wu, J1
Kusat Ol, K1
Kanbak, G2
Oğlakcı Ilhan, A1
Burukoglu, D1
Yücel, F2
Salem, A1
Noaman, E1
Kandil, E1
Badawi, A1
Mostafa, N1
FitzGerald, PF1
Butts, MD1
Roberts, JC1
Colborn, RE1
Torres, AS1
Lee, BD1
Yeh, BM1
Bonitatibus, PJ1
Koeberl, DD1
Park, SW1
Jun, HO1
Kwon, E1
Yun, JW1
Kim, JH2
Park, YJ1
Kang, BC1
Şehirli, AÖ1
Satılmış, B1
Tetik, Ş1
Çetinel, Ş1
Yeğen, B1
Aykaç, A1
Şener, G1
Sogut, I1
Uysal, O1
Oglakci, A1
Kartkaya, K1
Davis, SC1
Harding, A1
Gil, J1
Parajon, F1
Valdes, J1
Solis, M1
Higa, A1
Fan, RX1
Lü, SW1
DU, YP1
Hou, MJ1
Zhu, HL1
Lv, S1
Fan, R1
Du, Y1
Hou, M1
Tang, Z1
Ling, W1
Zhu, H1
Kim, SH1
Yang, SO1
Kim, HS1
Kim, Y1
Park, T1
Choi, HK1
Shi, QZ1
Wang, LW1
Zhang, W1
Gong, ZJ1
Wetzel, KJ1
Bjorge, D1
Schwan, WR1
Cordero, P1
Campion, J1
Milagro, FI1
Martínez, JA1
Niebergall, LJ1
Jacobs, RL1
Chaba, T1
Vance, DE1
Greiner, LS1
Allen, RH2
Pilonieta, MC1
Nagy, TA1
Jorgensen, DR1
Detweiler, CS1
Medici, V1
Shibata, NM1
Kharbanda, KK3
LaSalle, JM1
Woods, R1
Engelberg, JA1
Devaraj, S1
Török, NJ1
Jiang, JX1
Havel, PJ1
Lönnerdal, B1
Kim, K1
Halsted, CH2
Chai, GS1
Ni, ZF1
Ma, ZW1
Xie, AJ1
Cheng, XS1
Wang, Q1
Wang, JZ1
Liu, GP1
Kawakami, S1
Han, KH1
Nakamura, Y1
Shimada, K1
Kitano, T1
Aritsuka, T1
Nagura, T1
Ohba, K1
Nakamura, K1
Fukushima, M1
Billington, CJ1
Schmidt, B1
Zhang, L1
Hodges, JS1
Georgieff, MK1
Schotta, G1
Gopalakrishnan, R1
Petryk, A1
Ji, C1
Kaplowitz, N2
Sleator, RD1
Francis, GA1
O'Beirne, D1
Gahan, CG1
Hill, C1
Schwahn, BC2
Laryea, MD1
Melnyk, S1
Pogribny, I1
Garrow, T1
James, SJ1
Yagisawa, M1
Okawa, N1
Shigematsu, N1
Nakata, R1
Rogers, DD1
Mailliard, ME1
Siford, GL1
Barak, AJ1
Beckenhauer, HC1
Sorrell, MF1
Tuma, DJ1
Patton, DL1
Sweeney, YT1
Balkus, JE1
Hillier, SL1
Slow, S1
Vasudevamurthy, M1
Fraser, R1
McEntyre, C1
Lever, M2
Chambers, S1
George, P1
Purohit, V1
Abdelmalek, MF1
Barve, S1
Benevenga, NJ1
Liu, QY1
Lu, SC1
McClain, CJ3
Swanson, C1
Zakhari, S1
Wang, XL1
Mikael, LG1
Wu, Q1
Cohn, J1
Deaciuc, I2
Zhou, Z2
Song, M1
Chen, T2
Hill, D1
Tarnow, P1
Jönsson, A1
Lindblom, L1
Gustafsson, T1
Cassuto, J1
Ogborn, MR1
Nitschmann, E1
Bankovic-Calic, N1
Buist, R1
Peeling, J1
Dellow, WJ1
Chambers, ST1
Barrell, GK1
Robson, RA1
Higashi, Y1
Yokogawa, K1
Takeuchi, N1
Tamai, I1
Nomura, M1
Hashimoto, N1
Hayakawa, JI1
Miyamoto, KI1
Tsuji, A1
Wiśniewski, HM1
Bloom, BR1
Hülsmann, WC1
Schneijdenberg, CT1
Verkleij, AJ1
Shatrov, VA1
Kruglova, IF1
Fal', EA1
Kadan, LP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168]60 participants (Anticipated)Interventional2020-04-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for betaine and Disease Models, Animal

ArticleYear
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
    Nutrients, 2013, Sep-09, Volume: 5, Issue:9

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Mo

2013
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
    Annals of the New York Academy of Sciences, 2016, Volume: 1363

    Topics: Acetylcysteine; Amino Acids, Sulfur; Animals; Betaine; Cystathionine beta-Synthase; Diet; Dietary Su

2016
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
    The American journal of clinical nutrition, 2007, Volume: 86, Issue:1

    Topics: Animals; Betaine; Disease Models, Animal; Folic Acid; Humans; Liver Diseases, Alcoholic; Methionine;

2007

Other Studies

84 other studies available for betaine and Disease Models, Animal

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Betaine prevents and reverses the behavioral deficits and synaptic dysfunction induced by repeated ketamine exposure in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Betaine; Cognition; Disease Models, Animal; Disks L

2021
Preventive Effect of Betaine Against Cognitive Impairments in Amyloid β Peptide-Injected Mice Through Sirtuin1 in Hippocampus.
    Neurochemical research, 2022, Volume: 47, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Betaine; Cognitive Dysfunction; Disease Models, A

2022
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis.
    Molecular nutrition & food research, 2022, Volume: 66, Issue:22

    Topics: Animals; Betaine; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Huma

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Betaine supplementation alleviates dextran sulfate sodium-induced colitis
    Food & function, 2022, Dec-13, Volume: 13, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Betaine; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease M

2022
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy.
    Neuropathology and applied neurobiology, 2023, Volume: 49, Issue:4

    Topics: Alzheimer Disease; Animals; Betaine; Carbon; Choline; Dietary Supplements; Disease Models, Animal; F

2023
Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120

    Topics: Animals; Antioxidants; Betaine; Blood-Testis Barrier; Catalase; Diabetes Mellitus, Experimental; Dis

2019
Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD.
    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2020, Volume: 26, Issue:5

    Topics: Animals; Betaine; Choline; Collagen; Diet; Dietary Supplements; Disease Models, Animal; Hepatocytes;

2020
Betaine effects against asthma-induced oxidative stress in the liver and kidney of mice.
    Molecular biology reports, 2020, Volume: 47, Issue:8

    Topics: Animals; Antioxidants; Asthma; Betaine; Disease Models, Animal; Female; Glucocorticoids; Inflammatio

2020
Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9.
    Lipids in health and disease, 2020, Oct-14, Volume: 19, Issue:1

    Topics: Animals; Betaine; Body Weight; CRISPR-Cas Systems; Cystathionine beta-Synthase; Disease Models, Anim

2020
Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice.
    Scientific reports, 2020, 12-14, Volume: 10, Issue:1

    Topics: Animals; Bacteria; Betaine; Cell Line; Disease Models, Animal; Gastrointestinal Microbiome; Intestin

2020
Preventive Effects of Continuous Betaine Intake on Cognitive Impairment and Aberrant Gene Expression in Hippocampus of 3xTg Mouse Model of Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 79, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Betaine; Cognition; Cognitive Dysfunction; Diseas

2021
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
    Molecular genetics and metabolism, 2021, Volume: 132, Issue:2

    Topics: Adenosylhomocysteinase; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Folic

2021
Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport.
    Cell reports, 2021, 04-13, Volume: 35, Issue:2

    Topics: Actins; Animals; Behavior, Animal; Betaine; Biological Transport; Diet; Disease Models, Animal; Gene

2021
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
    European journal of pharmacology, 2021, Nov-05, Volume: 910

    Topics: Actins; Administration, Oral; Animals; Apoptosis; Arterioles; Betaine; Cardiotonic Agents; Disease M

2021
Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis.
    Biochemical and biophysical research communications, 2021, 10-20, Volume: 575

    Topics: Animals; Betaine; Diet, High-Fat; Disease Models, Animal; Gene Expression Profiling; Lipid Metabolis

2021
Effects of Lycium barbarum (goji berry) on dry eye disease in rats.
    Molecular medicine reports, 2018, Volume: 17, Issue:1

    Topics: Animals; Betaine; Disease Models, Animal; Dry Eye Syndromes; Kidney; Liver; Lycium; Male; Plant Extr

2018
The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease.
    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2018, Volume: 24, Issue:2

    Topics: Animals; Betaine; Cell Nucleus; Cell Proliferation; Chromatin; Disease Models, Animal; Gastrointesti

2018
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
    The Journal of nutrition, 2018, 03-01, Volume: 148, Issue:3

    Topics: Animals; Betaine; Chickens; Corticosterone; Dietary Supplements; Disease Models, Animal; DNA Methyla

2018
Chlorhexidine-releasing implant coating on intramedullary nail reduces infection in a rat model.
    European cells & materials, 2018, 03-22, Volume: 35

    Topics: Animals; Anti-Bacterial Agents; Betaine; Bone and Bones; Bone Nails; Cefazolin; Chlorhexidine; Coate

2018
Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Acute Disease; Animals; Betaine; Bile Ducts; Biomarkers; Chronic Disease; Disease Models, Animal; Li

2018
Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response.
    Molecules (Basel, Switzerland), 2018, May-26, Volume: 23, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betaine; Biomarkers; Chemokine CCL2; Cytokines; Di

2018
Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts.
    Nutrients, 2018, Oct-15, Volume: 10, Issue:10

    Topics: Animal Feed; Animals; Betaine; Biomarkers; Blood Glucose; Cell Line, Tumor; Choline; Diabetes, Gesta

2018
Sheathless CE-MS based metabolic profiling of kidney tissue section samples from a mouse model of Polycystic Kidney Disease.
    Scientific reports, 2019, 01-28, Volume: 9, Issue:1

    Topics: Animals; Betaine; Carnitine; Creatine; Creatinine; Disease Models, Animal; Electrophoresis, Capillar

2019
Taurine alleviates repression of betaine-homocysteine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:5

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Disease Models, Animal; Homocystinuria;

2019
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
    Psychiatry and clinical neurosciences, 2019, Volume: 73, Issue:6

    Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Anim

2019
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis.
    Metabolomics : Official journal of the Metabolomic Society, 2018, 12-29, Volume: 15, Issue:1

    Topics: Animals; Betaine; Carnitine; Chlorocebus aethiops; Disease Models, Animal; Gas Chromatography-Mass S

2018
Betaine-rich sugar beet molasses protects from homocysteine-induced reduction of survival in Caenorhabditis elegans.
    European journal of nutrition, 2020, Volume: 59, Issue:2

    Topics: Animals; Betaine; Caenorhabditis elegans; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay;

2020
Investigation of betaine as a novel psychotherapeutic for schizophrenia.
    EBioMedicine, 2019, Volume: 45

    Topics: Animals; Betaine; Brain; Choline Dehydrogenase; Dietary Supplements; Disease Models, Animal; DNA Met

2019
Premature impairment of methylation pathway and cardiac metabolic dysfunction in fa/fa obese Zucker rats.
    Journal of proteome research, 2013, Apr-05, Volume: 12, Issue:4

    Topics: Adipose Tissue, White; Age Factors; Animals; Betaine; Disease Models, Animal; Inositol; Liver; Magne

2013
Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:7

    Topics: Animals; Antibodies, Antinuclear; Betaine; CD40 Ligand; Choline; Coenzymes; Diet; Disease Models, An

2013
Surface zwitterionization of expanded poly(tetrafluoroethylene) membranes via atmospheric plasma-induced polymerization for enhanced skin wound healing.
    ACS applied materials & interfaces, 2013, Jul-24, Volume: 5, Issue:14

    Topics: Adsorption; Animals; Bacterial Adhesion; Betaine; Biocompatible Materials; Blood Proteins; Cell Line

2013
The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model.
    Antiviral research, 2013, Volume: 100, Issue:1

    Topics: Animals; Antiviral Agents; Betaine; Cornea; Disease Models, Animal; Fatty Acids, Unsaturated; Herpes

2013
Efficacy of osmoprotectants on prevention and treatment of murine dry eye.
    Investigative ophthalmology & visual science, 2013, Sep-19, Volume: 54, Issue:9

    Topics: Animals; Apoptosis; Betaine; Carnitine; Cornea; Disease Models, Animal; Disease Progression; Dry Eye

2013
Betaine reduces serum uric acid levels and improves kidney function in hyperuricemic mice.
    Planta medica, 2014, Volume: 80, Issue:1

    Topics: Acetylglucosaminidase; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding

2014
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
    The Biochemical journal, 2014, Jul-15, Volume: 461, Issue:2

    Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase;

2014
Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease.
    British journal of pharmacology, 2014, Volume: 171, Issue:17

    Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Betaine; Cells, Cultured; Cytoprotection; Disease Models, Ani

2014
Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor.
    Journal of pharmacological sciences, 2014, Volume: 125, Issue:2

    Topics: Animals; Betaine; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; G

2014
Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).
    Experimental and molecular pathology, 2014, Volume: 97, Issue:3

    Topics: Animals; Betaine; Blotting, Western; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; H

2014
Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Animals; Betaine; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypoxia-In

2015
Choline Alleviates Parenteral Nutrition-Associated Duodenal Motility Disorder in Infant Rats.
    JPEN. Journal of parenteral and enteral nutrition, 2016, Volume: 40, Issue:7

    Topics: Animals; Animals, Newborn; Betaine; Choline; Disease Models, Animal; Duodenum; Gastrointestinal Moti

2016
High homocysteine induces betaine depletion.
    Bioscience reports, 2015, Apr-28, Volume: 35, Issue:4

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Carrier Proteins; Disease Models, Animal

2015
Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice.
    Journal of inherited metabolic disease, 2016, Volume: 39, Issue:1

    Topics: Animals; Betaine; Bone Density; Cystathionine beta-Synthase; Diet; Dietary Supplements; Disease Mode

2016
Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients.
    Scientific reports, 2015, Nov-03, Volume: 5

    Topics: alpha-Fetoproteins; Animals; Betaine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cohort Studies;

2015
Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model.
    Neuroscience letters, 2016, Feb-26, Volume: 615

    Topics: Animals; Betaine; Brain; Chronic Disease; Dementia, Vascular; Disease Models, Animal; Disks Large Ho

2016
The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:3

    Topics: Animals; Betaine; Brain; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Fatty

2016
Crystal structure and chemotherapeutic efficacy of the novel compound, gallium tetrachloride betaine, against breast cancer using nanotechnology.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:8

    Topics: Animals; Apoptosis; Betaine; Crystallography, X-Ray; Disease Models, Animal; Drug Carriers; Female;

2016
A Proposed Computed Tomography Contrast Agent Using Carboxybetaine Zwitterionic Tantalum Oxide Nanoparticles: Imaging, Biological, and Physicochemical Performance.
    Investigative radiology, 2016, Volume: 51, Issue:12

    Topics: Acute Kidney Injury; Animals; Betaine; Contrast Media; Disease Models, Animal; Kidney; Male; Nanopar

2016
Vision of correction for classic homocystinuria.
    The Journal of clinical investigation, 2016, 06-01, Volume: 126, Issue:6

    Topics: Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Homocystinuria; Humans; Mice;

2016
Antiangiogenic effect of betaine on pathologic retinal neovascularization via suppression of reactive oxygen species mediated vascular endothelial growth factor signaling.
    Vascular pharmacology, 2017, Volume: 90

    Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Astrocytes; Betaine; Cell Movement; Cell Prolife

2017
Protective effect of betaine against burn-induced pulmonary injury in rats.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2016, Volume: 22, Issue:5

    Topics: Administration, Oral; Animals; Antioxidants; Betaine; Burns; Cytokines; Disease Models, Animal; Fema

2016
Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017, Volume: 33, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Blood Alcohol Content; Calpain; Caspase 3; Cathepsin

2017
Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model.
    International wound journal, 2017, Volume: 14, Issue:6

    Topics: Animals; Betaine; Biguanides; Biofilms; Disease Models, Animal; Disinfectants; Methicillin-Resistant

2017
[Anti-atherosclerotic effect of betaine in apolipoprotein E-deficient mice].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2008, Volume: 42, Issue:10

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Betaine; Chemokine CCL2; Dietary Supplements; Disease M

2008
Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice.
    European journal of nutrition, 2009, Volume: 48, Issue:4

    Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Betaine; Chemokine CCL2; Dietary Supplements; Di

2009
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
    Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:4

    Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine

2009
Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury.
    World journal of gastroenterology, 2010, Feb-21, Volume: 16, Issue:7

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Betaine; Biomarkers; Blotting, Western;

2010
Mutational and transcriptional analyses of the Staphylococcus aureus low-affinity proline transporter OpuD during in vitro growth and infection of murine tissues.
    FEMS immunology and medical microbiology, 2011, Volume: 61, Issue:3

    Topics: Amino Acid Transport Systems, Neutral; Animals; Betaine; Disease Models, Animal; DNA Mutational Anal

2011
Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:6

    Topics: Animals; Betaine; Choline; Dietary Fats; Dietary Sucrose; Dietary Supplements; Disease Models, Anima

2011
Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.
    Biochimica et biophysica acta, 2011, Volume: 1811, Issue:12

    Topics: Adenoviridae; Animals; Betaine; Ceramides; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosph

2011
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
    Molecular genetics and metabolism, 2012, Volume: 105, Issue:3

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Blood Coagulation; Cystathionine beta-Sy

2012
A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production.
    Molecular microbiology, 2012, Volume: 84, Issue:2

    Topics: Animals; Betaine; Disease Models, Animal; Gene Deletion; Hydrogen Peroxide; Hydrogen-Ion Concentrati

2012
Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.
    Molecular genetics and metabolism, 2012, Volume: 107, Issue:1-2

    Topics: Adolescent; Adult; Animals; Apolipoprotein A-I; Apolipoproteins A; Aryldialkylphosphatase; Betaine;

2012
Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:2

    Topics: Adenosylhomocysteinase; Animals; Betaine; Copper; Disease Models, Animal; DNA (Cytosine-5-)-Methyltr

2013
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
    Journal of neurochemistry, 2013, Volume: 124, Issue:3

    Topics: Alzheimer Disease; Animals; Betaine; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Lip

2013
Effects of dietary supplementation with betaine on a nonalcoholic steatohepatitis (NASH) mouse model.
    Journal of nutritional science and vitaminology, 2012, Volume: 58, Issue:5

    Topics: Alanine Transaminase; Animals; Betaine; Body Weight; Diet, High-Fat; Dietary Fats; Dietary Supplemen

2012
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice.
    The Journal of nutrition, 2013, Volume: 143, Issue:3

    Topics: Animals; Betaine; Choline; Craniofacial Abnormalities; Dietary Supplements; Disease Models, Animal;

2013
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice.
    Gastroenterology, 2003, Volume: 124, Issue:5

    Topics: Animals; Betaine; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum;

2003
Betaine and carnitine uptake systems in Listeria monocytogenes affect growth and survival in foods and during infection.
    Journal of applied microbiology, 2003, Volume: 95, Issue:4

    Topics: Animals; Betaine; Carnitine; Cryoprotective Agents; Disease Models, Animal; Food Microbiology; Human

2003
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
    The Biochemical journal, 2004, Sep-15, Volume: 382, Issue:Pt 3

    Topics: Animals; Animals, Suckling; Betaine; Body Weight; Brain; Disease Models, Animal; Female; Genotype; H

2004
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
    The Journal of nutritional biochemistry, 2004, Volume: 15, Issue:11

    Topics: Animals; Betaine; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Injections, I

2004
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes.
    The Journal of nutrition, 2005, Volume: 135, Issue:3

    Topics: Animals; Betaine; Disease Models, Animal; Ethanol; Fatty Liver; Hepatocytes; Male; Methionine; Methy

2005
Vaginal and rectal topical microbicide development: safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque.
    Sexually transmitted diseases, 2006, Volume: 33, Issue:11

    Topics: Administration, Intravaginal; Administration, Rectal; Animals; Anti-Infective Agents, Local; Betaine

2006
Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD).
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2007, Volume: 58, Issue:5

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Dialysis Solutions; Disease Models, Anim

2007
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
    Atherosclerosis, 2007, Volume: 195, Issue:2

    Topics: Animals; Animals, Genetically Modified; Aorta; Apolipoprotein A-I; Betaine; Cholesterol; Disease Mod

2007
Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:4

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Betaine; Cell Line; Dietary Carbohyd

2007
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.
    Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:3

    Topics: Adiponectin; Adipose Tissue; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal;

2008
Topical D-myo-inositol-1,2,6-trisphosphate and hexylbetaine treatment reduces albumin extravasation in experimental rat skin burn injury.
    Burns : journal of the International Society for Burn Injuries, 1998, Volume: 24, Issue:5

    Topics: Administration, Topical; Albumins; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Ster

1998
Dietary betaine modifies hepatic metabolism but not renal injury in rat polycystic kidney disease.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Betaine; Diet; Dietary Supplements; Disease Models, Animal; Kidney; Liver; Magnetic Resonan

2000
Glycine betaine excretion is not directly linked to plasma glucose concentrations in hyperglycaemia.
    Diabetes research and clinical practice, 2001, Volume: 52, Issue:3

    Topics: Animals; Betaine; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Model

2001
Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:4

    Topics: Animals; Betaine; Carnitine; Carrier Proteins; Disease Models, Animal; Fatty Acids; Infusions, Intra

2001
Experimental allergic optic neuritis (EAON) in the rabbit. A new model to study primary demyelinating diseases.
    Journal of the neurological sciences, 1975, Volume: 24, Issue:2

    Topics: Animals; Antigens; Betaine; Demyelinating Diseases; Disease Models, Animal; Epitopes; Freund's Adjuv

1975
Accumulation and excretion of long-chain acylcarnitine by rat hearts; studies with aminocarnitine.
    Biochimica et biophysica acta, 1991, Nov-21, Volume: 1097, Issue:4

    Topics: Animals; Betaine; Carnitine; Carnitine O-Palmitoyltransferase; Coronary Disease; Disease Models, Ani

1991
[Immunostimulating effect of synthetic surface-active agents in experimental tuberculosis].
    Problemy tuberkuleza, 1990, Issue:10

    Topics: Adjuvants, Immunologic; Animals; Betaine; Cyclic N-Oxides; Detergents; Disease Models, Animal; Macro

1990