Page last updated: 2024-10-16

betaine and Diabetes Mellitus, Adult-Onset

betaine has been researched along with Diabetes Mellitus, Adult-Onset in 36 studies

glycine betaine : The amino acid betaine derived from glycine.

Research Excerpts

ExcerptRelevanceReference
"Betaine is highly individual in overweight people with diabetes."9.20Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. ( Chambers, ST; Elmslie, JL; Florkowski, CM; George, PM; Krebs, JD; Lever, M; Lunt, H; McEntyre, CJ; Slow, S, 2015)
"In the present study, we attempted to elucidate whether molecular modulation of inflammation by betaine through the forkhead box O1 (FOXO1)-induced NLRP3 inflammasome improves insulin resistance."7.85Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. ( An, HJ; Chung, HY; Chung, KW; Kim, DH; Kim, KM; Kim, SM; Lee, B; Lee, EK; Moon, KM; Yu, BP, 2017)
"Betaine is highly individual in overweight people with diabetes."5.20Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. ( Chambers, ST; Elmslie, JL; Florkowski, CM; George, PM; Krebs, JD; Lever, M; Lunt, H; McEntyre, CJ; Slow, S, 2015)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
"Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)."4.02Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021)
"In the present study, we attempted to elucidate whether molecular modulation of inflammation by betaine through the forkhead box O1 (FOXO1)-induced NLRP3 inflammasome improves insulin resistance."3.85Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. ( An, HJ; Chung, HY; Chung, KW; Kim, DH; Kim, KM; Kim, SM; Lee, B; Lee, EK; Moon, KM; Yu, BP, 2017)
"Moreover, studies with animal models of type 2 diabetes have shown that betaine exerts anti-inflammatory and anti-oxidant effects, and also alleviates endoplasmic reticulum stress."2.82The anti-diabetic potential of betaine. Mechanisms of action in rodent models of type 2 diabetes. ( Szkudelska, K; Szkudelski, T, 2022)
"Identifying novel biomarkers of type 2 diabetes risk may improve prediction and prevention among individuals at high risk of the disease and elucidate new biological pathways relevant to diabetes development."2.82Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program. ( Clish, C; Florez, JC; Gerszten, RE; Ma, Y; Walford, GA; Wang, TJ, 2016)
"Betaine deficiency is a probable cardiovascular risk factor and a cause of elevated homocysteine."2.79Extreme urinary betaine losses in type 2 diabetes combined with bezafibrate treatment are associated with losses of dimethylglycine and choline but not with increased losses of other osmolytes. ( Chambers, ST; Elmslie, JL; George, PM; Krebs, JD; Lever, M; Lunt, H; McEntyre, CJ; Parry-Strong, A; Slow, S, 2014)
"Betaine prevented the increase in expression of N-methyl D-aspartate receptors in the hippocampus and in the cerebral cortex."1.62Betaine supplementation to rats alleviates disturbances induced by high-fat diet: pleiotropic effects in model of type 2 diabetes. ( Chan, MH; Jasaszwili, M; Lukomska, A; Malek, E; Okulicz, M; Shah, M; Sunder, S; Szkudelska, K; Szkudelski, T, 2021)
"The number of people affected by Type 2 diabetes mellitus (T2DM) is close to half a billion and is on a sharp rise, representing a major and growing public health burden."1.62Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes. ( Bararpour, N; Darrous, L; Froguel, P; Gasser, M; Gilardi, F; Kutalik, Z; Marques-Vidal, P; Porcu, E; Thomas, A; Waeber, G; Yengo, L, 2021)
"The incidence of type 2 diabetes is increasing more rapidly in adolescents than in any other age group."1.56Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes. ( Barshop, BA; Chen, K; Concepcion, J; Gangoiti, J; Kim, JJ; Mendez, E; Natarajan, L; Nikita, ME; Saito, R; Sharma, K, 2020)
"Among women, there was a higher risk of type 2 diabetes, comparing the highest to lowest dietary choline quartile (HR 1."1.56The Association of Dietary Choline and Betaine With the Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. ( Bidulescu, A; Dibaba, DT; Johnson, KC; Kucharska-Newton, AM; Meyer, K; Zeisel, SH, 2020)
"Betaine is a major osmolyte, also important in methyl group metabolism."1.40Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. ( Atkinson, W; Bellamy, D; Chambers, ST; Elmslie, JL; Frampton, CM; George, PM; Ho, M; Lever, M; McEntyre, CJ; Molyneux, SL; Richards, AM; Slow, S; Troughton, RW; Young, JM, 2014)
"Patients with type 2 diabetes (n  =  34) and control subjects (n  =  17) were recruited."1.38Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Slow, S, 2012)
"Elevated urinary glucose in HNF1A-MODY is consistent with the previously reported low renal threshold for glucose in this genetic subtype."1.38Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers. ( Baunsgaard, D; Faber, JH; Gloyn, AL; Lam, F; Malmodin, D; McCarthy, MI; Owen, KR; Thanabalasingham, G; Ueland, PM, 2012)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.78)18.2507
2000's2 (5.56)29.6817
2010's18 (50.00)24.3611
2020's15 (41.67)2.80

Authors

AuthorsStudies
Lu, X1
Huang, R2
Li, S1
Fang, A1
Chen, Y5
Chen, S1
Wang, F2
Lin, X1
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Edwards, TE1
Tanner, JJ1
Becker, DF1
Butcher, TW1
Yang, JL1
Hartwig, JF1
Yu, MF1
Xia, ZZ1
Yao, JC1
Feng, Z1
Li, DH1
Liu, T1
Cheng, GJ1
He, DL1
Li, XH1
Huurman, R1
Schinkel, AFL1
de Jong, PL1
van Slegtenhorst, MA1
Hirsch, A1
Michels, M1
Kataja, A1
Tarvasmäki, T1
Lassus, J1
Sionis, A1
Mebazaa, A1
Pulkki, K1
Banaszewski, M1
Carubelli, V1
Hongisto, M1
Jankowska, E1
Jurkko, R1
Jäntti, T1
Kasztura, M1
Parissis, J1
Sabell, T1
Silva-Cardoso, J1
Spinar, J1
Tolppanen, H1
Harjola, VP1
Carsetti, A1
Damiani, E1
Casarotta, E1
Scorcella, C1
Domizi, R1
Gasparri, F1
Gabbanelli, V1
Pantanetti, S1
Carozza, R1
Adrario, E1
Donati, A1
Almada, E1
Pariani, A1
Rivabella Maknis, T1
Hidalgo, F1
Vena, R1
Favre, C1
Larocca, MC1
Lu, ZY1
Jiang, WD1
Wu, P1
Kuang, SY1
Tang, L1
Yang, J1
Zhou, XQ1
Feng, L1
Leal, M1
Zampini, IC1
Mercado, MI1
Moreno, MA1
Simirgiotis, MJ1
Bórquez, J1
Ponessa, G1
Isla, MI1
Saliu, IO1
Amoo, ZA1
Khan, MF1
Olaleye, MT1
Rema, V1
Akinmoladun, AC1
Khan, AU1
Rahman, AU1
Yuan, Q1
Ahmad, A1
Khan, ZUH1
Mahnashi, MH1
Alyami, BA1
Alqahtani, YS1
Ullah, S1
Wirman, AP1
Gao, M1
Deng, L1
Zhang, K1
Wang, M1
Xia, Z1
Gao, D1
Balkissou, AD1
Poka-Mayap, V1
Massongo, M1
Djenabou, A1
Endale-Mangamba, LM1
Olomo, EJ1
Boulleys-Nana, JR1
Diffo-Sonkoue, L1
Adidigue-Ndiome, R1
Alexandra, AJE1
Haman-Wabi, AB1
Adama, S1
Iddi-Faical, A1
Pefura-Yone, EW1
Zhao, Q1
Tong, W1
Ge, C1
Zhao, D1
Norbäck, D1
Li, B1
Zhao, Z1
Huang, C1
Zhang, X1
Qian, H1
Yang, X1
Sun, Y1
Sundell, J1
Deng, Q1
Kim, HJ1
Jeon, JW1
Hwang, SM1
Chu, KI1
Cha, YH1
Kwak, YD1
Choi, SD1
Aslam, M1
Kim, CG1
Zhou, J1
Yang, E1
Yang, W1
Dibaba, DT1
Johnson, KC1
Kucharska-Newton, AM1
Meyer, K1
Zeisel, SH2
Bidulescu, A1
Kwee, LC1
Ilkayeva, O1
Muehlbauer, MJ1
Bihlmeyer, N1
Wolfe, B1
Purnell, JQ1
Xavier Pi-Sunyer, F1
Chen, H1
Bahnson, J1
Newgard, CB1
Shah, SH1
Laferrère, B1
Porcu, E1
Gilardi, F1
Darrous, L1
Yengo, L1
Bararpour, N1
Gasser, M1
Marques-Vidal, P1
Froguel, P1
Waeber, G1
Thomas, A1
Kutalik, Z1
Greenberg, JA1
Jiang, X1
Tinker, LF1
Snetselaar, LG1
Saquib, N1
Shadyab, AH1
Kim, DH1
Kim, SM1
Lee, B1
Lee, EK1
Chung, KW1
Moon, KM1
An, HJ1
Kim, KM1
Yu, BP1
Chung, HY1
Strand, E1
Rebnord, EW1
Flygel, MR1
Lysne, V1
Svingen, GFT1
Tell, GS1
Løland, KH1
Berge, RK2
Svardal, A2
Nygård, O1
Pedersen, ER1
Seeliger, J1
Estel, K1
Erwin, N1
Winter, R1
Chen, YM2
Wang, LJ1
Tan, YZ1
Zhou, JY1
Ling, WH1
Zhu, HL1
McEntyre, CJ3
Lever, M6
Chambers, ST6
George, PM4
Slow, S4
Elmslie, JL3
Florkowski, CM1
Lunt, H3
Krebs, JD2
Parry-Strong, A1
Bellamy, D1
Young, JM1
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Atkinson, W1
Molyneux, SL1
Troughton, RW1
Frampton, CM1
Richards, AM1
Walford, GA1
Ma, Y1
Clish, C1
Florez, JC1
Wang, TJ1
Gerszten, RE1
Trøseid, M1
Hov, JR1
Nestvold, TK1
Thoresen, H1
Lappegård, KT1
D'Onofrio, N1
Servillo, L1
Giovane, A1
Casale, R1
Vitiello, M1
Marfella, R1
Paolisso, G1
Balestrieri, ML1
Dullaart, RP1
Garcia, E1
Jeyarajah, E1
Tang, WH1
Fan, Y1
Li, DS1
Tassoni, E1
Conti, R1
Gallo, G1
Vincenti, S1
Dell'Uomo, N1
Mastrofrancesco, L1
Ricciolini, R1
Cabri, W1
Carminati, P1
Giannessi, F1
Patterson, AD1
Bonzo, JA1
Li, F1
Krausz, KW1
Eichler, GS1
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Tigno, X1
Weinstein, JN1
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Gloyn, AL1
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Thanabalasingham, G1
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Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Double Blind Study of the Effects of Homocysteine Lowering Therapy on Mortality and Cardiac Events in Patients Undergoing Coronary Angiography[NCT00354081]Phase 33,096 participants (Actual)Interventional1999-04-30Completed
[NCT00004992]Phase 33,234 participants (Actual)Interventional1996-07-31Completed
Effects of Flavanol-rich Dark Chocolate Consumption on Metabolic Profiles Among Obese[NCT04347304]74 participants (Anticipated)Interventional2022-03-23Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for betaine and Diabetes Mellitus, Adult-Onset

ArticleYear
The anti-diabetic potential of betaine. Mechanisms of action in rodent models of type 2 diabetes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150

    Topics: Animals; Betaine; Diabetes Mellitus, Type 2; Insulin; Insulin Resistance; Rodentia

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022

Trials

7 trials available for betaine and Diabetes Mellitus, Adult-Onset

ArticleYear
Associations between Serum Betaine, Methyl-Metabolizing Genetic Polymorphisms and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study in Community-Dwelling Chinese Adults.
    Nutrients, 2022, Jan-15, Volume: 14, Issue:2

    Topics: Adult; Aged; Asian People; Betaine; China; Cohort Studies; Diabetes Mellitus, Type 2; Female; Follow

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Metabolites and diabetes remission after weight loss.
    Nutrition & diabetes, 2021, 02-24, Volume: 11, Issue:1

    Topics: Amino Acids, Branched-Chain; Bariatric Surgery; Betaine; Biomarkers; Choline; Diabetes Mellitus, Typ

2021
Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period.
    Annals of clinical biochemistry, 2015, Volume: 52, Issue:Pt 3

    Topics: Aged; Betaine; Choline; Diabetes Mellitus, Type 2; Female; Glycerylphosphorylcholine; Humans; Male;

2015
Extreme urinary betaine losses in type 2 diabetes combined with bezafibrate treatment are associated with losses of dimethylglycine and choline but not with increased losses of other osmolytes.
    Cardiovascular drugs and therapy, 2014, Volume: 28, Issue:5

    Topics: Adult; Aged; Betaine; Bezafibrate; Choline; Diabetes Mellitus, Type 2; Female; Glycerylphosphorylcho

2014
Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program.
    Diabetes, 2016, Volume: 65, Issue:5

    Topics: Adult; Betaine; Biomarkers; Case-Control Studies; Cohort Studies; Combined Modality Therapy; Diabete

2016
Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women--a randomized control trial.
    Nutrition journal, 2012, Oct-22, Volume: 11

    Topics: Amino Acids, Branched-Chain; Betaine; Body Mass Index; Bread; Cross-Over Studies; Diabetes Mellitus,

2012

Other Studies

28 other studies available for betaine and Diabetes Mellitus, Adult-Onset

ArticleYear
Betaine supplementation to rats alleviates disturbances induced by high-fat diet: pleiotropic effects in model of type 2 diabetes.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2021, Volume: 72, Issue:5

    Topics: Animals; Betaine; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Supplements; Insulin Resistance

2021
Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort.
    Cardiovascular diabetology, 2022, 06-09, Volume: 21, Issue:1

    Topics: Aged; Betaine; Biomarkers; Carnitine; Choline; Cohort Studies; Cysteine; Diabetes Mellitus, Type 2;

2022
Integrating Choline and Specific Intestinal Microbiota to Classify Type 2 Diabetes in Adults: A Machine Learning Based Metagenomics Study.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adult; Betaine; Choline; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Gastrointestinal Microb

2022
Impaired Amino Acid Metabolism and Its Correlation with Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus.
    Nutrients, 2022, Aug-15, Volume: 14, Issue:16

    Topics: Asparagine; Betaine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dis

2022
Higher betaine is associated with lower incidence of microvascular complications in type 2 diabetes (Zodiac-61).
    European journal of clinical investigation, 2023, Volume: 53, Issue:1

    Topics: Betaine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Incidence; Risk Factors

2023
Healthy Nordic diet and associations with plasma concentrations of metabolites in the choline oxidation pathway: a cross-sectional study from Northern Sweden.
    Nutrition journal, 2023, 05-17, Volume: 22, Issue:1

    Topics: Betaine; Choline; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; Humans; Sweden

2023
Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes.
    PloS one, 2020, Volume: 15, Issue:6

    Topics: Adolescent; Amino Acids, Branched-Chain; Betaine; Biomarkers; Biosynthetic Pathways; Chromatography,

2020
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
    Diabetes & metabolism, 2021, Volume: 47, Issue:2

    Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female

2021
The Association of Dietary Choline and Betaine With the Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.
    Diabetes care, 2020, Volume: 43, Issue:11

    Topics: Betaine; Choline; Diabetes Mellitus, Type 2; Diet; Eating; Female; Follow-Up Studies; Humans; Logist

2020
Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes.
    Scientific reports, 2021, 03-18, Volume: 11, Issue:1

    Topics: Adult; Aged; Betaine; Biomarkers; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 2; Early

2021
Eggs, dietary cholesterol, choline, betaine, and diabetes risk in the Women's Health Initiative: a prospective analysis.
    The American journal of clinical nutrition, 2021, 07-01, Volume: 114, Issue:1

    Topics: Aged; Betaine; Cholesterol, Dietary; Choline; Cohort Studies; Diabetes Mellitus, Type 2; Eggs; Femal

2021
Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome.
    The Journal of nutritional biochemistry, 2017, Volume: 45

    Topics: Animals; Betaine; Carrier Proteins; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Gene Express

2017
Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris.
    The Journal of clinical endocrinology and metabolism, 2018, 03-01, Volume: 103, Issue:3

    Topics: Aged; Angina, Stable; Betaine; Body Mass Index; Carnitine; Chromatography, Liquid; Coronary Artery D

2018
Cosolvent effects on the fibrillation reaction of human IAPP.
    Physical chemistry chemical physics : PCCP, 2013, Jun-21, Volume: 15, Issue:23

    Topics: Amyloid; Betaine; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Methylamines; Protei

2013
Higher homocysteine and lower betaine increase the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C.
    Diabetes/metabolism research and reviews, 2013, Volume: 29, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Betaine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2

2013
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Betaine; Biomarkers; Cardiovascular Diseases; Case

2014
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery.
    Metabolic syndrome and related disorders, 2016, Volume: 14, Issue:4

    Topics: Adult; Atherosclerosis; Bariatric Surgery; Betaine; Body Mass Index; Cardiovascular Diseases; Carnit

2016
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
    Free radical biology & medicine, 2016, Volume: 96

    Topics: Antioxidants; Betaine; Cellular Senescence; Diabetes Mellitus, Type 2; Endothelial Cells; Ergothione

2016
Plasma phospholipid transfer protein activity is inversely associated with betaine in diabetic and non-diabetic subjects.
    Lipids in health and disease, 2016, Aug-31, Volume: 15, Issue:1

    Topics: Age Factors; Aged; Betaine; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Type 2; Female; Huma

2016
Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus.
    Clinical chemistry, 2017, Volume: 63, Issue:1

    Topics: Aged; Betaine; Blood Glucose; Choline; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Ma

2017
Aminocarnitine ureidic derivatives as inhibitors of carnitine palmitoyltransferase I.
    ChemMedChem, 2010, May-03, Volume: 5, Issue:5

    Topics: Animals; Betaine; Binding Sites; Carnitine; Carnitine O-Palmitoyltransferase; Computer Simulation; D

2010
Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus.
    The Journal of biological chemistry, 2011, Jun-03, Volume: 286, Issue:22

    Topics: Amino Acid Transport Systems, Neutral; Animals; Betaine; Citric Acid; Diabetes Mellitus, Experimenta

2011
Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study.
    Cardiovascular diabetology, 2012, Jul-11, Volume: 11

    Topics: Aged; Betaine; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Female; G

2012
Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Adult; Amino Acids; Betaine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diagnosis,

2012
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
    Diabetes, 2013, Volume: 62, Issue:6

    Topics: Adult; Betaine; Diabetes Mellitus, Type 2; Female; Glycine; Humans; Insulin Resistance; Male; Middle

2013
Homocysteine metabolism in ZDF (type 2) diabetic rats.
    Diabetes, 2005, Volume: 54, Issue:11

    Topics: Animals; Betaine; Cells, Cultured; Diabetes Mellitus, Type 2; Gene Expression Regulation, Enzymologi

2005
Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia.
    Diabetes research and clinical practice, 1999, Volume: 43, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Alkaloids; Betaine; Biomarkers; Carnitine; Creatinine; Diabetes Mell

1999
Glycine betaine excretion is not directly linked to plasma glucose concentrations in hyperglycaemia.
    Diabetes research and clinical practice, 2001, Volume: 52, Issue:3

    Topics: Animals; Betaine; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Model

2001