betaine has been researched along with Delayed Effects, Prenatal Exposure in 19 studies
glycine betaine : The amino acid betaine derived from glycine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years." | 7.79 | Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013) |
| "Abnormally high levels of homocysteine (Hcy) are associated with autism spectrum disorder." | 3.91 | Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. ( Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J, 2019) |
| "In this study, gestational sows were fed control or betaine-supplemented diets (3 g/kg) throughout the pregnancy, and the newborn piglets were used to elucidate whether maternal dietary betaine affected offspring hepatic gluconeogenic genes through epigenetic mechanisms." | 3.80 | Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. ( Cai, D; Jia, Y; Jiang, Z; Lu, J; Song, H; Sui, S; Zhao, R, 2014) |
| " Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years." | 3.79 | Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013) |
| " We examined the associations of maternal intake of folate, vitamin B12, choline, betaine and methionine during the first and second trimesters of pregnancy, with tests of cognitive performance in the offspring at 3 years of age using data from 1210 participants in Project Viva, a prospective pre-birth cohort study in Massachusetts." | 3.78 | Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. ( Gillman, MW; Oken, E; Rifas-Shiman, SL; Villamor, E, 2012) |
| " We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation." | 3.74 | A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats. ( Os'kina, IN; Plyusnina, IZ; Prasolova, LA; Shchepina, OA; Trut, LN, 2007) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide." | 2.66 | One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020) |
| "Betaine serves as a methyl donor for DNA methylation." | 1.56 | Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus. ( Jiang, W; Qi, F; Yang, S; Yang, Y; Zhao, R, 2020) |
| "Colitis was induced by dextran sulfate sodium." | 1.37 | Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. ( Dowd, SE; Harris, RA; Kellermayer, R; Schaible, TD; Smith, CW, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, S | 4 |
| Zhao, N | 3 |
| Sun, B | 3 |
| Yang, Y | 2 |
| Hu, Y | 2 |
| Zhao, R | 7 |
| Radziejewska, A | 1 |
| Muzsik, A | 1 |
| Milagro, FI | 1 |
| Martínez, JA | 1 |
| Chmurzynska, A | 1 |
| Jiang, W | 1 |
| Qi, F | 1 |
| Karunamuni, G | 1 |
| Sheehan, MM | 1 |
| Doughman, YQ | 1 |
| Gu, S | 1 |
| Sun, J | 2 |
| Li, Y | 1 |
| Strainic, JP | 1 |
| Rollins, AM | 1 |
| Jenkins, MW | 1 |
| Watanabe, M | 1 |
| Huang, F | 1 |
| Chen, X | 1 |
| Jiang, X | 1 |
| Niu, J | 1 |
| Cui, C | 1 |
| Chen, Z | 2 |
| Feng, Y | 2 |
| Boeke, CE | 1 |
| Gillman, MW | 2 |
| Hughes, MD | 1 |
| Rifas-Shiman, SL | 2 |
| Villamor, E | 2 |
| Oken, E | 2 |
| Surina, NM | 1 |
| Ashapkin, VV | 1 |
| Merzalov, IB | 1 |
| Perepelkina, OV | 1 |
| Fedotova, IB | 1 |
| Pavlova, GV | 1 |
| Poletaeva, II | 1 |
| Cai, D | 1 |
| Jia, Y | 2 |
| Song, H | 1 |
| Sui, S | 1 |
| Lu, J | 1 |
| Jiang, Z | 1 |
| Kusat Ol, K | 1 |
| Kanbak, G | 2 |
| Oğlakcı Ilhan, A | 1 |
| Burukoglu, D | 1 |
| Yücel, F | 2 |
| Sun, Q | 2 |
| Li, X | 1 |
| Pan, S | 1 |
| Li, R | 1 |
| Yang, X | 1 |
| Zong, Y | 1 |
| Liu, J | 1 |
| Idriss, AA | 1 |
| Omer, NA | 1 |
| Sogut, I | 1 |
| Uysal, O | 1 |
| Oglakci, A | 1 |
| Kartkaya, K | 1 |
| Prasolova, LA | 2 |
| Os'kina, IN | 2 |
| Pliusnina, IZ | 1 |
| Trut, LN | 2 |
| Schaible, TD | 1 |
| Harris, RA | 1 |
| Dowd, SE | 1 |
| Smith, CW | 1 |
| Kellermayer, R | 1 |
| Schwahn, BC | 1 |
| Wu, Q | 1 |
| He, X | 1 |
| Rozen, R | 1 |
| Plyusnina, IZ | 1 |
| Shchepina, OA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235] | 653 participants (Anticipated) | Interventional | 2021-02-12 | Recruiting | |||
| Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)[NCT03269110] | 2,578 participants (Anticipated) | Observational | 2017-07-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for betaine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi | 2020 |
18 other studies available for betaine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Topics: Animals; Betaine; Dietary Supplements; DNA Methylation; Female; Insulin-Like Growth Factor II; Liver | 2020 |
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Topics: Animals; Aromatase; Betaine; Body Weight; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; | 2020 |
Supplementation with the Methyl Donor Betaine Prevents Congenital Defects Induced by Prenatal Alcohol Exposure.
Topics: Animals; Betaine; Coturnix; Dietary Supplements; Embryonic Development; Ethanol; Female; Heart Defec | 2017 |
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Anim | 2019 |
Enhanced hepatic cholesterol accumulation induced by maternal betaine exposure is associated with hypermethylation of CYP7A1 gene promoter.
Topics: Animals; Betaine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; DNA Methylation; Female; Liver; Mate | 2019 |
Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation.
Topics: Adipose Tissue; Animals; Betaine; Dietary Supplements; DNA Methylation; Female; Glucocorticoids; Lip | 2020 |
Choline intake during pregnancy and child cognition at age 7 years.
Topics: Adult; Betaine; Child; Child Development; Choline; Cognition; Dietary Supplements; Female; Folic Aci | 2013 |
Audiogenic seizure proneness after methyl-enriched diet in ontogeny.
Topics: Animals; Betaine; Choline; Diet; DNA Methylation; Epilepsy, Reflex; Female; Methionine; Pregnancy; P | 2014 |
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Femal | 2014 |
The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3.
Topics: Animals; Betaine; Brain; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Fatty | 2016 |
Maternal betaine supplementation during gestation modifies hippocampal expression of GR and its regulatory miRNAs in neonatal piglets.
Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; Female; Gene Expression Regulation, Develop | 2016 |
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents; Betaine; Blotting, Western; Chickens; Ch | 2017 |
Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine.
Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Blood Alcohol Content; Calpain; Caspase 3; Cathepsin | 2017 |
[Methyl-containing diet of mothers affects the AGOUTI gene expression in the offspring of rats with various behavioral types].
Topics: Aggression; Agouti Signaling Protein; Animals; Behavior, Animal; Betaine; Choline; Dietary Supplemen | 2009 |
Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes.
Topics: Animals; Bacteria; Betaine; Choline; Colitis; Dietary Supplements; Disease Susceptibility; DNA Methy | 2011 |
Maternal intake of methyl-donor nutrients and child cognition at 3 years of age.
Topics: Adult; Betaine; Child Development; Child, Preschool; Choline; Cognition; Cohort Studies; Diet; DNA M | 2012 |
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase.
Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Body Patterning; Body Weight; Brain; Cell Division; C | 2005 |
A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats.
Topics: Age Factors; Animal Feed; Animals; Anxiety; Betaine; Brain; Choline; Critical Period, Psychological; | 2007 |