Page last updated: 2024-10-16

betaine and Delayed Effects, Prenatal Exposure

betaine has been researched along with Delayed Effects, Prenatal Exposure in 19 studies

glycine betaine : The amino acid betaine derived from glycine.

Research Excerpts

ExcerptRelevanceReference
" Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years."7.79Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013)
"Abnormally high levels of homocysteine (Hcy) are associated with autism spectrum disorder."3.91Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. ( Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J, 2019)
"In this study, gestational sows were fed control or betaine-supplemented diets (3 g/kg) throughout the pregnancy, and the newborn piglets were used to elucidate whether maternal dietary betaine affected offspring hepatic gluconeogenic genes through epigenetic mechanisms."3.80Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. ( Cai, D; Jia, Y; Jiang, Z; Lu, J; Song, H; Sui, S; Zhao, R, 2014)
" Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory (measured by the Wide Range Assessment of Memory and Learning, Second Edition (WRAML2), Design and Picture Memory subtests) and intelligence (measured using the Kaufman Brief Intelligence Test, Second Edition (KBIT-2)) at age 7 years."3.79Choline intake during pregnancy and child cognition at age 7 years. ( Boeke, CE; Gillman, MW; Hughes, MD; Oken, E; Rifas-Shiman, SL; Villamor, E, 2013)
" We examined the associations of maternal intake of folate, vitamin B12, choline, betaine and methionine during the first and second trimesters of pregnancy, with tests of cognitive performance in the offspring at 3 years of age using data from 1210 participants in Project Viva, a prospective pre-birth cohort study in Massachusetts."3.78Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. ( Gillman, MW; Oken, E; Rifas-Shiman, SL; Villamor, E, 2012)
" We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation."3.74A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats. ( Os'kina, IN; Plyusnina, IZ; Prasolova, LA; Shchepina, OA; Trut, LN, 2007)
"The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide."2.66One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. ( Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A, 2020)
"Betaine serves as a methyl donor for DNA methylation."1.56Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus. ( Jiang, W; Qi, F; Yang, S; Yang, Y; Zhao, R, 2020)
"Colitis was induced by dextran sulfate sodium."1.37Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. ( Dowd, SE; Harris, RA; Kellermayer, R; Schaible, TD; Smith, CW, 2011)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.79)29.6817
2010's12 (63.16)24.3611
2020's4 (21.05)2.80

Authors

AuthorsStudies
Yang, S4
Zhao, N3
Sun, B3
Yang, Y2
Hu, Y2
Zhao, R7
Radziejewska, A1
Muzsik, A1
Milagro, FI1
Martínez, JA1
Chmurzynska, A1
Jiang, W1
Qi, F1
Karunamuni, G1
Sheehan, MM1
Doughman, YQ1
Gu, S1
Sun, J2
Li, Y1
Strainic, JP1
Rollins, AM1
Jenkins, MW1
Watanabe, M1
Huang, F1
Chen, X1
Jiang, X1
Niu, J1
Cui, C1
Chen, Z2
Feng, Y2
Boeke, CE1
Gillman, MW2
Hughes, MD1
Rifas-Shiman, SL2
Villamor, E2
Oken, E2
Surina, NM1
Ashapkin, VV1
Merzalov, IB1
Perepelkina, OV1
Fedotova, IB1
Pavlova, GV1
Poletaeva, II1
Cai, D1
Jia, Y2
Song, H1
Sui, S1
Lu, J1
Jiang, Z1
Kusat Ol, K1
Kanbak, G2
Oğlakcı Ilhan, A1
Burukoglu, D1
Yücel, F2
Sun, Q2
Li, X1
Pan, S1
Li, R1
Yang, X1
Zong, Y1
Liu, J1
Idriss, AA1
Omer, NA1
Sogut, I1
Uysal, O1
Oglakci, A1
Kartkaya, K1
Prasolova, LA2
Os'kina, IN2
Pliusnina, IZ1
Trut, LN2
Schaible, TD1
Harris, RA1
Dowd, SE1
Smith, CW1
Kellermayer, R1
Schwahn, BC1
Wu, Q1
He, X1
Rozen, R1
Plyusnina, IZ1
Shchepina, OA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235]653 participants (Anticipated)Interventional2021-02-12Recruiting
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)[NCT03269110]2,578 participants (Anticipated)Observational2017-07-01Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for betaine and Delayed Effects, Prenatal Exposure

ArticleYear
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
    Lifestyle genomics, 2020, Volume: 13, Issue:2

    Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbi

2020

Other Studies

18 other studies available for betaine and Delayed Effects, Prenatal Exposure

ArticleYear
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
    Journal of the science of food and agriculture, 2020, Mar-15, Volume: 100, Issue:4

    Topics: Animals; Betaine; Dietary Supplements; DNA Methylation; Female; Insulin-Like Growth Factor II; Liver

2020
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
    Molecular nutrition & food research, 2020, Volume: 64, Issue:8

    Topics: Animals; Aromatase; Betaine; Body Weight; Dietary Supplements; DNA Methylation; Epigenesis, Genetic;

2020
Supplementation with the Methyl Donor Betaine Prevents Congenital Defects Induced by Prenatal Alcohol Exposure.
    Alcoholism, clinical and experimental research, 2017, Volume: 41, Issue:11

    Topics: Animals; Betaine; Coturnix; Dietary Supplements; Embryonic Development; Ethanol; Female; Heart Defec

2017
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
    Psychiatry and clinical neurosciences, 2019, Volume: 73, Issue:6

    Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Anim

2019
Enhanced hepatic cholesterol accumulation induced by maternal betaine exposure is associated with hypermethylation of CYP7A1 gene promoter.
    Endocrine, 2019, Volume: 64, Issue:3

    Topics: Animals; Betaine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; DNA Methylation; Female; Liver; Mate

2019
Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation.
    European journal of nutrition, 2020, Volume: 59, Issue:4

    Topics: Adipose Tissue; Animals; Betaine; Dietary Supplements; DNA Methylation; Female; Glucocorticoids; Lip

2020
Choline intake during pregnancy and child cognition at age 7 years.
    American journal of epidemiology, 2013, Jun-15, Volume: 177, Issue:12

    Topics: Adult; Betaine; Child; Child Development; Choline; Cognition; Dietary Supplements; Female; Folic Aci

2013
Audiogenic seizure proneness after methyl-enriched diet in ontogeny.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2014, Volume: 454

    Topics: Animals; Betaine; Choline; Diet; DNA Methylation; Epilepsy, Reflex; Female; Methionine; Pregnancy; P

2014
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Femal

2014
The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:3

    Topics: Animals; Betaine; Brain; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Fatty

2016
Maternal betaine supplementation during gestation modifies hippocampal expression of GR and its regulatory miRNAs in neonatal piglets.
    The Journal of veterinary medical science, 2016, Jul-01, Volume: 78, Issue:6

    Topics: Animals; Animals, Newborn; Betaine; Dietary Supplements; Female; Gene Expression Regulation, Develop

2016
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
    General and comparative endocrinology, 2017, 05-15, Volume: 246

    Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents; Betaine; Blotting, Western; Chickens; Ch

2017
Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017, Volume: 33, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Blood Alcohol Content; Calpain; Caspase 3; Cathepsin

2017
[Methyl-containing diet of mothers affects the AGOUTI gene expression in the offspring of rats with various behavioral types].
    Genetika, 2009, Volume: 45, Issue:5

    Topics: Aggression; Agouti Signaling Protein; Animals; Behavior, Animal; Betaine; Choline; Dietary Supplemen

2009
Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes.
    Human molecular genetics, 2011, May-01, Volume: 20, Issue:9

    Topics: Animals; Bacteria; Betaine; Choline; Colitis; Dietary Supplements; Disease Susceptibility; DNA Methy

2011
Maternal intake of methyl-donor nutrients and child cognition at 3 years of age.
    Paediatric and perinatal epidemiology, 2012, Volume: 26, Issue:4

    Topics: Adult; Betaine; Child Development; Child, Preschool; Choline; Cognition; Cohort Studies; Diet; DNA M

2012
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2005, Volume: 23, Issue:5

    Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Body Patterning; Body Weight; Brain; Cell Division; C

2005
A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats.
    Neuroscience and behavioral physiology, 2007, Volume: 37, Issue:5

    Topics: Age Factors; Animal Feed; Animals; Anxiety; Betaine; Brain; Choline; Critical Period, Psychological;

2007