betaine has been researched along with Deficiency, Vitamin B 12 in 26 studies
glycine betaine : The amino acid betaine derived from glycine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with combined methylmalonic acidemia and homocystinuria respond to a combined treatment consisting of supplementation of hydroxycobalamin, betaine, folic acid, vitamin B6 and L-carnitine with clinical and biochemical improvement." | 7.79 | [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. ( Gao, XL; Gu, XF; Han, LS; Huang, Z; Ji, WJ; Li, XY; Qiu, WJ; Wang, Y; Ye, J; Zhang, HW, 2013) |
| "Choline needs are increased in pregnancy." | 7.79 | Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013) |
| "The use of hydroxocobalamin (OH-B12), betaine, carnitine, and folinic acid were studied in two children with the cobalamin C form of methylmalonic acidemia and homocystinuria." | 7.67 | Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria. ( Allen, RH; Bartholomew, DW; Batshaw, ML; Francomano, CA; Roe, CR; Rosenblatt, D; Valle, DL, 1988) |
| "Patients with combined methylmalonic acidemia and homocystinuria respond to a combined treatment consisting of supplementation of hydroxycobalamin, betaine, folic acid, vitamin B6 and L-carnitine with clinical and biochemical improvement." | 3.79 | [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. ( Gao, XL; Gu, XF; Han, LS; Huang, Z; Ji, WJ; Li, XY; Qiu, WJ; Wang, Y; Ye, J; Zhang, HW, 2013) |
| "Choline needs are increased in pregnancy." | 3.79 | Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013) |
| " Nitrous oxide (N2O), which inactivates vitamin B-12 in vivo, results in neurological impairment leading to ataxia and death in the fruit bat Rousettus ." | 3.67 | Betaine delays the onset of neurological impairment in nitrous oxide-induced vitamin B-12 deficiency in fruit bats. ( Metz, J; van der Westhuyzen, J, 1984) |
| "The use of hydroxocobalamin (OH-B12), betaine, carnitine, and folinic acid were studied in two children with the cobalamin C form of methylmalonic acidemia and homocystinuria." | 3.67 | Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria. ( Allen, RH; Bartholomew, DW; Batshaw, ML; Francomano, CA; Roe, CR; Rosenblatt, D; Valle, DL, 1988) |
| "Betaine is an "alternate" methyl donor for homocysteine remethylation catalyzed by betaine homocysteine methyltransferase (BHMT), an enzyme mainly expressed in the liver and kidney." | 3.11 | Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. ( Alberti, C; Benoist, JF; de Baulny, HO; Feillet, F; Garcia-Segarra, N; Guilmin-Crépon, S; Haignere, J; Imbard, A; Kaguelidou, F; Kuster, A; Magréault, S; Perronneau, I; Schiff, M; Schlemmer, D; Toumazi, A, 2022) |
| "Among 13 patients who exhibited spastic paraplegia as the main manifestation, 11 patients carried c." | 1.72 | Late-onset cblC deficiency around puberty: a retrospective study of the clinical characteristics, diagnosis, and treatment. ( Chen, Z; Dong, H; He, R; Jin, Y; Kang, L; Li, D; Li, M; Liu, X; Liu, Y; Qi, J; Song, J; Wang, F; Xiao, H; Yan, H; Yang, Y; Zhang, Y; Zheng, H, 2022) |
| "Malignant hypertension was diagnosed." | 1.40 | Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency. ( Benoist, JF; Cornec-Le Gall, E; De Parscau, L; Delmas, Y; Doucet, L; Fremeaux-Bacchi, V; Le Meur, Y; Ogier, H, 2014) |
| "Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance." | 1.39 | Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (34.62) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 8 (30.77) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z | 1 |
| Dong, H | 1 |
| Liu, Y | 2 |
| He, R | 1 |
| Song, J | 1 |
| Jin, Y | 1 |
| Li, M | 1 |
| Liu, X | 2 |
| Yan, H | 1 |
| Qi, J | 1 |
| Wang, F | 1 |
| Xiao, H | 1 |
| Zheng, H | 1 |
| Kang, L | 1 |
| Li, D | 1 |
| Zhang, Y | 1 |
| Yang, Y | 1 |
| Imbard, A | 1 |
| Toumazi, A | 1 |
| Magréault, S | 1 |
| Garcia-Segarra, N | 1 |
| Schlemmer, D | 1 |
| Kaguelidou, F | 1 |
| Perronneau, I | 1 |
| Haignere, J | 1 |
| de Baulny, HO | 1 |
| Kuster, A | 1 |
| Feillet, F | 1 |
| Alberti, C | 1 |
| Guilmin-Crépon, S | 1 |
| Benoist, JF | 2 |
| Schiff, M | 1 |
| Jaisson, S | 1 |
| Desmons, A | 1 |
| Braconnier, A | 1 |
| Wynckel, A | 1 |
| Rieu, P | 1 |
| Gillery, P | 1 |
| Garnotel, R | 1 |
| Liu, J | 1 |
| Peng, Y | 1 |
| Zhou, N | 1 |
| Meng, Q | 1 |
| Xu, H | 1 |
| Zhao, S | 1 |
| Prasun, P | 1 |
| Chapel-Crespo, C | 1 |
| Williamson, A | 1 |
| Chu, P | 1 |
| Oishi, K | 1 |
| Diaz, G | 1 |
| Alsayed, R | 1 |
| Al Quobaili, F | 1 |
| Srour, S | 1 |
| Geisel, J | 1 |
| Obeid, R | 1 |
| Huang, Z | 1 |
| Han, LS | 1 |
| Ye, J | 1 |
| Qiu, WJ | 1 |
| Zhang, HW | 1 |
| Gao, XL | 1 |
| Wang, Y | 1 |
| Ji, WJ | 1 |
| Li, XY | 1 |
| Gu, XF | 1 |
| Iodice, FG | 1 |
| Di Chiara, L | 1 |
| Boenzi, S | 1 |
| Aiello, C | 1 |
| Monti, L | 1 |
| Cogo, P | 1 |
| Dionisi-Vici, C | 1 |
| Wu, BT | 1 |
| Innis, SM | 1 |
| Mulder, KA | 1 |
| Dyer, RA | 1 |
| King, DJ | 1 |
| Cornec-Le Gall, E | 1 |
| Delmas, Y | 1 |
| De Parscau, L | 1 |
| Doucet, L | 1 |
| Ogier, H | 1 |
| Fremeaux-Bacchi, V | 1 |
| Le Meur, Y | 1 |
| Nurk, E | 1 |
| Refsum, H | 1 |
| Bjelland, I | 1 |
| Drevon, CA | 1 |
| Tell, GS | 1 |
| Ueland, PM | 1 |
| Vollset, SE | 1 |
| Engedal, K | 1 |
| Nygaard, HA | 1 |
| Smith, DA | 1 |
| YOUNG, RJ | 1 |
| NORRIS, LC | 1 |
| HEUSER, GF | 1 |
| STEKOL, JA | 1 |
| WEISS, S | 1 |
| ANDERSON, EI | 1 |
| HSU, PT | 1 |
| WATJEN, A | 1 |
| Tsina, EK | 1 |
| Marsden, DL | 1 |
| Hansen, RM | 1 |
| Fulton, AB | 1 |
| Huemer, M | 1 |
| Simma, B | 1 |
| Fowler, B | 1 |
| Suormala, T | 1 |
| Bodamer, OA | 1 |
| Sass, JO | 1 |
| Navrátil, T | 1 |
| Petr, M | 1 |
| Senholdová, Z | 1 |
| Pristoupilová, K | 1 |
| Pristoupil, TI | 1 |
| Heyrovský, M | 1 |
| Pelclová, D | 1 |
| Kohlíková, E | 1 |
| Reed, MC | 1 |
| Nijhout, HF | 1 |
| Neuhouser, ML | 1 |
| Gregory, JF | 1 |
| Shane, B | 1 |
| James, SJ | 1 |
| Boynton, A | 1 |
| Ulrich, CM | 1 |
| van der Westhuyzen, J | 2 |
| Metz, J | 2 |
| Allen, RH | 3 |
| Stabler, SP | 2 |
| Lindenbaum, J | 2 |
| Savage, DG | 1 |
| Bartholomew, DW | 1 |
| Batshaw, ML | 1 |
| Roe, CR | 1 |
| Rosenblatt, D | 1 |
| Valle, DL | 1 |
| Francomano, CA | 1 |
| van Tonder, SV | 1 |
| Gibson, JE | 1 |
| Kilroe-Smith, TA | 1 |
| Nath, MC | 1 |
| Nath, N | 1 |
| Buehring, KU | 1 |
| Batra, KK | 1 |
| Stokstad, EL | 1 |
| Keshavarz, K | 1 |
| Fuller, HL | 1 |
| Marston, HR | 1 |
| Allen, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Betaine METABOLISM OF PATIENTS With Homocystinuria[NCT02404337] | Phase 2 | 12 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for betaine and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Animals; Betaine | 1993 |
1 trial available for betaine and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial.
Topics: Betaine; Child; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Methionine; Prosp | 2022 |
24 other studies available for betaine and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Late-onset cblC deficiency around puberty: a retrospective study of the clinical characteristics, diagnosis, and treatment.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Betaine; Carnitine; Child; Female; Homocyst | 2022 |
An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies.
Topics: Aged; Betaine; Female; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Leucovorin; Methy | 2020 |
Combined methylmalonic acidemia and homocysteinemia presenting predominantly with late-onset diffuse lung disease: a case series of four patients.
Topics: Betaine; Child; Child, Preschool; Female; Folic Acid; Homocystinuria; Humans; Infant; Lung Diseases; | 2017 |
Skin lesions in a patient with Cobalamin C disease in poor metabolic control.
Topics: Betaine; Biopsy; Child; Drug Therapy, Combination; Homocystinuria; Humans; Injections; Leucovorin; M | 2018 |
Elevated dimethylglycine in blood of children with congenital heart defects and their mothers.
Topics: Adult; Betaine; Betaine-Homocysteine S-Methyltransferase; Biomarkers; Child, Preschool; Choline; Chr | 2013 |
[Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Betaine; Carnitine; Child; Child, Preschool | 2013 |
Cobalamin C defect presenting with isolated pulmonary hypertension.
Topics: Betaine; Brain; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Folic Acid; Ge | 2013 |
Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants.
Topics: Adult; Betaine; British Columbia; Child Development; Choline; Dietary Supplements; Female; Folic Aci | 2013 |
Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Antibodies, Monoclonal, Humanized; Betaine; Biopsy; Car | 2014 |
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies | 2013 |
The utilization by vitamin B12-deficient chicks of monomethylaminoethanol, homocystine and betaine as precursors of choline and methionine.
Topics: Amino Acids; Amino Alcohols; Animals; Betaine; Chickens; Choline; Homocystine; Methionine; Vitamin B | 1954 |
Vitamin B12 and folic acid in relation to methionine synthesis from betaine in vivo and invitro.
Topics: Betaine; Choline; Folic Acid; Folic Acid Deficiency; Humans; Methionine; Vitamin B 12; Vitamin B 12 | 1957 |
Maculopathy and retinal degeneration in cobalamin C methylmalonic aciduria and homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Cobamides; Female; Homocysteine; Homocystinuria; Huma | 2005 |
Prenatal and postnatal treatment in cobalamin C defect.
Topics: Betaine; Carnitine; Female; Folic Acid; Hematinics; Humans; Hydroxocobalamin; Infant, Newborn; Lipot | 2005 |
Diagnostic significance of urinary thiodiglycolic acid as a possible tool for studying the role of vitamins B12 and folates in the metabolism of thiolic substances.
Topics: Adult; Betaine; Biomarkers; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Leucovorin; | 2007 |
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
Topics: Betaine; Carbon; DNA Methylation; Folic Acid; Formate-Tetrahydrofolate Ligase; Homocysteine; Humans; | 2006 |
Betaine delays the onset of neurological impairment in nitrous oxide-induced vitamin B-12 deficiency in fruit bats.
Topics: Animals; Ataxia; Betaine; Body Weight; Chiroptera; Diet; Homocysteine; Methionine; Nitrous Oxide; Vi | 1984 |
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.
Topics: Adolescent; Adult; Aged; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Chromatography; | 1993 |
Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria.
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Betaine; Carnitine; Child, Preschool; Fe | 1988 |
Plasma amino acids and tissue methionine levels in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency.
Topics: Amino Acids; Animals; Betaine; Chiroptera; Methionine; Nervous System; Nitrous Oxide; Vitamin B 12 D | 1985 |
Effect of ketone bodies and ACTH on the transmethylation reaction (S-adenosyl methionine independent system) in rats. I.
Topics: Acetoacetates; Adrenocorticotropic Hormone; Animals; Betaine; Depression, Chemical; Drug Synergism; | 1969 |
The effect of methionine on folic acid and histidine metabolism in perfused rat liver.
Topics: Animals; Betaine; Carbon Dioxide; Carbon Isotopes; Choline; Deficiency Diseases; Drug Synergism; Eth | 1972 |
Relationship of arginine and methionine to creatine formation in chicks.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Arginine; Betaine; Body Weight; Ch | 1971 |
Factors affecting formiminoglutamic acid excretion in vitamin B 12 deficiency.
Topics: Aminopterin; Animals; Betaine; Female; Folic Acid; Folic Acid Deficiency; Glutarates; Histidine; Mal | 1970 |